Reconstruction of a 450-My-old ancestral vertebrate protokaryotype
... consists of the large TNI 2 and 3 chromosomes, which are included in chromosomes TET 2, 3, 8 and 11 (Table 2), implying that TEL 1 is a large chromosome. By contrast, protochromosome TEL 12 consists of segments of TNI 6 and 15 and corresponds to the small chromosome OLA 20. Similar reconstructions o ...
... consists of the large TNI 2 and 3 chromosomes, which are included in chromosomes TET 2, 3, 8 and 11 (Table 2), implying that TEL 1 is a large chromosome. By contrast, protochromosome TEL 12 consists of segments of TNI 6 and 15 and corresponds to the small chromosome OLA 20. Similar reconstructions o ...
In search of essentiality: Mollicute-specific genes
... (21%) and cellular processes (11%). The poorly characterized COG categories (R and S) contain 21 genes (10%). The COG category J (translation, ribosomal structure and biogenesis), as expected (Santos et al. and Borges et al., in the present issue), contains the highest number of genes (82) (Table 1) ...
... (21%) and cellular processes (11%). The poorly characterized COG categories (R and S) contain 21 genes (10%). The COG category J (translation, ribosomal structure and biogenesis), as expected (Santos et al. and Borges et al., in the present issue), contains the highest number of genes (82) (Table 1) ...
S1 Appendix.
... chromosome number, type of feature, start/end coordinates, strand and attributes (shown as bold red colors in Figure B). The name of chromosomes, types of feature, and attributes are often annotation-specific, and should be optimized if custom annotation files are used. The current script can be use ...
... chromosome number, type of feature, start/end coordinates, strand and attributes (shown as bold red colors in Figure B). The name of chromosomes, types of feature, and attributes are often annotation-specific, and should be optimized if custom annotation files are used. The current script can be use ...
cis667-10
... • If a desire edge from one cycle crosses some desire edge from another cycle we say that the two cycles interleave Interleaved cycles allow us to change a bad cycle into a good one while breaking another ...
... • If a desire edge from one cycle crosses some desire edge from another cycle we say that the two cycles interleave Interleaved cycles allow us to change a bad cycle into a good one while breaking another ...
High performance solution-based target selection using individually
... The availability of solution-based genomic target selection techniques has enabled rapid development of targeted sequencing applications, some of which have led to the introduction of clinical sequencing tests. Commercialized hybridization capture reagents are based on array-synthesized oligonucleot ...
... The availability of solution-based genomic target selection techniques has enabled rapid development of targeted sequencing applications, some of which have led to the introduction of clinical sequencing tests. Commercialized hybridization capture reagents are based on array-synthesized oligonucleot ...
Transfer of genetic material between the chloroplast and nucleus
... The completed arabidopsis and rice genome sequences have facilitated the search for evolutionary evidence of the transfer of genes from the original endosymbiont to the nucleus. Proteins encoded by the arabidopsis nuclear genome that are most similar to proteins encoded by other species'chloroplast ...
... The completed arabidopsis and rice genome sequences have facilitated the search for evolutionary evidence of the transfer of genes from the original endosymbiont to the nucleus. Proteins encoded by the arabidopsis nuclear genome that are most similar to proteins encoded by other species'chloroplast ...
1 Comp. Funct. Genom. Copyright © (2002) John Wiley & Sons, Ltd.
... genes and proteins based on shared biology. It will also aid the interpretation of large datasets created by functional genomics projects [6]. The majority of eukaryotic genome projects already use the GO annotation system, and GO annotations are being incorporated into SWISSPROT and GeneDB (see sec ...
... genes and proteins based on shared biology. It will also aid the interpretation of large datasets created by functional genomics projects [6]. The majority of eukaryotic genome projects already use the GO annotation system, and GO annotations are being incorporated into SWISSPROT and GeneDB (see sec ...
PPT - Blumberg Lab
... • Strategy enriched for regions lost in DMD patient – Hybridized enzyme digested normal DNA with excess sheared DMD DNA – Only hybrids with restriction site ends could be cloned – Only hybrids with such ends would be from region absent in DMD DNA (since DMD DNA was in excess) • Made a library and te ...
... • Strategy enriched for regions lost in DMD patient – Hybridized enzyme digested normal DNA with excess sheared DMD DNA – Only hybrids with restriction site ends could be cloned – Only hybrids with such ends would be from region absent in DMD DNA (since DMD DNA was in excess) • Made a library and te ...
Basic Genetics and Genomics: A Primer for Nurses
... There are several different types of gene mutations. These include: deletion (loss), duplication (multiplication), inversion, insertion (addition), translocation (rearrangements), and point mutations (changes in base pair sequences) (NHGRI, 2008n). Examples of conditions caused by gene mutations inc ...
... There are several different types of gene mutations. These include: deletion (loss), duplication (multiplication), inversion, insertion (addition), translocation (rearrangements), and point mutations (changes in base pair sequences) (NHGRI, 2008n). Examples of conditions caused by gene mutations inc ...
Phylogenetic and evolutionary analyses of St. Louis encephalitis
... Ó 2008 Elsevier Inc. All rights reserved. Keywords: St. Louis encephalitis virus; Flavivirus; Phylogeny; Positive selection; Recombination; N-linked glycosylation; Divergence times ...
... Ó 2008 Elsevier Inc. All rights reserved. Keywords: St. Louis encephalitis virus; Flavivirus; Phylogeny; Positive selection; Recombination; N-linked glycosylation; Divergence times ...
Identification and analysis of functional elements in 1% of the human
... • The experimental design of ChIPSeq is considerably simpler. • ChIPSeq typically can achieve higher genomic coverage than ChIP-chip (also depends on read length vs. probe length). • The data from ChIPSeq is arguably cleaner and easier to process. • Costs are comparable (?). Mar. 19, 2008 ...
... • The experimental design of ChIPSeq is considerably simpler. • ChIPSeq typically can achieve higher genomic coverage than ChIP-chip (also depends on read length vs. probe length). • The data from ChIPSeq is arguably cleaner and easier to process. • Costs are comparable (?). Mar. 19, 2008 ...
Non-invasive prenatal assessment of trisomy 21 by multiplexed
... Peripheral venous blood samples (5–10 mL) were collected into tubes containing EDTA. A plasma sample would be accepted for analysis if it was collected before invasive obstetric procedures, was harvested within six hours of venepuncture, was at least 2 mL in volume, and was not haemolysed. The prosp ...
... Peripheral venous blood samples (5–10 mL) were collected into tubes containing EDTA. A plasma sample would be accepted for analysis if it was collected before invasive obstetric procedures, was harvested within six hours of venepuncture, was at least 2 mL in volume, and was not haemolysed. The prosp ...
From essential to persistent genes: a functional
... take into account gene–environment interactions. Others have centered on comparative genomics, and this allowed scientists to compare genomes from closely or distantly related microorganisms. But as an ever-increasing number of genome projects were completed, the outcome of the comparisons did not i ...
... take into account gene–environment interactions. Others have centered on comparative genomics, and this allowed scientists to compare genomes from closely or distantly related microorganisms. But as an ever-increasing number of genome projects were completed, the outcome of the comparisons did not i ...
Genomic Analysis of Arabidopsis Thaliana
... wild type and many mutants. The arrangement of various aspects of continuous morphogenesis in plants make this one of the best reference books even for biologists already familiar with plant anatomy.] Chang C., Bowman J.L., DeJohn A.W., Lander E.S., and Meyerowitz E.M. (1988). Restriction fragment l ...
... wild type and many mutants. The arrangement of various aspects of continuous morphogenesis in plants make this one of the best reference books even for biologists already familiar with plant anatomy.] Chang C., Bowman J.L., DeJohn A.W., Lander E.S., and Meyerowitz E.M. (1988). Restriction fragment l ...
Document
... resistance and the developmental stage of the potato leaves tested. The aggressiveness of P. infestans isolates is likely to be affected by the length of time in axenic culture and it is thus important to ‘passage’ isolates on leaf material to restore aggressiveness prior to any experiment. Isolates ...
... resistance and the developmental stage of the potato leaves tested. The aggressiveness of P. infestans isolates is likely to be affected by the length of time in axenic culture and it is thus important to ‘passage’ isolates on leaf material to restore aggressiveness prior to any experiment. Isolates ...
Functional constraints and frequency of deleterious mutations in
... depends critically on the genomic deleterious mutation rate, U. For example, under a multiplicative model the load is 1 ⫺ e⫺U (where U is the mutation rate per diploid; ref. 4). The mutation load also depends on the manner in which mutations interact with one another between and within loci (4), and ...
... depends critically on the genomic deleterious mutation rate, U. For example, under a multiplicative model the load is 1 ⫺ e⫺U (where U is the mutation rate per diploid; ref. 4). The mutation load also depends on the manner in which mutations interact with one another between and within loci (4), and ...
Stabilizing synthetic data in the DNA of living organisms
... Abstract Data-encoding synthetic DNA, inserted into the genome of a living organism, is thought to be more robust than the current media. Because the living genome is duplicated and copied into new generations, one of the merits of using DNA material is long-term data storage within heritable media. ...
... Abstract Data-encoding synthetic DNA, inserted into the genome of a living organism, is thought to be more robust than the current media. Because the living genome is duplicated and copied into new generations, one of the merits of using DNA material is long-term data storage within heritable media. ...
Ch15-Computational_Approaches_in_Comparative_Genomics
... By comparing genomes to gain a better understanding of the similarities & differences between genomes over evolutionary times ...
... By comparing genomes to gain a better understanding of the similarities & differences between genomes over evolutionary times ...
Illumina Infinium HumanMethylation450 BeadChip Data
... powerful embedded statistics and visualizations to yield deep biological interpretation. Going from raw data to biological interpretation has never been easier. ...
... powerful embedded statistics and visualizations to yield deep biological interpretation. Going from raw data to biological interpretation has never been easier. ...
Structural variations in the human genome
... With every single discovery that has been made, it seems as though ten new questions arise; the most important questions without exception being ‘what can we do with this new information’ and ‘what are the clinical implications of this knowledge’. Answering these (and other) questions is not always ...
... With every single discovery that has been made, it seems as though ten new questions arise; the most important questions without exception being ‘what can we do with this new information’ and ‘what are the clinical implications of this knowledge’. Answering these (and other) questions is not always ...
The distribution of substitutions reflects features of homologous
... per window are observed in DND: vertically inherited segments with low number of differences and recombined segments with high number of differences. The distribution of number of differences in vertically inherited segments is similar to the Poisson distribution, whereas the distribution of the num ...
... per window are observed in DND: vertically inherited segments with low number of differences and recombined segments with high number of differences. The distribution of number of differences in vertically inherited segments is similar to the Poisson distribution, whereas the distribution of the num ...
View poster
... genome sequencing (WGS) or targeted enrichment using exome or gene panels. Copy number variation (CNV) of genomic segments is a large category of structural variation and has been implicated in many Mendelian diseases and complex traits. The impact of CNVs on gene expression is not limited to only t ...
... genome sequencing (WGS) or targeted enrichment using exome or gene panels. Copy number variation (CNV) of genomic segments is a large category of structural variation and has been implicated in many Mendelian diseases and complex traits. The impact of CNVs on gene expression is not limited to only t ...
Intra-genomic 16S rRNA gene heterogeneity in
... and the hepatotoxic Nodularia spumigena CCY 9414 both have relatively high rates of divergence between their 16S rRNA genes (0.3% and 0.5% sequence divergence, respectively). A potential reason for this large divergence may be that the genomes of such cyanobacteria undergo higher rates of recombinat ...
... and the hepatotoxic Nodularia spumigena CCY 9414 both have relatively high rates of divergence between their 16S rRNA genes (0.3% and 0.5% sequence divergence, respectively). A potential reason for this large divergence may be that the genomes of such cyanobacteria undergo higher rates of recombinat ...
Copy number variants and genetic traits: closer to the resolution of
... became the gold-standard DNA markers for genetic studies7–14 and thousands of microsatellite markers were used to create linkage maps of all human chromosomes15–18. ...
... became the gold-standard DNA markers for genetic studies7–14 and thousands of microsatellite markers were used to create linkage maps of all human chromosomes15–18. ...
Whole genome sequencing
Whole genome sequencing (also known as full genome sequencing, complete genome sequencing, or entire genome sequencing) is a laboratory process that determines the complete DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast.Whole genome sequencing should not be confused with DNA profiling, which only determines the likelihood that genetic material came from a particular individual or group, and does not contain additional information on genetic relationships, origin or susceptibility to specific diseases. Also unlike full genome sequencing, SNP genotyping covers less than 0.1% of the genome. Almost all truly complete genomes are of microbes; the term ""full genome"" is thus sometimes used loosely to mean ""greater than 95%"". The remainder of this article focuses on nearly complete human genomes.High-throughput genome sequencing technologies have largely been used as a research tool and are currently being introduced in the clinics. In the future of personalized medicine, whole genome sequence data will be an important tool to guide therapeutic intervention. The tool of gene sequencing at SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response.