Vaccines and Autism
... and these conditions may exist prior to both vaccination and the onset of autism. A shift in the age of onset suggests an operative environmental factor. Thousands of parent reports collected during nearly 40 years by the Autism Research Institute demonstrate a reversal in the relative proportions o ...
... and these conditions may exist prior to both vaccination and the onset of autism. A shift in the age of onset suggests an operative environmental factor. Thousands of parent reports collected during nearly 40 years by the Autism Research Institute demonstrate a reversal in the relative proportions o ...
The sucrose-cleaving enzymes of plants are crucial for development
... weight ratios are unchanged, suggesting that sucrose synthase in carrot is a major determinant of plant growth, rather than of sucrose partitioning. In contrast to maize, the product of only one gene (Sus*Dc1) appears to provide the precursors for both starch and cellulose biosynthesis in carrot. It ...
... weight ratios are unchanged, suggesting that sucrose synthase in carrot is a major determinant of plant growth, rather than of sucrose partitioning. In contrast to maize, the product of only one gene (Sus*Dc1) appears to provide the precursors for both starch and cellulose biosynthesis in carrot. It ...
High Level Expression of HLA-A*0203
... High Level Expression of HLA-A*0203-BSP Fusion Protein in Escherichia coli and Construction of Soluble HLA-A*0203 Monomer and Tetramer Loaded with Epstein-Barr Virus Peptide Qiantao Jia1, Lihui Xu2, Qingbing Zha1, Xiaoyun Chi1, Fengyao Li1 and Xianhui He1, 3 Major histocompatibility complex (MHC) te ...
... High Level Expression of HLA-A*0203-BSP Fusion Protein in Escherichia coli and Construction of Soluble HLA-A*0203 Monomer and Tetramer Loaded with Epstein-Barr Virus Peptide Qiantao Jia1, Lihui Xu2, Qingbing Zha1, Xiaoyun Chi1, Fengyao Li1 and Xianhui He1, 3 Major histocompatibility complex (MHC) te ...
Biosensors
... if K[A]>>1, [AR]~{R} (response[AR] is propotional to {R}) if K[A]<<1, [AR]~K{R}[A]~K[R][A], {R}~[R], [AR] does not change with [R]=>saturation. A better approach is to use two wavelengths, one for AR and one for R (reference), and there will be a linear relationship between the ratio of the absorban ...
... if K[A]>>1, [AR]~{R} (response[AR] is propotional to {R}) if K[A]<<1, [AR]~K{R}[A]~K[R][A], {R}~[R], [AR] does not change with [R]=>saturation. A better approach is to use two wavelengths, one for AR and one for R (reference), and there will be a linear relationship between the ratio of the absorban ...
Embrionary way to create a fatty liver in portal hypertension
... We speculate that the induction of intraabdominal fat deposits around the portal venous system could represent ontogenic reminiscences, associated with yolk sac, or phylogenetic reminiscences, related to vitellogenesis[53,54] (Figure 5). Regarding the ontogenic origin, the liver, and in particular t ...
... We speculate that the induction of intraabdominal fat deposits around the portal venous system could represent ontogenic reminiscences, associated with yolk sac, or phylogenetic reminiscences, related to vitellogenesis[53,54] (Figure 5). Regarding the ontogenic origin, the liver, and in particular t ...
Science
... A molecule that treats multiple age-related diseases would have a major impact on global health and economics. The SIRT1 deacetylase has drawn attention in this regard as a target for drug design. Yet controversy exists around the mechanism of sirtuin-activating compounds (STACs). We found that spec ...
... A molecule that treats multiple age-related diseases would have a major impact on global health and economics. The SIRT1 deacetylase has drawn attention in this regard as a target for drug design. Yet controversy exists around the mechanism of sirtuin-activating compounds (STACs). We found that spec ...
Synthesis and Evaluation of Biological Activity of a Potential
... dendritic cells. The lymphoid progenitor cells give rise to T-cells and B-cells. Macrophages and dendritic cells, which play a key role in innate and adaptive immunity, are derived from monocytes. Mast cells, which are fixed in tissues, develop from the same precursor cell as the circulating basophi ...
... dendritic cells. The lymphoid progenitor cells give rise to T-cells and B-cells. Macrophages and dendritic cells, which play a key role in innate and adaptive immunity, are derived from monocytes. Mast cells, which are fixed in tissues, develop from the same precursor cell as the circulating basophi ...
New Zealand Colostrum
... product must all be in accordance with the New Zealand Food Safety Authority (NZFSA) code of practice which regulates the complete process from cow to consumer. All dairy farms and milk production facilities must be certified by MAF which has strict guidelines as to how the colostrum is harvested, t ...
... product must all be in accordance with the New Zealand Food Safety Authority (NZFSA) code of practice which regulates the complete process from cow to consumer. All dairy farms and milk production facilities must be certified by MAF which has strict guidelines as to how the colostrum is harvested, t ...
SERIES "INFECTION: FRIEND OR FOE TO THE DEVELOPMENT OF ASTHMA?"
... ABSTRACT: Conventional risk factors have been unable to explain most of the substantial increase in the prevalence of asthma observed in many countries during the last few decades. Much attention has been directed at the "hygiene hypothesis", the apparent inverse relationship between intense systemi ...
... ABSTRACT: Conventional risk factors have been unable to explain most of the substantial increase in the prevalence of asthma observed in many countries during the last few decades. Much attention has been directed at the "hygiene hypothesis", the apparent inverse relationship between intense systemi ...
RESPIRATORY PROBLEMS AND THEIR MANAGEMENT IN FARM
... alarmed when a cattle has signs and symptoms such as high fever, nasal discharge, wheezing, laboured breathing and poor appetite. The current issue of the newsletter features on the 'Respiratory Problems and Their Management in Farm Animals'. The root cause of any respiratory problem is breakdown of ...
... alarmed when a cattle has signs and symptoms such as high fever, nasal discharge, wheezing, laboured breathing and poor appetite. The current issue of the newsletter features on the 'Respiratory Problems and Their Management in Farm Animals'. The root cause of any respiratory problem is breakdown of ...
dendritic cell-specific ICAM- grabbing non-integrin
... C-type lectins are calcium-dependent carbohydrate-binding proteins with a wide range of biological functions, many of which are related to immunity. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin, where ICAM is intercellular adhesion molecule) is a recently described mannose-specific C- ...
... C-type lectins are calcium-dependent carbohydrate-binding proteins with a wide range of biological functions, many of which are related to immunity. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin, where ICAM is intercellular adhesion molecule) is a recently described mannose-specific C- ...
Identification of Functional Connections Between Calmodulin and the Yeast Actin Cytoskeleton.
... (Johnston et al. 1991; Brockerhoff et al. 1994) and the other is Nuf1p (Geiser et al. 1993; Kilmartin et al. 1993; Stirling et al. 1994). Myo2p is a class V myosin that is involved in polarized growth and functionally implicated in a post-Golgi stage of the secretory pathway (Johnston et al. 1991; G ...
... (Johnston et al. 1991; Brockerhoff et al. 1994) and the other is Nuf1p (Geiser et al. 1993; Kilmartin et al. 1993; Stirling et al. 1994). Myo2p is a class V myosin that is involved in polarized growth and functionally implicated in a post-Golgi stage of the secretory pathway (Johnston et al. 1991; G ...
... Thus, their physicochemical properties resemble that of hymenoptera venom toxins such as melittin or mastoporan [174, 337, 338], the ninth component of complement [339], and perforin 1 from natural killer and cytotoxic T-lymphocytes [340] as well as bacterial streptolysinO and staphylococcal α-toxin ...
evolutionary causes and consequences of
... changes to blood vessels of the brain, which can lead to coma and death during cerebral malaria (Hunt & Grau 2003). In milder malaria, too, as parasites rupture out of the RBCs, the host responds with bursts of TNF-α that lead to fever and malaise. Hosts must therefore balance the need to kill paras ...
... changes to blood vessels of the brain, which can lead to coma and death during cerebral malaria (Hunt & Grau 2003). In milder malaria, too, as parasites rupture out of the RBCs, the host responds with bursts of TNF-α that lead to fever and malaise. Hosts must therefore balance the need to kill paras ...
Intact skin and not stripped skin is crucial for the
... generates moisture and releases the allergen from its support. The allergen is then absorbed by the skin where it interacts with epidermal immune cells [1]. EPIT consists of repeated and prolonged administrations of peanut protein extract on intact skin, allowing to reach the immune system without a ...
... generates moisture and releases the allergen from its support. The allergen is then absorbed by the skin where it interacts with epidermal immune cells [1]. EPIT consists of repeated and prolonged administrations of peanut protein extract on intact skin, allowing to reach the immune system without a ...
Intravital Imaging of the Immune System
... This is of crucial importance for imaging into intact, complex tissues such as the lymph node, where cells and cell interactions may be localized hundreds of micrometers below the tissue surface. Moreover, infrared wavelengths cause minimal phototoxicity, thereby facilitating long-term imaging becau ...
... This is of crucial importance for imaging into intact, complex tissues such as the lymph node, where cells and cell interactions may be localized hundreds of micrometers below the tissue surface. Moreover, infrared wavelengths cause minimal phototoxicity, thereby facilitating long-term imaging becau ...
Immunological Studies in Malignant Melanoma: Importance of TNF and the Thioredoxin System
... The typical melanoma lesion is relatively easy to identify, even macroscopically, as an irregularly growing, pigmented lesion that after a long time (even decades) of inactivity can debut with symptoms such as accelerated growth, itching and bleeding. Pathologists have called malignant melanoma the ...
... The typical melanoma lesion is relatively easy to identify, even macroscopically, as an irregularly growing, pigmented lesion that after a long time (even decades) of inactivity can debut with symptoms such as accelerated growth, itching and bleeding. Pathologists have called malignant melanoma the ...
Phagocytosis: a repertoire of receptors and Ca as a key second
... molecules attach to the phagocytic target by recognizing specific surface epitopes [14]. C3b- or iC3b-opsonized particles are recognized by CRs (complement receptors) members of the integrin superfamily, whereas IgG-opsonized particles engage FcγRs [15]. In any case, receptor engagement leads to int ...
... molecules attach to the phagocytic target by recognizing specific surface epitopes [14]. C3b- or iC3b-opsonized particles are recognized by CRs (complement receptors) members of the integrin superfamily, whereas IgG-opsonized particles engage FcγRs [15]. In any case, receptor engagement leads to int ...
Cancer Immunotherapy - Society for Immunotherapy of Cancer
... Disclaimer: Information presented in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy is not intended as a substitute for the advice given by your health care provider. The opinions expressed in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy are those of the autho ...
... Disclaimer: Information presented in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy is not intended as a substitute for the advice given by your health care provider. The opinions expressed in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy are those of the autho ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.