Innate immune detection of microbial nucleic acids
... Structural basis of self versus non-self RNA discrimination by RLRs It was unclear for some time how RLRs bind their ligands because none of the helicases contain a classical RNAbinding motif. However, recent studies solving the crystal structure of both RIG-I and MDA5 in complex with RNA ligands ha ...
... Structural basis of self versus non-self RNA discrimination by RLRs It was unclear for some time how RLRs bind their ligands because none of the helicases contain a classical RNAbinding motif. However, recent studies solving the crystal structure of both RIG-I and MDA5 in complex with RNA ligands ha ...
Gene Section Transcription 3) Atlas of Genetics and Cytogenetics
... changes dimmer conformation). Tyrosine of the protein activates its high affinity DNA binding activity (TTCNNNGAA) and can stimulate nuclear translocation of the protein. Stimulation of STAT3 tyrosine phosphorylation occurs in response to a variety of cytokines and growth factors including LIF, OSM, ...
... changes dimmer conformation). Tyrosine of the protein activates its high affinity DNA binding activity (TTCNNNGAA) and can stimulate nuclear translocation of the protein. Stimulation of STAT3 tyrosine phosphorylation occurs in response to a variety of cytokines and growth factors including LIF, OSM, ...
Antiviral potency and functional analysis of tetherin orthologues
... viruses. Most knowledge regarding the interaction between tetherin and viruses has been obtained using the primate lentiviral system. However, much less is known about the functional roles of tetherin on other lentiviruses. Equine infectious anemia virus (EIAV) is an important macrophage-tropic lent ...
... viruses. Most knowledge regarding the interaction between tetherin and viruses has been obtained using the primate lentiviral system. However, much less is known about the functional roles of tetherin on other lentiviruses. Equine infectious anemia virus (EIAV) is an important macrophage-tropic lent ...
Determination of the DNA and Amino Acid Sequences of the Lactate
... isolated by screening a λgt11Tn5 expression library. DNA sequence analysis of one of these clones revealed a single open reading frame which showed a degree of homology to the Nterminal domain between residues 17 and 45 in the published LDH sequences. The complete gene coding for PfLDH strain Hondur ...
... isolated by screening a λgt11Tn5 expression library. DNA sequence analysis of one of these clones revealed a single open reading frame which showed a degree of homology to the Nterminal domain between residues 17 and 45 in the published LDH sequences. The complete gene coding for PfLDH strain Hondur ...
Relationship between codon biased genes, microarray expression
... universally highly expressed genes, such as the ribosomal protein (RP) genes, which are commonly used as a reference set. Algorithms developed for this purpose (Sharp & Li, 1987a; Karlin & Mrazek, 2000) are adequate for deciphering the general pattern of gene expression in the cell, and to detect sp ...
... universally highly expressed genes, such as the ribosomal protein (RP) genes, which are commonly used as a reference set. Algorithms developed for this purpose (Sharp & Li, 1987a; Karlin & Mrazek, 2000) are adequate for deciphering the general pattern of gene expression in the cell, and to detect sp ...
Chapter 12
... In the absence of ß-galactosides, the lac operon is expressed only at a very low (basal) level. Addition of specific ß-galactosides induces transcription of all three genes of the operon. The lac mRNA is extremely unstable; as a result, induction can be rapidly reversed. The same types of systems th ...
... In the absence of ß-galactosides, the lac operon is expressed only at a very low (basal) level. Addition of specific ß-galactosides induces transcription of all three genes of the operon. The lac mRNA is extremely unstable; as a result, induction can be rapidly reversed. The same types of systems th ...
MCB 371/372 - Gogarten Lab | UConn
... 1) download Cn3D 4.2 from the CD-Tree release (http://www.ncbi.nlm.nih.gov/Structure/cdtree/cdtree.shtml) 2) Load the cd of interest into Cn3D 4.2 (find the cd on the web and click structure view to view it in cn3d 4.2 3) In the sequence window of cn3d 4.2, choose View/Export/PSSM – this will produc ...
... 1) download Cn3D 4.2 from the CD-Tree release (http://www.ncbi.nlm.nih.gov/Structure/cdtree/cdtree.shtml) 2) Load the cd of interest into Cn3D 4.2 (find the cd on the web and click structure view to view it in cn3d 4.2 3) In the sequence window of cn3d 4.2, choose View/Export/PSSM – this will produc ...
Steroid hormone receptor homologs in development
... element has not been characterized, another apparent target of regulation for the retinoic acid receptors is the B receptor gene itself. From RNA analysis of hepatoma cells, the expression of the B receptor appears to increase in a cycloheximide-independent manner while the expression of the a recep ...
... element has not been characterized, another apparent target of regulation for the retinoic acid receptors is the B receptor gene itself. From RNA analysis of hepatoma cells, the expression of the B receptor appears to increase in a cycloheximide-independent manner while the expression of the a recep ...
Review Evolution of the coordinate regulation of glycolytic enzyme
... consequence have an absolute requirement for a reducing environment in order to function (Segerer et al., 1985). Likewise it may be expected that certain biological activities, pathways and regulatory processes function preferentially under conditions of hypoxia. This may be particularly true for an ...
... consequence have an absolute requirement for a reducing environment in order to function (Segerer et al., 1985). Likewise it may be expected that certain biological activities, pathways and regulatory processes function preferentially under conditions of hypoxia. This may be particularly true for an ...
MCB 135K Discussion
... allotted to an individuals and the faster these are used the shorter the life. ...
... allotted to an individuals and the faster these are used the shorter the life. ...
From Gene to Protein
... (b) Eukaryotic cell. The nucleus provides a separate compartment for transcription. The original RNA transcript, called pre-mRNA, is processed in various ways before leaving the nucleus as mRNA. ...
... (b) Eukaryotic cell. The nucleus provides a separate compartment for transcription. The original RNA transcript, called pre-mRNA, is processed in various ways before leaving the nucleus as mRNA. ...
Balancing Redox Cofactor Generation and ATP Synthesis: Key
... and KH2PO4 at pH 7.4). RNA was extracted using a Ambion® RboPure Bacteria RNA isolation kit (Life Technologies, Carlsbad, CA) as per manufacturer’s protocol. The RNA was eluted in 100 (µL elution buffer and treated with DNase I (Ambion) as per the protocol. The presence of residual genomic DNA withi ...
... and KH2PO4 at pH 7.4). RNA was extracted using a Ambion® RboPure Bacteria RNA isolation kit (Life Technologies, Carlsbad, CA) as per manufacturer’s protocol. The RNA was eluted in 100 (µL elution buffer and treated with DNase I (Ambion) as per the protocol. The presence of residual genomic DNA withi ...
GenomeSequencing_ver3_20040929
... Scaffold: a group of ordered and orientated contigs known to be physically linked to each other by paired read information. EST: expressed sequence tag generated by sequencing one end of a recombinant clone from a cDNA library. ESTs are single-pass reads and therefore prone to contain sequence error ...
... Scaffold: a group of ordered and orientated contigs known to be physically linked to each other by paired read information. EST: expressed sequence tag generated by sequencing one end of a recombinant clone from a cDNA library. ESTs are single-pass reads and therefore prone to contain sequence error ...
Slides of short summary on Molecular Biology
... encodes protein. Many repeats of non-coding sequences ¾ All chromosomes are contained in a membrane bound nucleus DNA is divided between two or more chromosomes ...
... encodes protein. Many repeats of non-coding sequences ¾ All chromosomes are contained in a membrane bound nucleus DNA is divided between two or more chromosomes ...
Fatty Acid Biosynthesis Pathways in Methylomicrobium buryatense
... Haloalcaliphilic methanotrophic bacteria belonging to the genus Methylomicrobium are among the most promising strains for methane-based biotechnology, providing easy and inexpensive cultivation, rapid growth, and the availability of established genetic tools. A number of methane bioconversions using ...
... Haloalcaliphilic methanotrophic bacteria belonging to the genus Methylomicrobium are among the most promising strains for methane-based biotechnology, providing easy and inexpensive cultivation, rapid growth, and the availability of established genetic tools. A number of methane bioconversions using ...
significance of the putative upstream polybasic nuclear localisation
... protonation states and the solvent accessibility of Lys86 and Lys87 in the putative upstream NLS essentially differ in the two subunits (monomers) of the homodimer and also that the Lys88 was inaccessible to the solvent in both subunits. In the hIFNγ/receptor complex Lys86 and Lys87 had high solvent ...
... protonation states and the solvent accessibility of Lys86 and Lys87 in the putative upstream NLS essentially differ in the two subunits (monomers) of the homodimer and also that the Lys88 was inaccessible to the solvent in both subunits. In the hIFNγ/receptor complex Lys86 and Lys87 had high solvent ...
Biology - Perry Beeches IV
... Explain why diets may be different for different people. Describe the functions of each part of the digestive system Describe the difference between medicinal and recreational drugs B3 – Genetics and evolution Describe how the base pairs are arranged in DNA Describe examples of variation which can b ...
... Explain why diets may be different for different people. Describe the functions of each part of the digestive system Describe the difference between medicinal and recreational drugs B3 – Genetics and evolution Describe how the base pairs are arranged in DNA Describe examples of variation which can b ...
Rapid Evolution and Gene-Specific Patterns of
... with larger numbers of nonsynonymous to synonymous differences between species than polymorphisms. Although this could be interpreted as evidence for positive selection at all three genes, formal tests of selection do not support such a conclusion. Departures from neutrality were detected only for d ...
... with larger numbers of nonsynonymous to synonymous differences between species than polymorphisms. Although this could be interpreted as evidence for positive selection at all three genes, formal tests of selection do not support such a conclusion. Departures from neutrality were detected only for d ...
CHANGES IN THE GENETIC CODE
... entire gene is switched involves the variation of a single trait – gene for big ears exchanges with gene for small ears ...
... entire gene is switched involves the variation of a single trait – gene for big ears exchanges with gene for small ears ...
Biosensor-based engineering of biosynthetic pathways
... stability of the mRNA transcript, directly affecting the translation of the encoded genes [23,24]. Sensors based on fluorescence resonance energy transfer (FRET) [25] use a conformational change in a protein domain brought about by ligand binding to change the proximity of two fluorophores capable o ...
... stability of the mRNA transcript, directly affecting the translation of the encoded genes [23,24]. Sensors based on fluorescence resonance energy transfer (FRET) [25] use a conformational change in a protein domain brought about by ligand binding to change the proximity of two fluorophores capable o ...
Laboratory Detection and Gene Cassette Stability of the
... The G170N mutation, ascribed to a CC to AA base pair substitution on positions 493-494 of the blaGES-2 coding region, distinguishes this ESBL from blaGES-1 and the blaIBC-type genes, making it an ideal target for developing a novel sequence-specific, peptide nucleic acid (PNA)-based, multiplex-PCR d ...
... The G170N mutation, ascribed to a CC to AA base pair substitution on positions 493-494 of the blaGES-2 coding region, distinguishes this ESBL from blaGES-1 and the blaIBC-type genes, making it an ideal target for developing a novel sequence-specific, peptide nucleic acid (PNA)-based, multiplex-PCR d ...
pam&blosum
... therefore the two sets of matrices differ. Comparing the efficiency of two matrices is done by calculating the ratio between the number of pairs of similar sequences discovered by a certain matrix but not discovered by another one and the number of pairs missed by the first but found by the other. A ...
... therefore the two sets of matrices differ. Comparing the efficiency of two matrices is done by calculating the ratio between the number of pairs of similar sequences discovered by a certain matrix but not discovered by another one and the number of pairs missed by the first but found by the other. A ...
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Page 1 United States Patent [19] Anderson et al
... CMV can transform cells and stimulate growth. Both human 50 clovir, ACV) and certain combinations of these drugs have and non-human cells can undergo transformation when been ineffective in controlling CMV infection. Based on incubated with CMV. Transformed cells contain CMV anti~ preclinical and cl ...
... CMV can transform cells and stimulate growth. Both human 50 clovir, ACV) and certain combinations of these drugs have and non-human cells can undergo transformation when been ineffective in controlling CMV infection. Based on incubated with CMV. Transformed cells contain CMV anti~ preclinical and cl ...
8679821 - Southern Illinois University System
... porated herein by reference. Such mutated nucleic acid derivatives may be used to study structure-function relation ships of a particular AP protein, or to alter properties of the protein that affect its function or regulation. In summary, the ...
... porated herein by reference. Such mutated nucleic acid derivatives may be used to study structure-function relation ships of a particular AP protein, or to alter properties of the protein that affect its function or regulation. In summary, the ...
Endogenous retrovirus
Endogenous retroviruses (ERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. They are abundant in the genomes of jawed vertebrates, and they comprise up to 5–8% of the human genome (lower estimates of ~1%). ERVs are a subclass of a type of gene called a transposon, which can be packaged and moved within the genome to serve a vital role in gene expression and in regulation. Researchers have suggested that retroviruses evolved from a type of transposable gene called a retrotransposon, which includes ERVs; these genes can mutate and instead of moving to another location in the genome they can become exogenous or pathogenic. This means that all ERVs may not have originated as an insertion by a retrovirus but that some may have been the source for the genetic information in the retroviruses they resemble.