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Transgenic bacteria development for minicircle production using
Transgenic bacteria development for minicircle production using

... therapeutic treatment of disease. The minicircles vectors (MC) plasmid have reduced size, they are devoid of bacterial sequences as the origin of replication and antibiotic resistance gene, allowing a prolonged transgene expression and low immunogenicity. These vectors are produced through the proce ...
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DNA Discovery

... Recombinant DNA Recombinant DNA •Bacteria often provide the appropriate machinery (enzymes and ribosomes) for us to produce proteins from a specific gene  insulin •Bacteria have small circular pieces of DNA called plasmids within their cytoplasm ...
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... 34. What would the mRNA product of transcription be for the template DNA strand: CTA GGA? 35. What are introns and exons? 36. What are some functions of proteins in the cell? (Think back to our molecules of life unit) 37. What is the monomer of a protein? 38. How many different amino acids are there ...
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... crown gall disease caused by Agrobacterium tumefaciens. C5. These medicines are difficult and expensive to purify from human sources. The advantage of genetically engineered organisms is that they can produce a large amount of these medical agents, at a fraction of the cost. There are some disadvant ...
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... 1. Translation involves using the _______ made during transcription and using it to make a _______________. Proteins have many functions, including acting as ________________, and cell membrane channels. 2. Where are the proteins made? ______________Outline the steps of translation. ...
DNA,RNA & Protein synthesis game
DNA,RNA & Protein synthesis game

... the debate regarding hereditary material over these two molecules ...
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... are taken from a cell sample, cut out and matched up in pairs • Humans have 23 pairs of chromosomes • Karyotypes can be used to determine if genetic disorder is present • If too many are present can indicate Down’s syndrome • If some are missing can indicate Turner’s syndrome ...
Genomics and animal agriculture
Genomics and animal agriculture

... to sequence the genomes of other species. The cow, chicken, and pig genomes have all recently been sequenced and this has led to the discovery of many thousands of naturally-occurring DNA sequence variations between individuals, in the form of SNPs (http://www.animalgenome.org). Researchers are now ...
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... prints. Interviews with neighbors indicate that a major quarrel was heard the night of the murder, with someone heard screaming "it’s my party and I'll cry if I want to". All suspects deny being present at the time of the murder. Forensic analysis of the crime scene indicated that the victims' finge ...
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Chapter 8: The Control of Microbial Growth

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Genetic Engineering and Biotechnology

... host cell (bacterium, yeast, or other cell), restriction enzymes (endonucleases), DNA ligase. Gene therapy: The treatment of certain diseases by introducing specific engineered genes in a patients cells. Vector: Is what is needed to carry the gene into the host cell; plasmids are often used as vecto ...
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The Good, the bad and the ugly of Genetic Engineering

... with restriction enzymes – restriction enzymes cut DNA at ...
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... each offspring has bristles with mutant characteristics, not wild-type. We can say that these two mutations A. complement and are therefore allelic. B. do not complement and are therefore allelic. C. complement and are therefore not allelic. D. do not complement and are therefore not allelic. E. do ...
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... When sequenced, this cDNA clone was 720 nucleotides in length and therefore incomplete. The amino terminal sequence of the protein encoding this gene was known, however, and a synthetic oligonucleotide that corresponded to amino acids 1 through 10 of this protein was produced and labeled; it hybridi ...
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... DNA with closely related sequences 2. Site-specific 3. Transposition - occurs between unrelated sequences (e.g. Transposons; jumping genes ) Homologous Recombination Three purposes: 1. Recombinational DNA repair 2. DNA organization during meiosis (eukaryotes) 3. Genetic diversity (exchanging alleles ...
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... Gene therapy is a technique which is used to treat genetic diseases, that involves replacing an absent gene in the DNA of a patient. Gene therapy became more feasible after the human genome project. ...
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Powerpoint Presentation: Gene Transfer

... Molecular scissors Restriction endonucleases  Enzymes used by bacteria to detect and cut out viral genes  Several hundred isolated  Each type identifies a specific sequence of DNA  Usually produce a staggered cut leaving a “sticky end” ...
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Zinc finger nuclease

Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain. Zinc finger domains can be engineered to target specific desired DNA sequences and this enables zinc-finger nucleases to target unique sequences within complex genomes. By taking advantage of endogenous DNA repair machinery, these reagents can be used to precisely alter the genomes of higher organisms.
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