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DR.R.MEHER ALI, M.D.
PROFESSOR OF
CLINICAL PHARMACOLOGY
MADRAS MEDICAL COLLEGE
CHENNAI.
IMPORTANCE OF PLANTS & THEIR PRODUCTS
•
Plants – Major source of drugs
Eg :
Digoxin
Vincristine
Vinblastine
Atropine
DRUG DISCOVERY
 IDENTIFICATION OF NEW DRUGS
 RATIONAL DRUG DESIGN
 CHEMICAL MODIFICATION OF KNOWN COMPOUND
 BIO TECHNOLOGY
 RANDOM SCREENING
ENVIRONMENTAL PHARMACOLOGY
ROLE OF NONI IN ENVIRONMENTAL
PHARMACOLOGY - HIGH SCOPE FOR
FUTURE RESEARCH
ROLE OF NONI IN HEALTH CARE SYSTEM
NONI PLANT
ORGAN
COMPOUNDS
EFFECTS
Fruit and Fruit Juice
Alkaloids
(Xeronine)
Enhances enzyme
activity & protein
structure
Foliage & Cell
suspensions
1.Anthroquinone
(Damnacanthal)
2.Glycosides
Antiseptic &
Antibacterial in GI
Anticancer Effect&
Anti oxidant Effect
Roots
1.Anthroquinones
2. Morindin &
Morindone
Anticancer Effect
Antibacterial Effect
METHODS TO PROVE THE CLAIM
• PROPER STANDARDIZATION
 UV SPECTROSCOPY
 FLUORIMETRY
 NMR
 IR
 MASS SPECTROMETRY
 CHROMATOGRAPHY – HPLC, LCMS & GCMS
FUTURE PLANS
• CONTAINS > 150 CONSTITUTIENTS
• YET TO PROVED EXPERIMENTALLY AND
CLINICALLY
• PROPER STANDARDIZATION