The Limb Girdle Muscular Dystrophies
... “Whilst looking down the rabbit hole, all I saw was bunnies. But once my eyes gazed ‘bout the glen, the panoply of species I did see.” (Old English Fairy Tale) ...
... “Whilst looking down the rabbit hole, all I saw was bunnies. But once my eyes gazed ‘bout the glen, the panoply of species I did see.” (Old English Fairy Tale) ...
POPULATION GENETICS AND EVOLUTION LAB
... In certain African countries, 4 percent of the newborn babies have sickle-cell anemia, which is a recessive trait. Out of a random population of 1000 newborn babiew, how many would you expect for each of the three possible genotypes? ...
... In certain African countries, 4 percent of the newborn babies have sickle-cell anemia, which is a recessive trait. Out of a random population of 1000 newborn babiew, how many would you expect for each of the three possible genotypes? ...
female mate choice in nonhuman mammals
... However, on the basis of the relatively higher level of maternal to paternal investment and generally lower potential rates of reproduction the females of most mammal species could be expected to select their mating partners (Trivers 1972; Clutton-Brock and Vincent 1991). Although the fitness payoff ...
... However, on the basis of the relatively higher level of maternal to paternal investment and generally lower potential rates of reproduction the females of most mammal species could be expected to select their mating partners (Trivers 1972; Clutton-Brock and Vincent 1991). Although the fitness payoff ...
DETECTION OF A RARE MUTATION IN FERROPORTIN GENE
... according to GOR IV server (http://mig.jouy.inra.fr). Double-headed arrow points to the loss of n alpha-helix motif. Percentage of main aminoacidic motifs are reported on the right, altered values in mutated protein are highlighted in red. (B) On the left, genealogical tree of the patient (II-1). O ...
... according to GOR IV server (http://mig.jouy.inra.fr). Double-headed arrow points to the loss of n alpha-helix motif. Percentage of main aminoacidic motifs are reported on the right, altered values in mutated protein are highlighted in red. (B) On the left, genealogical tree of the patient (II-1). O ...
Mutations in type I collagen genes resulting in osteogenesis
... Osteogenesis imperfecta (OI), commonly known as “brittle bone disease”, is a dominant autosomal disorder characterized by bone fragility and abnormalities of connective tissue. Biochemical and molecular genetic studies have shown that the vast majority of affected individuals have mutations in eithe ...
... Osteogenesis imperfecta (OI), commonly known as “brittle bone disease”, is a dominant autosomal disorder characterized by bone fragility and abnormalities of connective tissue. Biochemical and molecular genetic studies have shown that the vast majority of affected individuals have mutations in eithe ...
The genetical theory of multilevel selection
... The basic idea here is that, in a class-structured population, an allele’s frequency may undergo systematic change even if that allele is entirely neutral. Accordingly, even if natural selection is playing some role in driving allele frequency change, it may not be responsible for all of this change ...
... The basic idea here is that, in a class-structured population, an allele’s frequency may undergo systematic change even if that allele is entirely neutral. Accordingly, even if natural selection is playing some role in driving allele frequency change, it may not be responsible for all of this change ...
The genetical theory of multilevel selection - synergy
... The basic idea here is that, in a class-structured population, an allele’s frequency may undergo systematic change even if that allele is entirely neutral. Accordingly, even if natural selection is playing some role in driving allele frequency change, it may not be responsible for all of this change ...
... The basic idea here is that, in a class-structured population, an allele’s frequency may undergo systematic change even if that allele is entirely neutral. Accordingly, even if natural selection is playing some role in driving allele frequency change, it may not be responsible for all of this change ...
What can whole genome expression data tell us about the ecology
... sampling. Studying the molecular basis of behavioural traits, as opposed to morphological traits, poses unique challenges (Toth & Robinson 2009). For most of us interested in behaviour, we are primarily interested in the brain, but the brain is a heterogeneous organ (Greenwood et al. 2008). Studying ...
... sampling. Studying the molecular basis of behavioural traits, as opposed to morphological traits, poses unique challenges (Toth & Robinson 2009). For most of us interested in behaviour, we are primarily interested in the brain, but the brain is a heterogeneous organ (Greenwood et al. 2008). Studying ...
PDF
... Ranunculus and Beta (reviewed in Nogler 1984b). Usually one or, more rarely, a few aposporic initials differentiate from one or more nucellar cells which are in contact with the differentiated meiocyte or its derivatives, and which enlarges to form a large vacuole at the chalazal pole. This represen ...
... Ranunculus and Beta (reviewed in Nogler 1984b). Usually one or, more rarely, a few aposporic initials differentiate from one or more nucellar cells which are in contact with the differentiated meiocyte or its derivatives, and which enlarges to form a large vacuole at the chalazal pole. This represen ...
A rough guide to Drosophila mating schemes (version 1.2) 1
... mutation in this gene which, when present in two copies in embryos, correlates with aberrant muscle development. You hypothesise that this phenotype is caused by loss of Mef2 function. A standard approach to prove this hypothesis is to carry out "rescue experiments" by adding back a wild type copy o ...
... mutation in this gene which, when present in two copies in embryos, correlates with aberrant muscle development. You hypothesise that this phenotype is caused by loss of Mef2 function. A standard approach to prove this hypothesis is to carry out "rescue experiments" by adding back a wild type copy o ...
Are you your grandmother`s favorite
... focused on probability of genetic transmission, and not the probability of gene expression. Although the X-chromosome contains only about 4.4 per cent of our DNA, with its estimated 1529 genes, it contains perhaps approximately 8 per cent of all human genes (Pennisi 2003; NIH 2007; Parang et al. 200 ...
... focused on probability of genetic transmission, and not the probability of gene expression. Although the X-chromosome contains only about 4.4 per cent of our DNA, with its estimated 1529 genes, it contains perhaps approximately 8 per cent of all human genes (Pennisi 2003; NIH 2007; Parang et al. 200 ...
Mutations affecting craniofacial development in zebrafish
... Genetic analysis Genetic segregation of individual mutations was determined by assessing on average 1000 embryos from crosses of heterozygous parents for any given mutation. In order to test potential allelism of isolated mutations, complementation testing among members of the phenotypically defined ...
... Genetic analysis Genetic segregation of individual mutations was determined by assessing on average 1000 embryos from crosses of heterozygous parents for any given mutation. In order to test potential allelism of isolated mutations, complementation testing among members of the phenotypically defined ...
Full-Text PDF
... defects in pollen development or transmission, but pirl1;pirl9 double mutant microspores undergo consistent developmental arrest and are inviable [31,32]. Thus, detailed reverse genetic analysis revealed a functional context for these two genes whose gametophyte phenotypes would otherwise have remai ...
... defects in pollen development or transmission, but pirl1;pirl9 double mutant microspores undergo consistent developmental arrest and are inviable [31,32]. Thus, detailed reverse genetic analysis revealed a functional context for these two genes whose gametophyte phenotypes would otherwise have remai ...
P. roridus - Longwood Blogs
... This study investigated a sample of fungi gathered from a farm in Cumberland, Virginia. The fungi from the sample demonstrated the morphological characteristics of the genus Pilobolus. Classical spore sizing techniques provided a morphological basis to identify fungi from the length and width of ind ...
... This study investigated a sample of fungi gathered from a farm in Cumberland, Virginia. The fungi from the sample demonstrated the morphological characteristics of the genus Pilobolus. Classical spore sizing techniques provided a morphological basis to identify fungi from the length and width of ind ...
Sporadic ALS with compound heterozygous mutations in the
... bodies, are a feature of the remaining LMNs [12]. During the preparation of this manuscript, a related study was published, showing that all of the present cellular pathological alterations were observed in LMNs of three autopsied ALS patients with heterozygous SQSTM1 mutations [20]. However, in the ...
... bodies, are a feature of the remaining LMNs [12]. During the preparation of this manuscript, a related study was published, showing that all of the present cellular pathological alterations were observed in LMNs of three autopsied ALS patients with heterozygous SQSTM1 mutations [20]. However, in the ...
The influence of genomic imprinting on brain
... L.M. Goos, I. Silverman / Evolution and Human Behavior 22 (2001) 385–407 ...
... L.M. Goos, I. Silverman / Evolution and Human Behavior 22 (2001) 385–407 ...
Taking Heredity to Heart and Head: Cardiovascular Disease Genetics
... A large number of monogenic disorders can cause stroke However, these disorders only account for a small proportion of all strokes Important cause of stroke, especially in young stroke patients without known risk factors In some disorders stroke is the prevailing manifestation, whereas in others it ...
... A large number of monogenic disorders can cause stroke However, these disorders only account for a small proportion of all strokes Important cause of stroke, especially in young stroke patients without known risk factors In some disorders stroke is the prevailing manifestation, whereas in others it ...
Secrets T
... among the Comoro Islands. But hagfishes make coelacanths look like evolutionary newborns: coelacanths may have changed little since they first appeared in the fossil record 60 million years ago, but a fossilized hagfish, Myxinikela, was found in sediments deposited roughly 330 million years ago. Asi ...
... among the Comoro Islands. But hagfishes make coelacanths look like evolutionary newborns: coelacanths may have changed little since they first appeared in the fossil record 60 million years ago, but a fossilized hagfish, Myxinikela, was found in sediments deposited roughly 330 million years ago. Asi ...
Mating ecology explains patterns of genome elimination
... recipients are genes in potential zygotes, and they are separated into classes according to the sex of the individual, the sex of the parent of origin and the sex of the grandparent of origin. The condition for natural selection to favour an allele for GE is that instances of that allele are fitter ...
... recipients are genes in potential zygotes, and they are separated into classes according to the sex of the individual, the sex of the parent of origin and the sex of the grandparent of origin. The condition for natural selection to favour an allele for GE is that instances of that allele are fitter ...
(COX2) gene in giant panda, Ailuropoda melanoleuca
... in agreement with the dN/dS < 1 value obtained from the closely related COX2 sequences, indicating the conservation of this gene throughout evolution. Among the three haplotypes found, one had a more recent origin than the other two, suggesting that giant pandas had two colonies with some gene excha ...
... in agreement with the dN/dS < 1 value obtained from the closely related COX2 sequences, indicating the conservation of this gene throughout evolution. Among the three haplotypes found, one had a more recent origin than the other two, suggesting that giant pandas had two colonies with some gene excha ...
DETECTING AND CHARACTERIZING PLEIOTROPY: NEW
... such as femur length and femur width are one trait or two. Finally, there is discussion about whether the relationship between traits represents yet another phenotype that can be affected by genetic manipulation. Relationship QTL, or rQTL, which change the relationships between phenotypes have been ...
... such as femur length and femur width are one trait or two. Finally, there is discussion about whether the relationship between traits represents yet another phenotype that can be affected by genetic manipulation. Relationship QTL, or rQTL, which change the relationships between phenotypes have been ...
Research on diversity, utilization and production quality of local
... was bigger. There was 30% of inbred Slovak Pinzgau, 42.8% in Slovak Spotted and 83% in Holstein cows and sires in the reference populations. The average inbreeding coefficient ranged from 0.36% for the Slovak Spotted to 1.32% for the Holstein. The highest average individual increase of inbreeding ∆F ...
... was bigger. There was 30% of inbred Slovak Pinzgau, 42.8% in Slovak Spotted and 83% in Holstein cows and sires in the reference populations. The average inbreeding coefficient ranged from 0.36% for the Slovak Spotted to 1.32% for the Holstein. The highest average individual increase of inbreeding ∆F ...
Conclusions from Hardy
... – Luck plays no role. Eggs and sperm collide at same frequencies as the actual frequencies of p and q. – When assumption is violated, and by chance some individuals contribute more alleles than others to next generation, allele frequencies may change. This mechanism of allele frequency change is cal ...
... – Luck plays no role. Eggs and sperm collide at same frequencies as the actual frequencies of p and q. – When assumption is violated, and by chance some individuals contribute more alleles than others to next generation, allele frequencies may change. This mechanism of allele frequency change is cal ...
The Effects of Zygotic Lethal Mutations on Female Germ
... Three categories of effects were found. In the first group (13 out of 48), no maternal effect was detected. The second set (20 out of 48) exhibited maternal effects on oogenesis, embryogenesis, or both. In 13 of this last group, only a few eggs were produced before a progressive deterioration of dev ...
... Three categories of effects were found. In the first group (13 out of 48), no maternal effect was detected. The second set (20 out of 48) exhibited maternal effects on oogenesis, embryogenesis, or both. In 13 of this last group, only a few eggs were produced before a progressive deterioration of dev ...
“What is this Genetics, Anyway?” Understandings of
... research: interviews, observations of clinical consultations and participant observation. Pre-clinic interviews with participants were supplemented by observations of their clinical consultations, which identified potential disjunctures between clients’ and clinicians’ understandings. Emergent theme ...
... research: interviews, observations of clinical consultations and participant observation. Pre-clinic interviews with participants were supplemented by observations of their clinical consultations, which identified potential disjunctures between clients’ and clinicians’ understandings. Emergent theme ...
Koinophilia
Koinophilia is an evolutionary hypothesis concerning sexual selection which proposes that animals seeking mate preferentially choose individuals with a minimum of unusual features. Koinophilia intends to explain the clustering of organisms into species and other issues described by Darwin's Dilemma. The term derives from the Greek, koinos, ""the usual"", and philos, ""fondness"".Natural selection causes beneficial inherited features to become more common and eventually replace their disadvantageous counterparts. A sexually-reproducing animal would be expected to avoid individuals with unusual features, and to prefer to mate with individuals displaying a predominance of common or average features. This means that mates displaying mutant features are also avoided. This is advantageous because most mutations that manifest themselves as changes in appearance, functionality or behavior, are disadvantageous. Because it is impossible to judge whether a new mutation is beneficial or not, koinophilic animals avoid them all, at the cost of avoiding the occasional beneficial mutation. Thus, koinophilia, although not infallible in its ability to distinguish fit from unfit mates, is a good strategy when choosing a mate. A koinophilic choice ensures that offspring are likely to inherit features that have been successful in the past.Koinophilia differs from assortative mating, where ""like prefers like"". If like preferred like, leucistic animals (such as white peacocks) would be sexually attracted to one another, and a leucistic subspecies would come into being. Koinophilia predicts that this is unlikely because leucistic animals are attracted to the average in the same way as other animals. Since non-leucistic animals are not attracted by leucism, few leucistic individuals find mates, and leucistic lineages will rarely form.Koinophilia provides simple explanations for the rarity of speciation (in particular Darwin's Dilemma), evolutionary stasis, punctuated equilibria, and the evolution of cooperation. Koinophilia might also contribute to the maintenance of sexual reproduction, preventing its reversion to the much simpler and inherently more advantageous asexual form of reproduction.The koinophilia hypothesis is supported by research into the physical attractiveness of human faces by Judith Langlois and her co-workers. They found that the average of two human faces was more attractive than either of the faces from which that average was derived. The more faces (of the same gender and age) that were used in the averaging process the more attractive and appealing the average face became. This work into averageness supports koinophilia as an explanation of what constitutes a beautiful face, and how the individuality of a face is recognized.