Drugedrug interaction through molecular structure similarity analysis
... drug combinations that should be contraindicated. Indeed, there is currently strong interest among regulatory authorities, such as the US Food and Drug Administration,13 and pharmaceutical companies in developing better tools for assessing drug interactions.14 The concept that similar molecules resu ...
... drug combinations that should be contraindicated. Indeed, there is currently strong interest among regulatory authorities, such as the US Food and Drug Administration,13 and pharmaceutical companies in developing better tools for assessing drug interactions.14 The concept that similar molecules resu ...
Inotropic and vasoactive agents
... potentiate these vasodilatory effects by preventing the release of noradrenaline). Peripheral resistance falls, renal and hepatic blood flow increase, and urine output, GFR, fractional excretion of sodium and creatinine clearance can be improved. The importance of the renal vasodilator effect of dop ...
... potentiate these vasodilatory effects by preventing the release of noradrenaline). Peripheral resistance falls, renal and hepatic blood flow increase, and urine output, GFR, fractional excretion of sodium and creatinine clearance can be improved. The importance of the renal vasodilator effect of dop ...
Glucocorticoids
... Prednisone is a commonly used glucocorticoid. Prednisone is a pro-drug, therefore it must be metabolized to prednisolone to elicit its pharmacologic effect. Cats are variable metabolizers of prednisone to prednisolone, so the effect will also be variable and less predictable in cats. Prednisolone is ...
... Prednisone is a commonly used glucocorticoid. Prednisone is a pro-drug, therefore it must be metabolized to prednisolone to elicit its pharmacologic effect. Cats are variable metabolizers of prednisone to prednisolone, so the effect will also be variable and less predictable in cats. Prednisolone is ...
Sustained-Release Bupropion Overdose: A Case Report
... of neurologic and cardiovascular systems up to at least 12 hours. The treatment is support of ...
... of neurologic and cardiovascular systems up to at least 12 hours. The treatment is support of ...
HST-151
... response similar to the activation of the parasympathetic aspects of the autonomic n.s. Such drugs are called "parasympathomimetic". Antagonists of muscarinic transmission have roughly the opposite actions, and are called "parasympatholytic" agents. ...
... response similar to the activation of the parasympathetic aspects of the autonomic n.s. Such drugs are called "parasympathomimetic". Antagonists of muscarinic transmission have roughly the opposite actions, and are called "parasympatholytic" agents. ...
IV DRUGS in the EMERGENCY ROOM
... 9. Amnesia is while Propofol is starting to work, NOT when it is wearing off. 10. After the first dose of 1.5 mg/kg the patient may still be talking etc, but as long you have the given the patient adequate pre-analgesia, they will have amnesia for the event. ...
... 9. Amnesia is while Propofol is starting to work, NOT when it is wearing off. 10. After the first dose of 1.5 mg/kg the patient may still be talking etc, but as long you have the given the patient adequate pre-analgesia, they will have amnesia for the event. ...
The Effects of Morphine, Nicotine and Epibatidine on Lymphocyte
... findings reported with nicotine to those produced by morphine suggest a possible relationship between nicotinic and opioid receptor-mediated immunomodulation. To examine the potential overlap between opioid and nicotinic receptors in a neuroimmunomodulatory pathway, we compared the effects of morphi ...
... findings reported with nicotine to those produced by morphine suggest a possible relationship between nicotinic and opioid receptor-mediated immunomodulation. To examine the potential overlap between opioid and nicotinic receptors in a neuroimmunomodulatory pathway, we compared the effects of morphi ...
Extrapyramidal motor side-effects of first
... Effectiveness (CATIE) study demonstrated, similarly, that there was no significant difference between second-generation antipsychotics when compared with perphenazine in terms of the emergence of EPS.19,20 It has been suggested in the analysis of CATIE and elsewhere that the differences between firs ...
... Effectiveness (CATIE) study demonstrated, similarly, that there was no significant difference between second-generation antipsychotics when compared with perphenazine in terms of the emergence of EPS.19,20 It has been suggested in the analysis of CATIE and elsewhere that the differences between firs ...
Metaxalone ST - Psychotropical
... utility of such an understanding has been clearly illustrated by the story of methylene blue, dealt with extensively both on my website and in my peer reviewed publications (3). More recently its utility has been exemplified in the rebuttal of the warnings issued about triptans and ST (3-5) and abou ...
... utility of such an understanding has been clearly illustrated by the story of methylene blue, dealt with extensively both on my website and in my peer reviewed publications (3). More recently its utility has been exemplified in the rebuttal of the warnings issued about triptans and ST (3-5) and abou ...
UNIVERSITAT DE BARCELONA FACULTAT DE FARMÀCIA TARGETING OF ANTILEISHMANIAL DRUGS PRODUCED BY
... Although cutaneous leishmaniosis can be traced back many hundreds of years, one of the first and most important clinical descriptions was made in 1756 by Alexander Russell following an examination of a Turkish patient. The disease, then commonly known as "Aleppo boil", was described in terms which a ...
... Although cutaneous leishmaniosis can be traced back many hundreds of years, one of the first and most important clinical descriptions was made in 1756 by Alexander Russell following an examination of a Turkish patient. The disease, then commonly known as "Aleppo boil", was described in terms which a ...
- Minapharm Pharmaceuticals
... Dixit N, Baboota S, Kohli K, Ahmad S, Ali J. Silymarin: A review of pharmacological aspects and bioavailability enhancement approaches. Indian J Pharmacol 2007;39:172-9 How to cite this URL: Dixit N, Baboota S, Kohli K, Ahmad S, Ali J. Silymarin: A review of pharmacological aspects and bioavailabili ...
... Dixit N, Baboota S, Kohli K, Ahmad S, Ali J. Silymarin: A review of pharmacological aspects and bioavailability enhancement approaches. Indian J Pharmacol 2007;39:172-9 How to cite this URL: Dixit N, Baboota S, Kohli K, Ahmad S, Ali J. Silymarin: A review of pharmacological aspects and bioavailabili ...
pdf
... such as locomotion, grooming, climbing, yawning, stereotypy, lever pressing, and catalepsy (Duarte et al. 2003; Fujikawa et al. 1996; Goudie and Taylor 1998; Hirose et al. 2004; Nakai et al. 2003; Perrault et al. 1997). In recent years, we have used rat maternal behavior—a highly motivated and well- ...
... such as locomotion, grooming, climbing, yawning, stereotypy, lever pressing, and catalepsy (Duarte et al. 2003; Fujikawa et al. 1996; Goudie and Taylor 1998; Hirose et al. 2004; Nakai et al. 2003; Perrault et al. 1997). In recent years, we have used rat maternal behavior—a highly motivated and well- ...
II.2.1 Amphetamines and their metabolites
... The stimulant drugs include amphetamine (AP, 1-phenyl-2-aminopropane), MA (1-phenyl-2-methylaminopropane) and their salts. As an ethical drug for treatment of depression, only MA hydrochloride (commercial name: Philopon) is available from Dainippon Pharmaceutical Co., Ltd., Osaka in Japan. Most of M ...
... The stimulant drugs include amphetamine (AP, 1-phenyl-2-aminopropane), MA (1-phenyl-2-methylaminopropane) and their salts. As an ethical drug for treatment of depression, only MA hydrochloride (commercial name: Philopon) is available from Dainippon Pharmaceutical Co., Ltd., Osaka in Japan. Most of M ...
Coactifed® Preparations - GlaxoSmithKline
... obstruction, diabetes mellitus, ischemic heart disease and hyperthyroidism, unless its benefits outweigh its risks in these patients. COACTIFIED® contains sucrose. COACTIFIED® should be used with considerable caution in patients with diabetes mellitus. COACTIFED® should be prescribed with caution fo ...
... obstruction, diabetes mellitus, ischemic heart disease and hyperthyroidism, unless its benefits outweigh its risks in these patients. COACTIFIED® contains sucrose. COACTIFIED® should be used with considerable caution in patients with diabetes mellitus. COACTIFED® should be prescribed with caution fo ...
SEDATIVE-HYPNOTICS: Barbiturates (p.1) History these drugs were
... tolerance does not develop quickly to respiratory depression effects implications…. tolerance does not develop quickly to the antiseizure effects either implications…. physical dependence on barbs – a serious problem when attempt to D/C REM rebound, “dream anxiety attacks”, severe insomnia (that les ...
... tolerance does not develop quickly to respiratory depression effects implications…. tolerance does not develop quickly to the antiseizure effects either implications…. physical dependence on barbs – a serious problem when attempt to D/C REM rebound, “dream anxiety attacks”, severe insomnia (that les ...
Genetic variation associated with euphorigenic effects
... deficit hyperactivity disorder were also nominally associated with d-amphetamine response. Furthermore, we found that the source of this enrichment was an excess of alleles that increased sensitivity to the euphoric effects of d-amphetamine and decreased susceptibility to schizophrenia and attention ...
... deficit hyperactivity disorder were also nominally associated with d-amphetamine response. Furthermore, we found that the source of this enrichment was an excess of alleles that increased sensitivity to the euphoric effects of d-amphetamine and decreased susceptibility to schizophrenia and attention ...
Document
... somatostatin are neuroprotective. This research is novel because it is demonstrating that endogenous neuropeptides play key regulatory roles on survival of neurons in this part of the brain, a surprising finding with therapeutic potential. It is of high significance to elucidate the involvement of s ...
... somatostatin are neuroprotective. This research is novel because it is demonstrating that endogenous neuropeptides play key regulatory roles on survival of neurons in this part of the brain, a surprising finding with therapeutic potential. It is of high significance to elucidate the involvement of s ...
Does Amifostine Reduce Metabolic Rate? Effect of the Drug on Gas
... Cardiovascular responses were assessed because amifostine can cause hypotension but there were no changes in heart rate or blood pressure with amifostine (data not shown) and all subjects were cardiovascularly stable throughout the protocols. 4. Discussion We report the novel finding that high doses ...
... Cardiovascular responses were assessed because amifostine can cause hypotension but there were no changes in heart rate or blood pressure with amifostine (data not shown) and all subjects were cardiovascularly stable throughout the protocols. 4. Discussion We report the novel finding that high doses ...
Perspectives in Drug Discovery A Collection of Essays on the History
... the research and writings by European chemists, such as Jöns Jacob Berzelius, Friedrich Wöhler and Justus von Liebeg. As a typical example, Liebig synthesized chloroform (CHCl3) in 1831 and the anesthetic properties were discovered in 1847 when James Young Simpson (1811-1870) first used chloroform t ...
... the research and writings by European chemists, such as Jöns Jacob Berzelius, Friedrich Wöhler and Justus von Liebeg. As a typical example, Liebig synthesized chloroform (CHCl3) in 1831 and the anesthetic properties were discovered in 1847 when James Young Simpson (1811-1870) first used chloroform t ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Aegle marmelos (AM) is an ayurvedic medicinal tree commonly known as the bael fruit tree, bilva patra in local language (Kannada) is found all over India 3. This is also known as golden apple tree, stone apple tree. The tree has various medicinal properties. Several studies on different parts of AM ...
... Aegle marmelos (AM) is an ayurvedic medicinal tree commonly known as the bael fruit tree, bilva patra in local language (Kannada) is found all over India 3. This is also known as golden apple tree, stone apple tree. The tree has various medicinal properties. Several studies on different parts of AM ...
Biphasic effects of 7-OH-DPAT on the acquisition of responding for
... as an effective conditioned reward (Table 1). In this analysis, the number of responses made on each lever during the last 30 min of the five preexposure and two test sessions was averaged for each rat. The ratio of responding in the test vs. the preexposure sessions were then calculated, adding 1.0 ...
... as an effective conditioned reward (Table 1). In this analysis, the number of responses made on each lever during the last 30 min of the five preexposure and two test sessions was averaged for each rat. The ratio of responding in the test vs. the preexposure sessions were then calculated, adding 1.0 ...
Mechanism of action
... Some trials included too many women at later gestational ages when the time gained by the drug does not have a significant impact on neonatal survival or morbidity. In the Canadian Preterm Labor Investigators Group trial (n=708) 80% of women recruited were ≥28 weeks. 20 It may also be possible that ...
... Some trials included too many women at later gestational ages when the time gained by the drug does not have a significant impact on neonatal survival or morbidity. In the Canadian Preterm Labor Investigators Group trial (n=708) 80% of women recruited were ≥28 weeks. 20 It may also be possible that ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.