influence of oxcarbazepine on the antinociceptive action of
... The mechanisms of analgesic action of oxcarbazepine are not fully understood. Beside a blockade of ion currents, there is an evidence indicating that some receptors, e.g. adenosine A1 receptor and α2-adrenoreceptor are also involved in analgesic action of oxcarbazepine (13, 14). The presented study ...
... The mechanisms of analgesic action of oxcarbazepine are not fully understood. Beside a blockade of ion currents, there is an evidence indicating that some receptors, e.g. adenosine A1 receptor and α2-adrenoreceptor are also involved in analgesic action of oxcarbazepine (13, 14). The presented study ...
05 AIDS FOR CESSATION & CASE SCENARIO
... Use the inhaler longer and more often at first to help control cravings (best results are achieved with frequent continuous puffing over 20 minutes) Effectiveness of the nicotine inhaler may be reduced by some foods and beverages Do NOT eat or drink for 15 minutes BEFORE or while using the nicotine ...
... Use the inhaler longer and more often at first to help control cravings (best results are achieved with frequent continuous puffing over 20 minutes) Effectiveness of the nicotine inhaler may be reduced by some foods and beverages Do NOT eat or drink for 15 minutes BEFORE or while using the nicotine ...
Chloral hydrate has general CNS depressant effects believed to be
... Warnings: Abuse and Dependence: Chloral hydrate should be used as a hypnotic only for short-term use, usually 2 to 7 days. Prolonged use of chloral hydrate may produce tolerance and physical and/or psychological dependence. Sudden withdrawal after prolonged use may result in hallucinations and symp ...
... Warnings: Abuse and Dependence: Chloral hydrate should be used as a hypnotic only for short-term use, usually 2 to 7 days. Prolonged use of chloral hydrate may produce tolerance and physical and/or psychological dependence. Sudden withdrawal after prolonged use may result in hallucinations and symp ...
Ophthalmic adverse drug reactions to systemic drugs
... Purpose To perform a comprehensive and systematic review regarding ophthalmic adverse drug reactions (ADRs) to systemic drugs to: (i) systematically summarize existing evidence, (ii) identify areas, ophthalmic ADRs or drugs that lacked systematization or assessment (namely drugs with original studie ...
... Purpose To perform a comprehensive and systematic review regarding ophthalmic adverse drug reactions (ADRs) to systemic drugs to: (i) systematically summarize existing evidence, (ii) identify areas, ophthalmic ADRs or drugs that lacked systematization or assessment (namely drugs with original studie ...
How Marijuana Works article and questions
... hours to 10 days, depending on the amount and potency of the marijuana used. This means that if you take one milligram of THC that has a half-life of 20 hours, you will still have 0.031 mg of THC in your body more than four days later. The longer the half-life, the longer the THC lingers in your bod ...
... hours to 10 days, depending on the amount and potency of the marijuana used. This means that if you take one milligram of THC that has a half-life of 20 hours, you will still have 0.031 mg of THC in your body more than four days later. The longer the half-life, the longer the THC lingers in your bod ...
Dopamine and glucose, obesity, and reward deficiency syndrome
... (Stice and Dagher, 2010). They may become serious cocaine abusers or have unhealthy appetites, which lead to, eating disorders like obesity, overeating or at the other extreme, anorexia nervosa (AN), they also suffer from high levels of stress over an extended period of time. To activate their dopam ...
... (Stice and Dagher, 2010). They may become serious cocaine abusers or have unhealthy appetites, which lead to, eating disorders like obesity, overeating or at the other extreme, anorexia nervosa (AN), they also suffer from high levels of stress over an extended period of time. To activate their dopam ...
Opioid Receptors and Legal Highs - The Salvia divinorum Research
... and Malaysia by manual laborers to enhance productivity, and for its euphoric (also called “coca-like”) effect at low doses (33). At higher doses, Kratom has opioid-like effects, and its use to treat pain and opium withdrawal was described as early as the nineteenth century (32). In Thailand, the us ...
... and Malaysia by manual laborers to enhance productivity, and for its euphoric (also called “coca-like”) effect at low doses (33). At higher doses, Kratom has opioid-like effects, and its use to treat pain and opium withdrawal was described as early as the nineteenth century (32). In Thailand, the us ...
Evaluating Statin Drugs To Treat
... Under certain circumstances, your doctor may prescribe a statin drug even if you do not have high cholesterol. In February 2010, the FDA approved rosuvastatin (Crestor) for use by men 50 or older and women 60 or older with healthy cholesterol levels but an elevated CRP level and at least one other r ...
... Under certain circumstances, your doctor may prescribe a statin drug even if you do not have high cholesterol. In February 2010, the FDA approved rosuvastatin (Crestor) for use by men 50 or older and women 60 or older with healthy cholesterol levels but an elevated CRP level and at least one other r ...
The Health Consequences of Smoking - Rx for Change
... Image courtesy of Dr. Sol Silverman University of California San Francisco ...
... Image courtesy of Dr. Sol Silverman University of California San Francisco ...
Chronic Treatment with Dopamine Receptor Antagonists
... tissue wet weight/ml in this same biffer, followed by a lb min incubation (37°C). The incubation was stopped by the addition of 30 ml ice-cold 50 mM Tris-HCI. Tissue was centrifuged (35,000 x g, 10 min) and washed once more in this buffer, followed by a final resuspension in assay buffer consisting ...
... tissue wet weight/ml in this same biffer, followed by a lb min incubation (37°C). The incubation was stopped by the addition of 30 ml ice-cold 50 mM Tris-HCI. Tissue was centrifuged (35,000 x g, 10 min) and washed once more in this buffer, followed by a final resuspension in assay buffer consisting ...
Nicotine and Schizophrenia
... DA hyperactivity: positive symptoms • Mesocortical tract- midbrain (VTA) to frontal and DLPFC DA hypoactivity: negative symptoms ...
... DA hyperactivity: positive symptoms • Mesocortical tract- midbrain (VTA) to frontal and DLPFC DA hypoactivity: negative symptoms ...
Chapter_008
... First-line treatment Theophylline most often used, but caffeine citrate may be better choice (safer, higher therapeutic index) ...
... First-line treatment Theophylline most often used, but caffeine citrate may be better choice (safer, higher therapeutic index) ...
Concurrent Access to Nicotine and SucroseREVISION
... Background: Animal models that provide concurrent access to drug and nondrug reinforcers provide unique insight into the etiology, maintenance, and treatment of drug use. Objectives: We sought to develop and utilize a concurrent-access procedure with nicotine and sucrose in rats. Methods: Pressing o ...
... Background: Animal models that provide concurrent access to drug and nondrug reinforcers provide unique insight into the etiology, maintenance, and treatment of drug use. Objectives: We sought to develop and utilize a concurrent-access procedure with nicotine and sucrose in rats. Methods: Pressing o ...
concerta - Janssen
... CONCERTA® should be used cautiously in patients with mild hypertension and other cardiovascular conditions. Blood pressure should be monitored at appropriate intervals in patients receiving CONCERTA®, especially in patients with hypertension. In the laboratory classroom clinical trials in children ( ...
... CONCERTA® should be used cautiously in patients with mild hypertension and other cardiovascular conditions. Blood pressure should be monitored at appropriate intervals in patients receiving CONCERTA®, especially in patients with hypertension. In the laboratory classroom clinical trials in children ( ...
Thiazide and Thiazide
... •is a thiazide like drug • It is primarily used to treat congestive hear failure and HTN • Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess flui ...
... •is a thiazide like drug • It is primarily used to treat congestive hear failure and HTN • Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess flui ...
Influence of posture on pharmacokinetics
... addition to the factors discussed above, it may also depend on posture as to whether the rate-limiting step is dissolution or gastric emptying, with respective consequences for the pharmacokinetic profile. The resulting differences in the rate (and possibly extent) of absorption may affect various p ...
... addition to the factors discussed above, it may also depend on posture as to whether the rate-limiting step is dissolution or gastric emptying, with respective consequences for the pharmacokinetic profile. The resulting differences in the rate (and possibly extent) of absorption may affect various p ...
Kinetics of metoclopramide effects on human 5
... binding experiments may be accounted for by (1) slow kinetics of metoclopramide compared with the fast onset and offset kinetics of 5-HT-induced currents (for example, the wash out of pre-equilibrated metoclopramide is 150 times slower than the onset of 5HT-induced currents, see Fig. 2, right panel) ...
... binding experiments may be accounted for by (1) slow kinetics of metoclopramide compared with the fast onset and offset kinetics of 5-HT-induced currents (for example, the wash out of pre-equilibrated metoclopramide is 150 times slower than the onset of 5HT-induced currents, see Fig. 2, right panel) ...
Haloperidol and Slot Machine Gambling
... modest dose of haloperidol in non-Parkinsonian PG subjects may approximate the effects seen in PG subjects with Parkinson’s. That is, haloperidol may increase gamblinginduced DA release in otherwise healthy PG subjects. Frank and O’Reilly’s results suggest that this effect may also be observed in no ...
... modest dose of haloperidol in non-Parkinsonian PG subjects may approximate the effects seen in PG subjects with Parkinson’s. That is, haloperidol may increase gamblinginduced DA release in otherwise healthy PG subjects. Frank and O’Reilly’s results suggest that this effect may also be observed in no ...
Ignatowska-Jankowska et al, 2014
... the CB1 orthosteric agonists CP55,940 and N-arachidonoylethanolamine (AEA). ZCZ011 potentiated binding of [3H]CP55,940 to the CB1 receptor as well as enhancing AEA-stimulated [35S]GTPγS binding in mouse brain membranes and β-arrestin recruitment and ERK phosphorylation in hCB1 cells. In the whole an ...
... the CB1 orthosteric agonists CP55,940 and N-arachidonoylethanolamine (AEA). ZCZ011 potentiated binding of [3H]CP55,940 to the CB1 receptor as well as enhancing AEA-stimulated [35S]GTPγS binding in mouse brain membranes and β-arrestin recruitment and ERK phosphorylation in hCB1 cells. In the whole an ...
Commonly prescribed medication
... low attributable discontinuation rates. Other common adverse effects included insomnia, abnormal dreams and headaches. In the randomized, controlled phase III studies, serious adverse events were rare, with no treatment-related deaths during the treatment or follow-up phases. There are currently no ...
... low attributable discontinuation rates. Other common adverse effects included insomnia, abnormal dreams and headaches. In the randomized, controlled phase III studies, serious adverse events were rare, with no treatment-related deaths during the treatment or follow-up phases. There are currently no ...
Pharmacology of opioids
... Opioid: Any naturally occurring, semi-synthetic or synthetic compounds that bind specifically to opioid receptors (see below) and share the properties of one or more of the naturally occurring endogenous opioids. Opiate: Any naturally occurring opioid derived from opium (eg morphine). Narcotic: From ...
... Opioid: Any naturally occurring, semi-synthetic or synthetic compounds that bind specifically to opioid receptors (see below) and share the properties of one or more of the naturally occurring endogenous opioids. Opiate: Any naturally occurring opioid derived from opium (eg morphine). Narcotic: From ...
What are psychedelics?
... psychoemotional effects. LSD experiences can range from indescribably ecstatic to extraordinarily difficult; many difficult experiences (or "bad trips") result from a panicked user feeling that he or she has been permanently severed from reality and his or her ego. If the user is in a hostile or oth ...
... psychoemotional effects. LSD experiences can range from indescribably ecstatic to extraordinarily difficult; many difficult experiences (or "bad trips") result from a panicked user feeling that he or she has been permanently severed from reality and his or her ego. If the user is in a hostile or oth ...
POLIGUGUL COMPLEX
... While reducing dietary cholesterol may be helpful, not all cholesterol comes from dietary sources. The body also produces cholesterol. Policosanol, a mixture of long chain, high molecular weight alcohols isolated from sugar cane, helps reduce cholesterol levels by inhibiting its synthesis within the ...
... While reducing dietary cholesterol may be helpful, not all cholesterol comes from dietary sources. The body also produces cholesterol. Policosanol, a mixture of long chain, high molecular weight alcohols isolated from sugar cane, helps reduce cholesterol levels by inhibiting its synthesis within the ...
Interactions with Antineoplastic Agents Used in Veterinary Medicine
... Vaccinations with live viruses in patients on actinomycin D can lead to generalized disease from live virus,11 and actinomycin can inhibit efficacy of vaccine8 Actinomycin D produces recall radiation damage when given after ionizing radiation8 Synergistic effects7 possibly caused by increased cellul ...
... Vaccinations with live viruses in patients on actinomycin D can lead to generalized disease from live virus,11 and actinomycin can inhibit efficacy of vaccine8 Actinomycin D produces recall radiation damage when given after ionizing radiation8 Synergistic effects7 possibly caused by increased cellul ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.