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Immune System - kyoussef-mci
Immune System - kyoussef-mci

AP Biology - gwbiology
AP Biology - gwbiology

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Basic Structure of the Human Body Name
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... 16. mitosis – asexual cell division; divides into 2 identical cells 17. muscle tissue – produces power & movement 18. nerve tissue – made of neurons; transmits messages 19. nucleolus – manufactures RNA ( aids in synthesis production of protein) 20. nucleus – brain of the cell, controls cell activity ...
Cell Membrane PPT - Gulfport School District
Cell Membrane PPT - Gulfport School District

... different composition than the outside environment. This requires work—energy from ATP is needed to move substances against their concentration gradients (active transport). Specific carrier proteins move substances in only one direction, either into or out of the cell. ...
Scott Foresman Science
Scott Foresman Science

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2.24 MB - KFUPM Resources v3
2.24 MB - KFUPM Resources v3

... chains of nucleotides twisted together into a double helix with links of hydrogen bonds  Contains all inherited information necessary to build/maintain an organism, coded in the order of the nucleotide bases, with each three base “letters” forming a genetic code “word”  All living organisms have D ...
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AP Biology 042 – Biological Molecules Video

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... The ___________________ of an amino acid is the pH at which the concentration of the zwitterionic form reaches its maximum value. Peptides are comprised of amino acid _________ joined by peptide bonds. Peptide bonds experience restricted rotation, giving rise to two possible conformations, called __ ...
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Science - B3 Revision

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Cell-penetrating peptide



Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular uptake of various molecular cargo (from nanosize particles to small chemical molecules and large fragments of DNA). The ""cargo"" is associated with the peptides either through chemical linkage via covalent bonds or through non-covalent interactions. The function of the CPPs are to deliver the cargo into cells, a process that commonly occurs through endocytosis with the cargo delivered to the endosomes of living mammalian cells.CPPs hold great potential as in vitro and in vivo delivery vectors for use in research and medicine. Current use is limited by a lack of cell specificity in CPP-mediated cargo delivery and insufficient understanding of the modes of their uptake.CPPs typically have an amino acid composition that either contains a high relative abundance of positively charged amino acids such as lysine or arginine or has sequences that contain an alternating pattern of polar/charged amino acids and non-polar, hydrophobic amino acids. These two types of structures are referred to as polycationic or amphipathic, respectively. A third class of CPPs are the hydrophobic peptides, containing only apolar residues, with low net chargeor have hydrophobic amino acid groups that are crucial for cellular uptake.The first CPP was discovered independently by two laboratories in 1988, when it was found that the trans-activating transcriptional activator (TAT) from human immunodeficiency virus 1 (HIV-1) could be efficiently taken up from the surrounding media by numerous cell types in culture. Since then, the number of known CPPs has expanded considerably and small molecule synthetic analogues with more effective protein transduction properties have been generated.
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