Genetically modified yeasts as a new oral drug delivery system: from
... First, genetically modified microorganisms have potential as a biodetoxication system in the gut [1]. The aim is to increase the body’s protection against environmental xenobiotics, mainly those present in food (such as pesticides or chemical additives) by ingesting microorganisms expressing phase I ...
... First, genetically modified microorganisms have potential as a biodetoxication system in the gut [1]. The aim is to increase the body’s protection against environmental xenobiotics, mainly those present in food (such as pesticides or chemical additives) by ingesting microorganisms expressing phase I ...
CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative
... Human Liver Microsomes. Ethics approval was obtained from the Human Ethics Committee of the Royal Adelaide Hospital to obtain human liver samples (n ⫽ 7) during partial hepatectomy from patients who had given written informed consent for their tissue to be used, as reported previously (Hutchinson et ...
... Human Liver Microsomes. Ethics approval was obtained from the Human Ethics Committee of the Royal Adelaide Hospital to obtain human liver samples (n ⫽ 7) during partial hepatectomy from patients who had given written informed consent for their tissue to be used, as reported previously (Hutchinson et ...
EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF SEEDS OF
... phytconstituents by preliminary phytochemical tests. The median lethal dose (LD50) of the test drug was assessed in acute toxicity study which was found to be 2000 mg/kg, and based on this study the oral doses of HPE were fixed to 100, 200 and 400 mg/kg body weight to carry out the antiinflammatory ...
... phytconstituents by preliminary phytochemical tests. The median lethal dose (LD50) of the test drug was assessed in acute toxicity study which was found to be 2000 mg/kg, and based on this study the oral doses of HPE were fixed to 100, 200 and 400 mg/kg body weight to carry out the antiinflammatory ...
Anabolic Steroids hardcore info
... manufactured drugs may contain something other than what it says on the label, or could contain what it states on the label but at a higher or lower dose. The only source of information on dosage for non-medical purposes is from ‘Underground’ hand books and from other steroid users. The drug informa ...
... manufactured drugs may contain something other than what it says on the label, or could contain what it states on the label but at a higher or lower dose. The only source of information on dosage for non-medical purposes is from ‘Underground’ hand books and from other steroid users. The drug informa ...
Ritodrine (Systemic)
... In addition to stimulating the beta-2–adrenergic receptors of the uterine smooth muscle, ritodrine stimulates beta-adrenergic receptors of bronchial and vascular smooth muscles. The cardiostimulatory effects, including increased cardiac output, increased maternal and fetal heart rates, and widening ...
... In addition to stimulating the beta-2–adrenergic receptors of the uterine smooth muscle, ritodrine stimulates beta-adrenergic receptors of bronchial and vascular smooth muscles. The cardiostimulatory effects, including increased cardiac output, increased maternal and fetal heart rates, and widening ...
QUANTITATIVE ESTIMATION OF MUPIROCIN CALCIUM FROM PHARMACEUTICAL OINTMENT FORMULATION BY UV SPECTROPHOTOMETRY
... Assay procedure based on UV Spectrophotometry has been developed for the quantitative estimation of Mupirocin calcium from ointment formulation. The solvent system and wavelength of detection were optimized in order to maximize the sensitivity of the proposed met ...
... Assay procedure based on UV Spectrophotometry has been developed for the quantitative estimation of Mupirocin calcium from ointment formulation. The solvent system and wavelength of detection were optimized in order to maximize the sensitivity of the proposed met ...
Simvastatin and atorvastatin: beware of potential CYP3A4
... of these statins, resulting in either an increased risk of adverse effects (e.g. myopathy and rhabdomyolyis) or a reduction in the effectiveness of treatment.2 For example, one study which investigated the effect of erythromycin (a potent CYP3A4 inhibitor) on serum simvastatin concentrations found t ...
... of these statins, resulting in either an increased risk of adverse effects (e.g. myopathy and rhabdomyolyis) or a reduction in the effectiveness of treatment.2 For example, one study which investigated the effect of erythromycin (a potent CYP3A4 inhibitor) on serum simvastatin concentrations found t ...
Effects of Losartan on Blood Pressure, Plasma Renin
... Losartan is an orally active, nonpeptide angiotensin II (Ang II) (site-1) receptor antagonist. We conducted a multiple-dose study in healthy male volunteers to investigate the tolerability, blood pressure effects, and changes in plasma renin activity (PRA) and plasma Ang II concentration associated ...
... Losartan is an orally active, nonpeptide angiotensin II (Ang II) (site-1) receptor antagonist. We conducted a multiple-dose study in healthy male volunteers to investigate the tolerability, blood pressure effects, and changes in plasma renin activity (PRA) and plasma Ang II concentration associated ...
mAChR AntagWEB07
... contraction of some smooth muscles; a presynaptic receptor on some nerve terminals • M3- mediates contraction of smooth muscle, relaxation of vasculature, and secretion from ...
... contraction of some smooth muscles; a presynaptic receptor on some nerve terminals • M3- mediates contraction of smooth muscle, relaxation of vasculature, and secretion from ...
Lower critical solution temperature versus volume phase transition
... [4, 5]. Under pseudo-physiological conditions (PB at pH 7.4) the LCST decreases to lower temperatures [12]. In order to increase the LCST towards body temperature, NIPAAm is usually copolymerized with hydrophilic monomers [18, 19]. Here, HMAAm was selected to be copolymerized with NIPAAm. Note that ...
... [4, 5]. Under pseudo-physiological conditions (PB at pH 7.4) the LCST decreases to lower temperatures [12]. In order to increase the LCST towards body temperature, NIPAAm is usually copolymerized with hydrophilic monomers [18, 19]. Here, HMAAm was selected to be copolymerized with NIPAAm. Note that ...
IJCT 13(4) 360-366
... effects. In addition, it exhibits antimuscarine and calcium channel blocking activity. CPH is used to treat some hormonal disorders and may be used for treating side-effects of taking antidepressants. It has also been shown to stimulate appetite and weight gain in children and adults. CPH is some ti ...
... effects. In addition, it exhibits antimuscarine and calcium channel blocking activity. CPH is used to treat some hormonal disorders and may be used for treating side-effects of taking antidepressants. It has also been shown to stimulate appetite and weight gain in children and adults. CPH is some ti ...
DEVELOPMENT AND EVALUATION OF PARACETAMOL TASTE MASKED ORALLY
... The purpose of this research was to mask the intensely bitter taste of paracetamol and to formulate the orally disintegrating tablets (ODTs). TasteMasked orally disintegrating tablets of paracetamol were prepared by Flash Tab Technology. Taste masked granules of paracetamol were prepared by coating ...
... The purpose of this research was to mask the intensely bitter taste of paracetamol and to formulate the orally disintegrating tablets (ODTs). TasteMasked orally disintegrating tablets of paracetamol were prepared by Flash Tab Technology. Taste masked granules of paracetamol were prepared by coating ...
effects of cytochrome p450 enzyme inhibitors on the
... Cytochrome P450 (CYP) enzymes play a pivotal role in the metabolism of many drugs. Inhibition of CYP enzymes usually increases the plasma concentrations of their substrate drugs and can thus alter the safety and efficacy of these drugs. The metabolism of many widely used nonsteroidal anti-inflammato ...
... Cytochrome P450 (CYP) enzymes play a pivotal role in the metabolism of many drugs. Inhibition of CYP enzymes usually increases the plasma concentrations of their substrate drugs and can thus alter the safety and efficacy of these drugs. The metabolism of many widely used nonsteroidal anti-inflammato ...
Mechanism-based Inhibition: Deriving KI and kinact
... consequence, most studies and ranking schemes related to MBI rely on the inhibition constant (KI) and the rate of enzyme inactivation (kinact) rather than on IC50 values. In this article we derive a novel relation between potentially time-dependent IC50 values and KI, kinact parameters for different ...
... consequence, most studies and ranking schemes related to MBI rely on the inhibition constant (KI) and the rate of enzyme inactivation (kinact) rather than on IC50 values. In this article we derive a novel relation between potentially time-dependent IC50 values and KI, kinact parameters for different ...
INTERACTION BETWEEN GRAPEFRUIT JUICE AND DRUGS*
... juice, it is evident that this inhibition is not a simple competitive action on the metabolism of the substrate. Grapefruit juice reduced the post-translational CYP3A4 protein content without affecting CYP3A4 mRNA in the small intestine, suggesting that this is an irreversible enzyme inhibition with ...
... juice, it is evident that this inhibition is not a simple competitive action on the metabolism of the substrate. Grapefruit juice reduced the post-translational CYP3A4 protein content without affecting CYP3A4 mRNA in the small intestine, suggesting that this is an irreversible enzyme inhibition with ...
ANALYTICAL METHOD DEVELOPMENT AND METHOD VALIDATION FOR THE ESTIMATION
... inhibits hepatic gluconeogenesis also improves glycemic control while reducing circulating insulin levels. It is used for the treatment of diabetes mellitus type 2 (previously known as non-insulindependent diabetes mellitus, NIDDM) in monotherapy and in combination with a sulfonylurea, metformin, or ...
... inhibits hepatic gluconeogenesis also improves glycemic control while reducing circulating insulin levels. It is used for the treatment of diabetes mellitus type 2 (previously known as non-insulindependent diabetes mellitus, NIDDM) in monotherapy and in combination with a sulfonylurea, metformin, or ...
Development and Evaluation of Enteric Coated Tablet Containing
... agent) were mixed vigorously for half an hour. The coloring agent (Amaranth) was also added to the solution and filtered with a muslin cloth. 200 uncoated tablets were taken in a mini coating pan at 107 rpm (optimum) to develop three different batches. Coating solution was applied through spray gun ...
... agent) were mixed vigorously for half an hour. The coloring agent (Amaranth) was also added to the solution and filtered with a muslin cloth. 200 uncoated tablets were taken in a mini coating pan at 107 rpm (optimum) to develop three different batches. Coating solution was applied through spray gun ...
