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The Detection and Quantitative Analysis of the Psychoactive
The Detection and Quantitative Analysis of the Psychoactive

full text pdf - Department of Physical Chemistry
full text pdf - Department of Physical Chemistry

... nm with methyl orange concentration was investigated in the range 10-90 ppm MO. The linear range was 10-50 ppm MO. In order to minimise the photometric error for further investigations a concentration of 30 ppm MO was selected which presented an absorbance of 1.154. b) Optimisation of Ce(IV) sulfate ...
Methodological considerations for blood flow restricted resistance
Methodological considerations for blood flow restricted resistance

... Distal to the restrictive cuff, mid-thigh quadriceps CSA increased (0.21% increase per session) following the training although no significant increase in strength was observed.11 It should be noted that intermittent rather than continuous blood flow restriction was utilized in this study. This stud ...
Guideline on the investigation of drug interactions - EMA
Guideline on the investigation of drug interactions - EMA

micronization and dissolution enhancement of norethindrone
micronization and dissolution enhancement of norethindrone

... minutes and this led an impetus to search for an appropriate formulation that can give better dissolution profile. Mechanical methods of micronization are simple, efficient and cost effective way of achieving particle size reduction. The formulation developed using micronized Norethindrone produced ...
In vitro and in vivo studies of artemisinin endoperoxides
In vitro and in vivo studies of artemisinin endoperoxides

I J V S
I J V S

... vein of each acepromazine sedated dog. About 0.5ml of EDTA blood was collected from each dog through the catheter at 0 minutes, which is before administration of the epidural drugs and then at 15, 30, 60, 120, 180 and 240 minutes after the administration of the epidural drugs. The blood samples were ...
Determination of Carbamazepine in Pharmaceutical
Determination of Carbamazepine in Pharmaceutical

... pharmaceutical preparations. The most striking features of derivative spectrophotometric methods described here are their simplicity and rapidity, no requiring time-consuming sample preparation such as filtration, degassing that are need for HPLC procedure and also chromatographic methods need expen ...
5% GLUCOSE INTRAVENOUS INFUSION In
5% GLUCOSE INTRAVENOUS INFUSION In

... infusion is dependent upon the age, weight, concomitant therapy, clinical and metabolic conditions of the patient as well as laboratory determinations. Electrolyte supplementation may be indicated according to the clinical needs of the patient. When glucose is used as a diluent, the dosage administe ...
Secundum Artem
Secundum Artem

... samples should be performed; more if feasible. 5. Conclusions must fit the obtained data. It is improper to expand the results into areas not covered by the project. For example, stability studies done in glass containers cannot be extrapolated or applied to plastic containers. STABILITY STUDY DESIG ...
Pharmacokinetics of Erythromycin Ethylsuccinate
Pharmacokinetics of Erythromycin Ethylsuccinate

... erythromycin ethylsuccinate to each foal were subjected to statistical moment analysis to determine each of the following parameters: area under the curve (AUC), area under the first moment of the curve (AUMC), mean residence time (MRT), maximum concentration in plasma (Cmax), time to maximum plasma ...
VetyFormula2009
VetyFormula2009

... precise intervals. The infusion controller has a thumb-wheel which allows the operator to alter the flow of liquid. Some controllers require you to set the Flow Rate, which is measured in Millilitres per Hour. Others require you to set the Drip Rate, measured in Drips per Minute. It is important tha ...
with oxyphenisatin
with oxyphenisatin

UV-SPECTROPHOTOMETRIC AND RP-HPLC METHODS FOR THE ESTIMATION OF PRASUGREL
UV-SPECTROPHOTOMETRIC AND RP-HPLC METHODS FOR THE ESTIMATION OF PRASUGREL

... with more mobile phase (10 µg/ ml). Estimation of prasugrel hydrochloride solution Weighed accurately 20 tablets of formulation (EFIPLAT) contain 10 mg and the average weight of tablet was found and powdered. The powdered tablet equivalent to 25 gm of Prasugrel Hydrochloride was weighed and extracte ...
DEPLETION OF SOMATOSTATIN-LIKE IMMUNOREACTIVITY IN
DEPLETION OF SOMATOSTATIN-LIKE IMMUNOREACTIVITY IN

... SLI from the CNS than do animals given only 300 mg/ kg. Therefore, it may not be concluded that, under all circumstances, a maximum effect is seen after a single systemic dose of 300 mg/kg. Other routes of administration, such as intracerebral or intraventricular administration, and other dosage sch ...
FORMULATION AND CHARACTERIZATION OF MATRIX AND TRIPLE LAYER MATRIX
FORMULATION AND CHARACTERIZATION OF MATRIX AND TRIPLE LAYER MATRIX

... Objective: The investigation was concerned with formulation and evaluation of oral controlled release tablets of Tramadol Hydrochloride (THCL) in the form of triple layer matrix tablets using different hydrophilic polymers, Locust Bean Gum (LBG), Gum Ghatti (GG) and Xanthan Gum (XG) as matrix formin ...
DRUG ABSORPTION BY SUBLINGUAL AND RECTAL ROUTES
DRUG ABSORPTION BY SUBLINGUAL AND RECTAL ROUTES

... During maintenance treatment the time to steadystate was approximately 3 days, which correlated well with the value predicted from single-dose studies. The mean maximum and mean steady-state concentrations were independent of the formulation used. Etomidate. Although attempts have been made to admin ...
Creatine and Age-Related Loss of Muscle Mass and Strength
Creatine and Age-Related Loss of Muscle Mass and Strength

... women. However, the effects are not consistent, suggesting that other variables need to be considered. Since resistance training itself is known to have beneficial effects, most reviewers recommend combining creatine supplements with exercise. Some studies have examined the timing of creatine ingest ...
Low potential of dobutamine and dopexamine to block intestinal
Low potential of dobutamine and dopexamine to block intestinal

Peer-reviewed Article PDF
Peer-reviewed Article PDF

Antihistamine Toxicosis
Antihistamine Toxicosis

Cardioprotective effect of mangiferin on isoproterenol induced
Cardioprotective effect of mangiferin on isoproterenol induced

Definition of Terms, Style, and Conventions Used in ASPEN
Definition of Terms, Style, and Conventions Used in ASPEN

... A.S.P.E.N. Board of Directors–approved Documents (terms and definitions) Standards: Benchmarks representing a range of performance of competent care that should be provided to assure safe and efficacious nutrition care. Standards are documents that define the structure needed to provide competent c ...
Methadone—metabolism, pharmacokinetics and interactions
Methadone—metabolism, pharmacokinetics and interactions

O A
O A

... The developed chromatographic method was validated for specificity, linearity, range, precision, accuracy, sensitivity, ruggedness, robustness and system suitability. Selectivity or Specificity: Interference (if any) of excipients (used in pharmaceutical formulations) in the chromatogram of butamira ...
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Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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