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Give reasons for the following.(one mark each)
Give reasons for the following.(one mark each)

... 13. SN2 reaction always proceeds with inversion of configuration. 14. The order of reactivity of alkyl halides for SN2 is 1o> 2o>3o 15. The order of reactivity of alkyl halides for SN1 is 3o> 2o>1o 16. Even trace amounts of water has to be removed from Grignards reagent . 17. Haloarenes/ aryl halide ...
Asymmetric Catalytic Aldol
Asymmetric Catalytic Aldol

... Zirconium Catalysis • Bulky Zr catalysts afford preferentially anti aldols independent of the sily enolate geometry. • Small amounts of protic additives (alcohols) are critical for catalyst ...
TRANSLATION - Grade 12 Biology
TRANSLATION - Grade 12 Biology

... The next tRNA carrying the required a.a. enters the A site. At the catalytic site (b/w A and P) a peptide bond forms between the two amino acids. The ribosome moves over one codon. The second a.acid moves to the P site, a tRNA brings the next a.acid to the A site and it is added to the chain. The fi ...
One of the chemicals used to make soaps is sodium hydroxide
One of the chemicals used to make soaps is sodium hydroxide

... The common salts listed in the table can all be made by reacting an acid with a base. ...
Anhydrous copper (II) sulfate: an efficient catalyst for the liquid
Anhydrous copper (II) sulfate: an efficient catalyst for the liquid

... Received September 11, 1979 ...
Carboxylic Acid Structure and Chemistry
Carboxylic Acid Structure and Chemistry

amine
amine

... nonbonded electron pair on the nitrogen atom, interconversion cannot occur, and the N atom is just like a carbon atom with four different groups around it. ...
Insertion of SO2 into the Metal−Carbon Bonds of Rhodium and
Insertion of SO2 into the Metal−Carbon Bonds of Rhodium and

... been obtained. Acetonitrile has been observed to be capable of displacing the labile triflate ligand in other organometallic systems.5 Reaction of 5 with an excess of CH3CN in CH2Cl2 leads to an immediate color change of the solution from yellow to colorless. Removal of the excess of acetonitrile un ...
chm238f02.pracexam2.ans
chm238f02.pracexam2.ans

... Chlorine is o,p directing because of resonance. Note the bonus structure above. 4 resonance structures vs 3 for meta subst. Chlorine is EWG through sigma bonds because of its high electronegativity. Chloro-substituted benzene has less electron density to donate towards the NO2+ group. ...
Advanced Organic Chemistry II Chemistry 412/512 Spring 2012
Advanced Organic Chemistry II Chemistry 412/512 Spring 2012

... Basicity  Functions  of  Common  Bases   In  analogy  of  the  acidity  function  H0,  which  is   appropriate  for  dealing  with  acid  catalysis,  a  function  H–   was  developed  to  deal  with  base  catalysis     ...
Stoich chem reactions practice Answer Section
Stoich chem reactions practice Answer Section

... 2. In writing an equation that produces hydrogen gas, the correct representation of hydrogen gas is a. H. c. H2. b. 2H. d. OH. 3. To balance a chemical equation, it may be necessary to adjust the a. coefficients. c. formulas of the products. b. subscripts. d. number of products. 4. Which word equati ...
Document
Document

... Basicity: thermodynamic affinity toward H+ Nucleophilicity: affinity toward positively polarized C atom or hetero atom (P, S, etc.) ...
File
File

... But if secondary or tertiary alkyl halides are taken in place of primary alkyl halides, then elimination would compete over substitution. As a result, alkenes would be produced. This is because alkoxides are nucleophiles as well as strong bases. Hence, they react with alkyl halides, which results in ...
IUPAC Names for Carboxylic Acids
IUPAC Names for Carboxylic Acids

... • are found in fruits, milk, and sugar cane. • are naturally occurring carboxylic acids with a hydroxyl group on the carbon atom that is adjacent to the carboxyl group. ...
Chapter 8. CARBONYL COMPOUNDS
Chapter 8. CARBONYL COMPOUNDS

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Unit 6 web

... Isomers are compounds that have the same molecular formula but are ‘different’ in some aspect of their structure, eg. a. positional: structural chemical b. geometrical: ...
Introduction to Organic Synthesis 2011
Introduction to Organic Synthesis 2011

... use of several common reactions, introduce the concept of synthetic organic chemistry and how organic chemists design and carry out multi step synthesis. The following topics will be covered in this course: •Introduction to synthesis, chemoselectivity, regioselectivity and functional groups •Radical ...
SULFONATION OF BY SO3
SULFONATION OF BY SO3

... The sulfonation process relates to the sulfur trioxide sulfonation of long chain and branched chain aliphatic alcohols such as fatty alcohols, and to the sulfonation of the aromatic nucleus of alkyl aromatic compounds. The reaction of sulfur trioxide is with an alkyl benzene whereby the sulfonated a ...
Answers - Benjamin
Answers - Benjamin

... d The key feature of the i.r. spectrum is the change at ca 3000 cm–1 indicating the loss of a phenolic hydroxyl and/or carboxylic acid group. The n.m.r. spectra show the loss of a carboxylic acid –OH group, and the gain of a methyl group. The CH3 group is in an environment different to that in aspir ...
Παρουσίαση του PowerPoint
Παρουσίαση του PowerPoint

... colorings and flavorings, perfumes, detergents and disinfectants. Research chemists synthesize natural products whose structure is uncertain, compounds for mechanistic investigations, possible intermediate in chemical and biological processes, thousands of potential drugs used in medical practice, a ...
PRODUCTION OF MATERIALS SAMPLE
PRODUCTION OF MATERIALS SAMPLE

Παρουσίαση του PowerPoint
Παρουσίαση του PowerPoint

... Before and during these syntheses, groups of chemists sitting around blackboards or piles of paper plan the work they are about to undertake. Possible routes are drawn out, criticized, modified again when the behavior of the compounds in the flask turns out to be different from what was expected, un ...
Oxidation Reactions
Oxidation Reactions

... The oxidation of an alcohol can produce either an aldehyde or a ketone. Ethanol can be oxidized in the laboratory through a heating process combined with the addition of an oxidizing agent such as the dichromate ion, which catalyzes the reaction in an acidic solution. The reaction produces the aldeh ...
Aldehydes, Ketones and Carboxylic acids
Aldehydes, Ketones and Carboxylic acids

... Reactions of aldehydes and ketones: Aldehydes and ketones undergo nucleophilic substitution reaction. In nucleophilic substitution, a species that has extra electron or lone pair of electron attacks the carbonyl carbon of the ketone or the aldehyde leading to an alkoxide intermediate as shown in the ...
3672 been studied in detail by Kebarle, et al., who
3672 been studied in detail by Kebarle, et al., who

< 1 ... 59 60 61 62 63 64 65 66 67 ... 157 >

Petasis reaction



The Petasis reaction (alternatively called the Petasis borono–Mannich (PBM) reaction) is the chemical reaction of an amine, aldehyde, and vinyl- or aryl-boronic acid to form substituted amines.Reported in 1993 by Nicos Petasis as a practical method towards the synthesis of a geometrically pure antifungal agent, naftifine, the Petasis reaction can be described as a variation of the Mannich reaction. Rather than generating an enolate to form the substituted amine product, in the Petasis reaction, the vinyl group of the organoboronic acid serves as the nucleophile. In comparison to other methods of generating allyl amines, the Petasis reaction tolerates a multifunctional scaffold, with a variety of amines and organoboronic acids as potential starting materials. Additionally, the reaction does not require anhydrous or inert conditions. As a mild, selective synthesis, the Petasis reaction is useful in generating α-amino acids, and is utilized in combinatorial chemistry and drug discovery.
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