2 Neurotransmitters
... • Brain & Spinal Cord - regulates body functions • Receives signals from sensory receptors - pain, cold, smell - by way of afferent nerves • Info. is processed & controls body response w/ signals sent via efferent nerves for cellular action • Stimulation of the CNS may either increase nerve cell (ne ...
... • Brain & Spinal Cord - regulates body functions • Receives signals from sensory receptors - pain, cold, smell - by way of afferent nerves • Info. is processed & controls body response w/ signals sent via efferent nerves for cellular action • Stimulation of the CNS may either increase nerve cell (ne ...
Chemical Synapses activity and project
... functionally connected by synapses. The neuron conducting impulses toward the synapse is the presynaptic neuron, and the neuron transmitting the signal away from the synapse is the postsynaptic neuron. Chemical synapses are specialized for release and reception of chemical neurotransmitters. For the ...
... functionally connected by synapses. The neuron conducting impulses toward the synapse is the presynaptic neuron, and the neuron transmitting the signal away from the synapse is the postsynaptic neuron. Chemical synapses are specialized for release and reception of chemical neurotransmitters. For the ...
Drug-receptor interactions
... Drug molecules in the environment of receptors are attracted initially by relatively long-range electrostatic forces. • 2. Then, if the molecule is suitably shaped to fit closely to the binding site of the receptor, hydrogen bonds and Wan der Waals forces briefly bind the drug receptor. • Irreversib ...
... Drug molecules in the environment of receptors are attracted initially by relatively long-range electrostatic forces. • 2. Then, if the molecule is suitably shaped to fit closely to the binding site of the receptor, hydrogen bonds and Wan der Waals forces briefly bind the drug receptor. • Irreversib ...
Lecture 14
... – Increase levels of norepinephrine, serotonin and dopamine by preventing their metabolism – Use is declining due to side effects (can cause fatal hypertensive crisis) => Last choice of treatment today (only if other drugs fail) – Possibility of severe food-drug interaction (“cheese reaction”: Tyram ...
... – Increase levels of norepinephrine, serotonin and dopamine by preventing their metabolism – Use is declining due to side effects (can cause fatal hypertensive crisis) => Last choice of treatment today (only if other drugs fail) – Possibility of severe food-drug interaction (“cheese reaction”: Tyram ...
PowerPoint () slides - Drugs and the Brain
... signals using electrical signals called action potentials. Information is encoded in the frequency of action potentials. ...
... signals using electrical signals called action potentials. Information is encoded in the frequency of action potentials. ...
- SlideBoom
... panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). In Vitro: Recruit the steroid receptor coactivator 1 to human LXRα with EC50 of 125 nM in a cell-free ligand-sensing assay ...
... panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). In Vitro: Recruit the steroid receptor coactivator 1 to human LXRα with EC50 of 125 nM in a cell-free ligand-sensing assay ...
lec#7 done by Lama Abusharaf
... - Sites of loss: sites where some of the drug is lost by binding to something other than the site of action Slide 16: - Hydrogen bonding requires complementary structures between the drug and the receptor Slide 19: - Affinity expresses the strength of binding between the drug and the receptor… Sl ...
... - Sites of loss: sites where some of the drug is lost by binding to something other than the site of action Slide 16: - Hydrogen bonding requires complementary structures between the drug and the receptor Slide 19: - Affinity expresses the strength of binding between the drug and the receptor… Sl ...
Summary overview: Gi and Gs G-protein coupled receptors - Di-Et-Tri
... - Use depends on type of asthma, often combined with glucocorticoids - Sometimes: Muscarinic receptor antagonist (ipratropium) - Not common anymore: PDE inhibitor (theophylline) There are also inhibitory G-proteins . The stimulatory Gsα, when it binds GTP, activates Adenylate cyclase. . An inhibitor ...
... - Use depends on type of asthma, often combined with glucocorticoids - Sometimes: Muscarinic receptor antagonist (ipratropium) - Not common anymore: PDE inhibitor (theophylline) There are also inhibitory G-proteins . The stimulatory Gsα, when it binds GTP, activates Adenylate cyclase. . An inhibitor ...
210_Blanks_lecture3_drugs
... Raises the voltage for the NMDA receptors ___________responsible for blocking the NMDA receptors until high enough voltage NMDA allows both ______________________to enter Ca2+ causes long term changes in the cell Thought to be involved in long term memory GABA Synthesized from ___________ Two differ ...
... Raises the voltage for the NMDA receptors ___________responsible for blocking the NMDA receptors until high enough voltage NMDA allows both ______________________to enter Ca2+ causes long term changes in the cell Thought to be involved in long term memory GABA Synthesized from ___________ Two differ ...
Physiological Psychology
... Released neurotransmitter produces signals in postsynaptic neurons by binding to receptors. Receptors are specific for a given neurotransmitter. Ligand – a molecule that binds to another. A neurotransmitter is a ligand of its receptor. ...
... Released neurotransmitter produces signals in postsynaptic neurons by binding to receptors. Receptors are specific for a given neurotransmitter. Ligand – a molecule that binds to another. A neurotransmitter is a ligand of its receptor. ...
Drug Abuse or… For Big Kids - Department of Cognitive Science
... – one issue with this type of study is the ambiguity of the cause of reduced dopamine transporters/dopaminergic terminals – did meth abuse cause this difference or was it the result of previously existing factors such as genetics (in which case, did these genetic differences predispose the individua ...
... – one issue with this type of study is the ambiguity of the cause of reduced dopamine transporters/dopaminergic terminals – did meth abuse cause this difference or was it the result of previously existing factors such as genetics (in which case, did these genetic differences predispose the individua ...
1. Neurotransmitter released from the pre
... 13. Ways by which the effects on the postsynaptic cell can be enhanced are: a. Presynaptic facilitation b. High frequency of action potentials in the presynaptic terminal c. Adding an agonist for the receptors on the postsynaptic cell d. Blocking the reuptake of NT into the presynaptic terminal e. ...
... 13. Ways by which the effects on the postsynaptic cell can be enhanced are: a. Presynaptic facilitation b. High frequency of action potentials in the presynaptic terminal c. Adding an agonist for the receptors on the postsynaptic cell d. Blocking the reuptake of NT into the presynaptic terminal e. ...
Slide 1
... DRUGS • Most common description: A substance used as a medicine for the treatment of disease. • In a larger context: A substance taken because of its biologically active properties. This would include substances such as caffeine, nicotine, alcohol, cannabis, heroin and cocaine. ...
... DRUGS • Most common description: A substance used as a medicine for the treatment of disease. • In a larger context: A substance taken because of its biologically active properties. This would include substances such as caffeine, nicotine, alcohol, cannabis, heroin and cocaine. ...
Peripheral Nervous System
... neurons & effectors is called the synapse. • Transmission of a nerve impulse takes place when a neurotransmitter molecule stored in synaptic vesicles in the axon bulb is released into a synaptic cleft between the axon and the receiving neuron. ...
... neurons & effectors is called the synapse. • Transmission of a nerve impulse takes place when a neurotransmitter molecule stored in synaptic vesicles in the axon bulb is released into a synaptic cleft between the axon and the receiving neuron. ...
Document
... Alcohol acts as a depressant and slows down the brain’s activity. People may act more free and loosen up a bit after a few drinks because the area of the brain involved in inhibition and judgment slows down. Activities that involve intellectual functioning and motor skills become impaired. ...
... Alcohol acts as a depressant and slows down the brain’s activity. People may act more free and loosen up a bit after a few drinks because the area of the brain involved in inhibition and judgment slows down. Activities that involve intellectual functioning and motor skills become impaired. ...
CHEMICAL MESSENGERS
... Absorption: rate and extent to which drug leaves its site of administration; bioavailability: portion of drug that reaches its site of action Distribution: where the blood flows most is where most of the drug goes (where? Brain, liver, heart) Elimination: liver enzymes play biggest part in exp ...
... Absorption: rate and extent to which drug leaves its site of administration; bioavailability: portion of drug that reaches its site of action Distribution: where the blood flows most is where most of the drug goes (where? Brain, liver, heart) Elimination: liver enzymes play biggest part in exp ...
NeuroBiology
... Neurobiology and Communication Key Area 3.3 Cells of nervous system + neurotransmitters at synapses ...
... Neurobiology and Communication Key Area 3.3 Cells of nervous system + neurotransmitters at synapses ...
synapse - Central Connecticut State University
... Modifying Neural Messages • drug agonists - enhance potency of neurotransmitter • drug antagonists - reduce effectiveness ...
... Modifying Neural Messages • drug agonists - enhance potency of neurotransmitter • drug antagonists - reduce effectiveness ...
GABA Recognition Site
... o Reduce the sedative/hypnotic response thresholds to baclofen without displaying effects themselves o When administered alone they display anxiolytic, but not antidepressant, effects in laboratory animals without causing sedation, muscle relaxation or cognitive dysfunction ...
... o Reduce the sedative/hypnotic response thresholds to baclofen without displaying effects themselves o When administered alone they display anxiolytic, but not antidepressant, effects in laboratory animals without causing sedation, muscle relaxation or cognitive dysfunction ...
中枢神经系统药理学
... transmitter, depolarization of presynaptic membrane and extracellular calcium influx triggering transmitter release, combination of transmitter and receptor producing biological effect, and transmitter elimination and recycle to vesicle Message may be transmitted by two way at synapse ...
... transmitter, depolarization of presynaptic membrane and extracellular calcium influx triggering transmitter release, combination of transmitter and receptor producing biological effect, and transmitter elimination and recycle to vesicle Message may be transmitted by two way at synapse ...
Mainly 15-45 age range, but increasing in kids!
... http://www.hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/public/paxil_4_pc-cp_e.html ...
... http://www.hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/public/paxil_4_pc-cp_e.html ...
Neurotransmitter Receptors - VCC Library
... Student review only. May not be reproduced for classes. ...
... Student review only. May not be reproduced for classes. ...
Pharmacodynamics What the drug does to the body?
... Body adapts to drugs Change in receptors Refractory period after effect of first dose - Desensitisation Loss or addition of receptors Internalization of receptors due to prolonged exposure to agonist – and converse. Exhaustion of mediators ...
... Body adapts to drugs Change in receptors Refractory period after effect of first dose - Desensitisation Loss or addition of receptors Internalization of receptors due to prolonged exposure to agonist – and converse. Exhaustion of mediators ...