P97
... concurrently treated with theophylline or frusemide alone, or the combination of these two agents were included so that each infant served as his/her own control. Data on serial serum creatinine levels were also gathered to detect any significant change in this parameter in relation to the medicatio ...
... concurrently treated with theophylline or frusemide alone, or the combination of these two agents were included so that each infant served as his/her own control. Data on serial serum creatinine levels were also gathered to detect any significant change in this parameter in relation to the medicatio ...
Statement on the use of EFV in children less than 3 years of age
... compared to older children and adults and therefore require higher doses in order to maintain therapeutic plasma drug concentrations similar to adults. In the case of EFV, it has been found that some children (and adults) are genetically slow metabolisers of EFV and higher doses may result in toxici ...
... compared to older children and adults and therefore require higher doses in order to maintain therapeutic plasma drug concentrations similar to adults. In the case of EFV, it has been found that some children (and adults) are genetically slow metabolisers of EFV and higher doses may result in toxici ...
Comparison of Insomnia Treatments
... Insomnia is a very common disorder that can present in a number of different ways. Patients may have difficulty falling asleep (sleep latency), difficulty staying asleep (sleep maintenance), or may not feel rested by a night’s sleep (sleep quality).1 This disorder can be transient (lasts days to wee ...
... Insomnia is a very common disorder that can present in a number of different ways. Patients may have difficulty falling asleep (sleep latency), difficulty staying asleep (sleep maintenance), or may not feel rested by a night’s sleep (sleep quality).1 This disorder can be transient (lasts days to wee ...
Investigating the role of benzodiazepines in drug-related
... such adverse effects. At normal doses diazepam and other benzodiazepines have been shown to have arrhythmic effects on the heart, causing abnormal heart rhythms in susceptible individuals. These cardiac adverse effects are rarely reported with z-hypnotics. As substance users are more likely to use m ...
... such adverse effects. At normal doses diazepam and other benzodiazepines have been shown to have arrhythmic effects on the heart, causing abnormal heart rhythms in susceptible individuals. These cardiac adverse effects are rarely reported with z-hypnotics. As substance users are more likely to use m ...
The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
... under basic conditions. On the basis of this somewhat limited profile Bacq [15,16] inferred that "amphiporine" was an alkaloid similar to nicotine. King [52] showed that amphiporine acted as an organic base and attempted its further purification by crystallization with standard alkaloidal precipitan ...
... under basic conditions. On the basis of this somewhat limited profile Bacq [15,16] inferred that "amphiporine" was an alkaloid similar to nicotine. King [52] showed that amphiporine acted as an organic base and attempted its further purification by crystallization with standard alkaloidal precipitan ...
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) AND
... resources on behalf of their patients. These resources include not only interventions provided by themselves but also those offered by other health-related disciplines. Most patients presenting for physiotherapy treatment have received, or are are currently receiving, some form of pharmacotherapy of ...
... resources on behalf of their patients. These resources include not only interventions provided by themselves but also those offered by other health-related disciplines. Most patients presenting for physiotherapy treatment have received, or are are currently receiving, some form of pharmacotherapy of ...
The mechanism of action of aspirin
... cascade bioassay system developed by Vane [8] in the middle 1960s for use with blood or artificial salt solution. As expected, Piper and Vane found the release during anaphylaxis of histamine and SRS-A, but they also found some previously unreported substances: PGs, (mainly PGE2 but some PGF2a) and ...
... cascade bioassay system developed by Vane [8] in the middle 1960s for use with blood or artificial salt solution. As expected, Piper and Vane found the release during anaphylaxis of histamine and SRS-A, but they also found some previously unreported substances: PGs, (mainly PGE2 but some PGF2a) and ...
Pain management case studies Pharmacy
... have been to reduce paracetamol dosing in the elderly, rather than follow the usual 4gm per day for everyone. Her paracetamol clearance may be about half that of a 30 year old, so doses may need to reflect this (e.g. 500mg q6h). The New South Wales Therapeutic Group Inc. has developed paracetamol us ...
... have been to reduce paracetamol dosing in the elderly, rather than follow the usual 4gm per day for everyone. Her paracetamol clearance may be about half that of a 30 year old, so doses may need to reflect this (e.g. 500mg q6h). The New South Wales Therapeutic Group Inc. has developed paracetamol us ...
A functional dissociation of the anterior and posterior
... likely to be the result of altered regulation of VTA DA neurons (Alderson et al. 2006). One aim of the present study, therefore, was to investigate the involvement of pPPTg and aPPTg on the locomotor effects of repeated nicotine. We hypothesized that if PPTg connections with the VTA are of significa ...
... likely to be the result of altered regulation of VTA DA neurons (Alderson et al. 2006). One aim of the present study, therefore, was to investigate the involvement of pPPTg and aPPTg on the locomotor effects of repeated nicotine. We hypothesized that if PPTg connections with the VTA are of significa ...
Alcohol and Other Drugs Alcohol and Other Drugs
... athletes/players, coaches, support personnel and officials, will take part in alcohol education sessions based around the key messages from the National Binge Drinking Strategy (short- and long-term harms associated with drinking to intoxication, the need for personal responsibility and the need to ...
... athletes/players, coaches, support personnel and officials, will take part in alcohol education sessions based around the key messages from the National Binge Drinking Strategy (short- and long-term harms associated with drinking to intoxication, the need for personal responsibility and the need to ...
Pathways of drug metabolism
... 56% of drugs that cause ADRs are metabolized by polymorphic phase I enzymes, of which 86% are CYP P450; only 20% of drugs associated with ADRs are substrates for non-polymorphic enzymes ADRs cause > 100 000 deaths/y in the USA Up to 7% of all hospital admissions in the UK and Sweden are due to ADRs ...
... 56% of drugs that cause ADRs are metabolized by polymorphic phase I enzymes, of which 86% are CYP P450; only 20% of drugs associated with ADRs are substrates for non-polymorphic enzymes ADRs cause > 100 000 deaths/y in the USA Up to 7% of all hospital admissions in the UK and Sweden are due to ADRs ...
Can methylphenidate be used for adults with attention deficit
... Subgroup analysis comparing high versus low doses did not indicate that higher doses of IR methylphenidate were associated with greater efficacy. The trial data suggest that adverse effects from IR methylphenidate for adults with ADHD are not of serious clinical significance. (30) Evidence based gui ...
... Subgroup analysis comparing high versus low doses did not indicate that higher doses of IR methylphenidate were associated with greater efficacy. The trial data suggest that adverse effects from IR methylphenidate for adults with ADHD are not of serious clinical significance. (30) Evidence based gui ...
cat june2006 fri finley - California Association of Toxicologists
... – misdiagnosis (eg - bipolar depression, personality d/o) Pharmaceutical manufacturers should be required to disclose ALL results of clinical trials Clinical trial methodology is antiquated – naturalistic element must be integrated into RCT – more sensitive measures of suicidal behavior needed – pat ...
... – misdiagnosis (eg - bipolar depression, personality d/o) Pharmaceutical manufacturers should be required to disclose ALL results of clinical trials Clinical trial methodology is antiquated – naturalistic element must be integrated into RCT – more sensitive measures of suicidal behavior needed – pat ...
P. aeruginosa
... Other (nonallergic) adverse effects include diarrhoea due to alteration in normal intestinal flora which may progress to Clostridium difficile-associated diarrhoea. Neutropenia is a risk if penicillins (or other (β-lactam antibiotics) are used in high dose and usually for a period of longer than 10 ...
... Other (nonallergic) adverse effects include diarrhoea due to alteration in normal intestinal flora which may progress to Clostridium difficile-associated diarrhoea. Neutropenia is a risk if penicillins (or other (β-lactam antibiotics) are used in high dose and usually for a period of longer than 10 ...
statement on the use of codeine in children
... To date, individual paediatric teams have carried out a risk assessment (formally or informally) and on that basis have either continued cautiously with codeine or explored the alternative drugs and how to use them effectively and safely. The decisions have been based largely on personal and instit ...
... To date, individual paediatric teams have carried out a risk assessment (formally or informally) and on that basis have either continued cautiously with codeine or explored the alternative drugs and how to use them effectively and safely. The decisions have been based largely on personal and instit ...
CV - Med
... smoking severity after exposure to virtual reality cues”, PI K. C. Osborne, Project Lead – J. H. Yoon, National Cancer Institute. This project will assess the effects of cigarettes on cueinduced craving following exposure to virtual-reality-based smoking cues, nicotine withdrawal, and smoking severi ...
... smoking severity after exposure to virtual reality cues”, PI K. C. Osborne, Project Lead – J. H. Yoon, National Cancer Institute. This project will assess the effects of cigarettes on cueinduced craving following exposure to virtual-reality-based smoking cues, nicotine withdrawal, and smoking severi ...
EA_QA47.7Methylphenidateinadults
... Subgroup analysis comparing high versus low doses did not indicate that higher doses of IR methylphenidate were associated with greater efficacy. The trial data suggest that adverse effects from IR methylphenidate for adults with ADHD are not of serious clinical significance. (30) Evidence based gui ...
... Subgroup analysis comparing high versus low doses did not indicate that higher doses of IR methylphenidate were associated with greater efficacy. The trial data suggest that adverse effects from IR methylphenidate for adults with ADHD are not of serious clinical significance. (30) Evidence based gui ...
Pharmacological and Medical Considerations in Hypnotic Use
... ferent formulations have been shown to produce differences in blood levels within 20 to 30 min of administration, which then disappear within 60 min (16). The critical question is, what is the clinical significance of that difference in rate of absorption, particularly for patients with complaints o ...
... ferent formulations have been shown to produce differences in blood levels within 20 to 30 min of administration, which then disappear within 60 min (16). The critical question is, what is the clinical significance of that difference in rate of absorption, particularly for patients with complaints o ...
ARTICLE IN PRESS
... few questions. Samples of oral fluid were obtained from 88% of the drivers, of whom 30% were females and 70% males. The prevalence of each drug was estimated by a weighted average using weights adjusted for under- or over-sampling compared to traffic statistics. Alcohol or drugs were found in oral flui ...
... few questions. Samples of oral fluid were obtained from 88% of the drivers, of whom 30% were females and 70% males. The prevalence of each drug was estimated by a weighted average using weights adjusted for under- or over-sampling compared to traffic statistics. Alcohol or drugs were found in oral flui ...
The cardiotoxicity of macrolides: the role of interactions
... intravenous injection of erythromycin in the majority of the case reports [13]. However, the rate of sudden cardiac death was higher among current users of oral erythromycin in a retrospective study [14]. 2.2. Clarithromycin Clarithromycin also blocked IKr potassium current in HEK 293 cells at clini ...
... intravenous injection of erythromycin in the majority of the case reports [13]. However, the rate of sudden cardiac death was higher among current users of oral erythromycin in a retrospective study [14]. 2.2. Clarithromycin Clarithromycin also blocked IKr potassium current in HEK 293 cells at clini ...
Carbamazepine
... Limitations of Gabapentin In Bipolar Disorders • Not effective as monotherapy in treatmentresistant rapid cycling • Not effective as primary add-on antimanic agent • Possible use for associated anxiety/insomnia ...
... Limitations of Gabapentin In Bipolar Disorders • Not effective as monotherapy in treatmentresistant rapid cycling • Not effective as primary add-on antimanic agent • Possible use for associated anxiety/insomnia ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
... Used mainly for the treatment of active P. jirovecii pneumonia and for prophylaxis of P. jirovecii pneumonia in patients at high risk for initial or recurrent Pneumocystis infection, such as patients with HIV infection and AIDS Sometimes used to treat various other protozoal infections ...
... Used mainly for the treatment of active P. jirovecii pneumonia and for prophylaxis of P. jirovecii pneumonia in patients at high risk for initial or recurrent Pneumocystis infection, such as patients with HIV infection and AIDS Sometimes used to treat various other protozoal infections ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.