O A
... doses or because of its low efficacy for induction deep sedation. But, when added into Ketamine regime as oral spray it cause acceleration of CNS depression as well as causes profound CNS depression. Rapid CNS depression onset time in concomitant administration of promethazine with Ketamine in compa ...
... doses or because of its low efficacy for induction deep sedation. But, when added into Ketamine regime as oral spray it cause acceleration of CNS depression as well as causes profound CNS depression. Rapid CNS depression onset time in concomitant administration of promethazine with Ketamine in compa ...
MDMA in humans: factors which affect the neuropsychobiological
... clubbers/ravers, who had been using ecstasy/MDMA intensively. The overall sample reported an average of eight physical and four psychological problems which they attributed to ecstasy use. Around 35% reported bingeing on ecstasy, which was defined as using the drug on a continuous basis for 48 hour ...
... clubbers/ravers, who had been using ecstasy/MDMA intensively. The overall sample reported an average of eight physical and four psychological problems which they attributed to ecstasy use. Around 35% reported bingeing on ecstasy, which was defined as using the drug on a continuous basis for 48 hour ...
Treatment of opioid-induced gut dysfunction
... peptides and opioid receptors in the gastrointestinal tract The adverse influence of opioid analgesics on GI function remained an enigma to scientists until it was realised that both opioid peptides and opioid receptors are expressed in the digestive tract; therefore, it is important to briefly cons ...
... peptides and opioid receptors in the gastrointestinal tract The adverse influence of opioid analgesics on GI function remained an enigma to scientists until it was realised that both opioid peptides and opioid receptors are expressed in the digestive tract; therefore, it is important to briefly cons ...
(Cannabis genus) for use as animal feed
... received oral doses of 15 mg THC/m2 (square meter of body surface) corresponding to 25 mg THC for an average adult (body surface: 1.7 m2). A reduction to 5 mg THC/m2, about 8-10 mg THC, produced only mild reactions. In a study by Frytak et al. (1984), oral administration of 15 mg THC to 38 cancer pa ...
... received oral doses of 15 mg THC/m2 (square meter of body surface) corresponding to 25 mg THC for an average adult (body surface: 1.7 m2). A reduction to 5 mg THC/m2, about 8-10 mg THC, produced only mild reactions. In a study by Frytak et al. (1984), oral administration of 15 mg THC to 38 cancer pa ...
![[Salvia divinorum - a potential drug for abuse]](http://s1.studyres.com/store/data/007845527_1-baa04152dad6511298825048970e3c2d-300x300.png)
[Salvia divinorum - a potential drug for abuse]
... Selective kappa receptoragonists have been shown to produce analgesic effects with potential for reduced tolerance and dependence. However, psychotomimesis (hallucinogenic and/or psychotic effects), dysphoria and diuresis have been observed with their therapeutic use (Tidgewell et aI., 2004). In add ...
... Selective kappa receptoragonists have been shown to produce analgesic effects with potential for reduced tolerance and dependence. However, psychotomimesis (hallucinogenic and/or psychotic effects), dysphoria and diuresis have been observed with their therapeutic use (Tidgewell et aI., 2004). In add ...
The Health Consequences of Smoking - Rx for Change
... FDA Center for Tobacco Control Products will regulate other nicotine-containing products , including electronic cigarette products that do not make a therapeutic claim, in the future. ...
... FDA Center for Tobacco Control Products will regulate other nicotine-containing products , including electronic cigarette products that do not make a therapeutic claim, in the future. ...
Formulation of Effervescent Ibuprofen
... close a patent ductusarteriosus in a premature baby. It can be used by mouth or intravenously. It typically begins ...
... close a patent ductusarteriosus in a premature baby. It can be used by mouth or intravenously. It typically begins ...
Normal Thermoregulatory Responses to 3-iodothyronamine, Trace Amines and Amphetamine-like Psychostimulants in
... synaptosome preparations from different sources, and accordingly, data are normalized to the maximum level or the baseline and expressed as percentage values in each set of assays. Data for the drug effects on thermoregulation were normalized to the saline controls prior to statistical analyses. A t ...
... synaptosome preparations from different sources, and accordingly, data are normalized to the maximum level or the baseline and expressed as percentage values in each set of assays. Data for the drug effects on thermoregulation were normalized to the saline controls prior to statistical analyses. A t ...
Effects of Valerian Extract on the Sleep
... anxiety. For several decades, the use of valerian has rearing with an open fi eld test in mice. Leuschner et al. decreased, and benzodiazepine sleepinducers have taken ［9］also revealed that valerian root extract increased the theplaceoftheherb［1］. However, it is wellrecognized thiopental sleepingtime ...
... anxiety. For several decades, the use of valerian has rearing with an open fi eld test in mice. Leuschner et al. decreased, and benzodiazepine sleepinducers have taken ［9］also revealed that valerian root extract increased the theplaceoftheherb［1］. However, it is wellrecognized thiopental sleepingtime ...
Insomnia is not just a night-time problem
... listed in bold typeface. Where the drugs are being used “off label”, or there is currently insufficient evidence, the drugs have been included for completeness, since many patients turn to these substances to augment insomnia treatment. (Compiled from references 2,3,6,11,17,21) ...
... listed in bold typeface. Where the drugs are being used “off label”, or there is currently insufficient evidence, the drugs have been included for completeness, since many patients turn to these substances to augment insomnia treatment. (Compiled from references 2,3,6,11,17,21) ...
“DEVLOPMENT AND VALIDATION OF SPECTROSCOPIC AND
... dorsomedial nucleus of the vagus nerve and nucleus ambiguous (activating the parasympathetic nervous system), and the lateral hypothalamus (resulting in SNS activation). Anxiety is a normal reaction to stress and can actually be beneficial in some situations. For some people, however, anxiety can be ...
... dorsomedial nucleus of the vagus nerve and nucleus ambiguous (activating the parasympathetic nervous system), and the lateral hypothalamus (resulting in SNS activation). Anxiety is a normal reaction to stress and can actually be beneficial in some situations. For some people, however, anxiety can be ...
Eszopiclone
... The first two studies were randomized, double-blind, placebo controlled in patients who met the DSM-IV criteria for primary insomnia. The inclusion criteria were similar in that patients had to have total sleep time of less than approximately 6.5 hours per night and needed more than 30 minutes to fa ...
... The first two studies were randomized, double-blind, placebo controlled in patients who met the DSM-IV criteria for primary insomnia. The inclusion criteria were similar in that patients had to have total sleep time of less than approximately 6.5 hours per night and needed more than 30 minutes to fa ...
The Neurobiology of Ecstasy (MDMA)
... are several side effects or adverse effects that can occur, especially at high doses. However, some people who take only one ecstasy pill may have negative psychological effects such as clouded thinking, agitation, and disturbed behavior. Point to areas of the brain where ecstasy may produce these a ...
... are several side effects or adverse effects that can occur, especially at high doses. However, some people who take only one ecstasy pill may have negative psychological effects such as clouded thinking, agitation, and disturbed behavior. Point to areas of the brain where ecstasy may produce these a ...
Information Sheet Nitrous Oxide
... CSEW3 shows past year use by 7.6% of 16-24 year olds - the highest level after cannabis, while, the Global Drug Survey4 shows nitrous oxide was used by 20% of UK respondents in the past year. With the exception of 2010, when nitrous oxide was mentioned 5 times, there have been either 1 or zero drug- ...
... CSEW3 shows past year use by 7.6% of 16-24 year olds - the highest level after cannabis, while, the Global Drug Survey4 shows nitrous oxide was used by 20% of UK respondents in the past year. With the exception of 2010, when nitrous oxide was mentioned 5 times, there have been either 1 or zero drug- ...
10117sgp02
... The first two studies were randomized, double-blind, placebo controlled in patients who met the DSM-IV criteria for primary insomnia. The inclusion criteria were similar in that patients had to have total sleep time of less than approximately 6.5 hours per night and needed more than 30 minutes to fa ...
... The first two studies were randomized, double-blind, placebo controlled in patients who met the DSM-IV criteria for primary insomnia. The inclusion criteria were similar in that patients had to have total sleep time of less than approximately 6.5 hours per night and needed more than 30 minutes to fa ...
Pharmacology_1
... 94The excitation of benzodiazepine receptors is accompanied with: A Antipsychotic effect B Antivomiting effect C Arterial pressure increase D Arterial pressure decrease E Anxiolytic effect ANSWER: E 95Benzodiazepine tranquilizers intensify the action A Psychomotor stimulants B Analeptics C Antidepre ...
... 94The excitation of benzodiazepine receptors is accompanied with: A Antipsychotic effect B Antivomiting effect C Arterial pressure increase D Arterial pressure decrease E Anxiolytic effect ANSWER: E 95Benzodiazepine tranquilizers intensify the action A Psychomotor stimulants B Analeptics C Antidepre ...
Serotonin Syndrome
... serotonin syndrome continue to increase and include many different combinations of serotonergic drugs. Some of the reported drug combinations are listed in Table 4. The most well-known combination is an SSRI with an MAOI. However, the combination of any 2 serotonergic drugs can possibly precipitate ...
... serotonin syndrome continue to increase and include many different combinations of serotonergic drugs. Some of the reported drug combinations are listed in Table 4. The most well-known combination is an SSRI with an MAOI. However, the combination of any 2 serotonergic drugs can possibly precipitate ...
tWallace B. Mendelson, tHerbert Weingartner
... centage began to decrease with the initiation of drug treatment, and was significandy decreased on drug-administration nights 13 and is (p < 0.05); this actually reflected a smaller proportion (due to the increase in non-REM sleep) rather than a significant decrease in minutes of REM. Subjective rep ...
... centage began to decrease with the initiation of drug treatment, and was significandy decreased on drug-administration nights 13 and is (p < 0.05); this actually reflected a smaller proportion (due to the increase in non-REM sleep) rather than a significant decrease in minutes of REM. Subjective rep ...
Covariate Analysis of QTc and T
... T-wave morphology, such as those seen in congenital LQT2, can be used as sensitive descriptors of repolarization abnormality in this syndrome.14 These T-wave characteristics have also been shown to be independent of heart rate15 and to be more sensitive than QTcF (Fridericia’s correction) to repolar ...
... T-wave morphology, such as those seen in congenital LQT2, can be used as sensitive descriptors of repolarization abnormality in this syndrome.14 These T-wave characteristics have also been shown to be independent of heart rate15 and to be more sensitive than QTcF (Fridericia’s correction) to repolar ...
Reasons for Delegate`s final decision, July 2011
... receptors, CB1 and CB2. CB1 is the receptor thought responsible for the euphoric and psychoactive effects of cannabis. CB2 is mainly found in the immune system and may play a role in pain control as well as mood and behaviour regulation. The binding affinities for the CB1 and CB2 receptors vary betw ...
... receptors, CB1 and CB2. CB1 is the receptor thought responsible for the euphoric and psychoactive effects of cannabis. CB2 is mainly found in the immune system and may play a role in pain control as well as mood and behaviour regulation. The binding affinities for the CB1 and CB2 receptors vary betw ...
Soluble guanylate cyclase stimulators as a potential
... renal arteries (RAs), as shown by the higher production of reactive oxygen species (ROS) measured by chemiluminescence (photon counts?s-1). d and e) The different ROS production at normoxia and the opposing responses to acute hypoxia might be due to the fact that the mitochondria in the arterial smo ...
... renal arteries (RAs), as shown by the higher production of reactive oxygen species (ROS) measured by chemiluminescence (photon counts?s-1). d and e) The different ROS production at normoxia and the opposing responses to acute hypoxia might be due to the fact that the mitochondria in the arterial smo ...
Antiseizure drugs
... of phenytoin. However, it is also commonly used for Rx of mania and trigeminal neuralgia. Pharmacokinetics available as an oral form only Well absorbed 80 % protein bound Strong inducing agent including its own (can lead to failure of other drugs e.g. oral contraceptives, warfarin, etc. Metabolized ...
... of phenytoin. However, it is also commonly used for Rx of mania and trigeminal neuralgia. Pharmacokinetics available as an oral form only Well absorbed 80 % protein bound Strong inducing agent including its own (can lead to failure of other drugs e.g. oral contraceptives, warfarin, etc. Metabolized ...
Seizure
... – Very long half-life (up to ~5days); #Induces P450 – Tolerance may arise; Risk of dependence – Primidone, another barbiturate metabolized to Phenobarbital, and Phenobarbital are now seldom used in initial therapy, owing to side-effects ...
... – Very long half-life (up to ~5days); #Induces P450 – Tolerance may arise; Risk of dependence – Primidone, another barbiturate metabolized to Phenobarbital, and Phenobarbital are now seldom used in initial therapy, owing to side-effects ...
Pharmacology of Antiepileptic Drugs
... – Very long half-life (up to ~5days); #Induces P450 – Tolerance may arise; Risk of dependence – Primidone, another barbiturate metabolized to Phenobarbital, and Phenobarbital are now seldom used in initial therapy, owing to side-effects ...
... – Very long half-life (up to ~5days); #Induces P450 – Tolerance may arise; Risk of dependence – Primidone, another barbiturate metabolized to Phenobarbital, and Phenobarbital are now seldom used in initial therapy, owing to side-effects ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.