The role of different monocyte subsets and macrophages in asthma
... monocyte-dependent immune responses Given the predominant involvement of CD16-positive monocytes in the pathogenesis of asthma, it is tempting to hypothesize that targeting these particular cell subsets could be of potential ...
... monocyte-dependent immune responses Given the predominant involvement of CD16-positive monocytes in the pathogenesis of asthma, it is tempting to hypothesize that targeting these particular cell subsets could be of potential ...
Cancer Immunotherapy - Society for Immunotherapy of Cancer
... Disclaimer: Information presented in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy is not intended as a substitute for the advice given by your health care provider. The opinions expressed in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy are those of the autho ...
... Disclaimer: Information presented in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy is not intended as a substitute for the advice given by your health care provider. The opinions expressed in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy are those of the autho ...
Immunology and Immunopathogenesis of Malaria
... thorough understanding of the mechanisms and antigens recognized at both these stages, and the differentiation of immunity to disease and infection, will be important for the construction of an effective vaccine. For each stage of the infection there are several potential targets of the protective i ...
... thorough understanding of the mechanisms and antigens recognized at both these stages, and the differentiation of immunity to disease and infection, will be important for the construction of an effective vaccine. For each stage of the infection there are several potential targets of the protective i ...
Cervarix-H-C-721-P46-0088: EPAR - EMA
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
UNIVERSIDAD DE MURCIA FACULTAD DE VETERINARIA In vivo
... against PRRSV infection in the swine target cells and organs, paying special atention to the PRRSV ability to modulate the IIR and in consequence the AIR. First. Considering the central importance of MØ for PRRS pathogenesis and the role of IFNs and cytokines in regulating MØ functions, we hypothesi ...
... against PRRSV infection in the swine target cells and organs, paying special atention to the PRRSV ability to modulate the IIR and in consequence the AIR. First. Considering the central importance of MØ for PRRS pathogenesis and the role of IFNs and cytokines in regulating MØ functions, we hypothesi ...
Platelets (thrombocytes) – the other recognized functions A - CEON-a
... the mechanism of regulation of vascular development. Researches have shown that platelets are responsible for the separation of blood and lymph vessels by activating CLE-2 receptor via Podoplanin ligand (PDPN), which is located on the lymphatic endothelial cells (LECs). PDPN and CLEC-2 are both tran ...
... the mechanism of regulation of vascular development. Researches have shown that platelets are responsible for the separation of blood and lymph vessels by activating CLE-2 receptor via Podoplanin ligand (PDPN), which is located on the lymphatic endothelial cells (LECs). PDPN and CLEC-2 are both tran ...
Principal Investigator/Program Director (Last, First, Middle): Halonen
... Major Goal: To investigate the mechanism of IFNγ inhibition of Toxoplasma gondii in astrocytes. IFNγ Immune Effector Mechanisms in Cerebral Toxoplasmosis P.I.: Sandra K. Halonen Agency: National Institute of Allergy & Infectious Disease Type: R21 AI64652-01 Funding Period: 3/14/05- 3/14/08 Major Goa ...
... Major Goal: To investigate the mechanism of IFNγ inhibition of Toxoplasma gondii in astrocytes. IFNγ Immune Effector Mechanisms in Cerebral Toxoplasmosis P.I.: Sandra K. Halonen Agency: National Institute of Allergy & Infectious Disease Type: R21 AI64652-01 Funding Period: 3/14/05- 3/14/08 Major Goa ...
Psoriasis - New England Journal of Medicine
... understanding of molecular immune mechanisms can be translated into innovative therapies. Although many factors that contribute to the generation of psoriatic lesions remain obscure, compelling circumstantial and experimental evidence suggests a primary T-lymphocyte–based immunopathogenesis (Fig. 3) ...
... understanding of molecular immune mechanisms can be translated into innovative therapies. Although many factors that contribute to the generation of psoriatic lesions remain obscure, compelling circumstantial and experimental evidence suggests a primary T-lymphocyte–based immunopathogenesis (Fig. 3) ...
Macrophages and Dendritic Cells Entry Is Required for the Function
... of the CRAC channel (2–4). Opening of ORAI1 results in storeoperated Ca2+ entry (SOCE), thus called because this form of Ca2+ influx is regulated by the ER Ca2+ concentrations (5). SOCE has been demonstrated not only in T cells but also in many other types of immune cells, including B cells, mast ce ...
... of the CRAC channel (2–4). Opening of ORAI1 results in storeoperated Ca2+ entry (SOCE), thus called because this form of Ca2+ influx is regulated by the ER Ca2+ concentrations (5). SOCE has been demonstrated not only in T cells but also in many other types of immune cells, including B cells, mast ce ...
FONGAnti-inflammatoryRole2010
... expressing IKKβ dominant negative rescued the inhibitory effect of TNFα on IL12p40 production, indicating TNFα inhibits IL-12p40 via IKKβ activation. Macrophages are antigen presenting cells while IL-12 and MHC II are critical factors for TH1 cell development. I thus investigate the inhibitory effec ...
... expressing IKKβ dominant negative rescued the inhibitory effect of TNFα on IL12p40 production, indicating TNFα inhibits IL-12p40 via IKKβ activation. Macrophages are antigen presenting cells while IL-12 and MHC II are critical factors for TH1 cell development. I thus investigate the inhibitory effec ...
Testing the Effect of Changing Heat Shock Protein 90:
... peptides are detected by circulating immune system cells called APCs (antigen-presenting cells). The Hsp complexes bind the CD91 receptor on the APC cell surface. The APC can then take in the Hsp complexes, and then they travel to the lymph nodes. ...
... peptides are detected by circulating immune system cells called APCs (antigen-presenting cells). The Hsp complexes bind the CD91 receptor on the APC cell surface. The APC can then take in the Hsp complexes, and then they travel to the lymph nodes. ...
The function of tumour necrosis factor and receptors in models of
... at a site of immunological injury may lead to chronic activation of innate immune cells and to chronic inflammatory responses, which may consequently lead to organ specific inflammatory pathology and tissue damage. However, more cryptic functions of this molecule may be considered to play a signific ...
... at a site of immunological injury may lead to chronic activation of innate immune cells and to chronic inflammatory responses, which may consequently lead to organ specific inflammatory pathology and tissue damage. However, more cryptic functions of this molecule may be considered to play a signific ...
International Society for Biological Therapy of Cancer 24th Annual
... transposon/transposase system as a facile approach to genetically modifying T cells, derived from peripheral, neonatal blood, to introduce 1 or more CARs as well as other immunomodulatory imaging transgenes. When SB transposition of T cells is combined with their selected propagation on artificial an ...
... transposon/transposase system as a facile approach to genetically modifying T cells, derived from peripheral, neonatal blood, to introduce 1 or more CARs as well as other immunomodulatory imaging transgenes. When SB transposition of T cells is combined with their selected propagation on artificial an ...
The Pathogenesis of Rheumatoid Arthritis
... to have limited functional capability.36 This imbalance between Th17 and regulatory T cells may also reflect local TNF-α, which blocks the activity of regulatory T cells.37 An additional pathogen ic pathway comprises antigen-nonspecific, T-cell contact–mediated activation of macrophages and fibrobl ...
... to have limited functional capability.36 This imbalance between Th17 and regulatory T cells may also reflect local TNF-α, which blocks the activity of regulatory T cells.37 An additional pathogen ic pathway comprises antigen-nonspecific, T-cell contact–mediated activation of macrophages and fibrobl ...
Research Resources: Comparative MMM icroRNA
... (miRNA), has received wide-spread attention in ovarian granulosa cells during folliculogenesis [11–13]. miRNAs are endogenous non-coding RNAs. They average 21 nucleotides in size and function in the regulation of mRNA metabolism mainly via direct base-pairing interactions at the post-transcriptional ...
... (miRNA), has received wide-spread attention in ovarian granulosa cells during folliculogenesis [11–13]. miRNAs are endogenous non-coding RNAs. They average 21 nucleotides in size and function in the regulation of mRNA metabolism mainly via direct base-pairing interactions at the post-transcriptional ...
PDF - University of California, San Francisco
... We present and evaluate a model for the secondary structure and membrane orientation of 3-hydroxy-3methylglutaryl coenzyme A reductase, the glycoprotein of the endoplasmic reticulum that controls the rate of cholesterol biosynthesis. This model is derived from proteolysis experiments that separate t ...
... We present and evaluate a model for the secondary structure and membrane orientation of 3-hydroxy-3methylglutaryl coenzyme A reductase, the glycoprotein of the endoplasmic reticulum that controls the rate of cholesterol biosynthesis. This model is derived from proteolysis experiments that separate t ...
Microbe-induced apoptosis in phagocytic cells and its role in innate immunity Robert Blomgran
... phagocytes of the innate immune system, are highly equipped effectors that can sense, locate, ingest and kill bacterial pathogens. Inflammatory mediators and the presence of bacterial products at the foci of infection regulate the function and life span of these cells. Modulation of neutrophil apopt ...
... phagocytes of the innate immune system, are highly equipped effectors that can sense, locate, ingest and kill bacterial pathogens. Inflammatory mediators and the presence of bacterial products at the foci of infection regulate the function and life span of these cells. Modulation of neutrophil apopt ...
Complement-targeted therapeutics
... than merely a simple protection mechanism against microbial infections. As an essential connection between adaptive and innate immunity, complement components are able to orchestrate immune reactions by communicating with multiple immune cells (Fig. 1). In addition, complement contributes to the mai ...
... than merely a simple protection mechanism against microbial infections. As an essential connection between adaptive and innate immunity, complement components are able to orchestrate immune reactions by communicating with multiple immune cells (Fig. 1). In addition, complement contributes to the mai ...
University of Birmingham Antibody response to vaccination and
... Measurement of antibody response to specific antigen challenge in vivo provides a model for studying integrated immune responses. Stress may alter both quantity and quality of antigen-specific antibody present at different times after immunisation by modulating a variety of processes within the immu ...
... Measurement of antibody response to specific antigen challenge in vivo provides a model for studying integrated immune responses. Stress may alter both quantity and quality of antigen-specific antibody present at different times after immunisation by modulating a variety of processes within the immu ...
Cord Blood Transplantation: from the basics to what`s new
... • Reported incidences vary widely: • 10-20% to 89% after ablative single and double CBT • ~12% to 40% after reduced intensity CBT ...
... • Reported incidences vary widely: • 10-20% to 89% after ablative single and double CBT • ~12% to 40% after reduced intensity CBT ...
Read More - D5Pharma
... mechanisms to local injury but can also cause acute and chronic tissue damage.11,12 Despite advances in antibody and protein engineering, the major drawbacks of protein-based TNFα inhibitors are their immunogenicity arising from their chronic use and their production costs resulting in expensive the ...
... mechanisms to local injury but can also cause acute and chronic tissue damage.11,12 Despite advances in antibody and protein engineering, the major drawbacks of protein-based TNFα inhibitors are their immunogenicity arising from their chronic use and their production costs resulting in expensive the ...
Heat Shock Proteins-an
... cell killing and the biological significance of the released HSP have been difficult to prove. However, Melcher and co-workers demonstrated that non-apoptotic cell killing induces increased levels of HSP concomitant with enhanced immunogenicity, whereas cells killed predominantly by apoptosis showed ...
... cell killing and the biological significance of the released HSP have been difficult to prove. However, Melcher and co-workers demonstrated that non-apoptotic cell killing induces increased levels of HSP concomitant with enhanced immunogenicity, whereas cells killed predominantly by apoptosis showed ...
An Introduction to Lipid Rafts
... Relation between caveolae and lipid rafts In comparison with classical lipid rafts which are short of structural protein components, liquid-ordered domains may have a specific structural protein component, which tends to alter the features of lipid rafts in both appearance and function. In particul ...
... Relation between caveolae and lipid rafts In comparison with classical lipid rafts which are short of structural protein components, liquid-ordered domains may have a specific structural protein component, which tends to alter the features of lipid rafts in both appearance and function. In particul ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.