Lethal influenza infection in the absence of the natural killer cell
... and express little to no surface MHC class I molecules12,33. These two cell lines were used to establish the ‘missing-self’ hypothesis and to demonstrate that NK cells efficiently kill tumors that have lost MHC class I expression12. The in vivo RMA/HeLa ratio was approximately 0.8 in all strains (Fi ...
... and express little to no surface MHC class I molecules12,33. These two cell lines were used to establish the ‘missing-self’ hypothesis and to demonstrate that NK cells efficiently kill tumors that have lost MHC class I expression12. The in vivo RMA/HeLa ratio was approximately 0.8 in all strains (Fi ...
Author`s personal copy
... After introduction of the dengue virus through the bite of an infected Aedes mosquito, local viral duplication is thought to take place in target epidermal dendritic cells that are up to 10 times more permissive to dengue infection than monocytes or macrophages. A C-type lectin expressed by the dend ...
... After introduction of the dengue virus through the bite of an infected Aedes mosquito, local viral duplication is thought to take place in target epidermal dendritic cells that are up to 10 times more permissive to dengue infection than monocytes or macrophages. A C-type lectin expressed by the dend ...
Alterations of cell-mediated immunity following cardiac operations
... Cardiac surgery with cardiopulmonary bypass (CPB) is known to induce an immune response whose nature has been increasingly elucidated during the recent decade. Clinically, patients usually show two to three of the four symptoms, which define the so-called systemic inflammatory response syndrome (SIR ...
... Cardiac surgery with cardiopulmonary bypass (CPB) is known to induce an immune response whose nature has been increasingly elucidated during the recent decade. Clinically, patients usually show two to three of the four symptoms, which define the so-called systemic inflammatory response syndrome (SIR ...
Abstract
... The field of autoimmunity has proven a fertile ground for blood transcriptional studies. Alterations in transcript abundance in the blood of patients reflect the sustained response against self-antigens and, more generally, uncontrolled inflammatory processes. Such diseases often present with recurring ...
... The field of autoimmunity has proven a fertile ground for blood transcriptional studies. Alterations in transcript abundance in the blood of patients reflect the sustained response against self-antigens and, more generally, uncontrolled inflammatory processes. Such diseases often present with recurring ...
Expanding Allergy Treatment in Primary Care
... favorable safety profile Most studies of SLIT have been with single allergens and translation of these studies to treatment with multiple allergens needs to be further studied. Currently no FDA approved formulations in the US (studies to obtain such approval are underway) ...
... favorable safety profile Most studies of SLIT have been with single allergens and translation of these studies to treatment with multiple allergens needs to be further studied. Currently no FDA approved formulations in the US (studies to obtain such approval are underway) ...
Immune memory in CD4+ CD45RA+ T cells
... and CD45RAB (commonly referred to as CD45RA cells) and one that expresses CD45RB and CD45RO (commonly referred to as CD4RO cells), believed to represent naive T cells. After in vitro or in vivo activation, CD45RA+ cells rapidly lose CD45RA and become positive for CD45RO.7,8 In vivo, expression of CD ...
... and CD45RAB (commonly referred to as CD45RA cells) and one that expresses CD45RB and CD45RO (commonly referred to as CD4RO cells), believed to represent naive T cells. After in vitro or in vivo activation, CD45RA+ cells rapidly lose CD45RA and become positive for CD45RO.7,8 In vivo, expression of CD ...
CD8 T cell activation predominate early immune
... in the extra cellular matrix of the artery wall [16]. Oxidized LDL is targeted by both IgM and IgG autoantibodies [17] and as much as 10% of the T cells present in atherosclerotic plaques are specific for antigens formed in oxidized LDL [18]. T cells specific for oxidized LDL are also present in the ...
... in the extra cellular matrix of the artery wall [16]. Oxidized LDL is targeted by both IgM and IgG autoantibodies [17] and as much as 10% of the T cells present in atherosclerotic plaques are specific for antigens formed in oxidized LDL [18]. T cells specific for oxidized LDL are also present in the ...
Immunological and fibrotic mechanisms in Cardiac Allograft
... CAV only affects donor arteries and not recipient arteries. New evidence to support this approach is generated by a retrospective study by Guihaire et al. They show that patients who receive a heartlung transplantation (HLTx) develop significantly less severe CAV compared to HTx patients. The sugges ...
... CAV only affects donor arteries and not recipient arteries. New evidence to support this approach is generated by a retrospective study by Guihaire et al. They show that patients who receive a heartlung transplantation (HLTx) develop significantly less severe CAV compared to HTx patients. The sugges ...
INSTITUT PASTEUR, DI, E. COEFFIER 1
... infection and how the host limits the viral infection, we will be able to find a better way to prevent and treat HCV infection. Project description: The innate immune response against HCV infection has been extensively studied. HCV’s RNA genome contains a Pathogen-Associated Molecular Pattern (PAMP) ...
... infection and how the host limits the viral infection, we will be able to find a better way to prevent and treat HCV infection. Project description: The innate immune response against HCV infection has been extensively studied. HCV’s RNA genome contains a Pathogen-Associated Molecular Pattern (PAMP) ...
The Neuropsychiatry of Hematopoietic Stem Cell Transplantation
... additive contributions from radiotoxicity to vascular (Eissner et al. 1995) and subventricular cells (Tada et al. 1999). Many regimens for HSCT employ total body irradiation (TBI) as preparative treatment. TBI may precipitate both acute and longer-term neuropsychiatric effects. Within 2 days to one ...
... additive contributions from radiotoxicity to vascular (Eissner et al. 1995) and subventricular cells (Tada et al. 1999). Many regimens for HSCT employ total body irradiation (TBI) as preparative treatment. TBI may precipitate both acute and longer-term neuropsychiatric effects. Within 2 days to one ...
List of Publications: As a Corresponding/Senior Author 1. Tumor
... T,Haque E, Ghosh D, Mandal-Ghosh I, Pal S, Laskar S, Chattopadhyay U and Baral RN. Narosa Publishing House Pvt. Ltd, India, 2009, pp 148-152. 3. Suppression of Suppressors: Neem leaf glycoprotein Guided Crosstalk Between Regulatory T cells and T cells/NK Cells/ Macrophages in Cancer. In: “Treatments ...
... T,Haque E, Ghosh D, Mandal-Ghosh I, Pal S, Laskar S, Chattopadhyay U and Baral RN. Narosa Publishing House Pvt. Ltd, India, 2009, pp 148-152. 3. Suppression of Suppressors: Neem leaf glycoprotein Guided Crosstalk Between Regulatory T cells and T cells/NK Cells/ Macrophages in Cancer. In: “Treatments ...
Innate immune responses in hepatitis B virus (HBV
... recognize HBV and induce production of TNF-α, IL-6, IL8 and IL-1β. However, the ability to control viral replication was attributed to IL-6 via NF-κB activation [25]. Another major antiviral cytokine is TNF-α, which was initially shown in HBV chimpanzee model to contribute to the antiviral effects o ...
... recognize HBV and induce production of TNF-α, IL-6, IL8 and IL-1β. However, the ability to control viral replication was attributed to IL-6 via NF-κB activation [25]. Another major antiviral cytokine is TNF-α, which was initially shown in HBV chimpanzee model to contribute to the antiviral effects o ...
17-26
... million deaths annually. It is one of the most common neoplasms in Asia, Africa, and the Mediterranean basin, as well as the leading cause of death due to malignancy in some parts of Asia[2]. Most HCCs develop on the basis of liver cirrhosis, and in China, 15% of the HCC patients die of G1 bleeding ...
... million deaths annually. It is one of the most common neoplasms in Asia, Africa, and the Mediterranean basin, as well as the leading cause of death due to malignancy in some parts of Asia[2]. Most HCCs develop on the basis of liver cirrhosis, and in China, 15% of the HCC patients die of G1 bleeding ...
Dendritic Cells Promote Macrophage Infiltration and
... a-chain CD11c, defining these cells as “triple-positive” (triple+), since they also express the CD11b and F4/80 markers (16,17). However, CD11c is commonly recognized as a marker of DC, which can also express CD11b and F4/ 80 (18,19), raising the possibility that at least a proportion of the obesity- ...
... a-chain CD11c, defining these cells as “triple-positive” (triple+), since they also express the CD11b and F4/80 markers (16,17). However, CD11c is commonly recognized as a marker of DC, which can also express CD11b and F4/ 80 (18,19), raising the possibility that at least a proportion of the obesity- ...
Enteric glia: A new player in inflammatory bowel
... low-incidence areas, such as Asia, further pointing out the urgent need of new pharmacological approaches in the management of these diseases. Usually, therapies for IBD include chronic administration of glucocorticosteroids and sulfasalazine derivatives. However, these drugs are ...
... low-incidence areas, such as Asia, further pointing out the urgent need of new pharmacological approaches in the management of these diseases. Usually, therapies for IBD include chronic administration of glucocorticosteroids and sulfasalazine derivatives. However, these drugs are ...
Asthma, inflammation and anti-inflammatory treatments: Controlling
... release of a broad range of soluble mediators. These soluble mediators are a form of longer range biochemical communication that sends signals to other immune cell types, causing them to respond in ways appropriate to the nature of the invader. This type of cell to cell communication is known as ‘pa ...
... release of a broad range of soluble mediators. These soluble mediators are a form of longer range biochemical communication that sends signals to other immune cell types, causing them to respond in ways appropriate to the nature of the invader. This type of cell to cell communication is known as ‘pa ...
Human endometrial regenerative cells alleviate carbon tetrachloride
... liver diseases are required. Recent development in stem cell-based therapeutic strategies have already garnered extensive attention and been introduced to regenerative medicine for hepatic diseases [3–5]. It has been demonstrated that infused mesenchymal stem cells (MSCs) engrafting in the liver fac ...
... liver diseases are required. Recent development in stem cell-based therapeutic strategies have already garnered extensive attention and been introduced to regenerative medicine for hepatic diseases [3–5]. It has been demonstrated that infused mesenchymal stem cells (MSCs) engrafting in the liver fac ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.