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Holliday Poster - The HeliX group
Holliday Poster - The HeliX group

... Competitive dialysis or competition dialysis was initially described by Ren and Chaires1 and has since then been adapted in this laboratory. The aim of such an experiment is to determine which sequence a drug preferentially binds to in ...
molecular biology
molecular biology

... Chemically, DNA is a long polymer of simple units called nucleotides, with a backbone made of sugars and phosphate groups joined by ester bonds ...
Unit 11.1 Gene Transfer
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... In this unit students will explain the basic functions of DNA and RNA. Students will be able to describe an allele and predict how traits are passed from one offspring to another through gene transfer. Students will research the concept of dominant genes verses recessive genes as well as understand ...
Section 3 - Carbon Compounds
Section 3 - Carbon Compounds

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Macromolecules
Macromolecules

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Quiz 22
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Unit 5 quesitons
Unit 5 quesitons

... 3. Describe the work of Hershey and Chase. What did this add to our understanding of the genetic material? 4. Describe the discovery made by Chargaff and state its significance. 5. Describe the model proposed by Watson and Crick (with help from Franklin) 6. How are the deoxyribose sugars joined toge ...
Soon you will learn what HIV requires to come to life…
Soon you will learn what HIV requires to come to life…

Isolating, Cloning and Sequencing DNA
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... Unique methylation changes were found in the brain of patients with TLE as well as according to pathology. An analysis of what the genes do found many to be involved in brain development and structure, neurotransmission, cell death and DNA transcription. We also identified methylation changes to wha ...
современные проблемы молекулярной биологии
современные проблемы молекулярной биологии

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Using DNA to ID Pathogens
Using DNA to ID Pathogens

... this project, completed in 2003, scientists have determined the complete nucleotide sequence of the DNA of each human chromosome. In addition to mapping human DNA, the Human Genome Project has helped map the genomes of other species, including mice, the fruit fly, and various bacteria. Knowing the n ...
On Vacating the Conviction
On Vacating the Conviction

... agreed that a CODIS upload was most appropriate under the circumstances of the case as the source of the DNA profile was never identified. On June 28, 2006, Nina Morrison, Esq. of the Innocence Project submitted a proposed motion to my office seeking post-conviction DNA testing pursuant to CPL 440. ...
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... When you cross these varieties to each other, the F1 generation consists entirely of RED individuals. When the RED F1's are inbred (crossed among themselves) you obtain a population of F2's with a phenotypic ratio of 15 RED to 1 WHITE. Work out the genetics of the inheritance of the color difference ...
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Quantitative parameters for amino acid–base
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... from their frequencies in the three-dimensional structures of the complexes, similarly to the extraction of knowledge-based amino acid–amino acid contact energies. Pairwise contact potentials for amino acid–amino acid interactions were derived empirically from protein tertiary structures by several ...
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Bacterial Genetics

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The Proteomics of Epigenetics
The Proteomics of Epigenetics

... • The varients are subject to posttranslational modification as well • Some are very similar with subtle differences (ex. H3 and H3.3) • Others are very different (ex. H2A and macroH2A) • Specific tasks: Transcription activating and silencing, damaged DNA detection, etc. ...
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Nucleic acid analogue



Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four nucleobases.An analogue may have any of these altered. Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix).Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic acid (GNA) and threose nucleic acid (TNA). Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecule.In May 2014, researchers announced that they had successfully introduced two new artificial nucleotides into bacterial DNA, and by including individual artificial nucleotides in the culture media, were able to passage the bacteria 24 times; they did not create mRNA or proteins able to use the artificial nucleotides. The artificial nucleotides featured 2 fused aromatic rings.
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