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Guar gum/borax hydrogel - eXPRESS Polymer Letters
Guar gum/borax hydrogel - eXPRESS Polymer Letters

Reaction rate theory: What it was, where is it today, and where is it
Reaction rate theory: What it was, where is it today, and where is it

... understanding the critical factors which determine rates away from equilibrium. The nonequilibrium quantum theory is even less well developed than the classical, and suffers from the fact that even today, we do not know how to solve the real time quantum dynamics for systems with “many” degrees of f ...
Functions of the malaria ref lab in SADC 2014
Functions of the malaria ref lab in SADC 2014

Misoprostol Detection in Blood
Misoprostol Detection in Blood

... In order to detect misoprostol acid in blood, a validated assay is necessary. There are very few validated assays and even fewer that are commercially available. Most of the facilities with the capacity to detect misoprostol acid in blood are in Europe and Asia, and the assays are expensive. ...
LYOPHILIZED GLICLAZIDE­POLOXAMER SOLID DISPERSIONS FOR ENHANCEMENT OF  IN­ VITRO DISSOLUTION AND IN­VIVO BIOAVAILABILITY 
LYOPHILIZED GLICLAZIDE­POLOXAMER SOLID DISPERSIONS FOR ENHANCEMENT OF  IN­ VITRO DISSOLUTION AND IN­VIVO BIOAVAILABILITY 

... or  post‐receptor  sites.  It  also  inhibits  platelet  aggregation  and  increases  fibrinolysis3.  However,  the  drawback  of  this  potentially  useful  hypoglycemic  agent  is  that  it  is  highly  hydrophobic  and  practically insoluble in water4.  In general, rapid gastrointestinal (GI)  ab ...
local anesthetic agents
local anesthetic agents

ADRENOCEPTOR AGONIST SYMPATHOMIMETICS
ADRENOCEPTOR AGONIST SYMPATHOMIMETICS

... Unfractionated heparin (UFH) 1. Activated partial thromboplastin time (aPTT) 1.5 - 2.5 times that of the normal value (30 sec). 2. Whole blood clotting time (WBCT): 2 - 3 times the normal value (5 - 7 min). ...
Product Information Roar Ex Vivo CETP Activity
Product Information Roar Ex Vivo CETP Activity

... Cholesteryl ester transfer protein (CETP), present in normal human plasma, transfers neutral lipids among the different classes of lipoproteins (HDL, LDL, VLDL). CETP plays an important role in lipoprotein metabolism and influences the reverse cholesterol transport pathway. The Roar Ex Vivo CETP Act ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... Ropivacaine blocks Aδ and C fibres to a greater degree than Aβ fibres which is responsible for differential block.4,15 In-vitro study demonstrated that in equal doses, the depressant effect of bupivacaine on A-fibres was 16% greater than that of , Ropivacaine , but only 3% greater on C-fibers.19Dusa ...
The effect of food and gastrointestinal residence on drug
The effect of food and gastrointestinal residence on drug

SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE

... Short-term parenteral vitamin B12 administration may temporarily impair the diagnosis of funicular myelosis or pernicious anemia. If symptoms of peripheral sensory neuropathy (paraesthesia) occur, the dosage should be reviewed and treatment with the medicinal product discontinued, if necessary. Neur ...
Developmental Pharmacokinetics
Developmental Pharmacokinetics

s think!
s think!

Antihyperlipidemic effect of biochanin A on streptozotocin induced
Antihyperlipidemic effect of biochanin A on streptozotocin induced

... of many oral hypoglycemic agents such as sulphonylureas and biguanides. All of these pharmacological modalities also show limited efficacy and certain adverse effects such as liver toxicity, lactic acidosis, diarrhea and attenuation of response after prolonged use and are also expensive for developi ...
Antilipemic Agents
Antilipemic Agents

... 3. Inhibits FFA release from adipose tissues by inhibiting the intracellular lipase system 4. Reduces circulating fibrinogen (contributes to clot formation) and ↑ tissue plasminogen activator (clot dissolver) 5. HDL catabolic rate is decreased 6. Reduces the plasma level of Lp(a) lipoprotein, wh ...
Continuous nebulization therapy for asthma with
Continuous nebulization therapy for asthma with

... sulfate to patients with severe asthma and/or impending respiratory failure.14 –27 For example, physicians at the University of Michigan Medical Center and at the University of MissouriKansas City School of Medicine found continuous nebulization therapy with terbutaline sulfate to be effective for t ...
Guidance  for  Industry
Guidance for Industry

... Bioavailability is definedin 21 CFR 320.1 as ‘the rate and extentto which the activeingredient or activemoiety is absorbedfrom a drug product and becomesavailableat the site of action. For drug products that are not intendedto be absorbedinto the bloodstream,bioavailability may be assessed by measur ...
IN VITRO MICROSPHERES
IN VITRO MICROSPHERES

... ABSTRACT 5-Flurouracil (5-FU) is an antimetabolite with a broad spectrum activity against solid tumors. However, it’s very short half- life in plasma circulation greatly limited the in vivo antitumor efficacy and clinical application of the drug. The current research work aimed to solve this problem ...
A VALIDATED RP-HPLC METHOD FOR ESTIMATION OF DROTAVERINE HCL IN
A VALIDATED RP-HPLC METHOD FOR ESTIMATION OF DROTAVERINE HCL IN

... Stressed samples were injected into the HPLC system with UVVISIBLE detector by following test method conditions. All degradant peaks were resolved from Drotaverine HCl peak in the chromatograms of all samples and placebo did not shown any considerable peaks under the above conditions. The chromatogr ...
Exicted Baryons in Large Nc QCD:
Exicted Baryons in Large Nc QCD:

... world is rather different from the real world approach still may be useful for qualitative reasons – One can use known behavior at large Nc to illustrate issues of some principle. – The possible existence of exotic states (eg. states not in the dumbest version of the quark model) is such an issue. • ...
No Slide Title
No Slide Title

... Physical properties are measured for the molecule as a whole Properties are calculated using computer software No experimental constants or measurements are involved Properties are known as ‘Fields’ Steric field - defines the size and shape of the molecule Electrostatic field - defines electron rich ...
Pharmacological Approaches to Fat Loss: Targeting
Pharmacological Approaches to Fat Loss: Targeting

Location of enkephalinase and functional effects of
Location of enkephalinase and functional effects of

Clinical Pharmacokinetic Studies of Pharmaceuticals
Clinical Pharmacokinetic Studies of Pharmaceuticals

Gauss`s Hypergeometric Equation
Gauss`s Hypergeometric Equation

... Some comments and remarks on hypergeometric functions F: Formulas (0.6) and (0.7) show that the adaptability of the constants in equation GHE (0.1) makes it possible to express the general solution of this equation near each of its singular points in terms of the single function F. More than this i ...
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Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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