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INDIAN NONI AS A BOON
FOR ASTHMA PATIENTS
A CLINICAL TRAIL ON BRONCHIAL
ASTHMA
DR. BHABAGRAHI PATRI
B.H.M.S., M.D. (HOM)
P.G.D. D&N.M (Utkal University)
Dhabaleswar Homoeo Clinic & Research Centre
Ranihat Canal Road, Cuttack – 753 003, Orissa
INTRODUCTION
Bronchial Asthma has long been recognized as
an important global health problem affecting
almost all age group.
A number of explanations have been proposed
including increased environmental pollution
from motor vehicles, growing industrialization,
reduction on plant life on forest areas, dietary
changes with allergens to cause Bronchial
Asthma.
Now a days it is considered that between 100150 million people around the globe
are suffering from this distress.
Cont..
Worldwide deaths from this condition have
reached over 1,80,000 annually.
Advantageously enough for all these positive
factors, befitting answers could be provided by
Indian Noni.
Observing the positive effects of Indian Noni
on Bronchial Asthma many people are now
taking interest to administer the same in
different types of chronic diseases.
Indian Noni is effective for such chronic
diseases due to its high immuno-modulating
power.
AIMS AND OBJECTIVES
Keeping in view the above facts, a
clinical trial was conducted in my
personal clinic to study the efficacy of
Indian Noni along with Homoeopathic
Medicine. In case of both chronic and
acute exacerbations of Bronchial
Asthma.
WHAT IS ASTHMA
The American Society Committee on 1962 defined Asthma as
“A disease characterized by an increased responsiveness of
the trachea and bronchi to various stimuli and manifested by
widespread narrowing of the arrays that change in severity
either spontaneously or as a result of treatment.
Asthma is characterized by episodic, reversible
Bronchospasm, resulting from an exaggerated
bronchoconstrictor response to various stimuli (Robins).
However Bronchial Asthma is due to a specific antigen
antibody reaction (Type I immune Reaction – IgE mediated)
resulting in the excitation of the Bronchial end organs.
Bronchial hyper responsiveness due to the allergens and the
mediators humoral like histamine and lucotrines cause
following three facts.
Constriction of Bronchial smooth muscles.
Oedema of the mucous membrane.
Collection of mucous on the lumen.
Asthma has traditionally been classified into two basic types
Intrinsic (Non immune
mechanism, caused due to
Extrinsic (intiated by
IgE medicated
Atopic asthma
Ingestion of
aspirin
Occupational asthma
(extrinsic non-atopic)
Pulmonary
infections
Cold
Bronchopulmonary
aspergilloses
Inhealed
irritants
Stress
Exercise
AETIOLOGY
Asthma is a complex disorder involving automatic,
immunologic, infectious, endocrine and psycogenic factor in
varying degrees in different individuals as the causative index.
Predisposing factors such as :

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Heredity
Age – (Pediatric group most affected within 10 years of age)
Sex (Male : Female : : 2 : 1) within 10 year and equal on adults.
Allergens – Food, Inhalants, Bacteria.
Respiratory infections, pharmacologic stimulants, occupational
factors, exercise, climatic factors, low socio-economic status.
Passive smoking
Air pollution
Obesity are responsible for producing Bronchial Asthma.
PATHOPHYSIOLOGY
 A number of causes have been postulated for the increased




airway reactivity of Asthma but basic mechanism remains
unknown.
The most popular hypothesis at present is that of airway
inflammation.
Increased number of mast cell, epithelial cells, neutrophils,
oesinophils and lymphocytes have been found in the
bronchoalveolar lavage fluid of patient with asthma, as have a
variety of mediators.
It is widely believed that the physiologic and clinical features of
asthma derive from an interaction among the resident and
infiltrating inflammatory cells in the airways and the surface
epithelium.
The cells who have to play important roles are mast
cells, eosinophils, macrophages, neutrophils and
lymphocytes.
Cont..
The mediators released are histamine, bradykinin,
leukotriens, platelet activating factors and
prostaglandins they produce an intense, immediate
inflammatory reaction involving bronchoconstriction,
vascular congestion an oedema formation.
The leukotriens may also account for the other
pathophysiologic features of asthma e.g. increased
mucus production and impaired mucocilliary transport.
In early reaction mast cells and cosinophils play an
important role like destroying the epithelium, which is
then sloughed into the bronchial lumen in the form of
Creole bodies. Such damages elicit the production of
cytokines leading to further inflammation.
Cont..
Lymphocytes play a quiet important role in inflammatory
response.
They are present in increasing number in asthmatic
airways and produce cytokines that activate the cell
mediated immunity as well as humoral immune responses.
Cytokines e.g. interleukin (IL2) and interferon (IFN) can
promote the growth and differentiation of B cells and
activation of macrophages respectively.
The cytokine IL4 and IL5 stimulate B-cell growth and
immunoglobulin secretion and IL5 promotes casinophil
proliferation, differentiation and activation by stimulation
of B lymphocytes (Humoral lympho), the antibody
formation against the allergens enhanced which
subsequently reduces the hyper responsiveness of
tracheobronchial tree.
Cont..
Clinical features
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Shortness of breath.
Wheezing
Cough
Pain in abdomen in young children
Profuse Sweat
Symptoms of respiratory allergy.
On Auscultatron, Ronchi and Crepitation in
lungs field was found.
DIAGNOSTIC CRITERIA
Recurrent episodes of wheezing and
cough.
Appearance of allergic state.
On auscultation – Rhonchi +
crepitition + in lung field
LABORATORY
DIAGNOSIS
Blood investigation
D.C., T.L.C., E.S.R. and
radiology of chest,
pulmonary function test.
MATERIAL & METHOD
A clinical study was carried out at Dhabaleswar
Homoeo Clinic and Research Centre, Cuttack,
Orissa for a period of 4 months.
20 cases of Bronchial Asthma were screened out
from the above private clinics for the study.
A uniform schema of case taking was maintained
for level of the patients by one standardized case
taking format which was prepared strictly
according to Homoepathic methods of case taking
with an emphasis to different aspect of Bronchial
Asthma.
Indian Noni was administered to 10 patients along
with Homeopathic medicines and 10 patients were
administered only with Homeopathic medicines.
EVALUATION OF PARAMETERS
For clinical evaluation, preferred
parameters are



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Marked improvement-patient feels
completely well with no recurrences of
Asthmatic attach.
Moderate improvement-patients feels well
with recurrent attack.
No improvement-patient not feeling well.
Dropped out.
OBSERVATION
20 patients of Bronchial Asthma were taken for clinical
study. Indian Noni was administered to 10 patients along
with Homeopathic Medicine and only Homoeopathic
Medicine to other 10 patients.
The results are shown in a tabular manner below.
Group
Marked
improvement
Moderate
improvement
No
improvement
Dropped
out
Total
number
Indian Noni
with
Homoeopathic
Medicine
6
1
1
2
10
Only
Homoeopathic
Medicine
2
4
2
2
10
10
8
6
4
2
0
Marked improved
Moderate
improved
No Improved
Indian Noni with Homoe. Medicine
Dropped out
Total Number
Only Homoe. Medicine
ANALYSIS
‘Morinda Citrifolia’ – a predominant ingredient of Indian Noni
exhibits the following actions which controlled asthmatic attack
quickly.
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It stimulates IL1 and IL4 formation which subsequently helps for
the growth of B lymphocytes (Humoral lymphocytes) which
ultimately responsible for the more antibody formation in blood
against the infiltrating allergens so that reducing the rate of allergic
reactions.
Antibacterial activity : It acts against Bacillus subtilis,
staphylococcus aureas, streptococcus, kilebsiella & pneucoccus by
reducing the further superadded infection of Bronchial tree and long
field.
Anti inflammatory activity : It reduces the airway inflammation by
producing anti-hista minergic factors.
Antiviral Activity : Reduces the superadded infection.
C.N.S. effect : Anti cholinergic effect :
Producing bronchodilatation – Reducing asthmatic attack.
CONCLUSION
A clinical trial was conducted upon 20 patients of Bronchial
Asthma. 10 patients were administered with Homoeopathic
Medicines + Indian Noni and other 10 patients with only
Homoeopathic medicine.
It was observed that more no. of patients i.e., 6 patients of
Group – I exhibit marked improvement in comparison to 2
patients of Group – II i.e., (patients with only Homoeopathic
Medicine).
Again the study reveals that the Homoeopathic Medicines +
Indian Noni gives very quick improvement in acute
exacerbations of Bronchial Asthma. So it may be concluded
from the clinical trial that administration of Homoeopathic
Medicines along with Indian Noni produces better and quick
result than only Homoeopathic Medicines.
Bronchial asthma is usually a chromic disease and attacks
are episodic.
Therefore to study the effect of Indian Nomi on
patients it requires much time.
Cont..
That's why within last 4 months the effect of Indian Nomi in
acute excerbations was well studied and the result was quite
positive, but the recurrence of episodes takes place though
the interval increased to some extent.
In after 2 years of the clinical trial it can be concluded that
whether adult bronchial asthma patients get permanent relief
or not.
The study required more time and more number of patients
to establish the positive effect of Indian Nomi.
May the Almighty shower this External Bliss upon this
product so that it can occupy a better position in the Health
map of the world.
Due to insufficiency of time and less number of cases it
becomes quite difficult to study the effect of Indian Noni
upon adult asthma cases as regards permanent cure.
Sathyprakash Dash, 2+ yrs
S/O – Bishwaranjan Dash,
Mundamala, Choudwar,
Cuttack, Orissa, ( : 9338482947
Srusti Mohapatra, 10 yrs
D/O – Suresh Ch. Mohapatra,
Kapaleswar, Choudwar,
Cuttack, Orissa,
Chandan Rout, 23 yrs
Sikharpur, Upper Sahi,
Cuttack, Orissa
( : 9338483662
Sarita Mishra, 25 yrs
Sankarpur, Cuttack, Orissa
( : 0671- 2334759
Pratap Kr. Dalai , 26 yrs
Baragodia, Jagatpur,
Cuttack, Orissa
( : 9861242919
Mamata Mishra, 39 yrs
Choudwar Girl’s High School,
Choudwar, Cuttack, Orissa
( : 9861390114
Sudhansu Samal, 49 yrs
Rahania, Balichandrapur,
Jajpur, Orissa
( : 9937733566, 9861283839
Parbati Jena , 52 yrs
Qr. No. – 2R-81, Labour Tournment,
Charibatia, Cuttack, Orissa
( : 9861067111
Umesh Ch. Patnaik, 70 yrs
Chauliaganja, Cuttack, Orissa
( : 9861063269