187 Formulation and Evaluation of Rofecoxib Tablets
... values of the friability ranged from 0.85 – 0.97% which are acceptable values according to the USP XXV (15). The prepared ROF tablets show hardness levels in the range of 4 to 6 kg. Table (2) shows that the tablets formula No. 6 has a high hardness level of 6 ± 0.13 kg. The hardness / friability rat ...
... values of the friability ranged from 0.85 – 0.97% which are acceptable values according to the USP XXV (15). The prepared ROF tablets show hardness levels in the range of 4 to 6 kg. Table (2) shows that the tablets formula No. 6 has a high hardness level of 6 ± 0.13 kg. The hardness / friability rat ...
SIMULTANEOUS DETERMINATION OF CLOPIDOGREL AND
... steatohepatitis (fatty liver), but this use is presently considered experimental.[6] Pioglitazone has also been found to reduce the risk of conversion from prediabetes to diabetes mellitus type 2 by ...
... steatohepatitis (fatty liver), but this use is presently considered experimental.[6] Pioglitazone has also been found to reduce the risk of conversion from prediabetes to diabetes mellitus type 2 by ...
Clinical Actions of Specific Agents
... for local anesthetics and no longer adjusts them for inclusion of a vasoconstrictor -Changes in liver function, plasma protein binding, blood volume and other important physiological functions influence the manner in which local anesthetics are distributed and biotransformed in the body -The half li ...
... for local anesthetics and no longer adjusts them for inclusion of a vasoconstrictor -Changes in liver function, plasma protein binding, blood volume and other important physiological functions influence the manner in which local anesthetics are distributed and biotransformed in the body -The half li ...
DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR SIMULTANEOUS
... values were found to be 0.52 μg/mL and 0.27 μg/mL for Pantoprazole and Cinitapride, respectively. LOQ values were found to be 1.6 μg/mL and 0.82 μg/mL for Pantoprazole and Cinitapride, respectively. ...
... values were found to be 0.52 μg/mL and 0.27 μg/mL for Pantoprazole and Cinitapride, respectively. LOQ values were found to be 1.6 μg/mL and 0.82 μg/mL for Pantoprazole and Cinitapride, respectively. ...
Anti-inflammatory and Analgesic Activity of Methanolic Extract of
... Analgesics are drugs that selectively relieve pain by acting in the CNS or on peripheral pain mechanisms, without significantly altering consciousness. Analgesics relieve pain, without affecting its cause. Analgesics are divided into two groups, opioid analgesic and non-opioid analgesic [3]. The use ...
... Analgesics are drugs that selectively relieve pain by acting in the CNS or on peripheral pain mechanisms, without significantly altering consciousness. Analgesics relieve pain, without affecting its cause. Analgesics are divided into two groups, opioid analgesic and non-opioid analgesic [3]. The use ...
Physicochemical characterization of meloxicam–mannitol binary
... ME1 and mannitol particles with same particle size only mixed together, as it shown in Fig. 4. However, in the case of ME2, on increase of the amount of mannitol (1:10), the dissolution was faster. This is connected with the specific surfaces of ME2 and mannitol. ME2 with small particles presumably ...
... ME1 and mannitol particles with same particle size only mixed together, as it shown in Fig. 4. However, in the case of ME2, on increase of the amount of mannitol (1:10), the dissolution was faster. This is connected with the specific surfaces of ME2 and mannitol. ME2 with small particles presumably ...
FEASIBILITY BIOWAIVER EXTENSION OF IMMEDIATE RELEASE ORAL ACYCLOVIR 800 MG
... Drug physicochemical parameters including acid dissociation constant (Ka), lipophilicity, plasma protein binding, molecular weight, aqueous solubility, hepatic clearance, renal clearance as well as drug release data in vitro were set for simulations. Predicted results presented as plasma drug concen ...
... Drug physicochemical parameters including acid dissociation constant (Ka), lipophilicity, plasma protein binding, molecular weight, aqueous solubility, hepatic clearance, renal clearance as well as drug release data in vitro were set for simulations. Predicted results presented as plasma drug concen ...
VOLTAMMETRIC BEHAVIOR OF GEFITINIB AND ITS ADSORPTIVE STRIPPING VOLTAMMETRIC DETERMINATION IN PHARMACEUTICAL FORMULATIONS AND URINE
... The first and second peaks are attributed to the reduction of gefitinib with two‐electron signals and which are found to change with pH. In acidic media (pH 2.0 to 6.0) a four electron reduction is noticed and first step might be due to hydrolysis of –C=N‐ bond. The imine th ...
... The first and second peaks are attributed to the reduction of gefitinib with two‐electron signals and which are found to change with pH. In acidic media (pH 2.0 to 6.0) a four electron reduction is noticed and first step might be due to hydrolysis of –C=N‐ bond. The imine th ...
phytopharmacological review of trichosanthes dioica (patola)
... induced Sub & mild-diabetic rats in order to define its glycemic potential. The dose of 500mg/kg body weight was identified as the most effective dose which brings down the blood glucose level by 32.9% at 5 hr. during fasting blood glucose studies in normal rats. 5. Cholesterol Lowering Activity:The ...
... induced Sub & mild-diabetic rats in order to define its glycemic potential. The dose of 500mg/kg body weight was identified as the most effective dose which brings down the blood glucose level by 32.9% at 5 hr. during fasting blood glucose studies in normal rats. 5. Cholesterol Lowering Activity:The ...
... 1952). Afterwards, labels were required with the warning that blood dycariasis may be associated with the intermittent or prolonged use of CAP. Practitioners were instructed not to prescribe it intermittently. It is to be used for a very few serious and potentially fatal infections against which no ...
Lidoderm (Lidocaine Patch 5%)
... Patients allergic to para-aminobenzoic acid derivatives (procaine, tetracaine, benzocaine, etc.) have not shown cross sensitivity to lidocaine. However, LIDODERM should be used with caution in patients with a history of drug sensitivities, especially if the etiologic agent is uncertain. Non-intact S ...
... Patients allergic to para-aminobenzoic acid derivatives (procaine, tetracaine, benzocaine, etc.) have not shown cross sensitivity to lidocaine. However, LIDODERM should be used with caution in patients with a history of drug sensitivities, especially if the etiologic agent is uncertain. Non-intact S ...
enzyme induction and inhibition
... The ability of enzyme incuding agents to increase the rate of phase one reactions is recognized. However administration of these agents may also increase the activity of phase two enzymes, such as glucuronyl transferase as demonstrated by the ability of oral contraceptive steroids to increase glycin ...
... The ability of enzyme incuding agents to increase the rate of phase one reactions is recognized. However administration of these agents may also increase the activity of phase two enzymes, such as glucuronyl transferase as demonstrated by the ability of oral contraceptive steroids to increase glycin ...
Module 1. Clinical pharmacology of drugs affecting the
... A. elevation of body temperature is typically a useful defense mechanism B. * aspirin -- best available drug for reducing fever (in the absence of contraindications to its use recurrent C. aspirin -- more effective in lowering elevated temperature than normal body temperature D. aspirin-induced temp ...
... A. elevation of body temperature is typically a useful defense mechanism B. * aspirin -- best available drug for reducing fever (in the absence of contraindications to its use recurrent C. aspirin -- more effective in lowering elevated temperature than normal body temperature D. aspirin-induced temp ...
IN VIVO Research Article RANJITA SHEGOKAR AND KAMALINDER K. SINGH*
... The concentration of paracetamol in whole human blood was determined using spectrofluorimetric method at emission wavelength of 548 nm and excitation wavelength 467 nm. To 0.3 ml of blood, sufficient purified water was added to make the volume to 4 ml. After addition of 2.5 g of NaCl, the mixture wa ...
... The concentration of paracetamol in whole human blood was determined using spectrofluorimetric method at emission wavelength of 548 nm and excitation wavelength 467 nm. To 0.3 ml of blood, sufficient purified water was added to make the volume to 4 ml. After addition of 2.5 g of NaCl, the mixture wa ...
Paracetamol - A Review of Three Routes of Administration - e
... known drug interactions and breast-feeding women may use paracetamol. Paracetamol has been shown to have a comparable benefit to ibuprofen and diclofenac in general and orthopaedic surgery7 and can significantly reduce the opiate requirement postoperatively – it has an opioid-sparing effect.8 Number ...
... known drug interactions and breast-feeding women may use paracetamol. Paracetamol has been shown to have a comparable benefit to ibuprofen and diclofenac in general and orthopaedic surgery7 and can significantly reduce the opiate requirement postoperatively – it has an opioid-sparing effect.8 Number ...
COMPARATIVE STUDY ON EFFECT OF DIFERENT TECHNIQUES USED IN THE FORMULATION OF FELODIPINE FAST DISSOLVING TABLETS
... disintegration. In all the formulations, hardness test indicated good mechanical strength, friability is less than 1%, indicated that tablets had a good mechanical resistance. Thickness of the tablets range from 3.28 to 3.95 mm. Tablets prepared with mannitol showed highest th ...
... disintegration. In all the formulations, hardness test indicated good mechanical strength, friability is less than 1%, indicated that tablets had a good mechanical resistance. Thickness of the tablets range from 3.28 to 3.95 mm. Tablets prepared with mannitol showed highest th ...
The Effects of Caffeine on the Human Metabolism
... An experiment was designed to measure the effects that caffeine has on the time it takes to complete an exercise over a specific distance (Kovacs 710). An experiment was performed in which participants were given varying amounts of caffeine, placebo and a carbohydrateelectrolyte solution (Kovacs 712 ...
... An experiment was designed to measure the effects that caffeine has on the time it takes to complete an exercise over a specific distance (Kovacs 710). An experiment was performed in which participants were given varying amounts of caffeine, placebo and a carbohydrateelectrolyte solution (Kovacs 712 ...
722_Wk03_VitaminA
... promyelocytic leukemia. This is a rare leukemia with about 1,000 new patients in the United States each year. – Administration of the all-trans retinoic acid causes remissions in well over half of the patients. – One hypothesis is that the retinoic acid causes the immature leukemic cell to mature, a ...
... promyelocytic leukemia. This is a rare leukemia with about 1,000 new patients in the United States each year. – Administration of the all-trans retinoic acid causes remissions in well over half of the patients. – One hypothesis is that the retinoic acid causes the immature leukemic cell to mature, a ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... vecuronium from plasma, any peripheral effects on the cardiovascular system would be evident within 10 minute of its administration. In the group II after rocuronium administration heart rate increased to 85.3 beats/min. from the basal value of 83.83 beats/min (statistically insignificant). After on ...
... vecuronium from plasma, any peripheral effects on the cardiovascular system would be evident within 10 minute of its administration. In the group II after rocuronium administration heart rate increased to 85.3 beats/min. from the basal value of 83.83 beats/min (statistically insignificant). After on ...
Anabolic effects of testosterone are preserved during inhibition of 5
... May 8, 2007; doi:10.1152/ajpendo.00130.2007.—At replacement doses, testosterone produces only modest increases in muscle strength and bone mineral density in older hypogonadal men. Although higher doses of testosterone are more anabolic, there is concern over increased adverse effects, notably prost ...
... May 8, 2007; doi:10.1152/ajpendo.00130.2007.—At replacement doses, testosterone produces only modest increases in muscle strength and bone mineral density in older hypogonadal men. Although higher doses of testosterone are more anabolic, there is concern over increased adverse effects, notably prost ...
PDF - Problems of Forensic Sciences
... Clonazepam is a benzodiazepine exhibiting anticonvulsive activity. It is used in epilepsy treatment. In the practice of the Institute of Forensic Research in Krakow, 57 cases involving clonazepam in biological material were recorded from 2003 to 2006. The highest number of cases (29) associated with ...
... Clonazepam is a benzodiazepine exhibiting anticonvulsive activity. It is used in epilepsy treatment. In the practice of the Institute of Forensic Research in Krakow, 57 cases involving clonazepam in biological material were recorded from 2003 to 2006. The highest number of cases (29) associated with ...