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Powerpoint template for scientific posters (Swarthmore College)
Powerpoint template for scientific posters (Swarthmore College)

... The bright, red, color in cherries is what makes the fruit appealing on the outside, but it provides one of the biggest reasons why cherries have been such a hot topic within natural pain relief in previous years of research. Recent studies have shown that tart cherries (Prunus cerasus) carry antiox ...
Direct and quantitative evaluation of the human CYP3A4
Direct and quantitative evaluation of the human CYP3A4

... heterologous oligomers, etc.) (Parmentier et al., 2007). Other in vitro techniques, like human liver microsomes (HLM), require the use of inhibitors, which suffer from a lack of specificity (e.g. antibody anti-CYP450) or have too specific in vitro conditions of use (e.g. chemical competitive CYP450 ...
An Abbreviated History of Anabolic Steroids
An Abbreviated History of Anabolic Steroids

... and is best avoided. When making the personal decision to use anabolic steroids, one would want to pay special attention to the better steroids which are low in androgenic properties and low in toxic properties. This consideration greatly reduces the side effects that could potentially be experience ...
NEW VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF RITONAVIR IN... AND PHARMACEUTICAL DOSAGE FORM
NEW VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF RITONAVIR IN... AND PHARMACEUTICAL DOSAGE FORM

... class used to treat HIV infection and AIDS. Ritonavir is frequently prescribed with highly active anti-retroviral therapy, not for its antiretroviral action, but as it inhibits the same host enzyme that metabolizes other protease inhibitors. This inhibition leads to higher plasma concentrations of t ...
Lower Pediatric Oral Bioavailability of Voriconazole is Not Due to
Lower Pediatric Oral Bioavailability of Voriconazole is Not Due to

... contribute to differential absorption of voriconazole in children versus adults (Fig 2). This study aims to evaluate the effect of lower intestinal bile salt concentrations in children (compared to adults) ...
Full-Text  - Academic Journals
Full-Text - Academic Journals

... and extracts modifies the hemin spectrum; however the peak maximums of hemin are still at about 402 nm. This reveals that the complexation does not involve significant changes in the structure of the porphyrin ring of the ferriprotoporphyrin IX. The results also show that quinine, artemisia and extr ...
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Drug - University of Washington

... With advanced macrolide (azithromycin) for CAP treated on inpatient basis, non ICU (especially if aspiration pneumonia is a concern) ...
March 2017 PBAC Meeting Agenda (Word 67KB)
March 2017 PBAC Meeting Agenda (Word 67KB)

...  Major: Submissions to list new medicines on the Schedule of Pharmaceutical Benefits or to make substantial changes to current listings are generally classified as major submissions. Major submissions require presentation of an economic evaluation.  Minor: Submissions that relate to new forms of p ...
Clinical Pharmacology of Boceprevir (BOC): Metabolism
Clinical Pharmacology of Boceprevir (BOC): Metabolism

Evaluation of Kidney Function
Evaluation of Kidney Function

... along the distal tubule and collecting duct. Urine flow rate and physicochemical characteristics of the molecule influence these processes: highly ionized compounds are not reabsorbed unless pH changes within the urine increase the fraction unionized, so that reabsorption may be facilitated. ...
DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR SIMULTANEOUS
DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR SIMULTANEOUS

... concentration of the drug for which there was close match between the concentration of drug estimated by the developed method and the actual concentration. For this purpose, a sample of predetermined concentration was diluted several times and chromatogram recorded each time. For the purpose of dete ...
The Risk of Using Poppy Seed Tea Made from Several Varieties
The Risk of Using Poppy Seed Tea Made from Several Varieties

... ever published and the size and type of the population exposed to the substance [9]. The aim of this study was determine the amount of morphine and codeine in poppy seed tea, made from different types of poppy seeds, by four different infusion methods, in order to evaluate if there is a possibility ...
The pharmacokinetics and metabolism of ivermectin in domestic
The pharmacokinetics and metabolism of ivermectin in domestic

In vivo evaluation of 2-adrenoceptors in cats with
In vivo evaluation of 2-adrenoceptors in cats with

... drug absorption when medetomidine is administered IM, as has been reported in dogs.25 Sex or individual animal differences in α2-AR susceptibility to norepinephrine-mediated desensitization also may have been present. Moreover, if abnormalities exist in the α2-ARs, this could affect peripheral perfu ...
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Paediatric Advanced Life Support

Experimental and theoretical modelling of blind
Experimental and theoretical modelling of blind

Choose the Only FDA-approved Hyaluronidase
Choose the Only FDA-approved Hyaluronidase

... Pregnancy Category C. In an embryo-fetal study, mice have been dosed daily by subcutaneous injection with recombinant Enzyme Inactivation with Intravenous Administration human hyaluronidase at dose levels up to 2,200,000 U/ HYLENEX recombinant should not be administered kg. The study found no eviden ...
July 2013 IMSN best practice guidance for IV potassium use
July 2013 IMSN best practice guidance for IV potassium use

study of formulation, characterisation and wound healing potential of
study of formulation, characterisation and wound healing potential of

... dosage forms of a drug substance. It can be defined as an investigation of physical and chemical properties of a drug substance alone and when combined with excipients. The overall objective of pre-formulation study is to generate information useful to the formulator in developing stable and bio ava ...
analysis of polymers by gpc/sec pharmaceutical applications
analysis of polymers by gpc/sec pharmaceutical applications

... The exact nature and formulation of many additives are trade secrets. However, commercial confidentiality has quality implications for drug companies when using these compounds, particularly because of new regulatory requirements. For example, under ICH M4Q (Quality)1, novel excipients now require c ...
methotrexate
methotrexate

... Time to sample : The purpose of monitoring MTX PC is 2 fold.  MTX PC can be used to evaluate the potential efficacy of a given regimen, to determine if the quantity &/or duration of leucovorin rescue is adequate.  There are 2 situation when monitoring MTX levels for efficacy are useful. A)The 1s ...
Commentary: Reproductive Risks of Leflunomide (ArravaR
Commentary: Reproductive Risks of Leflunomide (ArravaR

... In vitro, after mitogen stimulation, the active metabolite of leflunomide, inhibits T cell proliferation, DNA synthesis, and expression of certain cell surface and nuclear antigens directly involved in T cell activation and proliferation. It inhibits mitogen-stimulated proliferation of human periphe ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... The efficacy of cabbage (Brassica oleracea) juice extract as a potential antiulcer agent and its effect as a potential antiulcer agent and its effect on the haemostatic mechanism of Male albino wistar rats has been evaluated. Peptic ulcer is among the most serious gastrointestinal diseases in the wo ...
First Oral Dose in Humans
First Oral Dose in Humans

... study in which a molecule is clinically tested. The term describes FTIM formulation decision tree formulations used in any early clinical studies conducted dur- A flow chart for FTIM formulation decision making is shown ing Phase I safety, pharmacokinetic, or proof-of-concept eval- in Figure 2. Trad ...
DESIGN AND DEVELOPMENT OF MUCOADHESIVE BUCCAL DELIVERY FOR PANTOPRAZOLE
DESIGN AND DEVELOPMENT OF MUCOADHESIVE BUCCAL DELIVERY FOR PANTOPRAZOLE

... Objective: Pantoprazole undergoes hepatic first pass metabolism, hence it shows poor bioavailability. Stability of Pantoprazole in human saliva was improved using magnesium oxide due to its strong waterproofing effect. In present study attempt has been done to improve the bioavailability by formulat ...
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Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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