Pharmaceutical Technology
... The in-process quality controls include periodic monitoring, and adjustment when required, of film thickness, cut lengths of both cap and body, color, and moisture content. Inspection processes to remove imperfect capsules which were previously done visually, have recently been automated following t ...
... The in-process quality controls include periodic monitoring, and adjustment when required, of film thickness, cut lengths of both cap and body, color, and moisture content. Inspection processes to remove imperfect capsules which were previously done visually, have recently been automated following t ...
Full Text
... identification of new drugs a critical unmet need. Highthroughput screening offers a powerful tool to identify new drug candidates for these patients. However, commonly available screening approaches rely on in vitro cell-based assays (Masimirembwa et al., 2001; Snowden and Green, 2008; Ko and Gelb, ...
... identification of new drugs a critical unmet need. Highthroughput screening offers a powerful tool to identify new drug candidates for these patients. However, commonly available screening approaches rely on in vitro cell-based assays (Masimirembwa et al., 2001; Snowden and Green, 2008; Ko and Gelb, ...
Review Biomedical applications of collagen
... after administration of the collagen film containing tetracycline demonstrated that tetracycline could be detected in the plasma for more than 7 days after implantation into rabbits (Minabe et al., 1989a,b). The microfibrous collagen sheets as a local delivery carrier for the treatment of cancer was ...
... after administration of the collagen film containing tetracycline demonstrated that tetracycline could be detected in the plasma for more than 7 days after implantation into rabbits (Minabe et al., 1989a,b). The microfibrous collagen sheets as a local delivery carrier for the treatment of cancer was ...
drug registration guidance document (drgd)
... Korsakovian centesimal), and so on. The number preceding the letters (e.g. D, C or LM) normally indicates the number of dilution steps employed (Table 1). As a consequence of different views in various approaches in homeotherapy and because the notion of these terms may depend on the nature of the s ...
... Korsakovian centesimal), and so on. The number preceding the letters (e.g. D, C or LM) normally indicates the number of dilution steps employed (Table 1). As a consequence of different views in various approaches in homeotherapy and because the notion of these terms may depend on the nature of the s ...
Carbamazepine-induced liver injury requires CYP3A
... (Bjornsson, 2008), suggesting that long-term CBZ treatment is a risk factor. It is known that long-term treatment with some drugs results in the induction of drug-metabolizing enzymes, such as cytochrome P450 (CYP) 3A4 (Oscarson et al., 2006). In fact, CBZ is known to induce CYP3A and/or other CYPs ...
... (Bjornsson, 2008), suggesting that long-term CBZ treatment is a risk factor. It is known that long-term treatment with some drugs results in the induction of drug-metabolizing enzymes, such as cytochrome P450 (CYP) 3A4 (Oscarson et al., 2006). In fact, CBZ is known to induce CYP3A and/or other CYPs ...
Ampicillin
... Ampicillin is relatively resistant to inactivation by gastric acid and is moderately well absorbed from the gastrointestinal tract after oral doses. Food can interfere with the absorption of ampicillin so doses should preferably be taken at least 30 minutes before meals. Peak concentrations in plasm ...
... Ampicillin is relatively resistant to inactivation by gastric acid and is moderately well absorbed from the gastrointestinal tract after oral doses. Food can interfere with the absorption of ampicillin so doses should preferably be taken at least 30 minutes before meals. Peak concentrations in plasm ...
drug registration guidance document (drgd) - NPRA
... Korsakovian centesimal), and so on. The number preceding the letters (e.g. D, C or LM) normally indicates the number of dilution steps employed (Table 1). As a consequence of different views in various approaches in homeotherapy and because the notion of these terms may depend on the nature of the s ...
... Korsakovian centesimal), and so on. The number preceding the letters (e.g. D, C or LM) normally indicates the number of dilution steps employed (Table 1). As a consequence of different views in various approaches in homeotherapy and because the notion of these terms may depend on the nature of the s ...
Conscious sedation in children
... In emergency departments and in hospital wards, some painful procedures can be managed using conscious sedation. Wound care and manipulation of fractures are common examples. Minimal sedation can be achieved with: † Nitrous oxide. In a maximum concentration of 50% in oxygen, it should be ‘self-admin ...
... In emergency departments and in hospital wards, some painful procedures can be managed using conscious sedation. Wound care and manipulation of fractures are common examples. Minimal sedation can be achieved with: † Nitrous oxide. In a maximum concentration of 50% in oxygen, it should be ‘self-admin ...
pdf 53Kb - NSW Bureau of Crime Statistics and Research
... (1992), suggest that, in some instances, increases in strength are possibly related to placebo effects (i.e. effects which occur as a result of a subject’s expectations rather than effects due to the action or effect of the drug) motivating improved training. Generally, strength and size have been s ...
... (1992), suggest that, in some instances, increases in strength are possibly related to placebo effects (i.e. effects which occur as a result of a subject’s expectations rather than effects due to the action or effect of the drug) motivating improved training. Generally, strength and size have been s ...
idarubicin
... Late (i.e., Delayed) Events. Delayed cardiotoxicity usually develops late in the course of therapy or within 2 to 3 months after completion of treatment, but later events, several months to years after completion of treatment have also been reported. Delayed cardiomyopathy is manifested by reduced l ...
... Late (i.e., Delayed) Events. Delayed cardiotoxicity usually develops late in the course of therapy or within 2 to 3 months after completion of treatment, but later events, several months to years after completion of treatment have also been reported. Delayed cardiomyopathy is manifested by reduced l ...
Drug Design - Problems in Prediction
... pEC50 = 7.80 (about 16 nM), binds also to the cannabinoid CB1 receptor and inhibits cellular anandamide uptake. ...
... pEC50 = 7.80 (about 16 nM), binds also to the cannabinoid CB1 receptor and inhibits cellular anandamide uptake. ...
Product Monograph - Paladin Labs Inc.
... recognized in vitro and in vivo assays for mutagenic-genotoxic activity and results indicate that glucagon (rDNA origin) should be considered non mutagenic. (See TOXICOLOGY) Cardiovascular In high concentrations, glucagon exerts positive inotropic and chronotropic(2) effect and may therefore cause t ...
... recognized in vitro and in vivo assays for mutagenic-genotoxic activity and results indicate that glucagon (rDNA origin) should be considered non mutagenic. (See TOXICOLOGY) Cardiovascular In high concentrations, glucagon exerts positive inotropic and chronotropic(2) effect and may therefore cause t ...
Saurashtra University
... gynecological infections, intra-abdominal infections, and in the treatment of meningococcal meningitis 1, 3 . With some exceptions, agents in the 4-fluoroquinolone classes can also be grouped by their clinical indications. The drugs can be further differentiated based on available formulations, requ ...
... gynecological infections, intra-abdominal infections, and in the treatment of meningococcal meningitis 1, 3 . With some exceptions, agents in the 4-fluoroquinolone classes can also be grouped by their clinical indications. The drugs can be further differentiated based on available formulations, requ ...
Manuscript_12122012_revised
... (ChemPrep Inc., FL., USA). The rationale for use of two different EIA kits for serum samples was that 10-fold lower serum volumes could be used for the Phoenix assay and it also had a wider linear concentration range. The Bachem EIA had greater sensitivity at low pM concentrations, which the Phoenix ...
... (ChemPrep Inc., FL., USA). The rationale for use of two different EIA kits for serum samples was that 10-fold lower serum volumes could be used for the Phoenix assay and it also had a wider linear concentration range. The Bachem EIA had greater sensitivity at low pM concentrations, which the Phoenix ...
CIPRO XL PRODUCT MONOGRAPH
... diagnosis of tendinitis or tendon rupture has been confidently excluded. The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart, o ...
... diagnosis of tendinitis or tendon rupture has been confidently excluded. The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart, o ...
PHARMACEUTICAL AND PHARMACOLOGICAL PROFILE OF GUAR GUM AN OVERVIEW Review Article
... Guar gum is an important source of nutrition to human and animals are the legume, it regenerates soil nitrogen and the endosperm of guar seed is an important hydrocolloid widely used across a broad spectrum of industries. There are more than 300 applications of guar gum. Guar gum is Generally Recogn ...
... Guar gum is an important source of nutrition to human and animals are the legume, it regenerates soil nitrogen and the endosperm of guar seed is an important hydrocolloid widely used across a broad spectrum of industries. There are more than 300 applications of guar gum. Guar gum is Generally Recogn ...
ziprasidone - PsychSearch
... 2) Ziprasidone 10 milligrams (mg) intramuscularly (IM) produced a rapid reduction in symptoms of acute agitation and was significantly more effective (p less than 0.01) compared to a 2 mg IM dose up to 4 hours after the first injection (Lesem et al, 2001). 1.3.2 Dosage in Renal Failure A) Ziprasidon ...
... 2) Ziprasidone 10 milligrams (mg) intramuscularly (IM) produced a rapid reduction in symptoms of acute agitation and was significantly more effective (p less than 0.01) compared to a 2 mg IM dose up to 4 hours after the first injection (Lesem et al, 2001). 1.3.2 Dosage in Renal Failure A) Ziprasidon ...
Neuroscience of psychoactive substance use and dependence
... and, in particular, the ethical implications of new biological intervention strategies. The various health and social problems associated with use of and dependence on tobacco, alcohol and illicit substances require greater attention by the public health community and appropriate policy responses ar ...
... and, in particular, the ethical implications of new biological intervention strategies. The various health and social problems associated with use of and dependence on tobacco, alcohol and illicit substances require greater attention by the public health community and appropriate policy responses ar ...
Characteristics and Consequences of Use of Anabolic Androgenic
... schedule III substances include opiates, amphetamines and barbiturates (Lukas 1993). The precursor androstenedione was also listed as a schedule III controlled substance in the U.S. in 2004 (Smurawa and Congeni 2007). However, the nature of use of AAS (e.g. “cycling”, where AAS is used for a period ...
... schedule III substances include opiates, amphetamines and barbiturates (Lukas 1993). The precursor androstenedione was also listed as a schedule III controlled substance in the U.S. in 2004 (Smurawa and Congeni 2007). However, the nature of use of AAS (e.g. “cycling”, where AAS is used for a period ...
Naproxen Naproxen Sodium
... spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in the morning and evening. Alternatively, 250 mg of naproxen (275 mg of naproxen sodium) may be given in the morning, and 500 mg (550 mg of the sodium salt ...
... spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in the morning and evening. Alternatively, 250 mg of naproxen (275 mg of naproxen sodium) may be given in the morning, and 500 mg (550 mg of the sodium salt ...
Supramolecularly engineered phospholipids
... carriers, gene delivery, contrast agents, as well as the surface modication of biomaterials.9–13 So far, several liposome-based drug delivery systems have been approved by the Food and Drug Administration (FDA) and numerous liposome-encapsulated agents have been used in clinical trials.14–17 Howeve ...
... carriers, gene delivery, contrast agents, as well as the surface modication of biomaterials.9–13 So far, several liposome-based drug delivery systems have been approved by the Food and Drug Administration (FDA) and numerous liposome-encapsulated agents have been used in clinical trials.14–17 Howeve ...
6-keto, 7,8
... Fentanyl is a μ agonist with about 80 times the poyency of morphine. The advantages of fentanyl over morphine for anesthetic procedures are its short duration of action (1to 2 hours). A fentenyl patch has been released for the treatment of severe chronic pain. Fentanyl’s short duration of acti ...
... Fentanyl is a μ agonist with about 80 times the poyency of morphine. The advantages of fentanyl over morphine for anesthetic procedures are its short duration of action (1to 2 hours). A fentenyl patch has been released for the treatment of severe chronic pain. Fentanyl’s short duration of acti ...
ASD v3.0 - Nucleic Acids Research
... Allosteric regulation fine-tunes most biological processes, including signal transduction, enzyme activity, metabolism and transport (1–3). Allostery, an intrinsic property of a protein, is referred to as the regulation of activity at one site (also known as an orthosteric site) in a protein by a to ...
... Allosteric regulation fine-tunes most biological processes, including signal transduction, enzyme activity, metabolism and transport (1–3). Allostery, an intrinsic property of a protein, is referred to as the regulation of activity at one site (also known as an orthosteric site) in a protein by a to ...
Amorphous solid dispersion effects on in vitro solution
... its hydrophobicity and crystallinity) and extensive phase-II metabolism. Improving the apparent solubility of quercetin has the potential to improve its in vivo bioavailability. Strategies to increase solution concentrations in the small intestinal lumen have the potential to substantially increase ...
... its hydrophobicity and crystallinity) and extensive phase-II metabolism. Improving the apparent solubility of quercetin has the potential to improve its in vivo bioavailability. Strategies to increase solution concentrations in the small intestinal lumen have the potential to substantially increase ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.