Segregated cholinergic transmission in the ventral tegmental area
... axons (albeit not significant; Supplementary Fig. 4) and with an area of higher density in the dorsal part of the parabrachial pigmented area (Fig. 1c and 2c). Consecutive sections were processed to reveal the YFP by a permanent peroxidase reaction product and processed for electron microscopy to ch ...
... axons (albeit not significant; Supplementary Fig. 4) and with an area of higher density in the dorsal part of the parabrachial pigmented area (Fig. 1c and 2c). Consecutive sections were processed to reveal the YFP by a permanent peroxidase reaction product and processed for electron microscopy to ch ...
Supplementary Motor Area and Presupplementary Motor Area
... differential origin of subcortical projections to the SMA and pre-SMA suggests that these cortical areas are nodes in distinct neural systems. Although both systems are the target of outputs from the basal ganglia and the cerebellum, these two cortical areas seem to be dominated by basal ganglia inp ...
... differential origin of subcortical projections to the SMA and pre-SMA suggests that these cortical areas are nodes in distinct neural systems. Although both systems are the target of outputs from the basal ganglia and the cerebellum, these two cortical areas seem to be dominated by basal ganglia inp ...
Corticotropin-Releasing Hormone Directly Activates Noradrenergic
... activation of LC neurons is unknown. Moreover, given the apparent absence of mRNA for CRH receptors in LC neurons, the exact location of action of CRH within the cerulear region is debated. Using in vitro intracellular recordings from rat brainstem, we examined whether CRH exerts a direct effect on ...
... activation of LC neurons is unknown. Moreover, given the apparent absence of mRNA for CRH receptors in LC neurons, the exact location of action of CRH within the cerulear region is debated. Using in vitro intracellular recordings from rat brainstem, we examined whether CRH exerts a direct effect on ...
thyroid hormones in brain development and
... neurogenesis, neuronal migration, neuronal and glial cell differentiation, myelination, and synaptogenesis. The actions of thyroid hormones are mostly due to interaction of the active hormone T3 with nuclear receptors and regulation of gene expression. T4 and T3 also perform non-genomic actions. The ...
... neurogenesis, neuronal migration, neuronal and glial cell differentiation, myelination, and synaptogenesis. The actions of thyroid hormones are mostly due to interaction of the active hormone T3 with nuclear receptors and regulation of gene expression. T4 and T3 also perform non-genomic actions. The ...
Neurophysiological involvement in hypervolemic hyponatremia
... that different mechanisms are working for in vivo and in vitro hypoosmotic regulations and prolonged in vitro hypoosmotic actions may cause additional reactions of the brain osmotic regulatory system. Importantly, the rebound increase in AVP release during hypoosmotic stimulation in vitro matches th ...
... that different mechanisms are working for in vivo and in vitro hypoosmotic regulations and prolonged in vitro hypoosmotic actions may cause additional reactions of the brain osmotic regulatory system. Importantly, the rebound increase in AVP release during hypoosmotic stimulation in vitro matches th ...
Local network regulation of orexin neurons in the lateral hypothalamus
... doi:10.1152/ajpregu.00674.2010.—Obesity and inadequate sleep are among the most common causes of health problems in modern society. Thus, the discovery that orexin (hypocretin) neurons play a pivotal role in sleep/wake regulation, energy balance, and consummatory behaviors has sparked immense intere ...
... doi:10.1152/ajpregu.00674.2010.—Obesity and inadequate sleep are among the most common causes of health problems in modern society. Thus, the discovery that orexin (hypocretin) neurons play a pivotal role in sleep/wake regulation, energy balance, and consummatory behaviors has sparked immense intere ...
Multimodal Integration in Rostral Fastigial Nucleus Provides an
... signals underlies the accurate computation of body motion. Furthermore, the same neurons that encode body motion (i.e., bimodal neurons) most likely encode vestibular signals in a body-referenced coordinate frame, since the integration of proprioceptive and vestibular information is required for bot ...
... signals underlies the accurate computation of body motion. Furthermore, the same neurons that encode body motion (i.e., bimodal neurons) most likely encode vestibular signals in a body-referenced coordinate frame, since the integration of proprioceptive and vestibular information is required for bot ...
Structure and Function of the Brain Serotonin System
... is a paramedian and median cluster of cells lying below and caudal to the SCD (Fig. 2). The group has a rostrocaudal oblique orientation (34,305), and the paramedian columns are separated by as much as 400 pm in cats and monkeys. Rostrally, the cells from this group end around and within the caudal ...
... is a paramedian and median cluster of cells lying below and caudal to the SCD (Fig. 2). The group has a rostrocaudal oblique orientation (34,305), and the paramedian columns are separated by as much as 400 pm in cats and monkeys. Rostrally, the cells from this group end around and within the caudal ...
The Study of Brain Activity in Sleep
... of arousal-related neurotransmitters) lead cortical and thalamic neurons to enter in a “bistable” state. In this condition, a spontaneous or induced opening of leakage K+ channels triggers a series of membrane currents that produce the slow oscillation. The slow oscillation is characterized by a hyp ...
... of arousal-related neurotransmitters) lead cortical and thalamic neurons to enter in a “bistable” state. In this condition, a spontaneous or induced opening of leakage K+ channels triggers a series of membrane currents that produce the slow oscillation. The slow oscillation is characterized by a hyp ...
concurrent, distributed control of saccade initiation in the frontal eye
... equivalent of the saccade neurons with buildup activity observed in the SC. FEF is also populated by fixation neurons that seem to parallel their counterparts in the SC84 . Hanes and Wurtz 69 showed that it was not possible to elicit saccades with microstimulation of the FEF, following reversible d ...
... equivalent of the saccade neurons with buildup activity observed in the SC. FEF is also populated by fixation neurons that seem to parallel their counterparts in the SC84 . Hanes and Wurtz 69 showed that it was not possible to elicit saccades with microstimulation of the FEF, following reversible d ...
Understanding Opioid Reward Howard L. Fields and Elyssa B
... mechanism that does not require dopamine. Unfortunately, our knowledge of the non-dopaminergic VTA circuitry supporting MOP positive reinforcement is currently extremely limited. Dopamine neuron firing can encode positive outcomes and produce positive reinforcement Although some pharmacological man ...
... mechanism that does not require dopamine. Unfortunately, our knowledge of the non-dopaminergic VTA circuitry supporting MOP positive reinforcement is currently extremely limited. Dopamine neuron firing can encode positive outcomes and produce positive reinforcement Although some pharmacological man ...
Postnatal Development of the Corticospinal Tract in the Reeler Mouse
... were anesthetized with 3.5% chloral hydrate by intraperitoneal injection and clamped in a stereotactic apparatus with auxiliary devices. Following an incision of skin, a small bur hole was made in the left parietal bone using a dental drill. A single injection of 0.1 l of 10% DiI solution dissolved ...
... were anesthetized with 3.5% chloral hydrate by intraperitoneal injection and clamped in a stereotactic apparatus with auxiliary devices. Following an incision of skin, a small bur hole was made in the left parietal bone using a dental drill. A single injection of 0.1 l of 10% DiI solution dissolved ...
University of Groningen Gustatory neural processing in the
... afferents, postsynaptic afferents or even interneurons involved in intranuclear data processing. Most units recorded are subject to this ambiguity. In two recent studies Nakamura and Norgren extracellularly recorded single-unit responses of NTS neurons in awake rats, after gustatory stimulation with ...
... afferents, postsynaptic afferents or even interneurons involved in intranuclear data processing. Most units recorded are subject to this ambiguity. In two recent studies Nakamura and Norgren extracellularly recorded single-unit responses of NTS neurons in awake rats, after gustatory stimulation with ...
Topographic Organization of Corticospinal Projections from the
... that the precentral motor field contained a complete map of the body. A large part of the body map was located in cytoarchitectonic area 4. However, the representation of axial body musculature was located in the caudal part of area 6. In fact, it was principally the presence of axial representation ...
... that the precentral motor field contained a complete map of the body. A large part of the body map was located in cytoarchitectonic area 4. However, the representation of axial body musculature was located in the caudal part of area 6. In fact, it was principally the presence of axial representation ...
Rostral Fastigial Nucleus Activity in the Alert Monkey During Three
... different orientations 157 apart (including roll, pitch, vertical canal plane and intermediate planes). In addition, sinusoidal rotations around an earth-vertical axis (yaw stimulus) included different roll and pitch positions ( {107, {207 ). The latter positions were also used for static stimulatio ...
... different orientations 157 apart (including roll, pitch, vertical canal plane and intermediate planes). In addition, sinusoidal rotations around an earth-vertical axis (yaw stimulus) included different roll and pitch positions ( {107, {207 ). The latter positions were also used for static stimulatio ...
Reverse pharmacology of orexin
... the basal forebrain cholinergic neurons and monoaminergic neurons in the brain stem to maintain arousal. In addition, orexin neurons also appear to act on LDT/PPT cholinergic neurons, because orexin neurons project directly to the PPT/ LDT nuclei and direct injection of orexin-A into the LDT of cats ...
... the basal forebrain cholinergic neurons and monoaminergic neurons in the brain stem to maintain arousal. In addition, orexin neurons also appear to act on LDT/PPT cholinergic neurons, because orexin neurons project directly to the PPT/ LDT nuclei and direct injection of orexin-A into the LDT of cats ...
Changes of Synaptic Density in the Primary Visual Cortex of the
... to estimate the degree of shrinkage from exposure to aldehydes during the perfusion itself because it would have required surgery before perfusion for each individual case. This is not, however, a limitation in our study since we compared densities of synapses at different stages of maturation rathe ...
... to estimate the degree of shrinkage from exposure to aldehydes during the perfusion itself because it would have required surgery before perfusion for each individual case. This is not, however, a limitation in our study since we compared densities of synapses at different stages of maturation rathe ...
View PDF - MRC BNDU - University of Oxford
... Neurons in the pedunculopontine nucleus (PPN) are highly heterogeneous in their discharge properties, their neurochemical markers, their pattern of connectivity and the behavioural processes in which they participate. Three main transmitter phenotypes have been described, cholinergic, GABAergic and ...
... Neurons in the pedunculopontine nucleus (PPN) are highly heterogeneous in their discharge properties, their neurochemical markers, their pattern of connectivity and the behavioural processes in which they participate. Three main transmitter phenotypes have been described, cholinergic, GABAergic and ...
THESIS D - Krishikosh
... and well wishes, I want to preserve a special love for my relatives and well wishers, which enable me to complete the entire research program successfully. I would always remember the invaluable help, active cooperation and constant inspiration of my wife Dr. Sanjivani and my lovely son Arjun who ma ...
... and well wishes, I want to preserve a special love for my relatives and well wishers, which enable me to complete the entire research program successfully. I would always remember the invaluable help, active cooperation and constant inspiration of my wife Dr. Sanjivani and my lovely son Arjun who ma ...
GABAergic neuron distribution in the pedunculopontine nucleus
... Indeed, recent studies have shown that there are also functional differences between the two portions of the PPN, which have been evaluated in terms of behavioral responses following excitotoxic lesions or electrical stimulation (Alderson et al., 2006, 2008; Andero et al., 2007). Taken together, the ...
... Indeed, recent studies have shown that there are also functional differences between the two portions of the PPN, which have been evaluated in terms of behavioral responses following excitotoxic lesions or electrical stimulation (Alderson et al., 2006, 2008; Andero et al., 2007). Taken together, the ...
Selectivity for the Shape, Size, and Orientation of Objects for
... orientation of objects for grasping in neurons of monkey parietal area AIP. J. Neurophysiol. 83: 2580 –2601, 2000. In this study, we mainly investigated the visual selectivity of hand-manipulation-related neurons in the anterior intraparietal area (area AIP) while the animal was grasping or fixating ...
... orientation of objects for grasping in neurons of monkey parietal area AIP. J. Neurophysiol. 83: 2580 –2601, 2000. In this study, we mainly investigated the visual selectivity of hand-manipulation-related neurons in the anterior intraparietal area (area AIP) while the animal was grasping or fixating ...
Selectivity for the Shape, Size, and Orientation of Objects for
... shapes, sizes, and orientations. We studied the activity of 132 task-related neurons during the hand-manipulation tasks in the light and in the dark, as well as during object fixation. Seventy-seven percent (101/132) of the hand-manipulation-related neurons were visually responsive, showing either l ...
... shapes, sizes, and orientations. We studied the activity of 132 task-related neurons during the hand-manipulation tasks in the light and in the dark, as well as during object fixation. Seventy-seven percent (101/132) of the hand-manipulation-related neurons were visually responsive, showing either l ...
Morphology of Thalamocortical Neurons Projecting
... were quantitatively analyzed and compared between the nuclei, and their relationships with the spinothalamic (STT) terminals were studied. From the earliest studies of Golgi impregnated cells (e.g., Cajal1911; Guillery, 1966; Tombol, 1967,19691,it has been observed that dendritic shapes in any given ...
... were quantitatively analyzed and compared between the nuclei, and their relationships with the spinothalamic (STT) terminals were studied. From the earliest studies of Golgi impregnated cells (e.g., Cajal1911; Guillery, 1966; Tombol, 1967,19691,it has been observed that dendritic shapes in any given ...
Sample
... 24) "All or none" is the principle stating that: A) a neuron either fires or does not fire. B) a neuron fires at full strength or not at all. C) all the dendrites must be receiving messages telling the neuron to fire or it will not fire at all. D) all axons must be receiving messages telling the neu ...
... 24) "All or none" is the principle stating that: A) a neuron either fires or does not fire. B) a neuron fires at full strength or not at all. C) all the dendrites must be receiving messages telling the neuron to fire or it will not fire at all. D) all axons must be receiving messages telling the neu ...
Sleep Neurobiology from a Clinical Perspective
... activity is too low, distractible and anxious if LC activity is too high, but optimally attentive and aroused with intermediate levels of activity. NE tone is clearly linked to cognition as LC neurons in monkeys fire phasically in response to a salient stimulus that signals a reward such as food, bu ...
... activity is too low, distractible and anxious if LC activity is too high, but optimally attentive and aroused with intermediate levels of activity. NE tone is clearly linked to cognition as LC neurons in monkeys fire phasically in response to a salient stimulus that signals a reward such as food, bu ...
Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. Only a few invertebrates such as sponges, jellyfish, adult sea squirts and starfish do not have a brain; diffuse or localised nerve nets are present instead. The brain is located in the head, usually close to the primary sensory organs for such senses as vision, hearing, balance, taste, and smell. The brain is the most complex organ in a vertebrate's body. In a typical human, the cerebral cortex (the largest part) is estimated to contain 15–33 billion neurons, each connected by synapses to several thousand other neurons. These neurons communicate with one another by means of long protoplasmic fibers called axons, which carry trains of signal pulses called action potentials to distant parts of the brain or body targeting specific recipient cells.Physiologically, the function of the brain is to exert centralized control over the other organs of the body. The brain acts on the rest of the body both by generating patterns of muscle activity and by driving the secretion of chemicals called hormones. This centralized control allows rapid and coordinated responses to changes in the environment. Some basic types of responsiveness such as reflexes can be mediated by the spinal cord or peripheral ganglia, but sophisticated purposeful control of behavior based on complex sensory input requires the information integrating capabilities of a centralized brain.The operations of individual brain cells are now understood in considerable detail but the way they cooperate in ensembles of millions is yet to be solved. Recent models in modern neuroscience treat the brain as a biological computer, very different in mechanism from an electronic computer, but similar in the sense that it acquires information from the surrounding world, stores it, and processes it in a variety of ways, analogous to the central processing unit (CPU) in a computer.This article compares the properties of brains across the entire range of animal species, with the greatest attention to vertebrates. It deals with the human brain insofar as it shares the properties of other brains. The ways in which the human brain differs from other brains are covered in the human brain article. Several topics that might be covered here are instead covered there because much more can be said about them in a human context. The most important is brain disease and the effects of brain damage, covered in the human brain article because the most common diseases of the human brain either do not show up in other species, or else manifest themselves in different ways.