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... Vertebrate hindbrain segmentation is an evolutionarily conserved process that involves a complex interplay of transcription factors and signalling pathways. Fibroblast growth factor (FGF) signalling plays a major role, notably by controlling the expression of the transcription factor Krox20 (Egr2), ...
... Vertebrate hindbrain segmentation is an evolutionarily conserved process that involves a complex interplay of transcription factors and signalling pathways. Fibroblast growth factor (FGF) signalling plays a major role, notably by controlling the expression of the transcription factor Krox20 (Egr2), ...
Melatonin Receptors Trigger cAMP Production and Inhibit Chloride
... Downloaded from jpet.aspetjournals.org at ASPET Journals on June 18, 2017 ...
... Downloaded from jpet.aspetjournals.org at ASPET Journals on June 18, 2017 ...
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... different progenitor domains in the ventral midbrain, and they are involved in establishing subpallial and hypothalamic identity in the ventral forebrain [45–51]. Because of its key role in pattering the ventral forebrain, defects in the SHH pathway cause holoprosencephaly, the most common congenita ...
... different progenitor domains in the ventral midbrain, and they are involved in establishing subpallial and hypothalamic identity in the ventral forebrain [45–51]. Because of its key role in pattering the ventral forebrain, defects in the SHH pathway cause holoprosencephaly, the most common congenita ...
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... 1993). Once inside the nucleus, the activated receptors regulate the expression of target genes by binding as homodimers to short DNA sequence motifs, termed hormone response elements (HREs) (Glass, 1994). In this manner, the steroid hormone receptors function as ligand-activated transcription facto ...
... 1993). Once inside the nucleus, the activated receptors regulate the expression of target genes by binding as homodimers to short DNA sequence motifs, termed hormone response elements (HREs) (Glass, 1994). In this manner, the steroid hormone receptors function as ligand-activated transcription facto ...
N o v e l s ite s o... Johan Ohlson
... Discovering ADAR2 and ADAR3 The most prominent sites of selective A-to-I editing have been found in the mRNA coding for glutamate receptor subunit B (GluR-B). There are at least two sites that are edited selectively in the coding region of the GluR-B transcript, the Q/R site that causes a glutamine ...
... Discovering ADAR2 and ADAR3 The most prominent sites of selective A-to-I editing have been found in the mRNA coding for glutamate receptor subunit B (GluR-B). There are at least two sites that are edited selectively in the coding region of the GluR-B transcript, the Q/R site that causes a glutamine ...
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... own independent laboratories and established a worldwide network that studied visual pigments and a number of other GPCRs. Most importantly, as the expression systems and purification methods were refined and improved, it became feasible to contemplate biophysical studies on engineered expressed rho ...
... own independent laboratories and established a worldwide network that studied visual pigments and a number of other GPCRs. Most importantly, as the expression systems and purification methods were refined and improved, it became feasible to contemplate biophysical studies on engineered expressed rho ...
acetylcholine receptors in regenerating muscle
... synaptic cleft . The axon terminals are phagocytized by Schwann cells, which then occupy the position of the terminal on the synaptic portion of the myofiber basal lamina . Eventually, the Schwann cell processes retract from much of the synaptic basal lamina (26, 33, 34, 37) . The basal lamina of th ...
... synaptic cleft . The axon terminals are phagocytized by Schwann cells, which then occupy the position of the terminal on the synaptic portion of the myofiber basal lamina . Eventually, the Schwann cell processes retract from much of the synaptic basal lamina (26, 33, 34, 37) . The basal lamina of th ...
The neutrophil in vascular inflammation
... advanced imaging techniques have yielded new insights into the mechanisms by which neutrophils contribute to defense against bacterial infections and also against sterile injury. In these settings, neutrophils are recruited by various mechanisms depending on the situation. We also describe how these ...
... advanced imaging techniques have yielded new insights into the mechanisms by which neutrophils contribute to defense against bacterial infections and also against sterile injury. In these settings, neutrophils are recruited by various mechanisms depending on the situation. We also describe how these ...
Possible Mechanism of Hepatocyte Injury Induced by
... was caused by mefenamic acid and diclofenac (data not shown). Protection by Fructose and Oligomycin against Hepatocyte Injury. Incubation of hepatocytes with mefenamic acid, diclofenac, and diphenylamine diminished cellular ATP contents, followed by LDH leakage. Fructose, a low Km substrate for glyc ...
... was caused by mefenamic acid and diclofenac (data not shown). Protection by Fructose and Oligomycin against Hepatocyte Injury. Incubation of hepatocytes with mefenamic acid, diclofenac, and diphenylamine diminished cellular ATP contents, followed by LDH leakage. Fructose, a low Km substrate for glyc ...
PowerPoint Template
... conducted into the cell interior. The cell uses mainly two mechanisms for transmission of signals at the cytosolic side of the membrane and in the cell interior. Signal transmission may be mediated by a protein-protein interaction. The proteins involved may be receptors, proteins with adaptor func ...
... conducted into the cell interior. The cell uses mainly two mechanisms for transmission of signals at the cytosolic side of the membrane and in the cell interior. Signal transmission may be mediated by a protein-protein interaction. The proteins involved may be receptors, proteins with adaptor func ...
IRK-1 Potassium Channels Mediate Peptidergic Inhibition
... receptors that inhibit egg laying in a Go-dependent manner: the muscarinic acetylcholine receptor GAR-2 (Lee et al., 2000; Bany et al., 2003), the orphan receptor EGL-47 (Moresco and Koelle, 2004), and the neuropeptide receptor EGL-6 (Ringstad and Horvitz, 2008). These Go-coupled receptors might coo ...
... receptors that inhibit egg laying in a Go-dependent manner: the muscarinic acetylcholine receptor GAR-2 (Lee et al., 2000; Bany et al., 2003), the orphan receptor EGL-47 (Moresco and Koelle, 2004), and the neuropeptide receptor EGL-6 (Ringstad and Horvitz, 2008). These Go-coupled receptors might coo ...
BAFF, APRIL and their receptors: Structure, function - Serval
... other hand, APRIL binds TACI and BCMA with high affinity (nanomolar range), but not at all to BAFF-R. When receptors are dimerized as Ig fusion proteins, all receptors efficiently bind ligands in the low to subnanomolar range, with the exception of BAFF-R that does not bind to APRIL (Table 1, and re ...
... other hand, APRIL binds TACI and BCMA with high affinity (nanomolar range), but not at all to BAFF-R. When receptors are dimerized as Ig fusion proteins, all receptors efficiently bind ligands in the low to subnanomolar range, with the exception of BAFF-R that does not bind to APRIL (Table 1, and re ...
Sepsis is a common condition, and more than 19 million cases of
... cell surface expression in LPS treated neutrophils whilst preserving efficient bacterial killing, support the notion that MPLA may hold promise as adjunctive therapy for Gram negative sepsis. Persistent activation of TLR pathways, as occurs in the early stages of sepsis, has been associated with exc ...
... cell surface expression in LPS treated neutrophils whilst preserving efficient bacterial killing, support the notion that MPLA may hold promise as adjunctive therapy for Gram negative sepsis. Persistent activation of TLR pathways, as occurs in the early stages of sepsis, has been associated with exc ...
Differential sensitivity of medium- and large
... both cell types. Spontaneous excitatory postsynaptic currents occurred frequently in medium-sized neurons but were relatively infrequent in large-sized neurons. Excitatory postsynaptic currents evoked by electrical stimulation were smaller in large- than in medium-sized neurons. A ®nal set of experi ...
... both cell types. Spontaneous excitatory postsynaptic currents occurred frequently in medium-sized neurons but were relatively infrequent in large-sized neurons. Excitatory postsynaptic currents evoked by electrical stimulation were smaller in large- than in medium-sized neurons. A ®nal set of experi ...
FGF signalling: diverse roles during early vertebrate embryogenesis
... How the switch from Sprouty to Spred gene expression occurs at the transcriptional level is still unknown, but resolving this question should provide us with important clues as to how cells control the way they interpret growth factor signals appropriately during development. The molecular mechanism ...
... How the switch from Sprouty to Spred gene expression occurs at the transcriptional level is still unknown, but resolving this question should provide us with important clues as to how cells control the way they interpret growth factor signals appropriately during development. The molecular mechanism ...
Dally cooperates with Drosophila Frizzled 2 to transduce Wingless
... blade, Dfz2 is involved in shaping the gradient of Wg distribution and determining the response of cells to Wg14. Uniform overexpression of Dfz2 in the wing pouch leads to ectopic bristle formation in the wing blade, probably re¯ecting activation of Wg signalling above its normal level. Ectopic expr ...
... blade, Dfz2 is involved in shaping the gradient of Wg distribution and determining the response of cells to Wg14. Uniform overexpression of Dfz2 in the wing pouch leads to ectopic bristle formation in the wing blade, probably re¯ecting activation of Wg signalling above its normal level. Ectopic expr ...
Receptor-like activity evoked by extracellular ADP in Arabidopsis
... Extracellular ADP increases PM Ca2+ influx and K+ efflux conductance As Figure 2B shows, fast delivery of 0.3 mM extracellular ADP increased both inwardly- and outwardly-directed currents across the PM of a single protoplast, resulting in a positive shift of reversal potential (Erev) away from the ...
... Extracellular ADP increases PM Ca2+ influx and K+ efflux conductance As Figure 2B shows, fast delivery of 0.3 mM extracellular ADP increased both inwardly- and outwardly-directed currents across the PM of a single protoplast, resulting in a positive shift of reversal potential (Erev) away from the ...
Gene Regulatory Potential of 1α,25-Dihydroxyvitamin D3
... chemical modi®cations in its A-ring. J. Cell. Biochem. Suppl. 36:179±190, 2001. # 2001 Wiley-Liss, Inc. Key words: vitamin D receptor; vitamin D analogues; receptor conformations; gene regulation; receptor agonists ...
... chemical modi®cations in its A-ring. J. Cell. Biochem. Suppl. 36:179±190, 2001. # 2001 Wiley-Liss, Inc. Key words: vitamin D receptor; vitamin D analogues; receptor conformations; gene regulation; receptor agonists ...
Purinergic signalling
Purinergic signalling (or signaling: see American and British English differences) is a form of extracellular signalling mediated by purine nucleotides and nucleosides such as adenosine and ATP. It involves the activation of purinergic receptors in the cell and/or in nearby cells, thereby regulating cellular functions.The purinergic signalling complex of a cell is sometimes referred to as the “purinome”.