Genetic analysis of innate immunity in resistance to
... cellular forms, including yeasts or blastospores, pseudohyphae, and hyphae. The dimorphic switch from yeast to hypha is thought to be one of the principal virulence mechanisms used by C. albicans to elude the host immune system during the switch from commensal to pathogen.6 Mutant strains of C. albi ...
... cellular forms, including yeasts or blastospores, pseudohyphae, and hyphae. The dimorphic switch from yeast to hypha is thought to be one of the principal virulence mechanisms used by C. albicans to elude the host immune system during the switch from commensal to pathogen.6 Mutant strains of C. albi ...
ANEXO-8 Interleukin-2 activated natural killer cells may hav
... To study the role of Natural Killer (NK) cells in Leishmania infection, peritoneal macrophages from BALB/c mice were infected with Leishmania (Leishmania) amazonensis promastigotes and incubated with interleukin-2 (IL-2)-activated NK (A-NK) cells at different ratios of A-NK cells to infected macroph ...
... To study the role of Natural Killer (NK) cells in Leishmania infection, peritoneal macrophages from BALB/c mice were infected with Leishmania (Leishmania) amazonensis promastigotes and incubated with interleukin-2 (IL-2)-activated NK (A-NK) cells at different ratios of A-NK cells to infected macroph ...
Regulation of 7-Dehydrocholesterol Reductase by Vitamin D3
... Regulation of 7-Dehydrocholesterol Reductase by Vitamin D3 7-Dehydrocholesterol (7-DHC) is the substrate of 7-dehydrocholesterol reductase (DHCR7) in the cholesterol synthesis pathway. Keratinocytes in human skin possess the enzymes necessary for cholesterol synthesis but are also responsible for vi ...
... Regulation of 7-Dehydrocholesterol Reductase by Vitamin D3 7-Dehydrocholesterol (7-DHC) is the substrate of 7-dehydrocholesterol reductase (DHCR7) in the cholesterol synthesis pathway. Keratinocytes in human skin possess the enzymes necessary for cholesterol synthesis but are also responsible for vi ...
Hannah Akuffo Publications 1990 to 1999
... diagnosis of leishmaniasis in Ethiopia.Trans R Soc Trop Med Hyg. 1992 Mar-Apr;86(2):154-7. 41. Akuffo HO, Britton SF. Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans. Clin Exp Immunol. 1992 Jan;87(1):58-64. 42. Maasho K, Akuffo HO. Cells from healthy ...
... diagnosis of leishmaniasis in Ethiopia.Trans R Soc Trop Med Hyg. 1992 Mar-Apr;86(2):154-7. 41. Akuffo HO, Britton SF. Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans. Clin Exp Immunol. 1992 Jan;87(1):58-64. 42. Maasho K, Akuffo HO. Cells from healthy ...
How is the STAT3 pathway activated?
... Summary STAT3 is a cytokine and growth factor activated transcription factor STAT3 has a wide range of functions, both anti and pro inflammatory depending on the tissue and physiological context STAT3 is also involved in disease states, such as asthma, colitis, and cancer STAT3 can suppress an ...
... Summary STAT3 is a cytokine and growth factor activated transcription factor STAT3 has a wide range of functions, both anti and pro inflammatory depending on the tissue and physiological context STAT3 is also involved in disease states, such as asthma, colitis, and cancer STAT3 can suppress an ...
Fc lessons from murine mercury-induced autoimmunity. -receptors in systemic autoimmune conditions -
... to the B cells producing them and their immunoglobulin (Ig) class [16]. The relationship between natural and pathogenic autoantibodies is not proven. However, several data show that B cells producing pathogenic autoantibodies do exist in healthy individuals, and a plausible explanation is that expos ...
... to the B cells producing them and their immunoglobulin (Ig) class [16]. The relationship between natural and pathogenic autoantibodies is not proven. However, several data show that B cells producing pathogenic autoantibodies do exist in healthy individuals, and a plausible explanation is that expos ...
Differential switching to IgG and IgA healthy controls
... (B-cell-activating factor of the tumour necrosis factor family) in these follicles, which is a marker of B-cell survival and activation, and has been associated with autoimmune diseases [11, 12]. In addition to B-cells, the presence of oligoclonal CD4-positive T-cells has been demonstrated in the lu ...
... (B-cell-activating factor of the tumour necrosis factor family) in these follicles, which is a marker of B-cell survival and activation, and has been associated with autoimmune diseases [11, 12]. In addition to B-cells, the presence of oligoclonal CD4-positive T-cells has been demonstrated in the lu ...
With Friends Like These: The Complex Role of Neutrophils in the
... expression of key membrane proteins that facilitate rolling through the endothelial monolayer in the blood vessels, thus initiating the process of extravasation to the site of infection (Borregaard et al., 2007; Bordon et al., 2013). This is followed by tertiary granules that are released during mig ...
... expression of key membrane proteins that facilitate rolling through the endothelial monolayer in the blood vessels, thus initiating the process of extravasation to the site of infection (Borregaard et al., 2007; Bordon et al., 2013). This is followed by tertiary granules that are released during mig ...
The Lymphoid System and Immunity
... Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
... Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
Research Plan - Manitoba HIV Research Group Home Page
... infected individuals . HIV-1 resistant women produced IL-2 in response to env peptides and gp120 greater than that produced by unexposed controls or HIV-1 infected individuals, indicating that resistant women have adaptive T cell memory to HIV-1. In further studies, we examined CTL to HIV-1 antigens ...
... infected individuals . HIV-1 resistant women produced IL-2 in response to env peptides and gp120 greater than that produced by unexposed controls or HIV-1 infected individuals, indicating that resistant women have adaptive T cell memory to HIV-1. In further studies, we examined CTL to HIV-1 antigens ...
Combined action of anti-CD4 autoantibodies
... anti-CD4 autoantibodies could mediate CD4+ T cell depletion. The aim of this study is to examine the role of anti-CD4 autoantibodies induced by gp120 HIV-1 in the development of CD4+ lymphocytopenia. The model chosen for study was immunization with purified gp120 protein from HIV, since under the au ...
... anti-CD4 autoantibodies could mediate CD4+ T cell depletion. The aim of this study is to examine the role of anti-CD4 autoantibodies induced by gp120 HIV-1 in the development of CD4+ lymphocytopenia. The model chosen for study was immunization with purified gp120 protein from HIV, since under the au ...
TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation
... interested in whether TRIM proteins also contribute to NOD2 signaling. To search for TRIM proteins that physically interact with human NOD2, we conducted a yeast two-hybrid screen with a panel of human TRIM proteins as bait and NOD2 as prey. This identified interactions of NOD2 with TRIM8, TRIM27, a ...
... interested in whether TRIM proteins also contribute to NOD2 signaling. To search for TRIM proteins that physically interact with human NOD2, we conducted a yeast two-hybrid screen with a panel of human TRIM proteins as bait and NOD2 as prey. This identified interactions of NOD2 with TRIM8, TRIM27, a ...
Document
... The views expressed in this presentation contain information derived from publicly available sources that have not been independently verified. No representation or warranty is made as to the accuracy, completeness or reliability of the information. Any forward looking statements in this presentatio ...
... The views expressed in this presentation contain information derived from publicly available sources that have not been independently verified. No representation or warranty is made as to the accuracy, completeness or reliability of the information. Any forward looking statements in this presentatio ...
Immature Myeloid Cells Promote Tumor Formation Via Non
... cells lacked immune suppressive activity and could not be defined as bona fide MDSC. When CS was combined with the single dose of urethane, it led to the accumulation of immune suppressive cells. The expansion of MDSC followed the onset of lung tumors development. This suggests that MDSC in this mod ...
... cells lacked immune suppressive activity and could not be defined as bona fide MDSC. When CS was combined with the single dose of urethane, it led to the accumulation of immune suppressive cells. The expansion of MDSC followed the onset of lung tumors development. This suggests that MDSC in this mod ...
Parasite resistance and the adaptive significance of sleep The
... and are a measure of immunocompetence [25,26]. White blood cells originate in bone marrow and are derived from the same hematopoietic stem cells that produce red blood cells and platelets [25]. As these latter cells have no direct immunological function, we use them as natural controls to test the s ...
... and are a measure of immunocompetence [25,26]. White blood cells originate in bone marrow and are derived from the same hematopoietic stem cells that produce red blood cells and platelets [25]. As these latter cells have no direct immunological function, we use them as natural controls to test the s ...
Parasite Resistance and the Adaptive Significance of Sleep
... and are a measure of immunocompetence [25,26]. White blood cells originate in bone marrow and are derived from the same hematopoietic stem cells that produce red blood cells and platelets [25]. As these latter cells have no direct immunological function, we use them as natural controls to test the s ...
... and are a measure of immunocompetence [25,26]. White blood cells originate in bone marrow and are derived from the same hematopoietic stem cells that produce red blood cells and platelets [25]. As these latter cells have no direct immunological function, we use them as natural controls to test the s ...
Pathogenesis of pneumonic pasteurellosis: Host
... Various P. haemolytica virulence factors influence the outcome of bacterialhost interactions. The pathogenic roles of several of those factors are documented. Those factors are endotoxin (lipopolysaccharide [LPS]), leukotoxin (LKT), and capsular polysaccharide (CPS). Other potential virulence factor ...
... Various P. haemolytica virulence factors influence the outcome of bacterialhost interactions. The pathogenic roles of several of those factors are documented. Those factors are endotoxin (lipopolysaccharide [LPS]), leukotoxin (LKT), and capsular polysaccharide (CPS). Other potential virulence factor ...
FIST/HIPK3: a Fas/FADD-interacting Serine/Threonine Kinase that
... Figure 1. Structure, expression and enzymatic activity of FIST/HIPK3. (A and B) Predicted aa sequence and structural organization of human and murine FIST/HIPK3. FIST/HIPK3 contains a kinase domain and a PEST sequence, which are linked by a region of ⵑ200 aa that was identified to interact with the ...
... Figure 1. Structure, expression and enzymatic activity of FIST/HIPK3. (A and B) Predicted aa sequence and structural organization of human and murine FIST/HIPK3. FIST/HIPK3 contains a kinase domain and a PEST sequence, which are linked by a region of ⵑ200 aa that was identified to interact with the ...
Mucosal IL-17 immunity in disease 12112012
... T cells are CD4 lymphocytes participating in cell-mediated immunity, and play a critical role in immune-mediated diseases. T cells divide further into subclasses such as Th1, Th2, and Th17 that participate in mucosal immunity responses caused by extracellular pathogens and also play a role in autoim ...
... T cells are CD4 lymphocytes participating in cell-mediated immunity, and play a critical role in immune-mediated diseases. T cells divide further into subclasses such as Th1, Th2, and Th17 that participate in mucosal immunity responses caused by extracellular pathogens and also play a role in autoim ...
A monoclonal antibody against a carbohydrate
... bound to 2→4/2→4Kdo3-BSA and Kdo4-BSA with comparable affinity (Figure 2E and F). Very weak binding was observed with 2→4Kdo2-BSA and 2→8Kdo2-BSA, and 2→8/2→4Kdo3-BSA (Figure 2B–D) only when high concentrations of antibody (>250 ng/mL) and antigen (>50 pmol/mL) were used. No binding to Kdo-BSA was o ...
... bound to 2→4/2→4Kdo3-BSA and Kdo4-BSA with comparable affinity (Figure 2E and F). Very weak binding was observed with 2→4Kdo2-BSA and 2→8Kdo2-BSA, and 2→8/2→4Kdo3-BSA (Figure 2B–D) only when high concentrations of antibody (>250 ng/mL) and antigen (>50 pmol/mL) were used. No binding to Kdo-BSA was o ...
Prolonged suckling period in organic piglet production – Effects on
... The trial was performed from spring 2006 to mid 2007 at the experimental organic farm of the Institute of Organic Farming of the Federal Agricultural Research Centre in Trenthorst, Germany, in accordance with Regulation 2092/91/EEC and the IFOAM Basic Guidelines. A total of 44 sows of the genotype “ ...
... The trial was performed from spring 2006 to mid 2007 at the experimental organic farm of the Institute of Organic Farming of the Federal Agricultural Research Centre in Trenthorst, Germany, in accordance with Regulation 2092/91/EEC and the IFOAM Basic Guidelines. A total of 44 sows of the genotype “ ...
Mammalian Cell Culture: High Throughput Applications of
... The history of cell culture dates back to early twentieth century. However, it was only during the 1940’s and 1950’s that there was a rapid development in the techniques for cell culture. Mammalian cells are cells which are generally part of an organ of an organism, differentiated to perform specifi ...
... The history of cell culture dates back to early twentieth century. However, it was only during the 1940’s and 1950’s that there was a rapid development in the techniques for cell culture. Mammalian cells are cells which are generally part of an organ of an organism, differentiated to perform specifi ...
Scientific Research Summary
... purified human NK cells results in expression of the activation marker CD69 on almost all CD3- CD56+ NK cells. ...
... purified human NK cells results in expression of the activation marker CD69 on almost all CD3- CD56+ NK cells. ...
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... dealing with those stressors while cellular/tissue damage is still localized and of low magnitude, i.e., before triggering the systemic response. Ideally, such a defense mechanism should possess stress-sensoring capability of very high sensitivity, because of the relatively low intensity of the cont ...
... dealing with those stressors while cellular/tissue damage is still localized and of low magnitude, i.e., before triggering the systemic response. Ideally, such a defense mechanism should possess stress-sensoring capability of very high sensitivity, because of the relatively low intensity of the cont ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.