pinacidil modulates mitochondrial function under experimental
... which single or multiple brief periods of ischaemia have been shown to produce a marked cardioprotection against injury, produced by a subsequent prolonged ischaemic insult (22). The protective action of the KATP channel openings is not limited to the heart, but also observed in the brain (2). There ...
... which single or multiple brief periods of ischaemia have been shown to produce a marked cardioprotection against injury, produced by a subsequent prolonged ischaemic insult (22). The protective action of the KATP channel openings is not limited to the heart, but also observed in the brain (2). There ...
MOLECULAR BASIS FOR MEMBRANE PHOSPHOLIPID
... accumulation of DAG, which is detrimental (33). Thus far DAG has not been associated with any regulatory process in E. coli, but it is interesting that E. coli has a cycle (7) analogous to the phosphatidylinositol (PI) signaling pathway of eukaryotic cells (2, 3) involving DAG, and an anionic phosph ...
... accumulation of DAG, which is detrimental (33). Thus far DAG has not been associated with any regulatory process in E. coli, but it is interesting that E. coli has a cycle (7) analogous to the phosphatidylinositol (PI) signaling pathway of eukaryotic cells (2, 3) involving DAG, and an anionic phosph ...
pdf file - John Innes Centre
... DMI1 and this dominant-negative mutant protein we show that DMI1 increases the sensitivity of a sodium- and lithiumhypersensitive yeast (Saccharomyces cerevisiae) mutant toward those ions and that the C-terminal domain plays a central role in regulating this response. We also show that DMI1 greatly ...
... DMI1 and this dominant-negative mutant protein we show that DMI1 increases the sensitivity of a sodium- and lithiumhypersensitive yeast (Saccharomyces cerevisiae) mutant toward those ions and that the C-terminal domain plays a central role in regulating this response. We also show that DMI1 greatly ...
Fatty acid modification and membrane lipids
... plot for the fluoride-stimulated adenyl cyclase activity remained linear, indicating that the lipid-phase transition occurred only in the one half of the bilayer which contained the hormone receptor and that fluidity in this lamella was important for receptor-enzyme coupling (Houslay et al. I 976). ...
... plot for the fluoride-stimulated adenyl cyclase activity remained linear, indicating that the lipid-phase transition occurred only in the one half of the bilayer which contained the hormone receptor and that fluidity in this lamella was important for receptor-enzyme coupling (Houslay et al. I 976). ...
A painful TR(i)P to lysosomes
... Plasma membrane TRPA1 is modulated by a variety of cellular cues, for instance, G protein and lipid and Ca2+ signaling. Strikingly, whereas plasma membrane TRPA1 is potently activated by Ca2+ (Zurborg et al., 2007), lysosomal TRPA1 is not. There are several possible explanations for this observation ...
... Plasma membrane TRPA1 is modulated by a variety of cellular cues, for instance, G protein and lipid and Ca2+ signaling. Strikingly, whereas plasma membrane TRPA1 is potently activated by Ca2+ (Zurborg et al., 2007), lysosomal TRPA1 is not. There are several possible explanations for this observation ...
Kinetic Analysis of the L-type Calcium Current in Enzymatically
... placed on the characteristics of the calcium influx through the dihydropyridinesensitive calcium channels (Campbell and Giles 1990; Pelzer et al. 1990). O n e of the main features of i c a - L is the presence of a time dependent decaying phase during a maintained depolarization. It was at first assu ...
... placed on the characteristics of the calcium influx through the dihydropyridinesensitive calcium channels (Campbell and Giles 1990; Pelzer et al. 1990). O n e of the main features of i c a - L is the presence of a time dependent decaying phase during a maintained depolarization. It was at first assu ...
ABA control of plant macroelement membrane transport systems in
... elevated temperatures and increased drought. A considerable amount of research in the past 20 yr has focused on elucidating the various mechanisms plants have evolved to cope with unfavorable environmental conditions (Wang et al., 2003; Vinocur & Altman, 2005; Tran & Mochida, 2010; Hadiarto & Tran, ...
... elevated temperatures and increased drought. A considerable amount of research in the past 20 yr has focused on elucidating the various mechanisms plants have evolved to cope with unfavorable environmental conditions (Wang et al., 2003; Vinocur & Altman, 2005; Tran & Mochida, 2010; Hadiarto & Tran, ...
A painful TR(i)P to lysosomes
... Plasma membrane TRPA1 is modulated by a variety of cellular cues, for instance, G protein and lipid and Ca2+ signaling. Strikingly, whereas plasma membrane TRPA1 is potently activated by Ca2+ (Zurborg et al., 2007), lysosomal TRPA1 is not. There are several possible explanations for this observation ...
... Plasma membrane TRPA1 is modulated by a variety of cellular cues, for instance, G protein and lipid and Ca2+ signaling. Strikingly, whereas plasma membrane TRPA1 is potently activated by Ca2+ (Zurborg et al., 2007), lysosomal TRPA1 is not. There are several possible explanations for this observation ...
A painful TR(i)P to lysosomes
... Plasma membrane TRPA1 is modulated by a variety of cellular cues, for instance, G protein and lipid and Ca2+ signaling. Strikingly, whereas plasma membrane TRPA1 is potently activated by Ca2+ (Zurborg et al., 2007), lysosomal TRPA1 is not. There are several possible explanations for this observation ...
... Plasma membrane TRPA1 is modulated by a variety of cellular cues, for instance, G protein and lipid and Ca2+ signaling. Strikingly, whereas plasma membrane TRPA1 is potently activated by Ca2+ (Zurborg et al., 2007), lysosomal TRPA1 is not. There are several possible explanations for this observation ...
A painful TR(i)P to lysosomes
... Plasma membrane TRPA1 is modulated by a variety of cellular cues, for instance, G protein and lipid and Ca2+ signaling. Strikingly, whereas plasma membrane TRPA1 is potently activated by Ca2+ (Zurborg et al., 2007), lysosomal TRPA1 is not. There are several possible explanations for this observation ...
... Plasma membrane TRPA1 is modulated by a variety of cellular cues, for instance, G protein and lipid and Ca2+ signaling. Strikingly, whereas plasma membrane TRPA1 is potently activated by Ca2+ (Zurborg et al., 2007), lysosomal TRPA1 is not. There are several possible explanations for this observation ...
Expression Profiles of High Voltage
... Voltage-activated Ca2⫹ channels (VACC) allow Ca2⫹ influx in response to membrane depolarization and mediate diverse neural functions, including transmitter release and excitability. In general, VACC are composed of an ␣1 subunit and differential auxiliary subunits (, ␣2␦, and ␥). Until now, molecul ...
... Voltage-activated Ca2⫹ channels (VACC) allow Ca2⫹ influx in response to membrane depolarization and mediate diverse neural functions, including transmitter release and excitability. In general, VACC are composed of an ␣1 subunit and differential auxiliary subunits (, ␣2␦, and ␥). Until now, molecul ...
Long-Term Maintenance of Channel Distribution in a Central Pattern
... Boltzmann fit, Vact (& V0.5) is the voltage of half-maximal activation of the peak current. Steady state inactivation of IA was measured from a holding potential of #50 mV. Voltage presteps (1.5 sec) were delivered at 5 mV increments from #120 to 0 mV, followed by a step to !50 mV, and the peak curr ...
... Boltzmann fit, Vact (& V0.5) is the voltage of half-maximal activation of the peak current. Steady state inactivation of IA was measured from a holding potential of #50 mV. Voltage presteps (1.5 sec) were delivered at 5 mV increments from #120 to 0 mV, followed by a step to !50 mV, and the peak curr ...
NG2 glial cells integrate synaptic input in global and dendritic
... additional analysis including all dendrite recordings. We binned trials according to stimulus 8 of 43 ...
... additional analysis including all dendrite recordings. We binned trials according to stimulus 8 of 43 ...
Study of reactive oxygen species-induced ion transport in different models by using
... The interaction between ROS and [Ca2+]cyt in plant cells was suggested not many years ago by Bowler & Fluhr (2000). Since then, it has been shown that an early event following the elevation in H2O2 levels is the alteration in calcium fluxes (Rentel & Knight., 2004). The activation of plasma membrane ...
... The interaction between ROS and [Ca2+]cyt in plant cells was suggested not many years ago by Bowler & Fluhr (2000). Since then, it has been shown that an early event following the elevation in H2O2 levels is the alteration in calcium fluxes (Rentel & Knight., 2004). The activation of plasma membrane ...
The proposed channel-enzyme transient receptor potential
... eLife digest Ion channels are proteins that allow specific charged particles to move across the membranes of cells – for example to travel in or out of a cell, or between different parts of the same cell. Almost all ion channels are gated, meaning that they can open and close in response to differen ...
... eLife digest Ion channels are proteins that allow specific charged particles to move across the membranes of cells – for example to travel in or out of a cell, or between different parts of the same cell. Almost all ion channels are gated, meaning that they can open and close in response to differen ...
OSMOSIS (A self-instructional package)
... 1. Define osmosis, osmotic pressure, and ideal semipermeable membrane. 2. Write van't Hoff's Law (π = iRTc) and use this equation to estimate the osmotic pressure of a solution. State that van't Hoff's Law applies exactly only to very dilute solutions. 3. State that the osmotic coefficient (Φ) is us ...
... 1. Define osmosis, osmotic pressure, and ideal semipermeable membrane. 2. Write van't Hoff's Law (π = iRTc) and use this equation to estimate the osmotic pressure of a solution. State that van't Hoff's Law applies exactly only to very dilute solutions. 3. State that the osmotic coefficient (Φ) is us ...
effect of ion concentration changes in t
... electrical activity that was the first to include a quantitative description of the transverse (t-) tubular system [1]. The preliminary simulations indicated that the electrical activity induces significant transient changes of Ca2+ and K+ concentration in human t-tubules that may reduce intracellular ...
... electrical activity that was the first to include a quantitative description of the transverse (t-) tubular system [1]. The preliminary simulations indicated that the electrical activity induces significant transient changes of Ca2+ and K+ concentration in human t-tubules that may reduce intracellular ...
Intravenously-Delivered Mesenchymal Stem Cells: Systemic Anti
... Another consideration of major practical consequence is the concept, driving the design of most preclinical and clinical studies, that any beneficial effect of MSCs derives from their local effects. It is commonly believed that once engrafted in damaged myocardium, stem cells either directly transdi ...
... Another consideration of major practical consequence is the concept, driving the design of most preclinical and clinical studies, that any beneficial effect of MSCs derives from their local effects. It is commonly believed that once engrafted in damaged myocardium, stem cells either directly transdi ...
Ionic and Osmotic Effects of NaCl-Induced
... High-salt stress is a major environmental factor that limits plant growth and productivity (Boyer, 1982). The detrimental effects of high concentrations of salt on plants can be observed at the whole-plant level as the death of plants and/or decreases in productivity. Reductions in plant growth due ...
... High-salt stress is a major environmental factor that limits plant growth and productivity (Boyer, 1982). The detrimental effects of high concentrations of salt on plants can be observed at the whole-plant level as the death of plants and/or decreases in productivity. Reductions in plant growth due ...
enterocolitica Yersinia Type III Secretion System of Properties of the
... Downloaded from http://jb.asm.org/ on February 21, 2013 by PENN STATE UNIV ...
... Downloaded from http://jb.asm.org/ on February 21, 2013 by PENN STATE UNIV ...
Mucolipin 1 channel activity is regulated by protein kinase A
... One way to gain information on the function of a protein is to analyse its distribution and trafficking into the cell. For example, consistent with its role in lysosomal function, MCOLN1 contains specific sorting signals that mediate its transport to lysosomes [24–26]. These sorting signals include ...
... One way to gain information on the function of a protein is to analyse its distribution and trafficking into the cell. For example, consistent with its role in lysosomal function, MCOLN1 contains specific sorting signals that mediate its transport to lysosomes [24–26]. These sorting signals include ...
The FluidMosaic Model of the Structure of Cell Membranes
... of the bilayer, thereby maximizing hydrophilic interactions. In the case of zwitterionic phospholipids such as phosphatidylcholine, dipole-dipole interactions between ion pairs at the surface of the bilayer may also contribute to the stabilization of the bilayer structure. In applying these -thermod ...
... of the bilayer, thereby maximizing hydrophilic interactions. In the case of zwitterionic phospholipids such as phosphatidylcholine, dipole-dipole interactions between ion pairs at the surface of the bilayer may also contribute to the stabilization of the bilayer structure. In applying these -thermod ...
Mating behavior, male sensory cilia, and polycystins
... response to mates, and location of vulva behaviors (see Lints review). The 21 male-specific neurons that express polycystins are: the four CEM neurons in the head, with ciliated sensory endings in the nose; the ray B-type neurons (RnBs, where n = 1–9 excluding 6) in the tail, with ciliated sensory en ...
... response to mates, and location of vulva behaviors (see Lints review). The 21 male-specific neurons that express polycystins are: the four CEM neurons in the head, with ciliated sensory endings in the nose; the ray B-type neurons (RnBs, where n = 1–9 excluding 6) in the tail, with ciliated sensory en ...
Muscarinic Activation of a Cation Current and Associated Current
... current noise in entorhinal-cortex layer-II neurons. J Neurophysiol 88: 1197–1211, 2002; 10.1152/jn.00032.2002. The effects of muscarinic stimulation on the membrane potential and current of in situ rat entorhinal-cortex layer-II principal neurons were analyzed using the whole cell, patch-clamp tech ...
... current noise in entorhinal-cortex layer-II neurons. J Neurophysiol 88: 1197–1211, 2002; 10.1152/jn.00032.2002. The effects of muscarinic stimulation on the membrane potential and current of in situ rat entorhinal-cortex layer-II principal neurons were analyzed using the whole cell, patch-clamp tech ...
Ca2+ signalling and control of guard-cell volume in stomatal
... explorations of the signal cascades that link guard-cell membrane transport to stomatal control. Of these, the signalling mechanisms evoked by the water-stress hormone abscisic acid (ABA) have received the greatest attention and, in the past four years, have yielded some of the most exciting new fin ...
... explorations of the signal cascades that link guard-cell membrane transport to stomatal control. Of these, the signalling mechanisms evoked by the water-stress hormone abscisic acid (ABA) have received the greatest attention and, in the past four years, have yielded some of the most exciting new fin ...
Mechanosensitive channels
Mechanosensitive channels or mechanosensitive ion channels are membrane proteins capable of responding to mechanical stress over a wide dynamic range of external mechanical stimuli. They are found in prokaryotes and eukaryotes. The channels vary in selectivity for the permeating ions from nonselective between anions and cations in bacteria, to cation selective allowing passage Ca2+, K+ and Na+ in eukaryotes, and highly selective K+ channels in bacteria and eukaryotes.All organisms, and apparently all cell types, sense and respond to mechanical stimuli. MSCs function as mechanotransducers capable of generating both electrical and ion flux signals as a response to external or internal stimuli. Under extreme turgor in bacteria, non selective MSCs such as MSCL and MSCS serve as safety valves to prevent lysis. In specialized cells of the higher organisms, other types of MSCs are probably the basis of the senses of hearing and touch and sense the stress needed for muscular coordination. However, none of these channels have been cloned. MSCs also allow plants to distinguish up from down by sensing the force of gravity. MSCs are not pressure-sensitive, but sensitive to local stress, most likely tension in the surrounding lipid bilayer.