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Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis

MS Word Version
MS Word Version

ppt
ppt

... • that are abrupt, pulse-like changes in the membrane potential that last a few ten thousandths of a second. • Action potentials can be divided into three phases: the resting or polarized state, depolarization, and repolarization • The amplitude of an action potential is nearly constant and is not r ...
PowerPoint for 9/29
PowerPoint for 9/29

... either fires or it doesn’t; more stimulation does nothing.  This is known as the “all-ornone” response. ...
Name: Date: Period: _____ Unit 9 Textbook Notes: The Nervous
Name: Date: Period: _____ Unit 9 Textbook Notes: The Nervous

... the pre-synaptic cell, or is degraded by enzymes in the synaptic cleft _____Calcium ions rush into the axon terminal and are packaged in synaptic vesicles _____Synaptic vesicles fuse with the axon terminal membrane and release calcium ions (the neurotransmitter) into the synaptic cleft. _____Calcium ...
Nervous System
Nervous System

... longer able to respond to the stimulus. C) The responding cell runs out of potassium and is no longer able to respond to the stimulus. D) The chemically gated ion channels of the receiving cell's membrane can only transport for a short period of time before they close. E) The neurotransmitter is bro ...
Nervous System
Nervous System

... Multiple Sclerosis - A progressive destruction of the myelin sheath of neurons in the CNS. The sheaths deteriorate to hardened scars or plaques, in multiple regions, thus the name. The plaques interfere with nerve impulse transmission. The average age of onset is 33. The disease is unpredictable. So ...
12-1 Chapter 12 Lecture Outline See PowerPoint Image Slides for
12-1 Chapter 12 Lecture Outline See PowerPoint Image Slides for

... • Local disturbances in membrane potential – occur when neuron is stimulated by chemicals, light, heat or mechanical disturbance – depolarization decreases potential across cell membrane due to opening of gated Na+ channels • Na+ rushes in down concentration and electrical gradients • Na+ diffuses f ...
Chapter 12
Chapter 12

... • Local disturbances in membrane potential – occur when neuron is stimulated by chemicals, light, heat or mechanical disturbance – depolarization decreases potential across cell membrane due to opening of gated Na+ channels • Na+ rushes in down concentration and electrical gradients • Na+ diffuses f ...
Chapter 48: Nervous System
Chapter 48: Nervous System

... junctions (channels that allow ion currents of action potential to flow) o Chemical synapses  Synaptic cleft: narrow gap separating the presynaptic cell from postsynaptic ...
The Nervous System
The Nervous System

... http://outreach.mcb.harvard.edu/ animations/actionpotential.swf ...
No Slide Title
No Slide Title

... • Local disturbances in membrane potential – occur when neuron is stimulated by chemicals, light, heat or mechanical disturbance – depolarization decreases potential across cell membrane due to opening of gated Na+ channels • Na+ rushes in down concentration and electrical gradients • Na+ diffuses f ...
Neuro2
Neuro2

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The Nervous System

... 10. Explain that a synapse is the region where two neurons come into close contact 11. Explain that a synaptic cleft is the gap between the neurons 12. Explain the activation and inactivation of neurotransmitters: 13. When neurotransmitters are activated by the ions they are released into the cleft ...
Objectives: The student shall know the facts, understand the
Objectives: The student shall know the facts, understand the

... NEUROMUSCULAR TRANSMISSION (Skeletal Muscle) Mechanisms of synaptic transmission Functional anatomy of the nerve-skeletal muscle junction; motor endplate region Steps in the transmission of excitation from the axon terminal to the muscle fiber membrane; neurotransmitter and receptor involved Charact ...
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The Nervous System

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nervous system physiology 7
nervous system physiology 7

... within 3 -5 sec. it can increase 2x the HR within 10-15 sec. the arterial pressure can be doubled The ANS has three divisions: sympathetic, parasympathetic, and enteric. Sympathetic and parasympathetic normally exert antagonistic effects on many of the same target organs. Enteric ANS is a system of ...
Neural-Ville
Neural-Ville

... 3. It may bind to the first cell's autoreceptors, which tell that cell not to release any more of the neurotransmitter molecules, then leave the autoreceptor and continue trying to bind again somewhere until its activity is ended by step 4, 5 or 6. ...
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neurocytol_lect

... The myelin sheath along a myelinated CNS axon is composed of sections of myelin made from a number of individual cells Remember, however, not all axons are myelinated. Small diameter axons generally have no myelin covering. ...
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here

... 27. Most neuron to neuron _______________occur between the axon terminal of one neuron and the dendrite of another. ...
AnS 214 SI Multiple Choice Set 2 Week 9/28 – 10/2 The following
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... A. Bind to the TI subunit of troponin, inducing a conformational change in tropomyosin that uncovers G-actin binding sites B. Allows myosin to bind to actin by causing tropomyosin to slide deeper into thin filament grooves C. Bind to tropomyosin, causing a conformational change in troponin that per ...
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CHAPTER 10

... If the stimulus is strong enough to cause a response in the neuron, it responds _______________________. A greater intensity of stimulation produces more impulses per second; not a _______________________ impulse. For a very short time following passage of a nerve impulse, a threshold stimulus will ...
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... Nodes of Ranvier – spaces between the myelin cells that help with quick signal transmission. Cell membrane – serves as a barrier around the entire cell. It excludes certain substances from the cell. This is what actually transmits the message. “Skin” of the cell. Nucleus – contains genetic informati ...
MS Word Version - Interactive Physiology
MS Word Version - Interactive Physiology

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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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