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Autoimmune Destruction of Pancreatic b Cells
... study suggested that a strong humoral response to GAD may actually be associated with less destructive pathology, as indicated by the negative correlation between insulitis and anti-GAD antibody levels. It was found that the initial immune response directed against pancreatic islets in NOD mice is a ...
... study suggested that a strong humoral response to GAD may actually be associated with less destructive pathology, as indicated by the negative correlation between insulitis and anti-GAD antibody levels. It was found that the initial immune response directed against pancreatic islets in NOD mice is a ...
Jenny Walldén Studies of immunological risk factors in type 1 diabetes
... If the innate immune system is bypassed or overwhelmed by the pathogens, the adaptive immune response is required. The adaptive immune response provides a specific response, with an enormous ability to recognize different antigens, and the responsiveness is improved on repeated exposure, providing i ...
... If the innate immune system is bypassed or overwhelmed by the pathogens, the adaptive immune response is required. The adaptive immune response provides a specific response, with an enormous ability to recognize different antigens, and the responsiveness is improved on repeated exposure, providing i ...
Local and systemic autonomic nervous effects
... four to six times higher than that of the liver or lung. Most splenic noradrenergic nerve fibers have vasoconstrictor function and reduce blood flow. Therefore, the high splenic perfusion rate observed under basal conditions and during immune responses is surprising, but it can be explained by our l ...
... four to six times higher than that of the liver or lung. Most splenic noradrenergic nerve fibers have vasoconstrictor function and reduce blood flow. Therefore, the high splenic perfusion rate observed under basal conditions and during immune responses is surprising, but it can be explained by our l ...
Local and systemic autonomic nervous effects on cell migration to
... four to six times higher than that of the liver or lung. Most splenic noradrenergic nerve fibers have vasoconstrictor function and reduce blood flow. Therefore, the high splenic perfusion rate observed under basal conditions and during immune responses is surprising, but it can be explained by our l ...
... four to six times higher than that of the liver or lung. Most splenic noradrenergic nerve fibers have vasoconstrictor function and reduce blood flow. Therefore, the high splenic perfusion rate observed under basal conditions and during immune responses is surprising, but it can be explained by our l ...
Hemocompatibility of medical devices, blood products
... solid materials and measuring C4 depletion. Other validated tests for C-activation in specific Complement components or split products may substitute serum by solid materials (2010). the assays described here. ASTMF2065. Standard Practice Describes procedures for exposing standard lot of C4-defici ...
... solid materials and measuring C4 depletion. Other validated tests for C-activation in specific Complement components or split products may substitute serum by solid materials (2010). the assays described here. ASTMF2065. Standard Practice Describes procedures for exposing standard lot of C4-defici ...
Preliminary evidence that the novel host-derived immunostimulant EP67 can act as a mucosal adjuvant
... Mucosal vaccines composed of killed (bacteria) or inactivated (virus) pathogens (killed/inactivated vaccines) or protective fragments of the pathogen (subunit vaccines) can potentially overcome problems associated with live attenuated vaccines but require the addition of an adjuvant because they are ...
... Mucosal vaccines composed of killed (bacteria) or inactivated (virus) pathogens (killed/inactivated vaccines) or protective fragments of the pathogen (subunit vaccines) can potentially overcome problems associated with live attenuated vaccines but require the addition of an adjuvant because they are ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... , 2012). Recognition of paternal antigens on the surface of syncytiotrophoblast could activate the complement cascade, resulting in death of trophoblastic cells (Thellinet al. , 2000). Complement dependent damage of trophoblasts may promote cell destruction or more likely increased permeability of t ...
... , 2012). Recognition of paternal antigens on the surface of syncytiotrophoblast could activate the complement cascade, resulting in death of trophoblastic cells (Thellinet al. , 2000). Complement dependent damage of trophoblasts may promote cell destruction or more likely increased permeability of t ...
Dr. Bhabagrahi Patri
... mucus production and impaired mucocilliary transport. In early reaction mast cells and cosinophils play an important role like destroying the epithelium, which is then sloughed into the bronchial lumen in the form of Creole bodies. Such damages elicit the production of cytokines leading to further i ...
... mucus production and impaired mucocilliary transport. In early reaction mast cells and cosinophils play an important role like destroying the epithelium, which is then sloughed into the bronchial lumen in the form of Creole bodies. Such damages elicit the production of cytokines leading to further i ...
Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC
... their egress from the ER and targeting to endocytic compartments. In this acidic environment, Ii is dissociated from class II molecules, and peptides derived from proteins traveling the endocytic pathway are loaded in its place. Class II–peptide complexes are then transported to the cell surface, wh ...
... their egress from the ER and targeting to endocytic compartments. In this acidic environment, Ii is dissociated from class II molecules, and peptides derived from proteins traveling the endocytic pathway are loaded in its place. Class II–peptide complexes are then transported to the cell surface, wh ...
PATH 417 Case 3 Week 1: The Body System- Hasrit
... Based on the signs and symptoms presented – lung crackles, decreased breath sounds, chronic cough, sputum production – it is likely that the primary body system that is affected is the respiratory system. Specifically, the lungs, which make up the lower respiratory system, are affected. In this sect ...
... Based on the signs and symptoms presented – lung crackles, decreased breath sounds, chronic cough, sputum production – it is likely that the primary body system that is affected is the respiratory system. Specifically, the lungs, which make up the lower respiratory system, are affected. In this sect ...
Immunotherapy Brings One-Two Punch 2016 - Dana
... multidisciplinary care to patients – as a surgeon, educator, and researcher investigating the causes and treatments of breast cancer. Dr. King joined the Susan F. Smith Center in August 2015 after serving as deputy chief and director of research in the breast service at Memorial Sloan Kettering Canc ...
... multidisciplinary care to patients – as a surgeon, educator, and researcher investigating the causes and treatments of breast cancer. Dr. King joined the Susan F. Smith Center in August 2015 after serving as deputy chief and director of research in the breast service at Memorial Sloan Kettering Canc ...
on Immune Function
... Pulmonary disease, the most common form of active tuberculosis, accounts for about 80% of cases, and clinical manifestations include chronic cough and sometimes hemoptysis, dyspnea, and chest pain. Other constitutional symptoms include fevers, night sweats, and weight loss. Extrapulmonary disease ac ...
... Pulmonary disease, the most common form of active tuberculosis, accounts for about 80% of cases, and clinical manifestations include chronic cough and sometimes hemoptysis, dyspnea, and chest pain. Other constitutional symptoms include fevers, night sweats, and weight loss. Extrapulmonary disease ac ...
Current and novel therapeutics in the treatment of systemic lupus erythematosus
... SLE, especially at the beginning of a flare. They have strong antiinflammatory effects on both acquired and innate immune pathways. They inhibit B- and T-cell responses and effector functions of monocytes and neutrophils through inhibition of nuclear factor kB activity.5 In patients with lupus, gluc ...
... SLE, especially at the beginning of a flare. They have strong antiinflammatory effects on both acquired and innate immune pathways. They inhibit B- and T-cell responses and effector functions of monocytes and neutrophils through inhibition of nuclear factor kB activity.5 In patients with lupus, gluc ...
The Cell Biology of Multi-nucleated Giant Cell Formation
... pathway shares common features with the TLR4 pathway induced by LPS, but in ...
... pathway shares common features with the TLR4 pathway induced by LPS, but in ...
CHAPTER I
... acceptable diagnostic tools. The radiological picture and tuberculin skin test have a low diagnostic yield in children, with the majority of children also being unable to expectorate sputum [18,19,92]. Unlike, HIV un-infected children, the presentation of TB can mimic acute pneumonia in HIV-infecte ...
... acceptable diagnostic tools. The radiological picture and tuberculin skin test have a low diagnostic yield in children, with the majority of children also being unable to expectorate sputum [18,19,92]. Unlike, HIV un-infected children, the presentation of TB can mimic acute pneumonia in HIV-infecte ...
Complex splicing in the human T-cell leukemia virus (HTLV) family
... Figure 3. Functions of the ORF-I proteins (p12 and p8) of HTLV-1. HTLV-1 p12 is translated from a singly spliced mRNA transcribed from ORF I. (1) In the endoplasmic reticulum (ER), p12 binds to and retains the immature form of the IL-2 receptor (IL-2R) γ and β chains and this accumulation in the ER ...
... Figure 3. Functions of the ORF-I proteins (p12 and p8) of HTLV-1. HTLV-1 p12 is translated from a singly spliced mRNA transcribed from ORF I. (1) In the endoplasmic reticulum (ER), p12 binds to and retains the immature form of the IL-2 receptor (IL-2R) γ and β chains and this accumulation in the ER ...
Identification and Characterization of Genes Involved in
... we have conducted a P-element screen to isolate mutations that affect crystal cell development in embryos. Crystal cells, composing only 5% of the total hemocyte population (amounting to ⵑ36 cells in a wild-type embryo), are ideal for a screen of this nature because the total number can be accuratel ...
... we have conducted a P-element screen to isolate mutations that affect crystal cell development in embryos. Crystal cells, composing only 5% of the total hemocyte population (amounting to ⵑ36 cells in a wild-type embryo), are ideal for a screen of this nature because the total number can be accuratel ...
Adhesion Proteins PCOL 582
... Chemokines produced by the antigenpresenting cell (APC) and signals induced by the TCR when it recognizes antigen both act on integrins and lead to their clustering and to conformational changes that increase the affinity of the integrins for their ligands. As a result, the integrins bind with high ...
... Chemokines produced by the antigenpresenting cell (APC) and signals induced by the TCR when it recognizes antigen both act on integrins and lead to their clustering and to conformational changes that increase the affinity of the integrins for their ligands. As a result, the integrins bind with high ...
HIV-specific antibody- dependent cellular cytotoxicity
... an important bridge between the innate and acquired immune systems, wherein antibodies binding to antigen presented on infected cells and recruit natural killer (NK) cells to kill the virus-infected target. The Thai RV 144 Phase III vaccine trial conducted from 2003 to 2009, using 16,000 volunteers, ...
... an important bridge between the innate and acquired immune systems, wherein antibodies binding to antigen presented on infected cells and recruit natural killer (NK) cells to kill the virus-infected target. The Thai RV 144 Phase III vaccine trial conducted from 2003 to 2009, using 16,000 volunteers, ...
The intestinal barrier function and its involvement in digestive disease
... lymphoid aggregates (M-cells) (22). Enterocytes are key elements in the epithelial lining, and are adapted to exert digestive, metabolic, and barrier physical integrity maintenance dunctions. They also play a role in the development of immune activity as they express receptors involved in the innate ...
... lymphoid aggregates (M-cells) (22). Enterocytes are key elements in the epithelial lining, and are adapted to exert digestive, metabolic, and barrier physical integrity maintenance dunctions. They also play a role in the development of immune activity as they express receptors involved in the innate ...
Full Text PDF
... lymphocytes and their malignant transformation. Since its discovery as the first human tumor virus, EBV has been implicated in the development of a wide range of human cancers. The evidence for an association with EBV is the strongest for Burkitt’s lymphoma, NK/T cell lymphoma, nasopharyngeal carcin ...
... lymphocytes and their malignant transformation. Since its discovery as the first human tumor virus, EBV has been implicated in the development of a wide range of human cancers. The evidence for an association with EBV is the strongest for Burkitt’s lymphoma, NK/T cell lymphoma, nasopharyngeal carcin ...
Activators - U of M wiki
... The complement system acts as an auxiliary system in immunity, both on its own and in conjunction with humoral immunity. In its role in innate immunity, it is a primitive surveillance and defense system for microbes, independent of T cells and antibodies. In its role in adaptive immunity, it is ...
... The complement system acts as an auxiliary system in immunity, both on its own and in conjunction with humoral immunity. In its role in innate immunity, it is a primitive surveillance and defense system for microbes, independent of T cells and antibodies. In its role in adaptive immunity, it is ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.