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... 11]. CRP recognizes additional pathogens, including fungi, yeasts, and bacteria, thus promoting phagocytosis and resistance to infection [24]. According to this, CRP transgenic mice are resistant to infection with Streptococcus pneumoniae, displaying longer survival time and lower mortality rate tha ...
... 11]. CRP recognizes additional pathogens, including fungi, yeasts, and bacteria, thus promoting phagocytosis and resistance to infection [24]. According to this, CRP transgenic mice are resistant to infection with Streptococcus pneumoniae, displaying longer survival time and lower mortality rate tha ...
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... and found similar expression levels of the various canonical mesenchymal stem cell markers. However, gene ontology analyses revealed significant differences in the expression of genes related to cell proliferation, angiogenesis, immune responses, growth factor activities, and signal transduction, ...
... and found similar expression levels of the various canonical mesenchymal stem cell markers. However, gene ontology analyses revealed significant differences in the expression of genes related to cell proliferation, angiogenesis, immune responses, growth factor activities, and signal transduction, ...
Transfusion Support Issues in Hematopoietic Stem Cell
... anemia, hemoglobinopathies) is capable of mounting an immune response to transfusions, leading to alloimmunization against platelet antigens, HLAs present on the surface of leukocytes and platelets, or both. Antibodies against HLA contribute to delayed engraftment and graft rejection in some patient ...
... anemia, hemoglobinopathies) is capable of mounting an immune response to transfusions, leading to alloimmunization against platelet antigens, HLAs present on the surface of leukocytes and platelets, or both. Antibodies against HLA contribute to delayed engraftment and graft rejection in some patient ...
Variable expression of immunoreactive surface proteins of
... Despite accumulating data implicating Propionibacterium acnes in a variety of diseases, its precise role in infection remains to be determined. P. acnes antigen-specific CD4+ T cells are present in early inflamed acne lesions and may be involved in the inflammatory response; however, little is known ...
... Despite accumulating data implicating Propionibacterium acnes in a variety of diseases, its precise role in infection remains to be determined. P. acnes antigen-specific CD4+ T cells are present in early inflamed acne lesions and may be involved in the inflammatory response; however, little is known ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... related bone or blood cancer using bone marrow transplants [1]. However during transplantation of adult stem cells, immune system tends to reject the transplant due to lack of compatibility [2].In the last few years, scientists have used the human gene associated with CD59 in xenotransplants (animal ...
... related bone or blood cancer using bone marrow transplants [1]. However during transplantation of adult stem cells, immune system tends to reject the transplant due to lack of compatibility [2].In the last few years, scientists have used the human gene associated with CD59 in xenotransplants (animal ...
- Royal College of Surgeons
... antigen presenting cells to the white cells in the immune system, the T-cells. And it is this presentation which forms the same process as the process by which bacteria and viruses are presented to the immune system. But you will see on the other side of the slide the direct allorecognition, this is ...
... antigen presenting cells to the white cells in the immune system, the T-cells. And it is this presentation which forms the same process as the process by which bacteria and viruses are presented to the immune system. But you will see on the other side of the slide the direct allorecognition, this is ...
colleagues. With regard to the use of statins, in a... Center for Cardiovascular Research, Aalborg Hospital,
... current immunisation guidelines [6]. We believe there is less evidence that mild obesity or being slightly overweight predicts severe respiratory tract infections, particularly where it is not associated with obesity-related comorbidities such as cardiovascular disease or diabetes [1]. We wholeheart ...
... current immunisation guidelines [6]. We believe there is less evidence that mild obesity or being slightly overweight predicts severe respiratory tract infections, particularly where it is not associated with obesity-related comorbidities such as cardiovascular disease or diabetes [1]. We wholeheart ...
Adrenocorticotropic hormone: a molecule for all seasons
... radioimmunoassays in different tissue of various species examined (Table 1). Moreover, in situ hybridization experiments using a bovine ACTH receptor cDNA probe evidenced that M. galloprovincialis immunocytes express an mRNA encoding for a molecule similar to ACTH receptor (Ottaviani et al., 1998). ...
... radioimmunoassays in different tissue of various species examined (Table 1). Moreover, in situ hybridization experiments using a bovine ACTH receptor cDNA probe evidenced that M. galloprovincialis immunocytes express an mRNA encoding for a molecule similar to ACTH receptor (Ottaviani et al., 1998). ...
Immune complex formation in IgA nephropathy
... immune complex formation in IgAN. However, to fully understand the implications of these data, the pathogenic importance of IgA1–IgG immune complexes in IgAN must be clarified. The relative paucity of mesangial IgG staining in most biopsy series of IgAN does raise questions over the pathological rol ...
... immune complex formation in IgAN. However, to fully understand the implications of these data, the pathogenic importance of IgA1–IgG immune complexes in IgAN must be clarified. The relative paucity of mesangial IgG staining in most biopsy series of IgAN does raise questions over the pathological rol ...
Introduction: Biology Today Chapter 1
... Surviving T cells enter the medulla of the thymus—macrophages dispose of the dead and dying T cells in the thymic cortex. Process = a natural prolongation or projection from a part of an organism. (http://wordnetweb.princeton.edu) Apoptosis = normal cellular process involving a genetically programme ...
... Surviving T cells enter the medulla of the thymus—macrophages dispose of the dead and dying T cells in the thymic cortex. Process = a natural prolongation or projection from a part of an organism. (http://wordnetweb.princeton.edu) Apoptosis = normal cellular process involving a genetically programme ...
Review of existing experimental methods for assessing the outcome
... cells, tissues, and organs, which together represent the body’s primary mechanism for preventing diseases that arise through toxins or infection from pathogenic microorganisms’ including bacteria, viruses and fungi (Parham, 2009). To prevent or overcome infection the immune system is therefore requi ...
... cells, tissues, and organs, which together represent the body’s primary mechanism for preventing diseases that arise through toxins or infection from pathogenic microorganisms’ including bacteria, viruses and fungi (Parham, 2009). To prevent or overcome infection the immune system is therefore requi ...
small cell lung cancer
... Lack of access to SCLC biospecimens to identify biomarkers and new therapeutic targets Inefficient clinical trial enrollment processes and data sharing As a result, SCLC patients and their families are still waiting for innovative medical solutions that could dramatically improve and or save the ...
... Lack of access to SCLC biospecimens to identify biomarkers and new therapeutic targets Inefficient clinical trial enrollment processes and data sharing As a result, SCLC patients and their families are still waiting for innovative medical solutions that could dramatically improve and or save the ...
EFFECT OF SHORT TERM USE OF SEDATING AND NON-SEDATING ANTIHISTAMINES... WOUND HEALING AND IMMUNE RESPONSE IN RATS
... the IgG class express their predominant activity during a secondary antibody response. Thus, the appearance of specific IgG antibodies generally corresponds with the maturation of the antibody response, which is switched on upon repeated contact with an antigen. In comparison to antibodies of the Ig ...
... the IgG class express their predominant activity during a secondary antibody response. Thus, the appearance of specific IgG antibodies generally corresponds with the maturation of the antibody response, which is switched on upon repeated contact with an antigen. In comparison to antibodies of the Ig ...
Chapter 12 ppt
... eukaryotic cells in response to viruses and a variety of natural and synthetic stimuli. There are several different interferons commonly used as therapeutics, termed alpha, beta, and gamma. These peptides are used to treat hairy cell leukemia, AIDS-related Kaposi's sarcoma, laryngeal papillomatosis, ...
... eukaryotic cells in response to viruses and a variety of natural and synthetic stimuli. There are several different interferons commonly used as therapeutics, termed alpha, beta, and gamma. These peptides are used to treat hairy cell leukemia, AIDS-related Kaposi's sarcoma, laryngeal papillomatosis, ...
Human T Cell Memory: A Dynamic View
... The introduction of vaccines has had a revolutionary effect on human health and life expectancy over the last 50 years. Despite these huge advances, many basic immunological questions about how long-term immunological memory is maintained remain unanswered. While many successful vaccines act primari ...
... The introduction of vaccines has had a revolutionary effect on human health and life expectancy over the last 50 years. Despite these huge advances, many basic immunological questions about how long-term immunological memory is maintained remain unanswered. While many successful vaccines act primari ...
Doctoral thesis from the Department of Immunology, the Wenner-Gren
... Malaria antigen-induced polarization of T cells into effectors Th1 and/or Th2 cells and their subsequent release of cytokines is known to affect antibody production. This thesis includes studies on early innate responses to the parasite, with a focus on γδT cells, and acquired specific responses in ...
... Malaria antigen-induced polarization of T cells into effectors Th1 and/or Th2 cells and their subsequent release of cytokines is known to affect antibody production. This thesis includes studies on early innate responses to the parasite, with a focus on γδT cells, and acquired specific responses in ...
Cotransplantation of third-party mesenchymal
... Accumulating clinical evidence demonstrates that the number of total nucleated cells in a given UCB unit is the single most important parameter for successful outcome, with low cell numbers frequently resulting in delayed or failed engraftment.4,5 Although ex vivo expansion of cord blood cells has b ...
... Accumulating clinical evidence demonstrates that the number of total nucleated cells in a given UCB unit is the single most important parameter for successful outcome, with low cell numbers frequently resulting in delayed or failed engraftment.4,5 Although ex vivo expansion of cord blood cells has b ...
production and quality control of monoclonal antibodies
... that human recipients are less likely to develop antibodies against them (although antiidiotypic and possibly anti-allotypic antibodies may still be produced) and that human antibodies are likely to have the full range of biological functions, such as those of the Fc region which may be species spec ...
... that human recipients are less likely to develop antibodies against them (although antiidiotypic and possibly anti-allotypic antibodies may still be produced) and that human antibodies are likely to have the full range of biological functions, such as those of the Fc region which may be species spec ...
Challenges and strategies: The immune responses in gene therapy
... derived from viral particles, viral genes, and CpG DNA in plasmid. These potential immunostimulants may play important roles in inducing the host immune responses when foreign genes are transferred into the targeted tissues.1 Generally, viral vectors containing the genes of interest are packaged int ...
... derived from viral particles, viral genes, and CpG DNA in plasmid. These potential immunostimulants may play important roles in inducing the host immune responses when foreign genes are transferred into the targeted tissues.1 Generally, viral vectors containing the genes of interest are packaged int ...
dendritic cell-based tumor vaccination for high
... CTL, cytotoxic T lymphocyte CTLA-4, cytotoxic T lymphocyte-associated antigen-4 DC, dendritic cell DTH, delayed-type hypersensitivity EGFRvIII, epidermal growth factor receptor class III variant EORTC, European Organization for Research and Treatment of Cancer FACS, fluorescence-activated cell sorti ...
... CTL, cytotoxic T lymphocyte CTLA-4, cytotoxic T lymphocyte-associated antigen-4 DC, dendritic cell DTH, delayed-type hypersensitivity EGFRvIII, epidermal growth factor receptor class III variant EORTC, European Organization for Research and Treatment of Cancer FACS, fluorescence-activated cell sorti ...
AH2.5 Parasitism
... White blood cells found mainly in lymph glands Each lymphocyte is part of a clone group of about 1000 identical cells made from a common ancestor cell each ancestral cell is committed to make just one type of receptor protein ...
... White blood cells found mainly in lymph glands Each lymphocyte is part of a clone group of about 1000 identical cells made from a common ancestor cell each ancestral cell is committed to make just one type of receptor protein ...
Poster
... negative (RhD-) mother. The mother’s immune system identifies the RhD protein on the baby’s erythrocytes as foreign, and produces anti-D antibodies which cross the placenta causing destruction of the baby’s red cells. Resulting symptoms range from mild jaundice and anemia to perinatal death. The RhD ...
... negative (RhD-) mother. The mother’s immune system identifies the RhD protein on the baby’s erythrocytes as foreign, and produces anti-D antibodies which cross the placenta causing destruction of the baby’s red cells. Resulting symptoms range from mild jaundice and anemia to perinatal death. The RhD ...
Cancer immunotherapy
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Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.