Impact of amiodarone and cisapride on simulated human ventricular
... to inhibit the rapid delayed rectifier potassium current IKr.5 Therefore, it led to the occurrence of torsades de pointes and was consequently withdrawn from market.3 In recent years, in silico modelling of cardiac drug effects started developing, e.g. for the investigation of adverse side effects o ...
... to inhibit the rapid delayed rectifier potassium current IKr.5 Therefore, it led to the occurrence of torsades de pointes and was consequently withdrawn from market.3 In recent years, in silico modelling of cardiac drug effects started developing, e.g. for the investigation of adverse side effects o ...
More efficient reversal of dabigatran inhibition of coagulation by activated prothrombin
... dabigatran. PCC improved haemostasis in a rabbit kidney injury model [19] and prevented excess intracerebral haematoma expansion in a murine intracerebral hemorrhage model [20]. PCC, APCC, rFVIIa all decreased the prolonged bleeding time in a rat tail bleeding model, but routine coagulation assays d ...
... dabigatran. PCC improved haemostasis in a rabbit kidney injury model [19] and prevented excess intracerebral haematoma expansion in a murine intracerebral hemorrhage model [20]. PCC, APCC, rFVIIa all decreased the prolonged bleeding time in a rat tail bleeding model, but routine coagulation assays d ...
Current and Potential Drugs for Treatment of Obesity
... with any comparable degree of caloric restriction because women have less lean body mass for any given weight. Also, heavier subjects tend to lose more weight than lighter ones. Trulson et al. (104) proposed criteria that scaled the amount of weight loss to the subjects initial weight. Feinstein (10 ...
... with any comparable degree of caloric restriction because women have less lean body mass for any given weight. Also, heavier subjects tend to lose more weight than lighter ones. Trulson et al. (104) proposed criteria that scaled the amount of weight loss to the subjects initial weight. Feinstein (10 ...
Bromide in drinking-water - World Health Organization
... nephrocalcinosis in female rats, less vacuolization in the zona fasciculata of the adrenals and less zymogen granulae in the pancreas were observed at the two highest doses. In the highest dose groups, fewer corpora lutea, retardation in maturation of the uterus, inhibition of spermatogenesis and le ...
... nephrocalcinosis in female rats, less vacuolization in the zona fasciculata of the adrenals and less zymogen granulae in the pancreas were observed at the two highest doses. In the highest dose groups, fewer corpora lutea, retardation in maturation of the uterus, inhibition of spermatogenesis and le ...
full document
... fields, stretching from indoor temperature control, to robotics or tracking in DVD players. However, it has had a comparably limited impact in the field of medicine. The suggestion of controlling drug delivery for maintaining an adequate anesthetic state during surgery is an exception and was propos ...
... fields, stretching from indoor temperature control, to robotics or tracking in DVD players. However, it has had a comparably limited impact in the field of medicine. The suggestion of controlling drug delivery for maintaining an adequate anesthetic state during surgery is an exception and was propos ...
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION
... The present study describes a simple, accurate, precise and cost effective UV-Spectrophotometric method for the estimation of Atazanavir sulphate, an Anti-HIV drug, in bulk and pharmaceutical dosage form. The drug was first dissolved in 20% glacial acetic acid and final volume was made up with disti ...
... The present study describes a simple, accurate, precise and cost effective UV-Spectrophotometric method for the estimation of Atazanavir sulphate, an Anti-HIV drug, in bulk and pharmaceutical dosage form. The drug was first dissolved in 20% glacial acetic acid and final volume was made up with disti ...
Table 1 - HAL
... Glucuronidation is a major drug metabolic pathway, catalyzed by uridine diphosphate (UDP)-glucuronosyltranferases (UGT). Two main families of UGTs have been identified in humans, namely UGT1A and UGT2 (subdivided in UGT2A and UGT2B) [1, 2]. The UGT 1A family consists of 9 functionally active protein ...
... Glucuronidation is a major drug metabolic pathway, catalyzed by uridine diphosphate (UDP)-glucuronosyltranferases (UGT). Two main families of UGTs have been identified in humans, namely UGT1A and UGT2 (subdivided in UGT2A and UGT2B) [1, 2]. The UGT 1A family consists of 9 functionally active protein ...
Intermittent Auscultation
... Allows FHR assessment of “the lady in the bath” EFM requires attention to monitor which takes time away from attention and support provided to the patient directly 1:1 support associated with better outcomes ...
... Allows FHR assessment of “the lady in the bath” EFM requires attention to monitor which takes time away from attention and support provided to the patient directly 1:1 support associated with better outcomes ...
development and validation of high performance liquid
... Preparation of standard solution of binary mixtures of CEF and SUL Accurately weighed 100 mg of CEF and 100 mg of SUL were transferred to 100 ml volumetric flask and diluted up to mark with mobile phase to give concentration of 1000 μg/ml of CEF and 1000 μg/ml of SUL. Preparation of working solutio ...
... Preparation of standard solution of binary mixtures of CEF and SUL Accurately weighed 100 mg of CEF and 100 mg of SUL were transferred to 100 ml volumetric flask and diluted up to mark with mobile phase to give concentration of 1000 μg/ml of CEF and 1000 μg/ml of SUL. Preparation of working solutio ...
Basal and Stimulated Sympathetic Responses After Epinephrine No
... infusion of epinephrine or placebo, the interventions used for adrenergic stimulation (Stroop test and cold pressor test) had statistically significant effects on all the parameters measured (data not shown). The absolute values of several measurements obtained during stress (eg, systolic blood pres ...
... infusion of epinephrine or placebo, the interventions used for adrenergic stimulation (Stroop test and cold pressor test) had statistically significant effects on all the parameters measured (data not shown). The absolute values of several measurements obtained during stress (eg, systolic blood pres ...
Controlling drug delivery
... and prevention of illness and disease by means of drugs of chemical or biological origin. It ranks among the most important methods of medical treatment, together with surgery, physical treatment, radiation and psychotherapy. There are many success stories concerning the use of drugs and vaccines in ...
... and prevention of illness and disease by means of drugs of chemical or biological origin. It ranks among the most important methods of medical treatment, together with surgery, physical treatment, radiation and psychotherapy. There are many success stories concerning the use of drugs and vaccines in ...
SPECTROPHOTOMETRIC DETERMINATION OF OXCARBAZEPINE IN PHARMACEUTICAL FORMULATIONS Research Article M. A. SATHISH AND G. NAGENDRAPPA*
... A simple, rapid, economical and highly sensitive spectrophotometric method is developed for determination of oxcarbazepine (OXC) in pure and in pharmaceutical formulations. The method is based on reaction of OXC with methanolic potassium hydroxide in dimethyl sulfoxide (DMSO) medium to form a col ...
... A simple, rapid, economical and highly sensitive spectrophotometric method is developed for determination of oxcarbazepine (OXC) in pure and in pharmaceutical formulations. The method is based on reaction of OXC with methanolic potassium hydroxide in dimethyl sulfoxide (DMSO) medium to form a col ...
the D-Ribose information sheet.
... the 20 participants who were recruited, twelve completed the study. Each subject participated in a heavy-resistance training program designed to increase skeletal muscle mass.The effects of ribose on body composition (body weight, body fat, lean body mass, fat mass, and bone mineral content) were al ...
... the 20 participants who were recruited, twelve completed the study. Each subject participated in a heavy-resistance training program designed to increase skeletal muscle mass.The effects of ribose on body composition (body weight, body fat, lean body mass, fat mass, and bone mineral content) were al ...
