The network of calcium regulation in muscle
... of about 130 kDa is present in the plasma membranes of most eukaryotic cells, including plants (Guerini & Carafoli, 1999; Strehler & Zacharias, 2001). It catalyzes the ATP-dependent transport of Ca2+ from the cytoplasm into the extracellular space. The Ca2+-dependent cleavage of ATP occurs with the ...
... of about 130 kDa is present in the plasma membranes of most eukaryotic cells, including plants (Guerini & Carafoli, 1999; Strehler & Zacharias, 2001). It catalyzes the ATP-dependent transport of Ca2+ from the cytoplasm into the extracellular space. The Ca2+-dependent cleavage of ATP occurs with the ...
Excitation-contraction Coupling in the Heart and the Negative
... From studying Ca2⫹ sparks we now know that excitation-contraction coupling in the heart is attributable to the spatio-temporal summation of a very large number of “elementary” Ca2⫹ sparks.37,42,43 It has been estimated that during excitation-contraction coupling the spontaneous spark rate is increas ...
... From studying Ca2⫹ sparks we now know that excitation-contraction coupling in the heart is attributable to the spatio-temporal summation of a very large number of “elementary” Ca2⫹ sparks.37,42,43 It has been estimated that during excitation-contraction coupling the spontaneous spark rate is increas ...
Plasma Gelsolin
... D. Gelsolin Interacts with Plasma ATP in a Ca2+-Dependent Manner Despite the low physiological concentration of ATP in plasma (~550 nM) compared to its intracellular concentration of 3-10 mM [55], plasma ATP exerts important effects through binding to its plasma membrane purinergic receptors. Most c ...
... D. Gelsolin Interacts with Plasma ATP in a Ca2+-Dependent Manner Despite the low physiological concentration of ATP in plasma (~550 nM) compared to its intracellular concentration of 3-10 mM [55], plasma ATP exerts important effects through binding to its plasma membrane purinergic receptors. Most c ...
... [58]. At present, the most important deactivating cytokines are IL-10 and transforming growth factor-β (TGFβ). IL-4 has an intermediate position, since some macrophage functions are induced by IL-4 (major histocompatibility complex (MHC) class II expression) and others are inhibited, e.g. production ...
375 Na+/Ca2+ ANTIPORT IN THE MAMMALIAN HEART
... mechanisms generate the various isoforms of the antiporter found in different tissues. Analysis of genomic clones reveals the presence of two mutually exclusive exons (A and B) coding for segments of 34 (B) or 35 (A) amino acids between positions 570 and 604/5; the amino acid sequences in these two ...
... mechanisms generate the various isoforms of the antiporter found in different tissues. Analysis of genomic clones reveals the presence of two mutually exclusive exons (A and B) coding for segments of 34 (B) or 35 (A) amino acids between positions 570 and 604/5; the amino acid sequences in these two ...
The COOH-terminal domain of agrin signals via a synaptic receptor
... identify neurons and glial cells, respectively. Consistent with our previous results, treatment with either C-Ag95 z0 or C-Ag95z8 caused a marked increase in Fos expression in neurons, but not nonneuronal cells (Fig. 2). Although differences in the level of Fos expression between neurons were appare ...
... identify neurons and glial cells, respectively. Consistent with our previous results, treatment with either C-Ag95 z0 or C-Ag95z8 caused a marked increase in Fos expression in neurons, but not nonneuronal cells (Fig. 2). Although differences in the level of Fos expression between neurons were appare ...
The scaffolding protein Cnk Interacts with Alk to Promote Visceral
... multiple roles of Alk-signalling and the variety of processes it is involved in, there is a gap in our ...
... multiple roles of Alk-signalling and the variety of processes it is involved in, there is a gap in our ...
Neurotransmitter signaling through heterotrimeric G
... 1.1. Neurotransmitters signal by gating ion channels and by activating G protein coupled receptors Neurotransmitters signal via two distinct classes of receptors, known within the neuroscience field as ionotropic and metabotropic receptors. Ionotropic receptors are neurotransmitter-gated ion channe ...
... 1.1. Neurotransmitters signal by gating ion channels and by activating G protein coupled receptors Neurotransmitters signal via two distinct classes of receptors, known within the neuroscience field as ionotropic and metabotropic receptors. Ionotropic receptors are neurotransmitter-gated ion channe ...
Differential Excitability Modulation of Striatal Medium Neuron
... The loss of striatal dopamine (DA) in Parkinson’s disease (PD) models triggers a cell-type-specific reduction in the density of dendritic spines in D2 receptor-expressing striatopallidal medium spiny neurons (D2 MSNs). How the intrinsic properties of MSN dendrites, where the vast majority of DA rece ...
... The loss of striatal dopamine (DA) in Parkinson’s disease (PD) models triggers a cell-type-specific reduction in the density of dendritic spines in D2 receptor-expressing striatopallidal medium spiny neurons (D2 MSNs). How the intrinsic properties of MSN dendrites, where the vast majority of DA rece ...
Plasma Membrane Depolarization and Disturbed Na Homeostasis
... across the plasma membrane, may be one of the impaired enzymes, yet this aspect of the action of protonophores has been given surprisingly little attention. It can be predicted that if the decrease in the ATP level and ATP/ADP ratio is sufficiently large to inhibit the Na1, K1/ATPase, this would res ...
... across the plasma membrane, may be one of the impaired enzymes, yet this aspect of the action of protonophores has been given surprisingly little attention. It can be predicted that if the decrease in the ATP level and ATP/ADP ratio is sufficiently large to inhibit the Na1, K1/ATPase, this would res ...
Artk96_CyclGMPReview_2016 - Pure
... there must be coding information to maintain specificity, a phenomenon that is only partially understood for Ca2+ but remains an enigma for most other intermediates. In the case of Ca2+, both frequency and amplitude coding affects Ca2+ binding proteins that show different affinities. For example, Ca ...
... there must be coding information to maintain specificity, a phenomenon that is only partially understood for Ca2+ but remains an enigma for most other intermediates. In the case of Ca2+, both frequency and amplitude coding affects Ca2+ binding proteins that show different affinities. For example, Ca ...
Towards the Physics of Calcium Signalling in Plants
... Ca2+ can be perceived by calcium binding proteins that can lead to the activation of different cellular programmes. It has been suggested that the need to reduce the toxic effects of high free Ca2+ concentrations drove the evolution of components that could then be taken advantage of as calcium sign ...
... Ca2+ can be perceived by calcium binding proteins that can lead to the activation of different cellular programmes. It has been suggested that the need to reduce the toxic effects of high free Ca2+ concentrations drove the evolution of components that could then be taken advantage of as calcium sign ...
The versatility of mitochondrial calcium signals: From stimulation of
... For the delivery of aequorin to the mitochondrial intermembrane space (MIMS), we exploited the characteristics of another mitochondrial protein. Glycerol phosphate dehydrogenase (GPD) is an enzyme present in the mitochondrial inner membrane with a C-terminal domain protruding into the MIMS. To targe ...
... For the delivery of aequorin to the mitochondrial intermembrane space (MIMS), we exploited the characteristics of another mitochondrial protein. Glycerol phosphate dehydrogenase (GPD) is an enzyme present in the mitochondrial inner membrane with a C-terminal domain protruding into the MIMS. To targe ...
Modulatory effects of histamine on cat carotid body chemoreception
... Histamine has been proposed to be an excitatory transmitter between the carotid body (CB) chemoreceptor (glomus) cells and petrosal ganglion (PG) neurons. The histamine biosynthetic pathway, its storage and release, as well as the presence of histamine H1, H2 and H3 receptors have been found in the ...
... Histamine has been proposed to be an excitatory transmitter between the carotid body (CB) chemoreceptor (glomus) cells and petrosal ganglion (PG) neurons. The histamine biosynthetic pathway, its storage and release, as well as the presence of histamine H1, H2 and H3 receptors have been found in the ...
Cell lysate and SR-enriched membrane fraction (SR - HAL
... Fig.4A, B and C, respectively). These results suggested that all recorded channel activity corresponded to RyRs, however, although the burst and long-lasting modes were observed in channels with and without aldosterone treatment, these modes occurred more frequently after aldosterone exposure (Fig.4 ...
... Fig.4A, B and C, respectively). These results suggested that all recorded channel activity corresponded to RyRs, however, although the burst and long-lasting modes were observed in channels with and without aldosterone treatment, these modes occurred more frequently after aldosterone exposure (Fig.4 ...
Purinergic signalling
Purinergic signalling (or signaling: see American and British English differences) is a form of extracellular signalling mediated by purine nucleotides and nucleosides such as adenosine and ATP. It involves the activation of purinergic receptors in the cell and/or in nearby cells, thereby regulating cellular functions.The purinergic signalling complex of a cell is sometimes referred to as the “purinome”.