Pharmacology of anabolic steroids
... cannot be divorced entirely from their androgenic effects. Hence, a more accurate term for anabolic steroids is anabolic–androgenic steroids, but, for simplicity, the shorter term is used within this paper. The disassociation of anabolic from androgenic effects can be at cellular level, depending on ...
... cannot be divorced entirely from their androgenic effects. Hence, a more accurate term for anabolic steroids is anabolic–androgenic steroids, but, for simplicity, the shorter term is used within this paper. The disassociation of anabolic from androgenic effects can be at cellular level, depending on ...
Safety and Side Effects of CBD
... at, to our knowledge, is that several cytochrome isozymes are not only expressed in the liver but also in the brain. It might be interesting to research organ-specific differences in the level of CBD-inhibition of various isozymes. Apart from altering the bioavailability in the overall plasma of the ...
... at, to our knowledge, is that several cytochrome isozymes are not only expressed in the liver but also in the brain. It might be interesting to research organ-specific differences in the level of CBD-inhibition of various isozymes. Apart from altering the bioavailability in the overall plasma of the ...
Gastrointestinal bleeding with the new oral anticoagulants â
... data from ROCKET-AF, it was noted that despite the increased rate of major GI bleeding with rivaroxaban, the incidence of life-threatening GI bleeding (i.e. requiring transfusion of ≥ 4 units of red blood cells) was similar with rivaroxaban and warfarin (n= 52 and 47, respectively) and there were fe ...
... data from ROCKET-AF, it was noted that despite the increased rate of major GI bleeding with rivaroxaban, the incidence of life-threatening GI bleeding (i.e. requiring transfusion of ≥ 4 units of red blood cells) was similar with rivaroxaban and warfarin (n= 52 and 47, respectively) and there were fe ...
Colchicine for pericarditis: hype or hope? REVIEW Massimo Imazio , Antonio Brucato
... to several therapeutic uses. However, the accumulation in leucocytes is slow with a peak intracellular concentration after 48 h from a 1 mg oral dose in healthy subjects. The biological effects require 24 –48 h to develop, and, when the drug is discontinued, colchicine declines with an elimination h ...
... to several therapeutic uses. However, the accumulation in leucocytes is slow with a peak intracellular concentration after 48 h from a 1 mg oral dose in healthy subjects. The biological effects require 24 –48 h to develop, and, when the drug is discontinued, colchicine declines with an elimination h ...
Important Drug Information
... It is important to note that there are substantive differences in the format and content of the labeling between the U.S.-approved Doxorubicin Hydrochloride for Injection, USP and the Hospira Limited’s Doxorubicin Hydrochloride 50 mg Powder for Injection. The product comparison tables attached high ...
... It is important to note that there are substantive differences in the format and content of the labeling between the U.S.-approved Doxorubicin Hydrochloride for Injection, USP and the Hospira Limited’s Doxorubicin Hydrochloride 50 mg Powder for Injection. The product comparison tables attached high ...
Chloramphenicol
... pregnenolone. This results in major hormone depletion, including DHEA and testosterone, that can result in death and also lowers the body's resistance to viral infection. Chloramphenicol can cause testes pain, possibly through hormone effects. Chinese research shows that chloramphenicol affects moto ...
... pregnenolone. This results in major hormone depletion, including DHEA and testosterone, that can result in death and also lowers the body's resistance to viral infection. Chloramphenicol can cause testes pain, possibly through hormone effects. Chinese research shows that chloramphenicol affects moto ...
Pharmacology and the Nursing Process, 4th ed
... Italian broad beans (fava beans) Mosby items and derived items © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... Italian broad beans (fava beans) Mosby items and derived items © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
TABLE OF CONTENTS - Epilepsy Foundation of Florida
... prescribed, fever, sleep deprivation, stress, over-exertion, consumption of excessive alcohol, and taking recreational drugs (for example cocaine). Hormonal changes, such as during the menstrual cycle, changes in sugar (glucose) level, dehydration, environmental factors such as high heat and humidit ...
... prescribed, fever, sleep deprivation, stress, over-exertion, consumption of excessive alcohol, and taking recreational drugs (for example cocaine). Hormonal changes, such as during the menstrual cycle, changes in sugar (glucose) level, dehydration, environmental factors such as high heat and humidit ...
P M harmacist’s anual
... This pharmacist’s manual is intended to summarize and explain the basic requirements for prescribing, administering, and dispensing controlled substances under the Controlled Substances Act (CSA), Title 21 United States Code (21 U.S.C.) 801-971 and the DEA regulations, Title 21, Code of Federal Regu ...
... This pharmacist’s manual is intended to summarize and explain the basic requirements for prescribing, administering, and dispensing controlled substances under the Controlled Substances Act (CSA), Title 21 United States Code (21 U.S.C.) 801-971 and the DEA regulations, Title 21, Code of Federal Regu ...
Attachment: Product Information: Atazanavir
... approximately 33% due to delayed absorption; the median Tmax increased from 2.0 to 5.0 hours. Coadministration of REYATAZ with ritonavir with either a light or a high-fat meal decreased the coefficient of variation of AUC and Cmax by approximately 25% compared to the fasting state. Distribution: ata ...
... approximately 33% due to delayed absorption; the median Tmax increased from 2.0 to 5.0 hours. Coadministration of REYATAZ with ritonavir with either a light or a high-fat meal decreased the coefficient of variation of AUC and Cmax by approximately 25% compared to the fasting state. Distribution: ata ...
BoNT_A Presentation UMass Dartmouth 081029
... Efficacy in vitro, & in neuronal cell culture or synaptosomes ...
... Efficacy in vitro, & in neuronal cell culture or synaptosomes ...
Pharmacokinetics of Erythromycin Ethylsuccinate
... prolonged and expensive, and the most common treatment regimen used is associated with important adverse effects.2 Erythromycin, a macrolide antibiotic, is suitable for treatment of pyogranulomatous lung inflammation such as that caused by R. equi because it can be administered orally, has wide tiss ...
... prolonged and expensive, and the most common treatment regimen used is associated with important adverse effects.2 Erythromycin, a macrolide antibiotic, is suitable for treatment of pyogranulomatous lung inflammation such as that caused by R. equi because it can be administered orally, has wide tiss ...
министерство здравоохранения республики беларусь
... 46. By means of a receptor competitive action include drugs. Variants of the answer: a) non-steroidal anti-inflammatory drugs; b) beta-blockers; c) a loop diuretic; d) nitrates; e) quinolones. 47. The drugs that are connected to the proteins more than 90 %, with a decrease of 10 %. Variants of the a ...
... 46. By means of a receptor competitive action include drugs. Variants of the answer: a) non-steroidal anti-inflammatory drugs; b) beta-blockers; c) a loop diuretic; d) nitrates; e) quinolones. 47. The drugs that are connected to the proteins more than 90 %, with a decrease of 10 %. Variants of the a ...
P-Glycoprotein functional activity in peripheral blood lymphocytes. Role of immunosuppressants,
... The efficacy of many drugs depends critically on their ability to cross cellular barriers to reach their target. Lipophilic drugs may cross these barriers in the absence of specialized transport systems. On the other hand, hydrophilic and charged compounds often require specific transport mechanisms ...
... The efficacy of many drugs depends critically on their ability to cross cellular barriers to reach their target. Lipophilic drugs may cross these barriers in the absence of specialized transport systems. On the other hand, hydrophilic and charged compounds often require specific transport mechanisms ...
the PDF
... psychomotor functions. The term nootropics was coined in 1972 when memory enhancing properties of piracetam were observed in clinical trials. In the meantime, hundreds of drugs have been evaluated in clinical trials or in preclinical experiments. To classify the compounds, a concept is proposed assi ...
... psychomotor functions. The term nootropics was coined in 1972 when memory enhancing properties of piracetam were observed in clinical trials. In the meantime, hundreds of drugs have been evaluated in clinical trials or in preclinical experiments. To classify the compounds, a concept is proposed assi ...
PRODUCT MONOGRAPH PRIMAXIN® (imipenem and cilastatin
... imipenem, to patients receiving valproic acid or divalproex sodium results in a reduction of serum valproic acid concentrations. The valproic acid concentrations may drop below the therapeutic range as a result of this interaction. In some cases of co-administration of imipenem with valproic acid, b ...
... imipenem, to patients receiving valproic acid or divalproex sodium results in a reduction of serum valproic acid concentrations. The valproic acid concentrations may drop below the therapeutic range as a result of this interaction. In some cases of co-administration of imipenem with valproic acid, b ...
Misuse and abuse of quetiapine
... patient experimented with intranasal use of quetiapine [9]. In addition, the cases of using quetiapine in combination with other psychoactive substances, such as cocaine, cannabinoles or opioids, mainly in order to intensify the sedative and anxiolytic effect were reported. Such mixtures are adminis ...
... patient experimented with intranasal use of quetiapine [9]. In addition, the cases of using quetiapine in combination with other psychoactive substances, such as cocaine, cannabinoles or opioids, mainly in order to intensify the sedative and anxiolytic effect were reported. Such mixtures are adminis ...
Regulatory requirements for the development of medicinal products
... differences in their body functions, unique response to treatment, requirements for forms of medications that can be safely administered given their especially small size.) Term newborn infants (0 to 27 days); volumes of distribution may be different than those in older pediatric patients, blood-bra ...
... differences in their body functions, unique response to treatment, requirements for forms of medications that can be safely administered given their especially small size.) Term newborn infants (0 to 27 days); volumes of distribution may be different than those in older pediatric patients, blood-bra ...
Azithromycin - Rebound Health
... been used to prevent bacterial infections in infants and those with weaker immune systems. It is also effective against certain venereal diseases, such as non-gonococcal urethritis, chlamydia, gonorrhea and cervicitis. Recent studies have also indicated it to be effective against late-onset asthma, ...
... been used to prevent bacterial infections in infants and those with weaker immune systems. It is also effective against certain venereal diseases, such as non-gonococcal urethritis, chlamydia, gonorrhea and cervicitis. Recent studies have also indicated it to be effective against late-onset asthma, ...
Ofloxacin as a Reference Marker in Hair of Various Colors
... The goal of this study was to determine if an oral dose of the antibiotic ofloxacin (OFLX) could be used as a "marker" substance to establish reference points with respect to time in hair of various colors. Male and female subjects (n = 32) between 18 and 40 years of age received 800 mg of OFLX as a ...
... The goal of this study was to determine if an oral dose of the antibiotic ofloxacin (OFLX) could be used as a "marker" substance to establish reference points with respect to time in hair of various colors. Male and female subjects (n = 32) between 18 and 40 years of age received 800 mg of OFLX as a ...
Synthetic cannabinoids in herbal products
... Since 2004, herbal mixtures called ‘Spice’ have been available in several European countries such as Germany, Switzerland and Great Britain. Initially, these products were not popular and were used by only a small group of experimental users. However, numerous reports on these products sur ...
... Since 2004, herbal mixtures called ‘Spice’ have been available in several European countries such as Germany, Switzerland and Great Britain. Initially, these products were not popular and were used by only a small group of experimental users. However, numerous reports on these products sur ...
Plavix - Sanofi Canada
... considered unsuitable for anticoagulation therapy The use of this dual antiplatelet therapy in patients with AF has been shown to reduce the incidence of cardiovascular events (fatal and non-fatal stroke, non-CNS systemic embolism, vascular death), but to significantly increase the incidence of majo ...
... considered unsuitable for anticoagulation therapy The use of this dual antiplatelet therapy in patients with AF has been shown to reduce the incidence of cardiovascular events (fatal and non-fatal stroke, non-CNS systemic embolism, vascular death), but to significantly increase the incidence of majo ...
Intravenous Anesthesia 1991
... Propofol boluses are much more suitable for briefly extending an anesthetic by a few minutes than thiopental boluses. It is our experience that patients wake up slowly, and are quite sedated, if a small bolus of thiopental is used to extend an anesthetic. For this reason, we suggest having a syringe ...
... Propofol boluses are much more suitable for briefly extending an anesthetic by a few minutes than thiopental boluses. It is our experience that patients wake up slowly, and are quite sedated, if a small bolus of thiopental is used to extend an anesthetic. For this reason, we suggest having a syringe ...
Bioavailability & Bioequivalence
... Reabsorption occurs all along the nephron; Active reabsorption usually occurs in the proximal tubule Appearance of drug in the urine is the net result of filtration, secretion, and reabsorption ...
... Reabsorption occurs all along the nephron; Active reabsorption usually occurs in the proximal tubule Appearance of drug in the urine is the net result of filtration, secretion, and reabsorption ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.