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Unit 5- Molecular Biology
Unit 5- Molecular Biology

... a. Describe the basic structure and function of DNA, mRNA, tRNA, amino acids, polypeptides, and proteins (e.g., replication, transcription, and translation) b. Describe the experiments of major scientists in determining both the structure of DNA and the central dogma c. Use mRNA codon charts to dete ...
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... Figure S3. DNA Sequences of Clones Encoding CREM and PCLB4 (A) DNA sequences of clones from a portion of the exon encoding the 3⬘ UTR of the camp-responsive element modulator gene (CREM). (B) DNA sequences of clones from a portion of the exon encoding the 3⬘ UTR of the phospholipase C, ␤ 4 gene (PCL ...
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... Microsatelitte sequences and variation "Microsatellites" are defined as loci (or regions within DNA sequences) where short sequences of DNA are repeated in tandem arrays. This means that the sequences are repeated one right after the other. The lengths of sequences used most often are di-, tri-, or ...
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Microsatellite



A microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 2–5 base pairs) are repeated, typically 5-50 times. Microsatellites occur at thousands of locations in the human genome and they are notable for their high mutation rate and high diversity in the population. Microsatellites and their longer cousins, the minisatellites, together are classified as VNTR (variable number of tandem repeats) DNA. The name ""satellite"" refers to the early observation that centrifugation of genomic DNA in a test tube separates a prominent layer of bulk DNA from accompanying ""satellite"" layers of repetitive DNA. Microsatellites are often referred to as short tandem repeats (STRs) by forensic geneticists, or as simple sequence repeats (SSRs) by plant geneticists.They are widely used for DNA profiling in kinship analysis and in forensic identification. They are also used in genetic linkage analysis/marker assisted selection to locate a gene or a mutation responsible for a given trait or disease.
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