![Jennifer Orthmann-Murphey, M.D., Ph.D., Postdoctoral Fellow](http://s1.studyres.com/store/data/008806776_1-cdb9cbff37ebf109f9896de0460a0e4a-300x300.png)
Jennifer Orthmann-Murphey, M.D., Ph.D., Postdoctoral Fellow
... scanning in people with relapsing-remitting MS using techniques that can look at myelin health and other specific aspects of MS brain lesions. The participants will then be involved in a clinical trial, using these advanced MRI techniques and other measures to see whether a test compound called MRF- ...
... scanning in people with relapsing-remitting MS using techniques that can look at myelin health and other specific aspects of MS brain lesions. The participants will then be involved in a clinical trial, using these advanced MRI techniques and other measures to see whether a test compound called MRF- ...
Lactobacillus paracasei Lpc-37
... Inherent or intrinsic: most, if not all, strains of a certain bacterial species are not normally susceptible to a certain antibiotic. T he antibiotic has no effect on these cells, being unable to kill or inhibit the bacterium. Acquired: most strains of a bacterial species are usually susceptible t ...
... Inherent or intrinsic: most, if not all, strains of a certain bacterial species are not normally susceptible to a certain antibiotic. T he antibiotic has no effect on these cells, being unable to kill or inhibit the bacterium. Acquired: most strains of a bacterial species are usually susceptible t ...
cell Destruction
... CD8, cluster of differentiation 8; FasL, Fas ligand; IFN-g, interferon g; IL-1, interleukin 1; MHC, major histocompatibility complex; NO, nitric oxide; TNF-a, tumor necrosis factor a. Maahs DM, et al. Endocrinol Metab Clin North Am. 2010;39:481-497. ...
... CD8, cluster of differentiation 8; FasL, Fas ligand; IFN-g, interferon g; IL-1, interleukin 1; MHC, major histocompatibility complex; NO, nitric oxide; TNF-a, tumor necrosis factor a. Maahs DM, et al. Endocrinol Metab Clin North Am. 2010;39:481-497. ...
Nerve growth factor levels and localisation in human asthmatic bronchi
... The asthmatics exhibited significantly enhanced NGF levels in BALF. Intense NGFimmunoreactivity was observed in bronchial epithelium, smooth muscle cells and infiltrating inflammatory cells in the submucosa, and to a lesser extent in the connective tissue. The asthmatics exhibited a higher number of ...
... The asthmatics exhibited significantly enhanced NGF levels in BALF. Intense NGFimmunoreactivity was observed in bronchial epithelium, smooth muscle cells and infiltrating inflammatory cells in the submucosa, and to a lesser extent in the connective tissue. The asthmatics exhibited a higher number of ...
Abundance of Early Functional HIV-Specific CD8 T Cells Does Not
... autologous sequence. However, it has been shown that a large proportion of all T cell responses detected using autologous peptides was detected using consensus sequences as well [36]. Although one could argue that different results might have been found if peptide pools derived from other proteins o ...
... autologous sequence. However, it has been shown that a large proportion of all T cell responses detected using autologous peptides was detected using consensus sequences as well [36]. Although one could argue that different results might have been found if peptide pools derived from other proteins o ...
Pathophysiology of Type 1 Diabetes
... CD8, cluster of differentiation 8; FasL, Fas ligand; IFN-g, interferon g; IL-1, interleukin 1; MHC, major histocompatibility complex; NO, nitric oxide; TNF-a, tumor necrosis factor a. Maahs DM, et al. Endocrinol Metab Clin North Am. 2010;39:481-497. ...
... CD8, cluster of differentiation 8; FasL, Fas ligand; IFN-g, interferon g; IL-1, interleukin 1; MHC, major histocompatibility complex; NO, nitric oxide; TNF-a, tumor necrosis factor a. Maahs DM, et al. Endocrinol Metab Clin North Am. 2010;39:481-497. ...
Linking immune defenses and life history at the
... face similar classes of pathogens (for example, viruses, bacteria and macroparasites) and a similar frequency of challenge; these are followed by a discussion of the consequences of relaxing these assumptions. 1. Immunological variation at the population or species scale A hypothetical model relatin ...
... face similar classes of pathogens (for example, viruses, bacteria and macroparasites) and a similar frequency of challenge; these are followed by a discussion of the consequences of relaxing these assumptions. 1. Immunological variation at the population or species scale A hypothetical model relatin ...
Kirvan, et al (2003) Mimicry and Auto-antibody
... memory27, and neurotransmitter synthesis and release28. Antibodymediated activation of CaM kinase II was analyzed to determine whether signal transduction is a potential mechanism of the chorea monoclonal antibodies. Monoclonal antibody 24.3.1 significantly activated CaM kinase II to 76% above the b ...
... memory27, and neurotransmitter synthesis and release28. Antibodymediated activation of CaM kinase II was analyzed to determine whether signal transduction is a potential mechanism of the chorea monoclonal antibodies. Monoclonal antibody 24.3.1 significantly activated CaM kinase II to 76% above the b ...
Distributed By: 864-408-8320 • www.anovahealth.com
... Avinotropin™ is the only all-natural 43:1 extract and the only IGF product that contains a full matrix of growth factors uniquely delivered and processed to allow for maximum absorption and effectiveness. It is the only all-natural proprietary matrix to deliver 100 mcg of IGF-1 per bottle (in additi ...
... Avinotropin™ is the only all-natural 43:1 extract and the only IGF product that contains a full matrix of growth factors uniquely delivered and processed to allow for maximum absorption and effectiveness. It is the only all-natural proprietary matrix to deliver 100 mcg of IGF-1 per bottle (in additi ...
Molecular Biology of the Cell
... The tight junctions between epithelial cell The acidic pH of the stomach The components of the mucus layers that inhibit colonization or even kill pathogenic bacteria. – The normal flora also have a role in protecting body surfaces against invaders by competing for the same ecological niche and ther ...
... The tight junctions between epithelial cell The acidic pH of the stomach The components of the mucus layers that inhibit colonization or even kill pathogenic bacteria. – The normal flora also have a role in protecting body surfaces against invaders by competing for the same ecological niche and ther ...
Exosomes: Looking back three decades and into the future
... it has become clear that exosomes contribute to many aspects of physiology and disease, including intercellular communication. We discuss the initial experiments that led to the discovery of exosomes and highlight some of the exciting current directions in the field. 30 years ago, a paper in JCB (Ha ...
... it has become clear that exosomes contribute to many aspects of physiology and disease, including intercellular communication. We discuss the initial experiments that led to the discovery of exosomes and highlight some of the exciting current directions in the field. 30 years ago, a paper in JCB (Ha ...
The Immunogenicity of a New Human Minor Histocompatibility
... was isolated from BLCLs with a Puregene kit (Gentra Systems). Adjacent intronic sequence required for genomic PCR analysis was obtained from a genomic DNA library constructed by TA cloning (35). Amplifications were performed with the allele-specific forward primers 5⬘-GTCAGCAGATCACCG-3⬘ (HA-8R) and ...
... was isolated from BLCLs with a Puregene kit (Gentra Systems). Adjacent intronic sequence required for genomic PCR analysis was obtained from a genomic DNA library constructed by TA cloning (35). Amplifications were performed with the allele-specific forward primers 5⬘-GTCAGCAGATCACCG-3⬘ (HA-8R) and ...
Chapter 22 PPT. - HCC Learning Web
... system and the immune response. • 22-9 Give examples of interactions between the lymphatic system and other organ systems we have studied so far and explain how the nervous and endocrine systems influence the immune response. ...
... system and the immune response. • 22-9 Give examples of interactions between the lymphatic system and other organ systems we have studied so far and explain how the nervous and endocrine systems influence the immune response. ...
CURRICULUM VITAE - University of Oxford
... and after allergen challenge. We have defined cytokine and lipid mediators that promote ILC2 activation, with therapeutic implications which we are investigating in a current clinical trial. More recently, in collaboration with Professor Cerundolo, we have found that allergens generate neolipids whi ...
... and after allergen challenge. We have defined cytokine and lipid mediators that promote ILC2 activation, with therapeutic implications which we are investigating in a current clinical trial. More recently, in collaboration with Professor Cerundolo, we have found that allergens generate neolipids whi ...
... and a modulatory effect on immune response, as well as antiviral activity [2]. Currently, interferon is divided into three subtypes: α-, β- and γ-interferon [3]. All three subtypes have been synthesized and used clinically against chronic active viral hepatitis [4], malignancies [5], or acquired imm ...
Allergy in the Management of Chronic Rhinosinusitis
... • From Wikipedia: Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affini ...
... • From Wikipedia: Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affini ...
Department of Biochemistry and Molecular Biology Honours/Masters
... Dr David Ascher Most proteins work within a network of interactions with other proteins, and the ability to selectively target specific interactions, modulating protein function and providing the opportunity to develop more selective and effective drugs. But while drugs are usually around 100 Å2, pr ...
... Dr David Ascher Most proteins work within a network of interactions with other proteins, and the ability to selectively target specific interactions, modulating protein function and providing the opportunity to develop more selective and effective drugs. But while drugs are usually around 100 Å2, pr ...
What is the T-cell receptor (TCR)? (abridged
... The αβ version of the TCR was described on the previous page. The αβ type is more common, however another TCR type called γδ can also exist. This type of receptor is made up of gamma (γ) and delta (δ) proteins. These are also composed of subunits, but are different from αβ. The type of TCR that is f ...
... The αβ version of the TCR was described on the previous page. The αβ type is more common, however another TCR type called γδ can also exist. This type of receptor is made up of gamma (γ) and delta (δ) proteins. These are also composed of subunits, but are different from αβ. The type of TCR that is f ...
Chapter 15 The Lymphatic System and Immunity
... bind to its surface antibodies, plus signal chemicals from T ...
... bind to its surface antibodies, plus signal chemicals from T ...
DDT objectives (combined)
... to specific drugs within that class. • Given patient-specific laboratory indicators of impaired liver and/or renal function, recommend dose modification for commonly used chemotherapy agents. • Describe at least three differences between cancerous and normal cells that have been successfully exploit ...
... to specific drugs within that class. • Given patient-specific laboratory indicators of impaired liver and/or renal function, recommend dose modification for commonly used chemotherapy agents. • Describe at least three differences between cancerous and normal cells that have been successfully exploit ...
Lymphocyte Populations Within the Lamina Propria
... In animals, where it is possible to experimentally control the gut flora, remarkable progress has been made on the texture of cytokine responses and their regulation by specific members of the microbiota (Figure 7.2). Germ-free mice monocolonized with the human gut bacterium, Bacteroides fragilis, s ...
... In animals, where it is possible to experimentally control the gut flora, remarkable progress has been made on the texture of cytokine responses and their regulation by specific members of the microbiota (Figure 7.2). Germ-free mice monocolonized with the human gut bacterium, Bacteroides fragilis, s ...
Antibody phage-displayed libraries derived from chicken
... using pooled splenic RNA. The single amino acid-linked scFv repertoire was evaluated as a source of highly specific diagnostic antibodies by panning against each of the five different antigens. After two rounds of panning, polyclonal phage ELISA showed the presence of antigen-specific phage antibodi ...
... using pooled splenic RNA. The single amino acid-linked scFv repertoire was evaluated as a source of highly specific diagnostic antibodies by panning against each of the five different antigens. After two rounds of panning, polyclonal phage ELISA showed the presence of antigen-specific phage antibodi ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.