Reith RM, McKenna J, Wu H, Hashmi SS, Cho SH, Dash PK, Gambello MJ. Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex. Neurobiology of Disease. 2013 Mar;51:93-103.
... in Tsc2f/f;Cre mice, suggesting that Purkinje cell pathology is sufficient to induce ASD-like behavior. Importantly, social behavior deficits were prevented with rapamycin treatment. Altogether, these results demonstrate that loss of Tsc2 in Purkinje cells in a Tsc2-haploinsufficient background leads t ...
... in Tsc2f/f;Cre mice, suggesting that Purkinje cell pathology is sufficient to induce ASD-like behavior. Importantly, social behavior deficits were prevented with rapamycin treatment. Altogether, these results demonstrate that loss of Tsc2 in Purkinje cells in a Tsc2-haploinsufficient background leads t ...
System
... Hypothesis, theory and models Theory ”A cluster of hypothses with a clear the connection between them. ” Hypothesis ”Explains, describes or interpret possible connections which one is uncertain about, but willing to investigate.” Model ”A representation of an idea or hypothesis.” (simplified ver ...
... Hypothesis, theory and models Theory ”A cluster of hypothses with a clear the connection between them. ” Hypothesis ”Explains, describes or interpret possible connections which one is uncertain about, but willing to investigate.” Model ”A representation of an idea or hypothesis.” (simplified ver ...
Student Questions/Comments
... that participants either automatically approach or avoid a stimulus, dependent on its positive or negative attitude solicitation. Similarly, the authors show response latency in their response when forced to respond in a way that differs from how they might automatically react. This could support Ka ...
... that participants either automatically approach or avoid a stimulus, dependent on its positive or negative attitude solicitation. Similarly, the authors show response latency in their response when forced to respond in a way that differs from how they might automatically react. This could support Ka ...
Module 10a--Operant and Cognitive Approaches
... Plotnik and Kouyoumdjian tell us about the starring performance of 1,800-pound Bart in The Bear to make the point that: A. although most animals do not have the capacity for learning, a few do quite well B. the key to learning (and teaching) is perseverance: keep working C. you shouldn’t believe tha ...
... Plotnik and Kouyoumdjian tell us about the starring performance of 1,800-pound Bart in The Bear to make the point that: A. although most animals do not have the capacity for learning, a few do quite well B. the key to learning (and teaching) is perseverance: keep working C. you shouldn’t believe tha ...
Neurochemical organization of chimpanzee inferior pulvinar complex
... Povinelli, 2000). These studies make it clear that although humans share many features of brain organization and function with apes and monkeys, there are important differences as well. Documenting the patterns of similarities and difference is essential for understanding how results derived from no ...
... Povinelli, 2000). These studies make it clear that although humans share many features of brain organization and function with apes and monkeys, there are important differences as well. Documenting the patterns of similarities and difference is essential for understanding how results derived from no ...
Annual Pavlovian Society Meeting ~ Sept 1820, 2014 Hilton Seattle
... of an unconditioned stimulus (US). In error prediction models inhibition develops because a cue signals the omission of an expected reward. In contingency models inhibition develops when the rate of US presentation in the presence of a cue is lower than the rate in the absence of that cue. In severa ...
... of an unconditioned stimulus (US). In error prediction models inhibition develops because a cue signals the omission of an expected reward. In contingency models inhibition develops when the rate of US presentation in the presence of a cue is lower than the rate in the absence of that cue. In severa ...
PDF
... of these correlations. If an amygdala neuron merely represents motivational significance then correlations between amygdala activity and reaction times would have the same sign regardless of the location of the saccade target. Increased activity, for example, would predict shorter reaction times for ...
... of these correlations. If an amygdala neuron merely represents motivational significance then correlations between amygdala activity and reaction times would have the same sign regardless of the location of the saccade target. Increased activity, for example, would predict shorter reaction times for ...
Cognitive reserve_Valenciano_Guàrdia_June2014
... 2011; Premi et al., 2013). All in all, through the cognitive reserve we evaluate brain function, whereas when we talk about brain reserve we focus on the brain size (Stern, ...
... 2011; Premi et al., 2013). All in all, through the cognitive reserve we evaluate brain function, whereas when we talk about brain reserve we focus on the brain size (Stern, ...
Levels of kinesin light chain and dynein intermediate
... Accumulations of organelles and of various proteins in axons and in cell body of neurons are observed in a number of neurodegenerative diseases [11]. A disruption of axoplasmic transport, an essential mechanism for maintenance of neuronal function is thought to underly the formation of these lesions ...
... Accumulations of organelles and of various proteins in axons and in cell body of neurons are observed in a number of neurodegenerative diseases [11]. A disruption of axoplasmic transport, an essential mechanism for maintenance of neuronal function is thought to underly the formation of these lesions ...
A Novel Mechanism and Treatment Target for Presynaptic
... the brain (Hess et al, 1992). These mice have a regionally specific greater level of noradrenalin but lower glutamate, dopamine, and serotonin neurotransmission, delayed acquisition of motor milestones, and hyperactivity as adults (Heyser et al, 1995; Jones et al, 2001; Raber et al, 1997). Hyperacti ...
... the brain (Hess et al, 1992). These mice have a regionally specific greater level of noradrenalin but lower glutamate, dopamine, and serotonin neurotransmission, delayed acquisition of motor milestones, and hyperactivity as adults (Heyser et al, 1995; Jones et al, 2001; Raber et al, 1997). Hyperacti ...
Quantified Distribution of the Noradrenaline Innervation in the
... the ratio between the numbers at this time interval and the theoretical maximum to correct for incomplete detection at the chosen exposure time. (2) A second transformation was needed to compensate for the lack of transparency to tritium in 4-pm-thick sections. Counts were obtained from adjacent pai ...
... the ratio between the numbers at this time interval and the theoretical maximum to correct for incomplete detection at the chosen exposure time. (2) A second transformation was needed to compensate for the lack of transparency to tritium in 4-pm-thick sections. Counts were obtained from adjacent pai ...
Chapter 13 Stress and Glucocorticoid Contributions to Normal and
... maintenance of the immune system, and inhibition of nonessential processes such as reproductive function. Collectively, these functions enable “fight or flight” behaviors to remove the organism from immediate danger, while later restoring bodily homeostasis. Although many hormones are released in re ...
... maintenance of the immune system, and inhibition of nonessential processes such as reproductive function. Collectively, these functions enable “fight or flight” behaviors to remove the organism from immediate danger, while later restoring bodily homeostasis. Although many hormones are released in re ...
Energy balance
... Now, back to caffeine. • Caffeine binds to the receptors for adenosine, but has no effect on the receptors. • When caffeine is bound, adenosine can’t bind. Adenosine Caffeine ...
... Now, back to caffeine. • Caffeine binds to the receptors for adenosine, but has no effect on the receptors. • When caffeine is bound, adenosine can’t bind. Adenosine Caffeine ...
an opponent-process theory of motivation: i. temporal
... A new theory of motivation is described along with its applications to addiction and aversion. The theory assumes that many hedonic, affective, or emotional states are automatically opposed by central nervous system mechanisms which reduce the intensity of hedonic feelings, both pleasant and aversiv ...
... A new theory of motivation is described along with its applications to addiction and aversion. The theory assumes that many hedonic, affective, or emotional states are automatically opposed by central nervous system mechanisms which reduce the intensity of hedonic feelings, both pleasant and aversiv ...
Late-onset Parkinsonism in NFjB/c-Rel
... rat anti-mouse CD11b (1:1000, Serotec). Brain sections were incubated in biotinylated secondary antibodies (all purchased from Vector) and visualized by avidin–biotin–horseradish peroxidase technique (ABC Elite; Vector Laboratories) using 0.025% 3,30 -diaminobenzidine (Sigma) as the chromogen. NeuN ...
... rat anti-mouse CD11b (1:1000, Serotec). Brain sections were incubated in biotinylated secondary antibodies (all purchased from Vector) and visualized by avidin–biotin–horseradish peroxidase technique (ABC Elite; Vector Laboratories) using 0.025% 3,30 -diaminobenzidine (Sigma) as the chromogen. NeuN ...
Is anterior cingulate cortex necessary for cognitive control?Brain, 128
... and as such will tend to be normally distributed according to the central limit theorem. Parametric statistical tests were therefore employed. Error rates were treated in the same way, except that they were first log-transformed to conform better to a normal distribution, where necessary. The key an ...
... and as such will tend to be normally distributed according to the central limit theorem. Parametric statistical tests were therefore employed. Error rates were treated in the same way, except that they were first log-transformed to conform better to a normal distribution, where necessary. The key an ...
Foundation and practice of neurofeedback for the treatment of epilepsy
... over sensorimotor cortex emerged above non-rhythmic low-voltage background activity. This rhythm was characterized by a frequency of 12–20 Hz, not unlike EEG sleep spindles, with a spectral peak around 12–14 Hz, and has been referred to as the “sensorimotor rhythm” (SMR) (Roth et al., 1967). The inv ...
... over sensorimotor cortex emerged above non-rhythmic low-voltage background activity. This rhythm was characterized by a frequency of 12–20 Hz, not unlike EEG sleep spindles, with a spectral peak around 12–14 Hz, and has been referred to as the “sensorimotor rhythm” (SMR) (Roth et al., 1967). The inv ...
PDF
... possible to distinguish a broad leg area, arm area, and face area, there appears to be little somatotopic organization within each of these areas. The significance of this apparent disorder is not clear. Second, when neurons at one location in the map become active, do they specify joint angle, musc ...
... possible to distinguish a broad leg area, arm area, and face area, there appears to be little somatotopic organization within each of these areas. The significance of this apparent disorder is not clear. Second, when neurons at one location in the map become active, do they specify joint angle, musc ...
Point-Light Biological Motion Perception Activates Human Premotor
... Image processing and analysis. Image preprocessing and statistical analysis were performed using Analysis of Functional Neuroimages (AFNI) (Cox, 1996), FreeSurfer (Dale et al., 1999; Fischl et al., 1999a), and Matlab (MathWorks, Natick, MA) software packages. For each individual subject, the B0 fiel ...
... Image processing and analysis. Image preprocessing and statistical analysis were performed using Analysis of Functional Neuroimages (AFNI) (Cox, 1996), FreeSurfer (Dale et al., 1999; Fischl et al., 1999a), and Matlab (MathWorks, Natick, MA) software packages. For each individual subject, the B0 fiel ...
Experiment 2 - fMRI Study
... To elucidate the extent to which production and comprehension share cognitive and neural processes, rather than simply linguistic and/or grammatical knowledge, here we chose to focus on processes that arguably involve competition between alternative representations. Such competition may occur in co ...
... To elucidate the extent to which production and comprehension share cognitive and neural processes, rather than simply linguistic and/or grammatical knowledge, here we chose to focus on processes that arguably involve competition between alternative representations. Such competition may occur in co ...
Effect Studies in Unobtrusive Advertising: From Recall to SOA
... Effect Studies in Unobtrusive Advertising: From Recall to SOA A New Experimental Paradigm Applied to Product Placement in Television This thesis examines product placements on television as an upcoming and increasingly important form of persuasive communication. Drawing its inspiration from previous ...
... Effect Studies in Unobtrusive Advertising: From Recall to SOA A New Experimental Paradigm Applied to Product Placement in Television This thesis examines product placements on television as an upcoming and increasingly important form of persuasive communication. Drawing its inspiration from previous ...
1 Removing the Constraints on Our Choices: A Psychobiological
... in charge of balancing the amount of incoming sensory stimuli. For example, sensation seekers will be attracted to crowded places while sensation avoiders will be repelled by them. Although the behavioral outcome is very different, in both cases a regulatory attempt is taking place leading to an inc ...
... in charge of balancing the amount of incoming sensory stimuli. For example, sensation seekers will be attracted to crowded places while sensation avoiders will be repelled by them. Although the behavioral outcome is very different, in both cases a regulatory attempt is taking place leading to an inc ...