PRODUCT MONOGRAPH OFLOXACIN TABLETS 200, 300 and 400 mg
... reported in patients receiving therapy with quinolones, including ofloxacin. These reactions often occur following the first dose. Some reactions were accompanied by cardiovascular collapse, hypotension/shock, seizure, loss of consciousness, tingling, angioedema (including tongue, laryngeal, throat ...
... reported in patients receiving therapy with quinolones, including ofloxacin. These reactions often occur following the first dose. Some reactions were accompanied by cardiovascular collapse, hypotension/shock, seizure, loss of consciousness, tingling, angioedema (including tongue, laryngeal, throat ...
Levitra - GSK Source
... 5.3 Risk of Priapism There have been rare reports of prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) for this class of compounds, including vardenafil. In the event that an erection persists longer than 4 hours, the patient should seek imme ...
... 5.3 Risk of Priapism There have been rare reports of prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) for this class of compounds, including vardenafil. In the event that an erection persists longer than 4 hours, the patient should seek imme ...
Codeine to Morphine Concentration Ratios in Samples
... analyzed at the Norwegian Institute of Public Health (NIPH). In forensic toxicology, the codeine to morphine concentration ratio, in blood and urine, is used to evaluate whether codeine has been ingested (10) or if the findings are due to a consumption of other opiates (10–13). The interpretation of ...
... analyzed at the Norwegian Institute of Public Health (NIPH). In forensic toxicology, the codeine to morphine concentration ratio, in blood and urine, is used to evaluate whether codeine has been ingested (10) or if the findings are due to a consumption of other opiates (10–13). The interpretation of ...
Sorting Through the Science on Marijuana: Facts, Fallacies,
... Administration (FDA) prior to approval for medical applications. This determination is independent of the process for determining whether a substance should be legal for non-medicinal consumption. If the FDA finds that a drug has risk of abuse, it petitions the Drug Enforcement Agency (DEA) to place ...
... Administration (FDA) prior to approval for medical applications. This determination is independent of the process for determining whether a substance should be legal for non-medicinal consumption. If the FDA finds that a drug has risk of abuse, it petitions the Drug Enforcement Agency (DEA) to place ...
ANTILIPEMICS 2012 - students [Read
... • good oral absorption • non-CYP hepatic metabolism • renal excretion • T1/2 - 2hr / 80hr • IR - TID, SR - double-dose OD / OD ...
... • good oral absorption • non-CYP hepatic metabolism • renal excretion • T1/2 - 2hr / 80hr • IR - TID, SR - double-dose OD / OD ...
Theracurmin | Information Sheet
... addition, the vanilloid part of the curcumin molecule is important for activation of the transient receptor potential vanilloid 1 (TRPV1, also known as the capsaicin receptor), which plays an important role in nociception.* Among the several modes of action identified for turmeric, experimental rese ...
... addition, the vanilloid part of the curcumin molecule is important for activation of the transient receptor potential vanilloid 1 (TRPV1, also known as the capsaicin receptor), which plays an important role in nociception.* Among the several modes of action identified for turmeric, experimental rese ...
Chapter 5.pmd - New Age International
... activity of human beings that simply occurs at will or pleasure of those who use it. It is a repetitive, stereotypic and compulsive behaviour characteristic of drug dependence. This seemingly irrational behaviour is strongly driven by the pharmacological actions of nicotine on the brain and that cig ...
... activity of human beings that simply occurs at will or pleasure of those who use it. It is a repetitive, stereotypic and compulsive behaviour characteristic of drug dependence. This seemingly irrational behaviour is strongly driven by the pharmacological actions of nicotine on the brain and that cig ...
Effect of Subconjunctivally Injected, Liposome
... Low molecular weight heparin (LMWH) produced from chemical or enzymatic hydrolytic cleavage of unfractionated heparin is an antithrombotic drug with an apparent molecular weight in the range of 3 to 9 kDa. LMWH is an improved anticoagulant compared with unfractionated heparin with respect to a longe ...
... Low molecular weight heparin (LMWH) produced from chemical or enzymatic hydrolytic cleavage of unfractionated heparin is an antithrombotic drug with an apparent molecular weight in the range of 3 to 9 kDa. LMWH is an improved anticoagulant compared with unfractionated heparin with respect to a longe ...
Download CV
... Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov JJ, Slusher BS. “Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhib ...
... Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov JJ, Slusher BS. “Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhib ...
Platelet inhibitory activity and pharmacokinetics of prasugrel
... 75 mg. Full recovery of platelet aggregation occurred between 48 h and 7 days suggesting irreversible inhibition by prasugrel and/or its metabolites. With prasugrel 2.5 and 10 mg, there was no measurable effect on platelet aggregation throughout the study (P > 0.05 for 2.5 and 10 mg prasugrel vs. pl ...
... 75 mg. Full recovery of platelet aggregation occurred between 48 h and 7 days suggesting irreversible inhibition by prasugrel and/or its metabolites. With prasugrel 2.5 and 10 mg, there was no measurable effect on platelet aggregation throughout the study (P > 0.05 for 2.5 and 10 mg prasugrel vs. pl ...
Amphetamines Assay
... • Do not use after expiration date. • Turbid or yellow reagents may indicate contamination or degradation and must be discarded. • Contains sodium azide (<0.1%) as a preservative. Sodium azide can react with copper or lead pipes in drain lines to form explosive compounds. Dispose of properly ...
... • Do not use after expiration date. • Turbid or yellow reagents may indicate contamination or degradation and must be discarded. • Contains sodium azide (<0.1%) as a preservative. Sodium azide can react with copper or lead pipes in drain lines to form explosive compounds. Dispose of properly ...
Report of the National Lipid Association`s Statin Safety Task Force
... is required for resale or distribution outside the institution. Permission of the publisher is required for all other derivative works, including compilations and translations. Electronic Storage: Permission of the publisher is required to store electronically any material contained in this journal, ...
... is required for resale or distribution outside the institution. Permission of the publisher is required for all other derivative works, including compilations and translations. Electronic Storage: Permission of the publisher is required to store electronically any material contained in this journal, ...
PRODUCT MONOGRAPH PrMONUROL® Fosfomycin powder, 3g
... Metoclopramide: When co‐administered with MONUROL, metoclopramide, a drug which increases gastrointestinal motility, lowers the serum concentration and urinary excretion of fosfomycin. Other drugs that increase gastrointestinal motility may produce similar effects. Probenecid should not be co‐prescr ...
... Metoclopramide: When co‐administered with MONUROL, metoclopramide, a drug which increases gastrointestinal motility, lowers the serum concentration and urinary excretion of fosfomycin. Other drugs that increase gastrointestinal motility may produce similar effects. Probenecid should not be co‐prescr ...
Winter 2013 - Ontario College of Pharmacists
... those training sites and preceptors who meet specific practice requirements are selected to be involved in this program, and was satisfied that the combined degree program will prepare students with the practice skills needed for entry-to-practice. As such, Council approved the practical training pr ...
... those training sites and preceptors who meet specific practice requirements are selected to be involved in this program, and was satisfied that the combined degree program will prepare students with the practice skills needed for entry-to-practice. As such, Council approved the practical training pr ...
TRAMADOL – A Drug to be used cautiously
... of the racemate. As one of the least potent opioid painkillers many people believe tramadol is not addictive. This false sense of security can lead some people to develop an addiction without even realizing it. Tramadol was originally considered to have a much better safety profile than other opioid ...
... of the racemate. As one of the least potent opioid painkillers many people believe tramadol is not addictive. This false sense of security can lead some people to develop an addiction without even realizing it. Tramadol was originally considered to have a much better safety profile than other opioid ...
Capsules
... Soft gelatin capsules can be used to encapsulate a variety of liquids, such as oils, hydrocarbons, organic acids, polyethylene glycols, and nonionic surfactants. Some liquids can migrate through the capsule shell, and those liquids can not be encapsulated into the soft gelatin capsules. These includ ...
... Soft gelatin capsules can be used to encapsulate a variety of liquids, such as oils, hydrocarbons, organic acids, polyethylene glycols, and nonionic surfactants. Some liquids can migrate through the capsule shell, and those liquids can not be encapsulated into the soft gelatin capsules. These includ ...
Print - Circulation
... It has been shown recently that the expression of H⫹/K⫹ATPase is not limited strictly to gastric tissue. It has also been identified in renal4 and colonic epithelial cells,5 vascular smooth muscle cells,6 and other tissues. In myocardium from rats, the expression of H⫹/K⫹-ATPase has been demonstrate ...
... It has been shown recently that the expression of H⫹/K⫹ATPase is not limited strictly to gastric tissue. It has also been identified in renal4 and colonic epithelial cells,5 vascular smooth muscle cells,6 and other tissues. In myocardium from rats, the expression of H⫹/K⫹-ATPase has been demonstrate ...
MDMA in humans: factors which affect the neuropsychobiological
... same literature provides extensive evidence for unimpaired neuropsychobiological functioning. The topic for this review is to examine some of the factors which may be contributing to this variance in findings. The focus here will be on four areas. First, aspects of ecstasy/MDMA usage, in particular ...
... same literature provides extensive evidence for unimpaired neuropsychobiological functioning. The topic for this review is to examine some of the factors which may be contributing to this variance in findings. The focus here will be on four areas. First, aspects of ecstasy/MDMA usage, in particular ...
ZOFRAN Tablets, Oral Solution and Injection PRODUCT MONOGRAPH
... significantly prolonged in subjects with severe impairment of hepatic function. In patients with moderate or severe impairment of hepatic function, reductions in dosage are therefore recommended and a total daily dose of 8 mg should not be exceeded. This may be given as a single intravenous or oral ...
... significantly prolonged in subjects with severe impairment of hepatic function. In patients with moderate or severe impairment of hepatic function, reductions in dosage are therefore recommended and a total daily dose of 8 mg should not be exceeded. This may be given as a single intravenous or oral ...
NLA Task Force On Statin Safety - 2014 Update
... evaluating adverse effects and potential risks associated with use of a drug.13–17 This is particularly true for adverse effects that (1) occur at a substantially lower frequency than the responses measured for efficacy, (2) may manifest over a period of extended use (ie, a longer period than what i ...
... evaluating adverse effects and potential risks associated with use of a drug.13–17 This is particularly true for adverse effects that (1) occur at a substantially lower frequency than the responses measured for efficacy, (2) may manifest over a period of extended use (ie, a longer period than what i ...
Salvia divinorum and Salvinorin A: An Update on Pharmacology and
... no water control was used in these experiments to evaluate possible effects of DMSO and salvinorin A was injected intraperitoneally. It has been shown by Lukas et al. [19] that compounds administered i. p. are absorbed primarily through the portal circulation and, therefore, must pass through the li ...
... no water control was used in these experiments to evaluate possible effects of DMSO and salvinorin A was injected intraperitoneally. It has been shown by Lukas et al. [19] that compounds administered i. p. are absorbed primarily through the portal circulation and, therefore, must pass through the li ...
Nocturnal Penile Tumescence
... Sleep stages and penile tumescence were scored visually in I-minute epochs by an experienced technician. Penile circumference changes from the tip gauge were analyzed in relation to sleep stages and tumescence phases (14). An American Board of Sleep MediProcedures cine-certified polysomnographer exa ...
... Sleep stages and penile tumescence were scored visually in I-minute epochs by an experienced technician. Penile circumference changes from the tip gauge were analyzed in relation to sleep stages and tumescence phases (14). An American Board of Sleep MediProcedures cine-certified polysomnographer exa ...
Pr VIAGRA*
... A small percentage of patients experience visual effects (e.g. impairment of colour discrimination, increased perception to light, blurred vision, eye pain, ocular redness) after taking VIAGRA. If this happens, then the patient should not operate a motor vehicle or any heavy machinery until the adv ...
... A small percentage of patients experience visual effects (e.g. impairment of colour discrimination, increased perception to light, blurred vision, eye pain, ocular redness) after taking VIAGRA. If this happens, then the patient should not operate a motor vehicle or any heavy machinery until the adv ...
Chronic tolerance to recreational MDMA
... (1996) similarly commented that a universal findings of descriptive studies of users of Ecstasy was that the first tablet was always the best, and with subsequent use the desired effects declined and side-effects increased. Winstock et al. (2001) undertook a questionnaire survey of 1151 readers of M ...
... (1996) similarly commented that a universal findings of descriptive studies of users of Ecstasy was that the first tablet was always the best, and with subsequent use the desired effects declined and side-effects increased. Winstock et al. (2001) undertook a questionnaire survey of 1151 readers of M ...
Gelsemium sempervirens - Southwest School of Botanical Medicine
... It was introduced from the outside and became attached to Eclecticism, but was discarded under protest, decades ago, by Eclectic physicians. It has since been used mainly by physicians who are not conversant with m’odern improved Eclectic pharmacy. Geisemin is an extractive mixture of such products ...
... It was introduced from the outside and became attached to Eclecticism, but was discarded under protest, decades ago, by Eclectic physicians. It has since been used mainly by physicians who are not conversant with m’odern improved Eclectic pharmacy. Geisemin is an extractive mixture of such products ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.