• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Haemodynamic and Metabolic Effects of Infused
Haemodynamic and Metabolic Effects of Infused

... for 5 min (once during basal conditions and once at each infusion step after 15-20 min of infusion), calculating oxygen uptake and measuring the systemic arterial-pulmonary arterial oxygen concentration difference (blood samples taken at start and end of air sampling, using the mean value for furthe ...
Document
Document

... previously used acetylcysteine infusion, used to treat paracetamol poisoning.2 We now examine carboplatin, used to treat cancer. Acetylcysteine bags are made up on the ward by staff who are not used to making up infusions, whereas carboplatin is made up by trained pharmacy staff in controlled and st ...
PHYSICIAN`S ORDERS - Walnut Hill Medical Center
PHYSICIAN`S ORDERS - Walnut Hill Medical Center

...  Have patient stand then recheck blood pressure and heart rate  Call IR MD if SBP drops by 20 points or pulse increases by 20 points with sitting or Standing ☐ Post Thrombolysis Nursing Orders  Monitor for and report blood in urine  No new IM or IV sticks while patient is receiveing tPA. Place s ...
View Full Text-PDF
View Full Text-PDF

... experiment, drug was found to reduce the blood sugar at 4th hour by 6.07 percent at dose level of 200mg/kg by weight and 18.7 percent at concentration of 1000mg/kg by weight. Continuous administration of drug produced significant reduction in blood sugar in alloxan diabetic rats. On 15th day values ...
Slide 1
Slide 1

... diabetes mellitus as per ADA. 4. Patient on stable Atorvastatin therapy (10 mg) for at least 4 weeks with LDL greater than or equal to 100mg%. 5. Triglycerides > 200 up to 500 mg/dl on screening visit. 6. Body mass index (BMI) > 23 kg/m2 7. Subject has given informed consent for participation in thi ...
Drug Testing: Answers to Frequently Asked
Drug Testing: Answers to Frequently Asked

...  Purified standards continue to be synthesized  Limited published research on retention ...
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF ATENOLOL FOR
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF ATENOLOL FOR

... The purpose of this research was to develop gastro-retentive delivery system of atenolol which, after oral administration should have the ability to prolong gastric residence time with desired in vitro release profile. Atenolol was chosen as a model drug because it is poorly absorbed from the lower ...
Creatinine Clearance When Does It Matter?
Creatinine Clearance When Does It Matter?

... From: Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guideline. Dosing is generally decreased due to decreased renal clearcence, increased ADR profile and complexity of disease. Ann Intern Med. 2014;160(3):182-189. doi:10 ...
oral bioavailability and first-pass effects
oral bioavailability and first-pass effects

Document
Document

... All trajectories approach the origin. Global attraction is verified numerically by randomly choosing 5000 sets of initial conditions. ...
sustained release matrix type drug delivery system: a review
sustained release matrix type drug delivery system: a review

... once daily dose is sufficient for penetration, polymer swelling, drug dissolution, drug diffusion and matrix erosion. Highly water soluble drugs like Diltiazem; Ranitidine has been formulated as sustained release matrix tablets. This article contains the basic information regarding design sustained ...
this paper (free) - International Journal of Pure and
this paper (free) - International Journal of Pure and

... Thus, all other models that exist for malaria dynamics are developed from the three basic models explained earlier by incorporating different factors to make them biologically more realistic in explaining disease prevalence and prediction[10]. For examples, a number of epidemiological studies [11], ...
Plasma shape reconstruction on-line algorithm in tokamaks
Plasma shape reconstruction on-line algorithm in tokamaks

... So, to compute coordinates of two current filaments it is necessary calculate plasma current moments with using experimental data and with using current filaments approach and equate each other. Solving algebraic equation system with four unknown (r1,z1) and (r2,z2), current filaments coordinates ca ...
Drug Administration Uglies
Drug Administration Uglies

... drugs, but if it does happen, then the unlisted chemo admin code 96549 should be reported. Multiple substances mixed in one bag are considered to be one infusion, not a concurrent infusion. There is no concurrent code for hydration. Still no separate payment for the concurrent infusion code (9636 ...
Drug Administration Uglies
Drug Administration Uglies

Enhancement of Dissolution Rate of Ritonavir: A Comparative
Enhancement of Dissolution Rate of Ritonavir: A Comparative

... decreased with increasing carrier concentration, demonstrating that the reaction became more favorable as the concentration of carrier increased. In vitro Dissolution Studies: All formulations of Ritonavir were subjected to in vitro dissolution studies using 0.1N HCl as the dissolution medium to ass ...
FORMULATION AND EVALUATION OF TOPICAL VALDECOXIB GEL Research Article
FORMULATION AND EVALUATION OF TOPICAL VALDECOXIB GEL Research Article

... Topical gels of valdecoxib were prepared using different gelling agents (carbopol, HPMC, sodium alginate, sodium CMC). Formulations were evaluated for pH, rheological behavior, drug content and in-vitro drug diffusion. Selected formulations of all the gelling agents were appeared to be non-Newtonian ...
1.37 MB - EngageNY
1.37 MB - EngageNY

... (b) Some entire careers revolve around a single modeling problem. (c) Eliminates questions regarding “what good is this stuff?” (d) Standards from multiple mathematical domains (and multiple grade levels) can occur together in modeling problems. This serves to make connections between mathematical c ...
Poisoning.Comm Volume 1 , Issue 4 (OCT 2006)
Poisoning.Comm Volume 1 , Issue 4 (OCT 2006)

Drug Interactions
Drug Interactions

... pharmacodynamics of one drug is altered by another  are a source of variability in drug response  are graded responses, that are dependent upon the concentration of the interacting species, and on dose and time  pharmacokinetic interactions may affect absorption rate, availability, distribution, ...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF

... studied by using USP type II apparatus with buffer pH 1.2 for one hour and followed by buffer pH 6.8 for seven hours. The drug release profile was compared with marketed formulation. Keywords: Sustained release, Verapamil hydrochloride, Ethyl cellulose, Stearic acid, Hydrogenated castor oil and Melt ...
Experiment Designs for the Assessment of Drug Combination
Experiment Designs for the Assessment of Drug Combination

IN VITRO Research Article SAKTHIVEL M*
IN VITRO Research Article SAKTHIVEL M*

... Oxcarbazepine niosomes were prepared by Thin Film Hydration Technique using Rotary flash Evaporator5. Weighed quantity of cholesterol and surfactant were dissolved in chloroform and methanol mixture (1:1 v/v) taken in a round bottom flask. The flask was rotated in rotary flash evaporator at 100 rpm ...
Physics 100A, Homework 12-Chapter 11
Physics 100A, Homework 12-Chapter 11

... A) Marcel is helping his two children, Jacques and Gilles, to balance on a seesaw so that they will be able to make it tilt back and forth without the heavier child, Jacques, simply sinking to the ground. Given that Jacques, whose weight is W , is sitting at distance L to the left of the pivot, at w ...
EpilEpsy BoARD REviEw MAnuAl Antiepilepsy Drugs: Mechanisms
EpilEpsy BoARD REviEw MAnuAl Antiepilepsy Drugs: Mechanisms

... serum creatinine levels, including the Modification of Diet in Renal Disease study equation (MDRD), the Cockcroft-Gault equation, and most recently, the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-Epi).10 The MDRD and CKD-Epi are used to stage kidney function.11,12 The Cockcroft- ...
< 1 ... 38 39 40 41 42 43 44 45 46 ... 157 >

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report