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Review #2
Review #2

... 1. Alternate version of genes (alleles) cause variations in inherited characteristics among offspring. 2. For each character, every organism inherits one allele from each parent. 3. If 2 alleles are different, the dominant allele will be fully expressed; the recessive allele will have no noticeable ...
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Dioxyribose Nucleic Acid
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REVIEW OF MOLECULAR GENETICS - Pascack Valley Regional
REVIEW OF MOLECULAR GENETICS - Pascack Valley Regional

... fragments from an organism cloned into a vector Ideally contains at least one copy of every DNA sequence. Easily maintained in the laboratory Can be manipulated in various ways to facilitate the isolation of a DNA fragment of interest to a scientist. Numerous types of libraries exist for various ...
I Will Divide
I Will Divide

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Single Nucleotide Polymorphism
Single Nucleotide Polymorphism

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THINK ABOUT THESE………………

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Evolution #1
Evolution #1

... Mutations: Substitutions can accidentally happen in DNA. Changes in the number, type, or order of bases on a piece of DNA are known as mutations. Do Mutations Matter? There are three possible consequences to changes in DNA: an improved trait, no change, or a harmful trait. Fortunately, cells make so ...
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Lecture 6 pdf - Institute for Behavioral Genetics

... 3000 (out of 20,000) human genes known to have at least 1 mutation that causes an inherited disease Information kept on NCBI (National Center for Biotechnology Information) 1/3 to ½ of all genes are expressed in the brain - more than any other organ reflected in large number of neurogenetic disorder ...
Mutations
Mutations

Human karyotype
Human karyotype

... • Each human cell contains 2 metres of DNA (3,000,000,000 bases in a haploid cell) • Nucleus is 5 microns (0.005 mm) diameter • DNA must be properly packaged, not just tangled up and stuffed into nucleus • Packaging involves coiling and folding the DNA in specific ways • Special proteins are associa ...
Gene Section MCPH1 (microcephalin 1) Atlas of Genetics and Cytogenetics
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... size. One form of primary microcephaly, MCPH, is caused by mutation in the gene encoding microcephalin 1 (that is, MCPH1). In these patients, the MCPH1deficient cells show cellular phenotype of premature chromosome condensation in the early G2 phase of the cell cycle, which, therefore, appears to be ...
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... Human estimate is ~1 x 10-6 spontaneous mutations/gene /generation Mutation rates per gene differ. May be hot spots ...
Slide 1
Slide 1

... So how does it all fit into the nucleus? ...
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Mutagen



In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level. As many mutations can cause cancer, mutagens are therefore also likely to be carcinogens. Not all mutations are caused by mutagens: so-called ""spontaneous mutations"" occur due to spontaneous hydrolysis, errors in DNA replication, repair and recombination.
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