02-Lecture_2 doc2008-10-31 07:3483 KB
... 1. Lipid soluble drugs: general anesthetics,thiopental(given intravenously ,and it is well distributed). 2. Actively transported drugs (L-dopa) 3. In some inflammation cases as menegitis the permability increases so penicillin and gentamycin are given (which are polar drugs). Warfarin is an antico ...
... 1. Lipid soluble drugs: general anesthetics,thiopental(given intravenously ,and it is well distributed). 2. Actively transported drugs (L-dopa) 3. In some inflammation cases as menegitis the permability increases so penicillin and gentamycin are given (which are polar drugs). Warfarin is an antico ...
Katherine Douglas Hallucinogens Reaction Paper Hallucinogens
... to work by stimulating serotonin-2 receptors which may cause hallucinations. The belladonna alkaloids work by preventing acetylcholine from acting at one of its receptors. PCP and Ketamine seem to block the action of glutamate. The differences in how all these drugs work in the brain explains why ea ...
... to work by stimulating serotonin-2 receptors which may cause hallucinations. The belladonna alkaloids work by preventing acetylcholine from acting at one of its receptors. PCP and Ketamine seem to block the action of glutamate. The differences in how all these drugs work in the brain explains why ea ...
“Development of IPF drugs: a slow process fraught with failures” Not
... “Development of IPF drugs: a slow process fraught with failures” Not long ago, doctors had no proven treatment options for their IPF patients. Today, Canadian IPF patients can be treated with Esbriet (pirfenidone), and encouraging clinical data suggests a second option, nintenamib, may soon be avail ...
... “Development of IPF drugs: a slow process fraught with failures” Not long ago, doctors had no proven treatment options for their IPF patients. Today, Canadian IPF patients can be treated with Esbriet (pirfenidone), and encouraging clinical data suggests a second option, nintenamib, may soon be avail ...
CH4 part 2
... Other sites of biotransformation: kidneys, small intestines, brain, lungs, skin, neurologic tissue ...
... Other sites of biotransformation: kidneys, small intestines, brain, lungs, skin, neurologic tissue ...
The Semantic Web in Ten Passages
... elderly: aminoglycosides, atenolol, diazepam, digoxin, oral hypoglycemic agents, warfarin, NSAIDs ...
... elderly: aminoglycosides, atenolol, diazepam, digoxin, oral hypoglycemic agents, warfarin, NSAIDs ...
Narcotics and Dangerous Drugs Brochure
... Amphetamines produced under these conditions are often contaminated with chemical by-products that occur during the manufacture, many of which are poisonous, can cause cancer, or brain damage. ...
... Amphetamines produced under these conditions are often contaminated with chemical by-products that occur during the manufacture, many of which are poisonous, can cause cancer, or brain damage. ...
With each succeeding year, more drugs are released, every one
... With each succeeding year, more drugs are released, every one with the hope and the promise that it is an improvement over its *predecessor. Although the pharmaceutical industry must be given most of the **credit for advances in drug therapy, it is also true that many new drugs have only a marginal ...
... With each succeeding year, more drugs are released, every one with the hope and the promise that it is an improvement over its *predecessor. Although the pharmaceutical industry must be given most of the **credit for advances in drug therapy, it is also true that many new drugs have only a marginal ...
Lec-9 (1)
... • It is often found that a drug fails clinical trials because of its toxic side effects. • This may be due to toxic metabolites, in which case the drug should be made more resistant to metabolism as described previously. • It is know that functional groups such as aromatic nitro groups, aromatic am ...
... • It is often found that a drug fails clinical trials because of its toxic side effects. • This may be due to toxic metabolites, in which case the drug should be made more resistant to metabolism as described previously. • It is know that functional groups such as aromatic nitro groups, aromatic am ...
Pharmacology PT020D - Porterville College Home
... • Identify medications commonly prescribed for D.D. clients by both generic and trade names. ...
... • Identify medications commonly prescribed for D.D. clients by both generic and trade names. ...
Powerpoint slides
... Once absorbed, the drug has to get past the blood brain barrier Get across the membrane through passive or active transport Protein binding stops some Taken out of blood stream by kidneys, liver – Measured in half life ...
... Once absorbed, the drug has to get past the blood brain barrier Get across the membrane through passive or active transport Protein binding stops some Taken out of blood stream by kidneys, liver – Measured in half life ...
Psychology 2800 Drugs and Behaviour
... Once absorbed, the drug has to get past the blood brain barrier Get across the membrane through passive or active transport Protein binding stops some Taken out of blood stream by kidneys, liver – Measured in half life ...
... Once absorbed, the drug has to get past the blood brain barrier Get across the membrane through passive or active transport Protein binding stops some Taken out of blood stream by kidneys, liver – Measured in half life ...
ENZYMES
... The most important are inducers of CYP3A4 and include carbamazepine, phenobarbital, phenytoin, rifampicin and St John’s wort (Hypericum perforatum). An example of an interaction in psychiatric practice is the reduced efficacy of haloperidol (or alprazolam) when carbamazepine is started, resulting fr ...
... The most important are inducers of CYP3A4 and include carbamazepine, phenobarbital, phenytoin, rifampicin and St John’s wort (Hypericum perforatum). An example of an interaction in psychiatric practice is the reduced efficacy of haloperidol (or alprazolam) when carbamazepine is started, resulting fr ...
Psychopharm Study Guide
... 27. The 3 major categories of adverse drug reactions are 28. The benzodiazepines (such as diazepam): 29. The benzodiazepines are MOST effective in treating: 30. The dose of a drug which will be fatal to half of the population is called: 31. The fact that caffeine cannot exert as much CNS stimulation ...
... 27. The 3 major categories of adverse drug reactions are 28. The benzodiazepines (such as diazepam): 29. The benzodiazepines are MOST effective in treating: 30. The dose of a drug which will be fatal to half of the population is called: 31. The fact that caffeine cannot exert as much CNS stimulation ...
ENZYMES
... The most important are inducers of CYP3A4 and include carbamazepine, phenobarbital, phenytoin, rifampicin and St John’s wort (Hypericum perforatum). An example of an interaction in psychiatric practice is the reduced efficacy of haloperidol (or alprazolam) when carbamazepine is started, resulting fr ...
... The most important are inducers of CYP3A4 and include carbamazepine, phenobarbital, phenytoin, rifampicin and St John’s wort (Hypericum perforatum). An example of an interaction in psychiatric practice is the reduced efficacy of haloperidol (or alprazolam) when carbamazepine is started, resulting fr ...
Acceleron to start trial in liver cancer patients early next year
... The Cambridge company (Nasdaq: XLRN) gave on update Tuesday on its drug, dalantercept, which inhibits the formation of new blood vessels from existing ones, at the Piper Jaffray health care conference in New York. The drug is aimed primarily at patients with advanced cancer who have not responded to ...
... The Cambridge company (Nasdaq: XLRN) gave on update Tuesday on its drug, dalantercept, which inhibits the formation of new blood vessels from existing ones, at the Piper Jaffray health care conference in New York. The drug is aimed primarily at patients with advanced cancer who have not responded to ...
Psychotropic drug interactions
... such as digoxin, warfarin, sulfonylureas or phenytoin. Most psychotropics are protein-bound to a certain extent with the exception of lithium and gabapentin. Induction increases the metabolism of the substrate drug, causing reduced plasma levels. This is significant for drugs where a reduced plasma ...
... such as digoxin, warfarin, sulfonylureas or phenytoin. Most psychotropics are protein-bound to a certain extent with the exception of lithium and gabapentin. Induction increases the metabolism of the substrate drug, causing reduced plasma levels. This is significant for drugs where a reduced plasma ...
What Tests are Required and When Will I Be Tested?
... Reporting for duty or remaining on duty to perform a safety-sensitive function with an alcohol concentration of 0.04 or greater; Use during the 8 hours following an accident, or until the driver undergoes a post-accident test; and Refusal to take a required test. ...
... Reporting for duty or remaining on duty to perform a safety-sensitive function with an alcohol concentration of 0.04 or greater; Use during the 8 hours following an accident, or until the driver undergoes a post-accident test; and Refusal to take a required test. ...
popular drugs
... DRUGS INTERFERE WITH LEARNING & MEMORY ESPECIALLY IN ADOLESCENTS AGE OF FIRST USE HAS A PROFOUND EFFECTS ON ADDICTION PROBABILITY DRUG AVAILABILITY INCREASES USE LONG-TERM MEDICAL EFFECTS OF THE LEGAL ALCOHOL & TOBACCO COST ...
... DRUGS INTERFERE WITH LEARNING & MEMORY ESPECIALLY IN ADOLESCENTS AGE OF FIRST USE HAS A PROFOUND EFFECTS ON ADDICTION PROBABILITY DRUG AVAILABILITY INCREASES USE LONG-TERM MEDICAL EFFECTS OF THE LEGAL ALCOHOL & TOBACCO COST ...
Option D IB Chemistry Definitions SL
... dish had died off after some foreign appearance. Prevent cell walls from being made in bacteria; does not affect mammalian cells or viruses as they do not have a cell wall selectively toxic. [Relatively] narrow spectrum antibiotic. ...
... dish had died off after some foreign appearance. Prevent cell walls from being made in bacteria; does not affect mammalian cells or viruses as they do not have a cell wall selectively toxic. [Relatively] narrow spectrum antibiotic. ...
Lecture 19
... catecholamine ! (this will decrease blood pressure) but the first side effect is depression. -tranquillizer have the same mechanism of action. -the first step of their degradation is methylation . -ephedrine can be degraded by these enzyme also -when we use adrenaline and ephedra( we notice that adr ...
... catecholamine ! (this will decrease blood pressure) but the first side effect is depression. -tranquillizer have the same mechanism of action. -the first step of their degradation is methylation . -ephedrine can be degraded by these enzyme also -when we use adrenaline and ephedra( we notice that adr ...
Cholinergic–Anticholinergic Drug Interactions
... the pharmacologic class of the drugs involved (Pharmacy Times, June 2005). Several instances exist, however, where a drug’s pharmacologic class accurately predicts potential pharmacodynamic interactions. For example, many computerized drug interaction screening programs contain algorithms to detect ...
... the pharmacologic class of the drugs involved (Pharmacy Times, June 2005). Several instances exist, however, where a drug’s pharmacologic class accurately predicts potential pharmacodynamic interactions. For example, many computerized drug interaction screening programs contain algorithms to detect ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.