Transporters as drug carriers and targets in the GIT
... Use of energy from another source-another secondary diffusion gradient set up across the membrane using another ion. Because this secondary diffusion gradient initially established using an ion pump, as in primary active transport, the energy is ultimately derived from the same source-ATP hydrolysis ...
... Use of energy from another source-another secondary diffusion gradient set up across the membrane using another ion. Because this secondary diffusion gradient initially established using an ion pump, as in primary active transport, the energy is ultimately derived from the same source-ATP hydrolysis ...
Inquiry into Life Twelfth Edition
... Class III Factors • In 1980 a transcription factor was found that bound to the internal promoter of the 5S rRNA gene and stimulated its transcription – TFIIIA • Two other transcription factors TFIIIB and TFIIIC have also been studied • Transcription of all classical class III genes requires TFIIIB ...
... Class III Factors • In 1980 a transcription factor was found that bound to the internal promoter of the 5S rRNA gene and stimulated its transcription – TFIIIA • Two other transcription factors TFIIIB and TFIIIC have also been studied • Transcription of all classical class III genes requires TFIIIB ...
Full Text - PDF
... Co-stimulatory molecules play a critical role in controlling the immune response. The central role of CD28 family, especially the CTLA-4, makes it a useful tool for immunotherapy in autoimmune disease and transplant rejection 6,10. Two approaches have been selected in respect to the potential clinic ...
... Co-stimulatory molecules play a critical role in controlling the immune response. The central role of CD28 family, especially the CTLA-4, makes it a useful tool for immunotherapy in autoimmune disease and transplant rejection 6,10. Two approaches have been selected in respect to the potential clinic ...
Gene Section HAS2 (hyaluronan synthase 2) Atlas of Genetics and Cytogenetics
... Studies dating over 50 years have suggested an association between the increasing deposition of HA and tumors. Because hyaluronan is associated with such a variety of important biological cellular processes, it has been suggested that the abnormal overexpression of HAS2, among the other HA synthases ...
... Studies dating over 50 years have suggested an association between the increasing deposition of HA and tumors. Because hyaluronan is associated with such a variety of important biological cellular processes, it has been suggested that the abnormal overexpression of HAS2, among the other HA synthases ...
In Vivo Selection Yields AAV-B1 Capsid for Central
... comprised of 60 subunits of VP1, VP2, and VP3 capsid proteins in a ratio of ~1:1:10, and an encapsidated single-stranded DNA viral genome. In addition to protecting the genome, the capsid mediates interactions with cell surface receptors and postentry intracellular trafficking and as such, is the ma ...
... comprised of 60 subunits of VP1, VP2, and VP3 capsid proteins in a ratio of ~1:1:10, and an encapsidated single-stranded DNA viral genome. In addition to protecting the genome, the capsid mediates interactions with cell surface receptors and postentry intracellular trafficking and as such, is the ma ...
Cloning, Sequencing, and Characterization of the Pradimicin
... PrmA is highly similar to the KSα (RubA) found from the rubromycin biosynthetic gene cluster [22]. All KSαs contain active-site cysteine in a highly conserved sequence, STGCTSGLD. The same sequence was found in PrmA and contains Cys176 at the presumed active site. PrmB showed a high level of similar ...
... PrmA is highly similar to the KSα (RubA) found from the rubromycin biosynthetic gene cluster [22]. All KSαs contain active-site cysteine in a highly conserved sequence, STGCTSGLD. The same sequence was found in PrmA and contains Cys176 at the presumed active site. PrmB showed a high level of similar ...
Topic 1: Statistical analysis (2 hours)
... vesicle is made by pinching off a piece of membrane; fluidity of membrane allows this; vesicles can be used to transport material around inside cells; proteins are transported in vesicles; from the rough endoplasmic reticulum to the Golgi apparatus; from the Golgi apparatus to the plasma membrane; f ...
... vesicle is made by pinching off a piece of membrane; fluidity of membrane allows this; vesicles can be used to transport material around inside cells; proteins are transported in vesicles; from the rough endoplasmic reticulum to the Golgi apparatus; from the Golgi apparatus to the plasma membrane; f ...
Brief Rapid Communications
... therapy. First, this vector can only accept transgenes less than '4.5 kb in length. Second, current techniques do not allow the convenient production of large amounts of rAAV. Finally, although our studies have demonstrated efficient transduction of cardiomyocytes after 15 minutes of coronary artery ...
... therapy. First, this vector can only accept transgenes less than '4.5 kb in length. Second, current techniques do not allow the convenient production of large amounts of rAAV. Finally, although our studies have demonstrated efficient transduction of cardiomyocytes after 15 minutes of coronary artery ...
Divergent Amphibian Species Nonclassical MHC Class I Lineages
... Downloaded from http://www.jimmunol.org/ by guest on August 11, 2017 ...
... Downloaded from http://www.jimmunol.org/ by guest on August 11, 2017 ...
CopyRight v2.0 BAC Cloning Kits
... incorporates transcription-free cloning for the highest stability BAC cloning. The vector is supplied precut at a choice of BamHI, EcoRI, or HindIII sites, with dephosphorylated ends. Insert DNAs with 5phosphorylated ends are ligated to the CopyRight vector and transformed into Lucigens BACOptimiz ...
... incorporates transcription-free cloning for the highest stability BAC cloning. The vector is supplied precut at a choice of BamHI, EcoRI, or HindIII sites, with dephosphorylated ends. Insert DNAs with 5phosphorylated ends are ligated to the CopyRight vector and transformed into Lucigens BACOptimiz ...
Disease name
... Research and development of new procedures for diagnosis and control Development of a polymerase chain reaction for the detection of abalone herpes-like virus infection based on the DNA polymerase gene: This is a consecutive study. In this study, abalone herpesvirus particles were separated from Tai ...
... Research and development of new procedures for diagnosis and control Development of a polymerase chain reaction for the detection of abalone herpes-like virus infection based on the DNA polymerase gene: This is a consecutive study. In this study, abalone herpesvirus particles were separated from Tai ...
Back Matter
... --, induction in mice with pneumoeoccal polysaceharide, 929 Immunization, prolonged, effect on immunologic activity of erythrocyte serum, 584 Immunochemistry of antigen-antibody complex, ...
... --, induction in mice with pneumoeoccal polysaceharide, 929 Immunization, prolonged, effect on immunologic activity of erythrocyte serum, 584 Immunochemistry of antigen-antibody complex, ...
Moonlighting proteins—an update
... Different methods have been reported for a moonlighting protein to switch between functions, including secretion into the extracellular space, interactions with DNA or RNA, a change in temperature, a change in the redox state of the cell, a change in oligomeric state of the protein, interactions with ...
... Different methods have been reported for a moonlighting protein to switch between functions, including secretion into the extracellular space, interactions with DNA or RNA, a change in temperature, a change in the redox state of the cell, a change in oligomeric state of the protein, interactions with ...
DNA, RNA and Protein Synthesis
... c. Nitrogenous base contains nitrogen atoms and carbon atoms and is a base (accepted hydrogen ions) Bonds hold DNA together 1. The nitrogenous bases on one strand of DNA face and form bonds called hydrogen bonds with the bases on the other strand. 2. Nitrogen bases are bonded together by 2 or 3 hy ...
... c. Nitrogenous base contains nitrogen atoms and carbon atoms and is a base (accepted hydrogen ions) Bonds hold DNA together 1. The nitrogenous bases on one strand of DNA face and form bonds called hydrogen bonds with the bases on the other strand. 2. Nitrogen bases are bonded together by 2 or 3 hy ...
PPARγ Regulated Fatty Acid Metabolism Antibody Sampler Kit
... each of which is encoded by two or three distinct genes (α1, 2; β1, 2; γ1, 2, 3) (1). The kinase is activated by an elevated AMP/ATP ratio due to cellular and environmental stress, such as heat shock, hypoxia, and ischemia (1). The tumor suppressor LKB1 phosphorylates AMPKα at Thr172 in the activati ...
... each of which is encoded by two or three distinct genes (α1, 2; β1, 2; γ1, 2, 3) (1). The kinase is activated by an elevated AMP/ATP ratio due to cellular and environmental stress, such as heat shock, hypoxia, and ischemia (1). The tumor suppressor LKB1 phosphorylates AMPKα at Thr172 in the activati ...
A Fruit-Specific Putative Dihydroflavonol 4
... was the DFR from V. vinifera, the fruit of which, like that of strawberry, is considered nonclimacteric. DFR is encoded either by a small multigene family (Beld et al., 1989; Helariutta et al., 1993) or by only one gene (Kristiansen and Rohde, 1991; Bongue-Bartelsman et al., 1994; Sparvoli et al., 1 ...
... was the DFR from V. vinifera, the fruit of which, like that of strawberry, is considered nonclimacteric. DFR is encoded either by a small multigene family (Beld et al., 1989; Helariutta et al., 1993) or by only one gene (Kristiansen and Rohde, 1991; Bongue-Bartelsman et al., 1994; Sparvoli et al., 1 ...
5-Aminoimidazole-4-Carboxamide Riboside Mimics the
... expression. H4IIE cells were serum starved overnight before a 3-h incubation with hormones as indicated. Total RNA was isolated, and an RNase protection assay was performed as described in RESEARCH DESIGN ANDMETHODS . The concentrations of hormones used were as follows: dexamethasone, 500 nmol/l; 8C ...
... expression. H4IIE cells were serum starved overnight before a 3-h incubation with hormones as indicated. Total RNA was isolated, and an RNase protection assay was performed as described in RESEARCH DESIGN ANDMETHODS . The concentrations of hormones used were as follows: dexamethasone, 500 nmol/l; 8C ...
The anti-adipogenic effect of vitexin is associated with regulation of
... problem of obesity has increased significantly in recent decades and has become an important public health issue. Chu and Pan (2007) showed that about one third of the boys and one quarter of the girls were overweight and/or obesity in Taiwan. The prevalence and trend of overweight and obesity in Ta ...
... problem of obesity has increased significantly in recent decades and has become an important public health issue. Chu and Pan (2007) showed that about one third of the boys and one quarter of the girls were overweight and/or obesity in Taiwan. The prevalence and trend of overweight and obesity in Ta ...
Parallel Analysis of Gene Expression: Microarrays
... that is likely to be representative of genes expressed under different conditions. It is possible to generate a cDNA microarray simply from randomly picked, unsequenced, clones. This leads to overrepresentation of a small subset of highly expressed genes on the microarray; however, molecular subtra ...
... that is likely to be representative of genes expressed under different conditions. It is possible to generate a cDNA microarray simply from randomly picked, unsequenced, clones. This leads to overrepresentation of a small subset of highly expressed genes on the microarray; however, molecular subtra ...
Studies on the Phosphorylation of the 58000 Dalton Early Region
... Phosphoamino acid determination. The area on SDS polyacrylamide gels containing the 58K band was excised, the gel piece was diced into small pieces and the protein was eluted for 24 h at 37 °C with constant shaking into a small volume of 0.05 M-ammonium bicarbonate containing 0.1% SDS. The gel fragm ...
... Phosphoamino acid determination. The area on SDS polyacrylamide gels containing the 58K band was excised, the gel piece was diced into small pieces and the protein was eluted for 24 h at 37 °C with constant shaking into a small volume of 0.05 M-ammonium bicarbonate containing 0.1% SDS. The gel fragm ...
1_Standards for the Safety Assessment of Genetically Modified Foods (Seed Plants).pdf
... Properties of the inserted DNA or genes (including the drug-resistance gene) and their gene products (1) Methods for cloning or synthesis of the inserted gene Methods used for cloning or synthesizing the inserted gene should be described. (2) Size, nucleotide sequence, and restriction map The number ...
... Properties of the inserted DNA or genes (including the drug-resistance gene) and their gene products (1) Methods for cloning or synthesis of the inserted gene Methods used for cloning or synthesizing the inserted gene should be described. (2) Size, nucleotide sequence, and restriction map The number ...
Mitochondrial Uncoupling Proteins in Mammals and Plants
... SfUCPb does not contain this signature. However, alignment of both SfUCPs showed their very identity; the only difference is that 35 amino acids of SfUCPa (position 204–238) are missing in SfUCPb. The third signature in SfUCPa starts in position Pro235, four amino acids before end of deletion in SfU ...
... SfUCPb does not contain this signature. However, alignment of both SfUCPs showed their very identity; the only difference is that 35 amino acids of SfUCPa (position 204–238) are missing in SfUCPb. The third signature in SfUCPa starts in position Pro235, four amino acids before end of deletion in SfU ...
Table S10. List of the Databases and Software used in the H
... identified by various genome projects. This database mainly uses sequence homology analyses and features extensive utilization of information on three-dimensional structures. ...
... identified by various genome projects. This database mainly uses sequence homology analyses and features extensive utilization of information on three-dimensional structures. ...
A Drosophila Third Chromosome Minute Locus Encodes
... M i n u t e s are non-additive in their phenotypic effect, i. e., the phenotype of a M I / + ; M 2 / + fly is not more extreme than the phenotypeof any ofthe single mutants. He concluded that the genes code for proteins with similar function (s) . The non-additive property of this type of mutations ...
... M i n u t e s are non-additive in their phenotypic effect, i. e., the phenotype of a M I / + ; M 2 / + fly is not more extreme than the phenotypeof any ofthe single mutants. He concluded that the genes code for proteins with similar function (s) . The non-additive property of this type of mutations ...
Endogenous retrovirus
Endogenous retroviruses (ERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. They are abundant in the genomes of jawed vertebrates, and they comprise up to 5–8% of the human genome (lower estimates of ~1%). ERVs are a subclass of a type of gene called a transposon, which can be packaged and moved within the genome to serve a vital role in gene expression and in regulation. Researchers have suggested that retroviruses evolved from a type of transposable gene called a retrotransposon, which includes ERVs; these genes can mutate and instead of moving to another location in the genome they can become exogenous or pathogenic. This means that all ERVs may not have originated as an insertion by a retrovirus but that some may have been the source for the genetic information in the retroviruses they resemble.