Functional characterization of rare FOXP2 variants in
... Background: Heterozygous disruption of FOXP2 causes a rare form of speech and language impairment. Screens of the FOXP2 sequence in individuals with speech/language-related disorders have identified several rare protein-altering variants, but their phenotypic relevance is often unclear. FOXP2 encode ...
... Background: Heterozygous disruption of FOXP2 causes a rare form of speech and language impairment. Screens of the FOXP2 sequence in individuals with speech/language-related disorders have identified several rare protein-altering variants, but their phenotypic relevance is often unclear. FOXP2 encode ...
Origins and Early Evolution of the tRNA Molecule
... opposite sides of the tRNA acceptor stem, thus suggesting a possible organization of the genetic such as HIGH and KMSKS. In contrast, class II synthetases have active sites composed of antiparallel code [23,24]. The amino domains of classes Class Imay and have II aaRSs have been coded by opposite β- ...
... opposite sides of the tRNA acceptor stem, thus suggesting a possible organization of the genetic such as HIGH and KMSKS. In contrast, class II synthetases have active sites composed of antiparallel code [23,24]. The amino domains of classes Class Imay and have II aaRSs have been coded by opposite β- ...
A Comparative Study - Carlos Ibanez Lab @ KI
... NGF. Although all three NGFs were recognized equally well in the immunoblotting, only one-third of the chicken NGF protein could be detected by immunoprecipitation or by the EIA as compared to the rat and human NGFs. Thus, changes in the three-dimensional structure of the NGF molecule are most likel ...
... NGF. Although all three NGFs were recognized equally well in the immunoblotting, only one-third of the chicken NGF protein could be detected by immunoprecipitation or by the EIA as compared to the rat and human NGFs. Thus, changes in the three-dimensional structure of the NGF molecule are most likel ...
Unusual ADP-forming acetyl-coenzyme A synthetases from the
... In the sequenced genome of P. aerophilum, the genes putatively encoding the a and b subunits of ACD were identified by BLAST search using the amino acid sequences of the a and b subunits of the ACD isoenzyme I from P. furiosus. The ORFs PAE3250 and PAE3249, designated acdA and acdB, respectively, wer ...
... In the sequenced genome of P. aerophilum, the genes putatively encoding the a and b subunits of ACD were identified by BLAST search using the amino acid sequences of the a and b subunits of the ACD isoenzyme I from P. furiosus. The ORFs PAE3250 and PAE3249, designated acdA and acdB, respectively, wer ...
The antagonistic pleiotropy model
... Demographic information from a historical population of 16,500 families that inhabited the Krummhorn region of Germany between 1720-1870. They focused on two fundamental predictions of the disposable soma theory 1. That marred women should have shorter life spans than their unmarried counterpart ...
... Demographic information from a historical population of 16,500 families that inhabited the Krummhorn region of Germany between 1720-1870. They focused on two fundamental predictions of the disposable soma theory 1. That marred women should have shorter life spans than their unmarried counterpart ...
UNIVERSITAT ROVIRA I VIRGILI CODON USAGE ADAPTATION IN PROKARYOTIC GENOMES
... selection, mutational and positional bias and random genetic drift (4, 5). One of the currently accepted views is that genome-wide codon bias is determined primarily by mutational processes and only secondarily by translational selection (6). The available sequences of more than a hundred prokaryoti ...
... selection, mutational and positional bias and random genetic drift (4, 5). One of the currently accepted views is that genome-wide codon bias is determined primarily by mutational processes and only secondarily by translational selection (6). The available sequences of more than a hundred prokaryoti ...
Identification of a structural motif that confers specific interaction with
... (STH) (Figure 2). The STO homolog has been sequenced by the Arabidopsis genome initiative and is located on chromosome II. The predicted protein (DDBJ/EMBL/ GenBank accession No. AAD26481) is one amino acid shorter than the protein encoded by the STH cDNA due to an error in exon±intron boundary pred ...
... (STH) (Figure 2). The STO homolog has been sequenced by the Arabidopsis genome initiative and is located on chromosome II. The predicted protein (DDBJ/EMBL/ GenBank accession No. AAD26481) is one amino acid shorter than the protein encoded by the STH cDNA due to an error in exon±intron boundary pred ...
Functional Characterization of Nine Norway
... 2002). While many terpenoids exist as pairs of enantiomers (Fig. 1), TPS exhibit preferential catalysis toward one stereoisomer resulting in mostly optically pure product profiles (Davis and Croteau, 2000; Phillips et al., 2003). The exact structural features that determine substrate specificity and ...
... 2002). While many terpenoids exist as pairs of enantiomers (Fig. 1), TPS exhibit preferential catalysis toward one stereoisomer resulting in mostly optically pure product profiles (Davis and Croteau, 2000; Phillips et al., 2003). The exact structural features that determine substrate specificity and ...
5 The structure and function of membrane proteins
... occurred with the rapid development of cost-effective, powerful, desktop computers with performance equivalent to the previous generation of supercomputers. Many experimental techniques relied on the codevelopment of computer hardware but software has also played a vital role in protein biochemistry ...
... occurred with the rapid development of cost-effective, powerful, desktop computers with performance equivalent to the previous generation of supercomputers. Many experimental techniques relied on the codevelopment of computer hardware but software has also played a vital role in protein biochemistry ...
Biotechnology CTY Course Syllabus Introduction
... Like all CTY science experiences, this inquiry-driven course is designed to develop your critical thinking and analytical reasoning skills in the specific context of Biotechnology and its 21st century applications. In order to maintain fidelity to CTY general objectives, we will explore a plethora o ...
... Like all CTY science experiences, this inquiry-driven course is designed to develop your critical thinking and analytical reasoning skills in the specific context of Biotechnology and its 21st century applications. In order to maintain fidelity to CTY general objectives, we will explore a plethora o ...
Complete genome sequence of the prototype lactic acid bacterium
... sequence were identified using the program SIGI (for score-based identification of genomic islands) (69), based on the scoring of codon frequencies combined with cluster analysis. Alien genes are defined as those that are potentially acquired through horizontal gene transfer (HGT). This program has ...
... sequence were identified using the program SIGI (for score-based identification of genomic islands) (69), based on the scoring of codon frequencies combined with cluster analysis. Alien genes are defined as those that are potentially acquired through horizontal gene transfer (HGT). This program has ...
A1018 High oleic GM soybean AppR SD1 Safety Assess AMENDED
... Recently there has been interest in genetically modifying oilseed fatty acids, particularly via directed gene down-regulation strategies (see discussion in Durrett et al., 2008; Liu et al., 2002). The increased levels of oleic acid in soybean 305423 have been achieved through the introduction of a p ...
... Recently there has been interest in genetically modifying oilseed fatty acids, particularly via directed gene down-regulation strategies (see discussion in Durrett et al., 2008; Liu et al., 2002). The increased levels of oleic acid in soybean 305423 have been achieved through the introduction of a p ...
ASD v2.0: updated content and novel features
... Morpheerin model (24–26). In addition to these concerted/sequential models, allosteric pathways achieved by the propagation of a perturbation signal from the allosteric site to the orthosteric site were experimentally observed in some proteins (e.g. CREB binding protein), which not only provides ins ...
... Morpheerin model (24–26). In addition to these concerted/sequential models, allosteric pathways achieved by the propagation of a perturbation signal from the allosteric site to the orthosteric site were experimentally observed in some proteins (e.g. CREB binding protein), which not only provides ins ...
PKU - Nutricia Learning Center
... Since all foods with protein contain PHE, a person with PKU must restrict the amount and types of food containing protein. For this reason, PKU is managed with a low PHE diet consisting of foods low in protein and a PHE-free metabolic formula. The main sources of foods with protein allowed in the lo ...
... Since all foods with protein contain PHE, a person with PKU must restrict the amount and types of food containing protein. For this reason, PKU is managed with a low PHE diet consisting of foods low in protein and a PHE-free metabolic formula. The main sources of foods with protein allowed in the lo ...
From Sequence to Structure
... Replication of the AIDS virus HIV depends on the action of a protein-cleaving enzyme called HIV protease. This enzyme is the target for protease-inhibitor drugs (shown in grey). (PDB 1a8k) ...
... Replication of the AIDS virus HIV depends on the action of a protein-cleaving enzyme called HIV protease. This enzyme is the target for protease-inhibitor drugs (shown in grey). (PDB 1a8k) ...
THE MULTIFARIOUS AND DYNAMIC REGULATION OF THE LIVING CELL Karen van Eunen
... organisms such that it may harm the organism. In order to survive, the organism should have the ability to rapidly adjust its physiology to the new conditions [110]. For instance, mammals can adapt their physiology such that a constant body temperature is maintained even when the ambient temperature ...
... organisms such that it may harm the organism. In order to survive, the organism should have the ability to rapidly adjust its physiology to the new conditions [110]. For instance, mammals can adapt their physiology such that a constant body temperature is maintained even when the ambient temperature ...
METABOLIC CUES AND REGULATORY PROTEINS
... macrophages to cause the severe pneumonia, Legionnaires’ disease. To persist within these diverse niches, L. pneumophila alternates between at least two distinct phenotypic phases: a non-infectious, replicative form required for intracellular growth and an infectious, transmissive form that enhances ...
... macrophages to cause the severe pneumonia, Legionnaires’ disease. To persist within these diverse niches, L. pneumophila alternates between at least two distinct phenotypic phases: a non-infectious, replicative form required for intracellular growth and an infectious, transmissive form that enhances ...
Nicotinamide adenine dinucleotide, a metabolic regulator of
... pathway is compartmentalised in the nucleus, where NAD can be readily utilised by Sir2p [15]. Consistent with this notion, components of the salvage pathway, such as Npt1p, are localised primarily to the nucleus, whereas components of the de novo pathway reside evenly throughout the cell and have n ...
... pathway is compartmentalised in the nucleus, where NAD can be readily utilised by Sir2p [15]. Consistent with this notion, components of the salvage pathway, such as Npt1p, are localised primarily to the nucleus, whereas components of the de novo pathway reside evenly throughout the cell and have n ...
A Comparison of Murine and Human Factor XI
... pooled normal human or murine plasma. The factor XI concentration of undiluted pooled normal human plasma was considered to represent 100% activity (1 U factor XI/mL). Preparations were also tested for factor IX activity by substituting factor IX–deficient plasma for factor XI–deficient plasma in th ...
... pooled normal human or murine plasma. The factor XI concentration of undiluted pooled normal human plasma was considered to represent 100% activity (1 U factor XI/mL). Preparations were also tested for factor IX activity by substituting factor IX–deficient plasma for factor XI–deficient plasma in th ...
and Rhizobiales-Like PPP-Family Protein Phosphatases from
... affinity purification protein isolation strategy, with specific protein interactor complements indicating independent regulatory roles within plant cells involving chloroplast energy biosynthesis and mitochondrial intermembrane space processes, respectively. Lastly, phenotypic analysis of atslp2 ins ...
... affinity purification protein isolation strategy, with specific protein interactor complements indicating independent regulatory roles within plant cells involving chloroplast energy biosynthesis and mitochondrial intermembrane space processes, respectively. Lastly, phenotypic analysis of atslp2 ins ...
The Major Component of the Paraflagellar Rod of Trypanosoma
... similarity to the intermediate filament proteins (solubility properties, amino acid composition, and high degree of helicity), the PFR protein does not belong in this class of cytoskeletal proteins. The PFR protein is coded for by two tandemly linked genes of identical nucleotide sequence. Both gene ...
... similarity to the intermediate filament proteins (solubility properties, amino acid composition, and high degree of helicity), the PFR protein does not belong in this class of cytoskeletal proteins. The PFR protein is coded for by two tandemly linked genes of identical nucleotide sequence. Both gene ...