Suppression of adaptive immunity to heterologous antigens during
... after LPS stimulation (Figure 2e,f), suggesting that the presence of parasites does not result in DC activation. The viability of treated DCs and control cells was quantified after 24 hours of culture by trypan blue exclusion (Figure 2g) and propidium iodide (PI) and annexin V staining (data not sho ...
... after LPS stimulation (Figure 2e,f), suggesting that the presence of parasites does not result in DC activation. The viability of treated DCs and control cells was quantified after 24 hours of culture by trypan blue exclusion (Figure 2g) and propidium iodide (PI) and annexin V staining (data not sho ...
dental stem cells and their potential role in regenrative
... the first commercial tooth bank was established as a venture company at National Hiroshima University in Japan in 2004. By systematic organization, an increasing number of teeth have been cryopreserved for future generative medicine.[40-45] CONCLUSION : Stem cells of dental origin have multiple appl ...
... the first commercial tooth bank was established as a venture company at National Hiroshima University in Japan in 2004. By systematic organization, an increasing number of teeth have been cryopreserved for future generative medicine.[40-45] CONCLUSION : Stem cells of dental origin have multiple appl ...
Positive and negative regulation of Natural Killer cells: Therapeutic
... can be seen with their phenotypic differences. Murine NK cells can be defined as NK1.1+ CD3− or DX5+ CD3− cells. Most NK cells in mice also express asialoGM1, but other cells, including macrophages and activated T cells, are also asialoGM1+ making this marker not NK cell-exclusive [12,13]. Many labo ...
... can be seen with their phenotypic differences. Murine NK cells can be defined as NK1.1+ CD3− or DX5+ CD3− cells. Most NK cells in mice also express asialoGM1, but other cells, including macrophages and activated T cells, are also asialoGM1+ making this marker not NK cell-exclusive [12,13]. Many labo ...
Control of neutrophil inflammation at mucosal surfaces by secreted
... at a high flow rate, and the initial tethering process serves to slow the neutrophil’s movement and allow it to “roll” along the endothelial cell surface in order to sample for other potential signals. This tethering occurs via interaction of lectins and lectin receptors, and in the intestine is med ...
... at a high flow rate, and the initial tethering process serves to slow the neutrophil’s movement and allow it to “roll” along the endothelial cell surface in order to sample for other potential signals. This tethering occurs via interaction of lectins and lectin receptors, and in the intestine is med ...
Maternal Recognition of Pregnancy
... identified growth factors are implicated, but unique systems could also be at play. During implantation, some insight into the proteinases, proteinase inhibitors, and cell adhesive molecules that regulate trophoblast invasion is being realized. There are many species, however, in which access to mat ...
... identified growth factors are implicated, but unique systems could also be at play. During implantation, some insight into the proteinases, proteinase inhibitors, and cell adhesive molecules that regulate trophoblast invasion is being realized. There are many species, however, in which access to mat ...
The human liver contains multiple populations of NK cells, T cells
... The human liver contains significant numbers of T cells, NK cells, and lymphocytes that coexpress T and NK cell receptors. To evaluate their functional activities, we have compared the cytotoxic activities and cytokines produced by normal adult hepatic CD31CD562 (T) cells, CD32CD561 (NK) cells, and ...
... The human liver contains significant numbers of T cells, NK cells, and lymphocytes that coexpress T and NK cell receptors. To evaluate their functional activities, we have compared the cytotoxic activities and cytokines produced by normal adult hepatic CD31CD562 (T) cells, CD32CD561 (NK) cells, and ...
Age and menopause affect the expression of
... has resulted in increased incidence of cancer and autoimmune disorders [3-7]. Importantly, aging is also associated with defects in the immune response to multiple infections [5,8,9]. In fact, aging has been associated with decrease in lymphocyte proliferative responses, reduced delayed type hyperse ...
... has resulted in increased incidence of cancer and autoimmune disorders [3-7]. Importantly, aging is also associated with defects in the immune response to multiple infections [5,8,9]. In fact, aging has been associated with decrease in lymphocyte proliferative responses, reduced delayed type hyperse ...
QuickTime™ and a TIFF (Uncompressed) decompressor QuickTime
... in mice and humans carrying Atg16L1 mutations ...
... in mice and humans carrying Atg16L1 mutations ...
REVIEW Using death to one`s advantage: HIV modulation
... far, the 13 caspases identified differ with regard to the activation stimuli and to their substrate specificity and sensitivity to various inhibitors.34,35 In addition to caspases, other apoptosis-inducing proteases can be activated in response to certain stimuli. One of these proteases, calpain, is ...
... far, the 13 caspases identified differ with regard to the activation stimuli and to their substrate specificity and sensitivity to various inhibitors.34,35 In addition to caspases, other apoptosis-inducing proteases can be activated in response to certain stimuli. One of these proteases, calpain, is ...
Rapamycin specifically interferes with GM-CSF
... is required for the normal development and maintenance of tissue homeostasis.1 It is an active process that is regulated by gene products, which either block or accelerate programmed cell death. In most cells, the apoptotic program is always ready to be executed unless continuously inhibited by extr ...
... is required for the normal development and maintenance of tissue homeostasis.1 It is an active process that is regulated by gene products, which either block or accelerate programmed cell death. In most cells, the apoptotic program is always ready to be executed unless continuously inhibited by extr ...
A. Anemia caused by decreased production of red blood cells
... Sustained stimulation of monocytic-macrophage system because of chronic inflammation, autoimmune diseases or tumors, decrease life of erythrocytes by increasing phagocytosis. During inflammation, iron releasing from macrophages and liver deposits is significantly inhibited. ...
... Sustained stimulation of monocytic-macrophage system because of chronic inflammation, autoimmune diseases or tumors, decrease life of erythrocytes by increasing phagocytosis. During inflammation, iron releasing from macrophages and liver deposits is significantly inhibited. ...
Differential expression of surface membrane Trypanosoma congolense
... antigens on bovine monocytes activated with recombinant cytokines and during Trypanosoma congolense infection . Onderstepoort Journal of Veterinary Research, 67:289-296 The expression of surface membrane antigens on peripheral blood monocytes (PBM) of cattle of the Boran and N'Dama breeds activated ...
... antigens on bovine monocytes activated with recombinant cytokines and during Trypanosoma congolense infection . Onderstepoort Journal of Veterinary Research, 67:289-296 The expression of surface membrane antigens on peripheral blood monocytes (PBM) of cattle of the Boran and N'Dama breeds activated ...
microRNA-155 Regulates the Generation of Immunoglobulin Class
... MicroRNA-155 (miR-155) is expressed by cells of the immune system following activation and has been shown to be required for antibody production following vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymusdependent and independent ...
... MicroRNA-155 (miR-155) is expressed by cells of the immune system following activation and has been shown to be required for antibody production following vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymusdependent and independent ...
R. Mantegazza
... Innate immunity is the first line of defense against infection. The characteristics of the innate immune response include the following: Responses are broad-spectrum (non-specific) There is no memory or lasting protective immunity There is a limited repertoire of recognition molecules The re ...
... Innate immunity is the first line of defense against infection. The characteristics of the innate immune response include the following: Responses are broad-spectrum (non-specific) There is no memory or lasting protective immunity There is a limited repertoire of recognition molecules The re ...
Optimizing Intracellular Flow Cytometry
... Cytokines • Soluble polypeptides produced by most nucleated cells in the body • Some potent producers include endothelial and epithelial cells and resident macrophages, especially near the interface with the external environment • Critical to the development and functioning of both the innate and a ...
... Cytokines • Soluble polypeptides produced by most nucleated cells in the body • Some potent producers include endothelial and epithelial cells and resident macrophages, especially near the interface with the external environment • Critical to the development and functioning of both the innate and a ...
Cocoon Nutrition 864-895-6250
... Avinotropin™ is the only all-natural 43:1 extract and the only IGF product that contains a full matrix of growth factors uniquely delivered and processed to allow for maximum absorption and effectiveness. It is the only all-natural proprietary matrix to deliver 100 mcg of IGF-1 per bottle (in additi ...
... Avinotropin™ is the only all-natural 43:1 extract and the only IGF product that contains a full matrix of growth factors uniquely delivered and processed to allow for maximum absorption and effectiveness. It is the only all-natural proprietary matrix to deliver 100 mcg of IGF-1 per bottle (in additi ...
brain regeneration in physiology and pathology: the immune
... cells (NPCs) residing within the healthy CNS, or surviving injury, are considered crucial in sustaining these processes. Thus a large number of experimental stem cell-based transplantation systems for CNS repair have recently been established. The results suggest that transplanted NPCs promote tissu ...
... cells (NPCs) residing within the healthy CNS, or surviving injury, are considered crucial in sustaining these processes. Thus a large number of experimental stem cell-based transplantation systems for CNS repair have recently been established. The results suggest that transplanted NPCs promote tissu ...
thesis
... intercellular communication. Exosomes are produced and released through the endosomal compartment and reflect the type and the activation state of the cells that produce and secrete them. They carry cytosolic and membranebound proteins and nucleic acids and can influence and re-program recipient cel ...
... intercellular communication. Exosomes are produced and released through the endosomal compartment and reflect the type and the activation state of the cells that produce and secrete them. They carry cytosolic and membranebound proteins and nucleic acids and can influence and re-program recipient cel ...
DoReMi Barometer of publications
... The high doses of radiation received in the wake of the Chernobyl incident and the atomic bombing of Hiroshima and Nagasaki have been linked to the increased appearance of thyroid cancer in the children living in the vicinity of the site. However, the data gathered on the effect of low doses of radi ...
... The high doses of radiation received in the wake of the Chernobyl incident and the atomic bombing of Hiroshima and Nagasaki have been linked to the increased appearance of thyroid cancer in the children living in the vicinity of the site. However, the data gathered on the effect of low doses of radi ...
Adjuvants in the use of allergen immunotherapy Aluminium
... An adjuvant shall not be introduced into a product unless there is satisfactory evidence that it does not affect adversely the safety or potency of the product. As with other ingredients in the final formulation, the adjuvant should be shown to be compatible with all components in the formulation. I ...
... An adjuvant shall not be introduced into a product unless there is satisfactory evidence that it does not affect adversely the safety or potency of the product. As with other ingredients in the final formulation, the adjuvant should be shown to be compatible with all components in the formulation. I ...
Latent viral immune inflammatory response model for chronic
... Latent herpetic viruses have been infecting people for thousands of years [10]. The inflammatory nature of latent herpes zoster and herpes simplex I & II viruses in tissues of the nervous system and in other tissues of the body has been well documented [11–15]. The LVIIR model proposes that inflamma ...
... Latent herpetic viruses have been infecting people for thousands of years [10]. The inflammatory nature of latent herpes zoster and herpes simplex I & II viruses in tissues of the nervous system and in other tissues of the body has been well documented [11–15]. The LVIIR model proposes that inflamma ...
Analysis of the Original Antigenic Sin Antibody Response to the
... activation of naive B cells, because coengagement of the immunoglobulin and Fc receptor on the B cell surface leads to an activation signal in memory B cells but not in naive B cells [12]. Thus, in the presence of anti-hapten antibody, memory B cells are preferentially activated in vivo by a structu ...
... activation of naive B cells, because coengagement of the immunoglobulin and Fc receptor on the B cell surface leads to an activation signal in memory B cells but not in naive B cells [12]. Thus, in the presence of anti-hapten antibody, memory B cells are preferentially activated in vivo by a structu ...
Natural killer cell cytotoxicity: how do they pull the trigger?
... NK cells. Conversely the lack of engagement of these receptors can activate NK cytotoxicity.5–7 In addition, NK cells recognize other signals associated with aberrant cells. Viral infection and malignant transformation of cells can induce the expression of the MHC class I chain-related (MIC) molecul ...
... NK cells. Conversely the lack of engagement of these receptors can activate NK cytotoxicity.5–7 In addition, NK cells recognize other signals associated with aberrant cells. Viral infection and malignant transformation of cells can induce the expression of the MHC class I chain-related (MIC) molecul ...
estrogen receptors in human thyroid gland
... DISCUSSION It is generally accepted that for a steroid hormone to have a direct effect on target organs, presence of a specific, high affinity intracellular receptor is an absolute prerequisite. 16 This concept is further substantiated by the findings that abundant amount of ER is present in target ...
... DISCUSSION It is generally accepted that for a steroid hormone to have a direct effect on target organs, presence of a specific, high affinity intracellular receptor is an absolute prerequisite. 16 This concept is further substantiated by the findings that abundant amount of ER is present in target ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.