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www.xtremepapers.net
www.xtremepapers.net

... Choose the one you consider correct and record your choice in soft pencil on the separate answer sheet. Read the instructions on the answer sheet very carefully. Each correct answer will score one mark. A mark will not be deducted for a wrong answer. Any rough working should be done in this booklet. ...
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... 55. Which pair of solutions forms a buffer when equal volumes of each are mixed? A) 0.20 M HCl and 0.20 M NaCl C) 0.20 M HCl and 0.20 M NH3 B) 0.40 M HC2H3O2 and 0.20 M NaOH D) 0.40 M HCl and 0.20 M NH3 56. A student is attempting to standardize a NaOH solution with a 0.500 molar solution of oxalic ...
Chemical Reactions - We can`t sign you in
Chemical Reactions - We can`t sign you in

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Grade 11 Chemistry E.. - hrsbstaff.ednet.ns.ca
Grade 11 Chemistry E.. - hrsbstaff.ednet.ns.ca

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Chapter 4 - Colby College Wiki

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Lewis acid catalysis



In Lewis acid catalysis of organic reactions, a metal-based Lewis acid acts as an electron pair acceptor to increase the reactivity of a substrate. Common Lewis acid catalysts are based on main group metals such as aluminum, boron, silicon, and tin, as well as many early (titanium, zirconium) and late (iron, copper, zinc) d-block metals. The metal atom forms an adduct with a lone-pair bearing electronegative atom in the substrate, such as oxygen (both sp2 or sp3), nitrogen, sulfur, and halogens. The complexation has partial charge-transfer character and makes the lone-pair donor effectively more electronegative, activating the substrate toward nucleophilic attack, heterolytic bond cleavage, or cycloaddition with 1,3-dienes and 1,3-dipoles.Many classical reactions involving carbon–carbon or carbon–heteroatom bond formation can be catalyzed by Lewis acids. Examples include the Friedel-Crafts reaction, the aldol reaction, and various pericyclic processes that proceed slowly at room temperature, such as the Diels-Alder reaction and the ene reaction. In addition to accelerating the reactions, Lewis acid catalysts are able to impose regioselectivity and stereoselectivity in many cases.Early developments in Lewis acid reagents focused on easily available compounds such as TiCl4, BF3, SnCl4, and AlCl3. The relative strengths of these (and other) Lewis acids may be estimated from NMR spectroscopy by the Childs method or the Gutmann-Beckett method. Over the years, versatile catalysts bearing ligands designed for specific applications have facilitated improvement in both reactivity and selectivity of Lewis acid-catalyzed reactions. More recently, Lewis acid catalysts with chiral ligands have become an important class of tools for asymmetric catalysis.Challenges in the development of Lewis acid catalysis include inefficient catalyst turnover (caused by catalyst affinity for the product) and the frequent requirement of two-point binding for stereoselectivity, which often necessitates the use of auxiliary groups.
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