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5.2 Skeletal Muscle Actions
5.2 Skeletal Muscle Actions

... muscle) and all muscle fibers stimulated by it (100 – 2,000 fibers) 1. Generating Action Potentials (nerve to muscle communication) - Motor neuron cell body (located in the spinal cord) is connected to the muscle cell by a long, thin fiber – the axon - The axon terminals (branches) lie close to a mu ...
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control systems of the body - chapter 11

... neuron and a muscle cell, gland, or organ. In a typical synapse between two neurons the neuron before the synapse is called the presynaptic neuron and the neuron after the synapse is called the postsynaptic neuron. A nerve impulse causes a release of neurotransmitters (a chemical signaler) into the ...
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Muscle Twitches - Mount Carmel Academy

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Muscles - Part 3

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... contain the neurotransmitter acetylcholine (ACh) – The motor end plate of a muscle, which is a specific part of the sarcolemma that contains ACh receptors and helps form the neuromuscular junction ...
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... neurotransmitters into the synaptic cleft. These neurotransmitters bind to receptors proteins and open the ion channels of the new neuron cell. • If enough ion channels are opened, the action potential will continue through the new neuron. If not, the nervous signal will be terminated. • After the n ...
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Membrane Biophysics and Synaptic Physiology

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Neurons - University of San Diego Home Pages

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Diseases of peripheral nervous system. Myasthenic, myopatic
Diseases of peripheral nervous system. Myasthenic, myopatic

... junction ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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