Gene Section GAST (gastrin) Atlas of Genetics and Cytogenetics
... The two principal biologically active forms of circulating gastrin are gastrin-17 (G17) and gastrin-34 (G34). In rodent and human G cells of antrum and proximal duodenum, approximately 95% of the progastrin is processed to partially sulfated G17 (85%) and G34 (10%). Although G17 is the predominant p ...
... The two principal biologically active forms of circulating gastrin are gastrin-17 (G17) and gastrin-34 (G34). In rodent and human G cells of antrum and proximal duodenum, approximately 95% of the progastrin is processed to partially sulfated G17 (85%) and G34 (10%). Although G17 is the predominant p ...
Organization and Integration of Large-scale Datasets for
... Mycoplasma pneumoniae, one of the smallest known self-replicating organisms, is a promising model organism in systems biology when aiming to assess understanding of an entire living cell. One of the key steps towards this goal is the design of mathematical models that describe the cellular processes ...
... Mycoplasma pneumoniae, one of the smallest known self-replicating organisms, is a promising model organism in systems biology when aiming to assess understanding of an entire living cell. One of the key steps towards this goal is the design of mathematical models that describe the cellular processes ...
Transcription factor Sp3 is silenced through - IMT
... domains A and B, and three black stripes the zinc ®ngers of the DNAbinding domain (DBD) of Sp3. The ID of Sp3 is depicted by hatched stripes. Amino acids that are deleted in the Sp3SD mutant protein are shown. The single lysine within this sequence is underlined. (B) Western blot analyses of epitope ...
... domains A and B, and three black stripes the zinc ®ngers of the DNAbinding domain (DBD) of Sp3. The ID of Sp3 is depicted by hatched stripes. Amino acids that are deleted in the Sp3SD mutant protein are shown. The single lysine within this sequence is underlined. (B) Western blot analyses of epitope ...
- Wiley Online Library
... in excitation–contraction coupling enabling Ca2+ release. Ca2+ then activates contractile proteins supporting actin and myosin cross-bridge cycling. Force generated by cross-bridges is transmitted via cytoskeletal proteins through the sarcolemma and out to critical proteins that support the muscle e ...
... in excitation–contraction coupling enabling Ca2+ release. Ca2+ then activates contractile proteins supporting actin and myosin cross-bridge cycling. Force generated by cross-bridges is transmitted via cytoskeletal proteins through the sarcolemma and out to critical proteins that support the muscle e ...
NPTEL-Module-1: Introduction to Bioorganic Chemistry Dr. S. S. Bag
... 1980s, it became clear that an emerging series of naturally occurring antitumor antibiotics such as calicheamicin, esperamicin, dynemicin, kedarcidin chromophore and C-1027 chromophore possessing the enediyne core and showed biological activity through the generation of active biradical specis via B ...
... 1980s, it became clear that an emerging series of naturally occurring antitumor antibiotics such as calicheamicin, esperamicin, dynemicin, kedarcidin chromophore and C-1027 chromophore possessing the enediyne core and showed biological activity through the generation of active biradical specis via B ...
A Truncated Laminin Chain Homologous to the B2 Chain: Structure
... colocalization of these chains in basement membranes (58). In vitro de- and renaturation studies with EHS laminin have shown that the assembly of this laminin is a specific process and only molecules with one Ae chain, one Ble chain, and one B2e chain are formed (35, 36). The carboxyl-terminal parts ...
... colocalization of these chains in basement membranes (58). In vitro de- and renaturation studies with EHS laminin have shown that the assembly of this laminin is a specific process and only molecules with one Ae chain, one Ble chain, and one B2e chain are formed (35, 36). The carboxyl-terminal parts ...
Lessons from the Genome Sequence of Neurospora crassa: Tracing
... University, Columbus, Ohio 4321025; The Institute for Genomic Research, Rockville, Maryland 2087826; and Department of Molecular Biology and Biochemistry, University of California, Irvine, California 9269727 INTRODUCTION ............................................................................... ...
... University, Columbus, Ohio 4321025; The Institute for Genomic Research, Rockville, Maryland 2087826; and Department of Molecular Biology and Biochemistry, University of California, Irvine, California 9269727 INTRODUCTION ............................................................................... ...
Engineering of polyketide biosynthetic pathways for bioactive
... career. Without his instructions, it would have been impossible for me to get so much work done in four years and finish this dissertation. I would also like to thank my committee members, Dr. Randy Lewis, Dr. David Britt, Dr. Dong Chen and Dr. Foster Agblevor for their advice and feedback, which he ...
... career. Without his instructions, it would have been impossible for me to get so much work done in four years and finish this dissertation. I would also like to thank my committee members, Dr. Randy Lewis, Dr. David Britt, Dr. Dong Chen and Dr. Foster Agblevor for their advice and feedback, which he ...
Expression and activity of hexokinase in the early mouse embryo
... 1982). Hexokinase I has been the most extensively studied (largely in the rat) and is the only isoenzyme whose DNA sequence is available for mouse, derived from tumour tissue (Arora et al., 1990). The gene consists of two structural halves, both coding for proteins containing an ATP and a glucose bi ...
... 1982). Hexokinase I has been the most extensively studied (largely in the rat) and is the only isoenzyme whose DNA sequence is available for mouse, derived from tumour tissue (Arora et al., 1990). The gene consists of two structural halves, both coding for proteins containing an ATP and a glucose bi ...
Xenopus Spinal Neurons Express Kv2 Potassium Channel
... unknown. Two lines of evidence are consistent with the notion that regulation of functional expression of I,<- occurs at the trancriptional level. First, maturation of Z,, requires new transcription during a critical period (Ribera and Spitzer, 1989). Second, increasing the levels of a delayed recti ...
... unknown. Two lines of evidence are consistent with the notion that regulation of functional expression of I,<- occurs at the trancriptional level. First, maturation of Z,, requires new transcription during a critical period (Ribera and Spitzer, 1989). Second, increasing the levels of a delayed recti ...
Genome-wide Investigation of Cellular Functions for tRNA Nucleus
... In eukaryotic cells tRNAs are transcribed in the nucleus and exported to the cytoplasm for their essential role in protein synthesis. This export event was thought to be unidirectional. Surprisingly, several lines of evidence showed that mature cytoplasmic tRNAs shuttle between nucleus and cytoplasm ...
... In eukaryotic cells tRNAs are transcribed in the nucleus and exported to the cytoplasm for their essential role in protein synthesis. This export event was thought to be unidirectional. Surprisingly, several lines of evidence showed that mature cytoplasmic tRNAs shuttle between nucleus and cytoplasm ...
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases
... (a) energy (ATP) production, (b) reactive oxygen species (ROS) production, and (c) initiation of apoptosis through the mitochondrial permeability transition pore (mtPTP). The OXPHOS complexes, designated I to V, are complex I (NADH: ubiquinone oxidoreductase) encompassing a FMN (flavin mononucleotide ...
... (a) energy (ATP) production, (b) reactive oxygen species (ROS) production, and (c) initiation of apoptosis through the mitochondrial permeability transition pore (mtPTP). The OXPHOS complexes, designated I to V, are complex I (NADH: ubiquinone oxidoreductase) encompassing a FMN (flavin mononucleotide ...
Iron mediated methylthiolation of tRNA as a regulator of operon
... E. coli 0111 grown in the presence of ovotransferrin, and lacking ms , performed poorly in a protein synthesising system directed by poly-U. Figure 2 shows that it had only 20-30% efficiency of the normal methylthiolated tRNA p e from iron replete bacteria. Altered tRNA p h e translated poly-UC with ...
... E. coli 0111 grown in the presence of ovotransferrin, and lacking ms , performed poorly in a protein synthesising system directed by poly-U. Figure 2 shows that it had only 20-30% efficiency of the normal methylthiolated tRNA p e from iron replete bacteria. Altered tRNA p h e translated poly-UC with ...
Engineering the pentose phosphate pathway of
... The baker’s yeast Saccharomyces cerevisiae has a long tradition in alcohol production from D-glucose of e.g. starch. However, without genetic modifications it is unable to utilise the 5-carbon sugars D-xylose and L-arabinose present in plant biomass. In this study, one key metabolic step of the cata ...
... The baker’s yeast Saccharomyces cerevisiae has a long tradition in alcohol production from D-glucose of e.g. starch. However, without genetic modifications it is unable to utilise the 5-carbon sugars D-xylose and L-arabinose present in plant biomass. In this study, one key metabolic step of the cata ...
thèse - Université Evry Val d`Essonne
... hypothesis of mitochondrial origin, popularized in the early seventies by Lynn Margulis’s book “the origin of eukaryotic cells”, stating that mitochondria evolved from a bacterial progenitor through symbiosis with an amitochondrial eukaryotic cell. These primitive eukaryotes were formally put in the ...
... hypothesis of mitochondrial origin, popularized in the early seventies by Lynn Margulis’s book “the origin of eukaryotic cells”, stating that mitochondria evolved from a bacterial progenitor through symbiosis with an amitochondrial eukaryotic cell. These primitive eukaryotes were formally put in the ...
The shikimate pathway in apicomplexan parasites: Implications for
... single effector type (15). ...
... single effector type (15). ...
Origin of the catalytic activity of bovine seminal ribonuclease against
... N103K), b ) A(A19S L35M K37Q N103K), c ) A(T3S A19S K37Q N103K), d ) A(T3S A19S K37Q N103E), e ) A(T3S S15P A19S K31Q K37Q S59F T70S Y76N T78A S80H A96V N103E), f ) A(T3S A19S K37Q N103E), g ) A(T3S A19S K37Q Y76N S80R N103E), h1 ) A(T3S S16G T17S A19S A20S N34K L35M K37Q D38G A64T Y76N S80R A102V N ...
... N103K), b ) A(A19S L35M K37Q N103K), c ) A(T3S A19S K37Q N103K), d ) A(T3S A19S K37Q N103E), e ) A(T3S S15P A19S K31Q K37Q S59F T70S Y76N T78A S80H A96V N103E), f ) A(T3S A19S K37Q N103E), g ) A(T3S A19S K37Q Y76N S80R N103E), h1 ) A(T3S S16G T17S A19S A20S N34K L35M K37Q D38G A64T Y76N S80R A102V N ...
The Vitamin K-dependent Carboxylase*
... active site (35, 36). The physiologically important reaction is the addition of carbon dioxide to glutamate to form Gla. The other reaction is the oxygenation of vitamin K hydroquinone (KH2) to Vitamin K 2,3 epoxide; this four electron oxidation of KH2 occurs with concomitant reduction of molecular ...
... active site (35, 36). The physiologically important reaction is the addition of carbon dioxide to glutamate to form Gla. The other reaction is the oxygenation of vitamin K hydroquinone (KH2) to Vitamin K 2,3 epoxide; this four electron oxidation of KH2 occurs with concomitant reduction of molecular ...
evidence for nonsense mutations in the arom gene
... in each of the four structural genes for which mutants are available in the arom cluster. These results are consistent with the conclusion that some non-complementing pleiotropic arom mutants are a consequence of nonsense mutations within the proximal structural gene (arom-2) of the arom gene cluste ...
... in each of the four structural genes for which mutants are available in the arom cluster. These results are consistent with the conclusion that some non-complementing pleiotropic arom mutants are a consequence of nonsense mutations within the proximal structural gene (arom-2) of the arom gene cluste ...
Is transcriptomic regulation of berry development more
... [30,31]. Studies of gene expression by transcriptomics were the first global experiments to provide information on the molecular rhythms at the whole plant level [32]. Early time–course studies estimated that 2–16% of the steady state transcriptome is regulated by the circadian clock with peak phase ...
... [30,31]. Studies of gene expression by transcriptomics were the first global experiments to provide information on the molecular rhythms at the whole plant level [32]. Early time–course studies estimated that 2–16% of the steady state transcriptome is regulated by the circadian clock with peak phase ...
Diversity and origins of anaerobic metabolism in mitochondria and
... Mitochondria and related organelles are ubiquitous among eukaryotes. The last half-century of cellular and molecular evolutionary research has conclusively shown that mitochondria are descended from an a-proteobacterial endosymbiont that took up residence within a host cell prior to the last eukaryo ...
... Mitochondria and related organelles are ubiquitous among eukaryotes. The last half-century of cellular and molecular evolutionary research has conclusively shown that mitochondria are descended from an a-proteobacterial endosymbiont that took up residence within a host cell prior to the last eukaryo ...
Glucosamine-Induced Insulin Resistance in Primary Rat
... 142g/day (Felig, Marliss et al. 1969; Gottstein 1979). The second reason for regulating glucose concentration is that glucose is toxic. The amount of glucose in the bloodstream is tightly regulated by actions of insulin and glucagon during fed and fasting states (Flakoll PJ 2000). Insulin, a hormon ...
... 142g/day (Felig, Marliss et al. 1969; Gottstein 1979). The second reason for regulating glucose concentration is that glucose is toxic. The amount of glucose in the bloodstream is tightly regulated by actions of insulin and glucagon during fed and fasting states (Flakoll PJ 2000). Insulin, a hormon ...
PRH/Hex - Biochemical Journal
... located downstream of the homeodomain in NK proteins. These differences suggest the possibility that PRH could equally be placed in a subclass of its own. The consensus PRH-binding site is 5 -C/TA/TATTAAA/G-3 as determined by SELEX (systematic evolution of ligands by exponential enrichment) experi ...
... located downstream of the homeodomain in NK proteins. These differences suggest the possibility that PRH could equally be placed in a subclass of its own. The consensus PRH-binding site is 5 -C/TA/TATTAAA/G-3 as determined by SELEX (systematic evolution of ligands by exponential enrichment) experi ...