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Ch.05The Structure and Function of Large Biological Molecules
Ch.05The Structure and Function of Large Biological Molecules

Ch.05The Structure and Function of Large Biological Molecules
Ch.05The Structure and Function of Large Biological Molecules

... such a way that it creates a ...
Ch.05The Structure and Function of Large Biological Molecules
Ch.05The Structure and Function of Large Biological Molecules

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... to give the modified adenosines, purine riboside, tubercidin, and 1-deazaadenosine,12 shown in Figure 2. In addition to lacking the functional groups that participate in hydrogen bonds, these modified adenosines also vary in their ability to stack with C7 and Phe56. Since studies on stacking interac ...
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... You have a restriction enzyme that makes a blunt cut between an A and a T. What will the size of the DNA fragments be after the following DNA molecule is cut with this restriction enzyme: 5′-TTGTTCGGATCCCGTAGG-3′? a) one 9-bp fragment, one 6-bp fragment, and one 3bp fragment b) one 15-bp fragment a ...
PDF - Bentham Open
PDF - Bentham Open

... into NORF1 and NORF2 in the forward strand. Similar divisions are carried out in the reverse strand. The size of ORF1 is almost equal to that of complement ORF2, and similarly that of NORF1 is equal to that of NORF2. The size of coding region is independent on that of noncoding region. G, C, T and A ...
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... which encodes a fusion protein consisting of DmMterf3 with an in-frame addition of green fluorescent protein (GFP) at its carboxy-terminus (DmMTERF3-FLAG-GFP). Schneider 2R+ and HeLa cells were transfected as previously described [6]. Mitochondria were counter-stained with 100nM MitoTracker Deep Red ...
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Nucleic acid analogue



Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four nucleobases.An analogue may have any of these altered. Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix).Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic acid (GNA) and threose nucleic acid (TNA). Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecule.In May 2014, researchers announced that they had successfully introduced two new artificial nucleotides into bacterial DNA, and by including individual artificial nucleotides in the culture media, were able to passage the bacteria 24 times; they did not create mRNA or proteins able to use the artificial nucleotides. The artificial nucleotides featured 2 fused aromatic rings.
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