Organ-derived dendritic cells have differential effects
... Langerhans cells seems to be efficient in preventing skin GVHD.12 However, there is also increasing evidence implicating crosspresenting donor APCs in acute13 and chronic14 GVHD. The importance of antigen expression by epithelial, nonhematopoietic GVHD target organ cells is still being disputed.15,1 ...
... Langerhans cells seems to be efficient in preventing skin GVHD.12 However, there is also increasing evidence implicating crosspresenting donor APCs in acute13 and chronic14 GVHD. The importance of antigen expression by epithelial, nonhematopoietic GVHD target organ cells is still being disputed.15,1 ...
The high proliferative potential colony assay
... http://www.copewithcytokines.de/cope.cgi The term cytokine, or Immunocytokines , was used initially to separate a group of immunomodulatory proteins, called also Immunotransmitters , from other Growth factors that modulate the proliferation and bioactivities of non-immune cells. Some cytokines ...
... http://www.copewithcytokines.de/cope.cgi The term cytokine, or Immunocytokines , was used initially to separate a group of immunomodulatory proteins, called also Immunotransmitters , from other Growth factors that modulate the proliferation and bioactivities of non-immune cells. Some cytokines ...
Chapter Twenty Four
... consists of T- and B-lymphocytes and macrophages. • In the center of each cluster is a central artery. • The red pulp is associated with the venous supply. • Red pulp consists of splenic cords and splenic sinusoids that contain erythrocytes, platelets, macrophages, and some plasma cells. • Blood cel ...
... consists of T- and B-lymphocytes and macrophages. • In the center of each cluster is a central artery. • The red pulp is associated with the venous supply. • Red pulp consists of splenic cords and splenic sinusoids that contain erythrocytes, platelets, macrophages, and some plasma cells. • Blood cel ...
Jeopardy
... IgG antibodies inactivate microbes by blocking their attachment to host cells in the binding process known as a. neutralization. b. agglutination. c. antibody-dependent cell-mediated cytotoxicity. d. opsonization. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. ...
... IgG antibodies inactivate microbes by blocking their attachment to host cells in the binding process known as a. neutralization. b. agglutination. c. antibody-dependent cell-mediated cytotoxicity. d. opsonization. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. ...
- Wiley Online Library
... study, we aimed to address the effect of safrole on immune responses in leukemic mice in vivo. Herein, we established leukemic BALB/c mice through the intraperitoneal injection with murine WEHI-3 cells (Yang et al., 2006; Lu et al., 2007), and then chronically treated mice with safrole. Our findings ...
... study, we aimed to address the effect of safrole on immune responses in leukemic mice in vivo. Herein, we established leukemic BALB/c mice through the intraperitoneal injection with murine WEHI-3 cells (Yang et al., 2006; Lu et al., 2007), and then chronically treated mice with safrole. Our findings ...
Immune suppression in cancer: Effects on immune cells
... Also, delayed type hypersensitivity responses (DTH) to recall antigens were found to be absent in individuals who later developed a malignancy [12]. However, these are sporadic or anecdotal reports that have not been uniformly accepted as evidence for a lack of immune surveillance in individuals at ...
... Also, delayed type hypersensitivity responses (DTH) to recall antigens were found to be absent in individuals who later developed a malignancy [12]. However, these are sporadic or anecdotal reports that have not been uniformly accepted as evidence for a lack of immune surveillance in individuals at ...
3d bio-printing - Ulster Institutional Repository
... remembered that heterogeneity of the tumour cells leads to the huge diversity with a high degree of genetic instability and phenotypic variation. Prior to plunge into the trial of a promising anticancer drug, pharmaceutical companies and institutional investigators conduct wide pre-clinical experime ...
... remembered that heterogeneity of the tumour cells leads to the huge diversity with a high degree of genetic instability and phenotypic variation. Prior to plunge into the trial of a promising anticancer drug, pharmaceutical companies and institutional investigators conduct wide pre-clinical experime ...
B Lymphocytes in Cancer Immunology
... patients, often recognize structures associated with apoptosis and cell death which are processes that accompany tumor progression [39, 40]. Tumor-Infiltrating B Cells Lymphocytic infiltrates are found in most solid tumors. The dominant cell population is usually T cells; in general, the more T cell ...
... patients, often recognize structures associated with apoptosis and cell death which are processes that accompany tumor progression [39, 40]. Tumor-Infiltrating B Cells Lymphocytic infiltrates are found in most solid tumors. The dominant cell population is usually T cells; in general, the more T cell ...
From blood typing to a transport metabolon at a crossroad. Focus on
... extracellular ion gradients created within the unstirred layer on the surface of ion-transporting epithelial cells (18, 19). SIET uses a microelectrode having a tip diameter of ⬃5 m and a thin layer (⬃250 m) of an ion-selective ionophore cocktail in its tip. By a modulation technique using a vibra ...
... extracellular ion gradients created within the unstirred layer on the surface of ion-transporting epithelial cells (18, 19). SIET uses a microelectrode having a tip diameter of ⬃5 m and a thin layer (⬃250 m) of an ion-selective ionophore cocktail in its tip. By a modulation technique using a vibra ...
Journal of Allergy and Clinical Immunology
... bordeline between a normal, useful immune response and hypersensitivity is blurred. Hypersensitivity reactions may also occur in many other conditions involving immune reactions, particularly autoimmunity and transplantation. In type II hypersensitivity, antibody directed against cell surface or tis ...
... bordeline between a normal, useful immune response and hypersensitivity is blurred. Hypersensitivity reactions may also occur in many other conditions involving immune reactions, particularly autoimmunity and transplantation. In type II hypersensitivity, antibody directed against cell surface or tis ...
Deciphering the tête-à-tête between the microbiota and the
... that PRRs may contribute to recognition of some immunomodulatory bacteria but that other, yet-unidentified pathways exist as well. After the host recognizes the bacteria, the transfer of immunogenic signals to the lamina propria, which eventually leads to T cell proliferation, must take place. This ...
... that PRRs may contribute to recognition of some immunomodulatory bacteria but that other, yet-unidentified pathways exist as well. After the host recognizes the bacteria, the transfer of immunogenic signals to the lamina propria, which eventually leads to T cell proliferation, must take place. This ...
University of Groningen Bottlenecks, budgets and immunity
... the liver produces acute phase proteins and diverts amino acids away from normal processes (such as growth or reproduction). In addition, regular body cells increase protein turnover and MHC type I presentation to CD8 T-cells. At the same time dendritic cells, which have engulfed the pathogen, are m ...
... the liver produces acute phase proteins and diverts amino acids away from normal processes (such as growth or reproduction). In addition, regular body cells increase protein turnover and MHC type I presentation to CD8 T-cells. At the same time dendritic cells, which have engulfed the pathogen, are m ...
Aplastic Anemia: Current Thinking on the Disease
... • The rates are double this in Asia • The incidence between males and females is equal, although this may differ depending on location and age • The ages where this is most common include ages 15-24 and those greater than age 45 • The highest incidence is in patients greater than age 65 • In this st ...
... • The rates are double this in Asia • The incidence between males and females is equal, although this may differ depending on location and age • The ages where this is most common include ages 15-24 and those greater than age 45 • The highest incidence is in patients greater than age 65 • In this st ...
Pulparesponser
... increased body temperature which expresses itself as fever. IL-1 is therefore called an endogenous pyrogen. The increased body temperature helps the body's immune system to fight infection. IL-1 is also important in the regulation of hematopoiesis. IL-1β production in peripheral tissue has also been ...
... increased body temperature which expresses itself as fever. IL-1 is therefore called an endogenous pyrogen. The increased body temperature helps the body's immune system to fight infection. IL-1 is also important in the regulation of hematopoiesis. IL-1β production in peripheral tissue has also been ...
Sex hormones and the immune response in humans
... structures specific for microbes. The effector cells of the nonspecific immune response are monocytes, macrophages, granulocytes (neutrophils, eosinophils and basophils), dendritic cells and natural killer (NK) cells. These cells attack microbes that have entered the circulation. They do so by phago ...
... structures specific for microbes. The effector cells of the nonspecific immune response are monocytes, macrophages, granulocytes (neutrophils, eosinophils and basophils), dendritic cells and natural killer (NK) cells. These cells attack microbes that have entered the circulation. They do so by phago ...
Granzyme A activates another way to die
... but how PFN delivers Gzms into the target cell is still not completely worked out (14). Although PFN multimerizes in the target cell plasma membrane to form pores (98, 99), the original model of Gzm entry through plasma membrane pores (7, 8) is probably not correct (100). That model would predict th ...
... but how PFN delivers Gzms into the target cell is still not completely worked out (14). Although PFN multimerizes in the target cell plasma membrane to form pores (98, 99), the original model of Gzm entry through plasma membrane pores (7, 8) is probably not correct (100). That model would predict th ...
FGF-23 Is a Negative Regulator of Prenatal and Postnatal
... impaired bone mineralization results in a defect in HSC localization to the endosteal niche (25). Because normal osteogenesis is required for hematopoiesis and Fgf-23⫺/⫺ mice display severe bone abnormalities as well as significant reduction in lymphatic organ size such as spleen and thymus, in the ...
... impaired bone mineralization results in a defect in HSC localization to the endosteal niche (25). Because normal osteogenesis is required for hematopoiesis and Fgf-23⫺/⫺ mice display severe bone abnormalities as well as significant reduction in lymphatic organ size such as spleen and thymus, in the ...
Human NK cell lytic granules and regulation of their exocytosis
... stressed cells through a variety of germline-encoded activating cell surface receptors and utilize their cytotoxic ability to eliminate abnormal cells. Killing of target cells is a complex, multi-stage process that concludes in the directed secretion of lytic granules, containing perforin and granzy ...
... stressed cells through a variety of germline-encoded activating cell surface receptors and utilize their cytotoxic ability to eliminate abnormal cells. Killing of target cells is a complex, multi-stage process that concludes in the directed secretion of lytic granules, containing perforin and granzy ...
Mice that “conditionally” lack basophils, AT LAST
... the failure of Fcer1g-deficient splenocytes to restore tick resistance in Mcpt8DTR mice treated with DT, it is likely that tick-specific antibodies crosslink Ig receptors on basophils that then secrete mediators that deter tick engorgement. However, whether basophils are directly involved in anti-ti ...
... the failure of Fcer1g-deficient splenocytes to restore tick resistance in Mcpt8DTR mice treated with DT, it is likely that tick-specific antibodies crosslink Ig receptors on basophils that then secrete mediators that deter tick engorgement. However, whether basophils are directly involved in anti-ti ...
The Immune System
... The skin is the largest organ of the vertebrate body, accounting for 15% of an adult human’s total weight. The skin not only defends the body by providing a nearly impenetrable barrier, but also reinforces this defense with chemical weapons on the surface. Oil and sweat glands give the skin’s surfac ...
... The skin is the largest organ of the vertebrate body, accounting for 15% of an adult human’s total weight. The skin not only defends the body by providing a nearly impenetrable barrier, but also reinforces this defense with chemical weapons on the surface. Oil and sweat glands give the skin’s surfac ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.