Monocytes high Differentiation of Ly-6C from the CCR2
... anisms responsible for the accumulation of these cells within inflamed lungs are not well understood; knowledge of these mechanisms might result in novel therapies designed to increase (or diminish) lung DC numbers for the treatment of pulmonary disease. We previously demonstrated that CCR2 mediates ...
... anisms responsible for the accumulation of these cells within inflamed lungs are not well understood; knowledge of these mechanisms might result in novel therapies designed to increase (or diminish) lung DC numbers for the treatment of pulmonary disease. We previously demonstrated that CCR2 mediates ...
Cancer Vaccine Therapies: Failures and Future Opportunities
... Pharmaceuticals, Rituxan® is a chimeric monoclonal antibody against the protein CD20 that is currently approved for the treatment of chronic lymphocytic leukemia (CLL), non-Hodgkin’s Lymphoma (NHL), and rheumatoid arthritis (RA) 3. After reporting its first year of profitability in 1998, shares of I ...
... Pharmaceuticals, Rituxan® is a chimeric monoclonal antibody against the protein CD20 that is currently approved for the treatment of chronic lymphocytic leukemia (CLL), non-Hodgkin’s Lymphoma (NHL), and rheumatoid arthritis (RA) 3. After reporting its first year of profitability in 1998, shares of I ...
Understanding Host-Pathogen Interactions in Chronic CNS Infection
... Journal of Parasitology Research with the potential for intense immunopathology. While most subclinical infections of Toxoplasma demonstrate this balance, it should be noted that the interplay between various host and parasite genotypes allows for considerable variation in observed immune response ...
... Journal of Parasitology Research with the potential for intense immunopathology. While most subclinical infections of Toxoplasma demonstrate this balance, it should be noted that the interplay between various host and parasite genotypes allows for considerable variation in observed immune response ...
Mucosal immune response in common carp (Cyprinus carpio L
... defence system. Among them, β-glucans, naturally occurring polysaccharides found in the cell wall of plants, bacteria and fungi, are some of the most powerful and extensively investigated immune modulants. β-glucans have been proven to enhance the immune system and pharmacologically they are classif ...
... defence system. Among them, β-glucans, naturally occurring polysaccharides found in the cell wall of plants, bacteria and fungi, are some of the most powerful and extensively investigated immune modulants. β-glucans have been proven to enhance the immune system and pharmacologically they are classif ...
IL-17/IL-17 receptor system in autoimmune disease
... subsets of IL-17-producing cells that arise independently of IL-6, including iNKT cells, γ δ T-cells, LTi-like cells (lymphoid-tissue inducer-like cell) and NK-like cells [11]. Another important transcriptional regulator that regulates innate IL-17-producing cells is AHR. It has been suggested that ...
... subsets of IL-17-producing cells that arise independently of IL-6, including iNKT cells, γ δ T-cells, LTi-like cells (lymphoid-tissue inducer-like cell) and NK-like cells [11]. Another important transcriptional regulator that regulates innate IL-17-producing cells is AHR. It has been suggested that ...
Slide 1
... gene translocation which results in an over expressed gene called BCL-2, which blocks apoptosis. ...
... gene translocation which results in an over expressed gene called BCL-2, which blocks apoptosis. ...
Rhesus macaque and mouse models for down
... replicated in CHMI model where irradiated Plasmodium falciparum sporozoite vaccine elicited protection was also characterized by induction of CD8+ T cell responses [3, 24, 25]. The rhesus model has not only predicted the success but also the failure of many experimental malaria vaccines. Formulation ...
... replicated in CHMI model where irradiated Plasmodium falciparum sporozoite vaccine elicited protection was also characterized by induction of CD8+ T cell responses [3, 24, 25]. The rhesus model has not only predicted the success but also the failure of many experimental malaria vaccines. Formulation ...
View PDF - Cardiovascular Research
... pressure maintenance, as well as the role of IL-17 in hypertension and hypertensive auto-immune diseases, we examined the direct, acute endothelial and vascular effects as well as chronic in vivo effects of IL-17 on eNOS phosphorylation, NO production, endothelial function, and blood pressure. Resul ...
... pressure maintenance, as well as the role of IL-17 in hypertension and hypertensive auto-immune diseases, we examined the direct, acute endothelial and vascular effects as well as chronic in vivo effects of IL-17 on eNOS phosphorylation, NO production, endothelial function, and blood pressure. Resul ...
Adverse Transfusion Reactions
... Once the virus is introduced into the body, the immune system will become activated So are viruses the only thing that can activate an immune response? No, bacteria, chemicals, even food (i.e. fish or peanuts) can do this. Any particle that causes an immune response is referred to as an antigen. Whe ...
... Once the virus is introduced into the body, the immune system will become activated So are viruses the only thing that can activate an immune response? No, bacteria, chemicals, even food (i.e. fish or peanuts) can do this. Any particle that causes an immune response is referred to as an antigen. Whe ...
Full text - Universiteit Leiden
... innate immune system and gradually evolves into a chronic, autoimmune like, inflammatory disease via the adaptive immune system. Therefore, the regulation and crosstalk between innate and adaptive immune cells is very important in the initiation and development of atherosclerosis. Although several e ...
... innate immune system and gradually evolves into a chronic, autoimmune like, inflammatory disease via the adaptive immune system. Therefore, the regulation and crosstalk between innate and adaptive immune cells is very important in the initiation and development of atherosclerosis. Although several e ...
Neuropilin 1 is expressed on thymus-derived natural
... Soyoung Oh,8 Ming O. Li,8 Rachel E. Niec,8,9 Alexander Y. Rudensky,8,9 Michael L. Dustin,1,3 Dan R. Littman,1,3,4 and Juan J. Lafaille1,3 3Department ...
... Soyoung Oh,8 Ming O. Li,8 Rachel E. Niec,8,9 Alexander Y. Rudensky,8,9 Michael L. Dustin,1,3 Dan R. Littman,1,3,4 and Juan J. Lafaille1,3 3Department ...
from um.ac.ir
... been corrected. This study for the first time showed the potential of iPS cells in regenerative medicine. Since the cells are derived from self, there is no requirement for immunosuppression. However, the cells were targeted by NK cells, although they were from “self.” We recently reported that ES c ...
... been corrected. This study for the first time showed the potential of iPS cells in regenerative medicine. Since the cells are derived from self, there is no requirement for immunosuppression. However, the cells were targeted by NK cells, although they were from “self.” We recently reported that ES c ...
Molecular cloning of Per a 1 and definition of the cross
... been published.26 A comparison of the cDNAs, their predicted protein size, GenBank accession numbers, and WHO/IUIS allergen nomenclature is shown in Table I. The nomenclature was developed by considering 1 cDNA as the reference clone. If 2 clones shared 67% or greater amino acid sequence identity, t ...
... been published.26 A comparison of the cDNAs, their predicted protein size, GenBank accession numbers, and WHO/IUIS allergen nomenclature is shown in Table I. The nomenclature was developed by considering 1 cDNA as the reference clone. If 2 clones shared 67% or greater amino acid sequence identity, t ...
View PDF - FEMS Microbiology Reviews
... source, for protection against the environment and for transmission and spreading. In general, parasite virulence and high parasite densities within a host are positively associated with increased transmission (Mackinnon and Read 2004). Excessive virulence rapidly kills the host and results in abrog ...
... source, for protection against the environment and for transmission and spreading. In general, parasite virulence and high parasite densities within a host are positively associated with increased transmission (Mackinnon and Read 2004). Excessive virulence rapidly kills the host and results in abrog ...
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... functions. Thus. in one aspect. the invention is directed to recom ...
... functions. Thus. in one aspect. the invention is directed to recom ...
Recombinant thrombin receptor and related pharmaceuticals
... receptor permits the design of agonist and antagonist com pounds Which are useful diagnostically and therapeutically. The availability of the thrombin receptor also permits pro duction of antibodies speci?cally immunoreactive With the receptor per se or With speci?c regions thereof Which are ...
... receptor permits the design of agonist and antagonist com pounds Which are useful diagnostically and therapeutically. The availability of the thrombin receptor also permits pro duction of antibodies speci?cally immunoreactive With the receptor per se or With speci?c regions thereof Which are ...
Matricellular Protein Cyr61 Bridges Lysophosphatidic Acid and
... identified: LPA1– 6 (12). It has also been shown that LPA binds the nuclear receptor peroxisome proliferator-activated receptor (PPAR␥) and induces PPAR␥-dependent gene expression (13). In the present study, the specific PPAR␥ antagonist and primary SMCs isolated from wild type and LPA receptor knoc ...
... identified: LPA1– 6 (12). It has also been shown that LPA binds the nuclear receptor peroxisome proliferator-activated receptor (PPAR␥) and induces PPAR␥-dependent gene expression (13). In the present study, the specific PPAR␥ antagonist and primary SMCs isolated from wild type and LPA receptor knoc ...
Aryl Hydrocarbon Receptor Control of Adaptive Immunity
... the absence of a ligand is uncertain. Most of the effects of AhR on the immune response apparently involve its activation by one or more ligands. Indeed, the AhR was initially identified as a receptor for dioxins, and much of our understanding on the biology of AhR results from experiments performed ...
... the absence of a ligand is uncertain. Most of the effects of AhR on the immune response apparently involve its activation by one or more ligands. Indeed, the AhR was initially identified as a receptor for dioxins, and much of our understanding on the biology of AhR results from experiments performed ...
The age-dependent expression of the F18 E. coli receptor
... (FUT1M307A/A) showed no HBGA expression (91.7%) and no F18+ E. coli adherence (83.3%). In addition, it was found that F18R expression levels rise with increasing age during the first 3 weeks after birth and that F18R expression is maintained in older pigs (3–23 weeks old). Taken together, these data ...
... (FUT1M307A/A) showed no HBGA expression (91.7%) and no F18+ E. coli adherence (83.3%). In addition, it was found that F18R expression levels rise with increasing age during the first 3 weeks after birth and that F18R expression is maintained in older pigs (3–23 weeks old). Taken together, these data ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.