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Intravascular Dosing, Clearance, and Volume of Distribution
Intravascular Dosing, Clearance, and Volume of Distribution

... Basics of CL and Vd  True or False: If CL is increased, then Vd is also ...
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pmcjcr/ pharmacokinetics

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Tina said you all learned ALOT last week

... concentration or amount of drug in the body to be reduced by one-half 4-5 X half-life=Steady State – As repeated doses of a drug are administered its plasma concentration builds up and reaches what is known as a steady state. This is when the amount of drug in the plasma has built up to a concentrat ...
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Click here to see today`s lesson

PHT 415 HomeWork
PHT 415 HomeWork

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1 PHA 5128 Homework I 1. Hydrocortisone (20 mg) was given by an

... K.L., a 75 kg male smoker with chronic obstructive pulmonary disease, is to be started on an oral regimen of aminophylline (85% of which is theophylline). The pharmacokinetic parameters for this patient are Vd (0.5 L/kg), CL (80 mL/h/kg) and F (1.0). a. Design an oral dosage regimen of aminophylline ...
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Abstract Pengembangan perangkat lunak simulasi komputer

... This research usus mammilary model as compartment model, in which a single drug administration is given via oral and intravenous. Mathematical modeling in differential equations can be derived from a pharmacokinetics model. The solutions are pharmacokinetikcs variables and parameters that can be sol ...
< 1 ... 153 154 155 156 157

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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